Experts and Doctors on intracellular signaling peptides and proteins in Oxford, England, United Kingdom


Locale: Oxford, England, United Kingdom
Topic: intracellular signaling peptides and proteins

Top Publications

  1. Cash J, Christian A, Greaves D. Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner. J Immunol. 2010;184:5315-24 pubmed publisher
  2. Burdakov D, Liss B, Ashcroft F. Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger. J Neurosci. 2003;23:4951-7 pubmed
    ..Because GABA is a potent stimulus for feeding, in both the ARC and its main projection site, these results suggest a mechanism for how orexin may control appetite. ..
  3. Ahmad T, Zhang L, Gogus F, Verity D, Wallace G, Madanat W, et al. CARD15 polymorphisms in Behçet's disease. Scand J Rheumatol. 2005;34:233-7 pubmed
    ..CARD15 variant alleles are not associated with susceptibility to BD. Other shared loci, currently under investigation, may determine susceptibility to both CD and BD. ..
  4. Robinson R, Lu X, Jones E, Siebold C. Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure. 2008;16:259-68 pubmed publisher
    ..These results suggest that the binding properties of iASPP render it a target for antitumor therapeutics and provide a peptide-based template for compound design. ..
  5. Brockmeyer C, Paster W, Pepper D, Tan C, Trudgian D, McGowan S, et al. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem. 2011;286:7535-47 pubmed publisher
    ..Our study reveals the dynamics of TCR-dependent signaling networks and suggests a specific role for THEMIS in early TCR signalosome function. ..
  6. Botchway S, Reynolds P, Parker A, O Neill P. Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells. Methods Enzymol. 2012;504:3-28 pubmed publisher
  7. Coxon C, Sadler A, Huo J, Campbell R. An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b. PLoS ONE. 2012;7:e49543 pubmed publisher
    ..In addition, the presence of dual phosphorylated G6B-b in washed human platelets can reduce the EC(50) for both CRP and collagen. ..
  8. Crompton M, Purnell T, Tyrer H, Parker A, Ball G, Hardisty Hughes R, et al. A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways. PLoS Genet. 2017;13:e1006969 pubmed publisher
    ..Our analysis implicates PAK1 and RAC1, and downstream signalling in LIMK1 and NF-κB pathways in the development of chronic OM. ..
  9. Chapel H, Puel A, von Bernuth H, Picard C, Casanova J. Shigella sonnei meningitis due to interleukin-1 receptor-associated kinase-4 deficiency: first association with a primary immune deficiency. Clin Infect Dis. 2005;40:1227-31 pubmed
    ..sonnei infection in the intestinal mucosa. IRAK-4 deficiency and related disorders should be considered in patients with systemic shigellosis. ..

More Information


  1. Tatham A, Crabtree M, Warrick N, Cai S, Alp N, Channon K. GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. J Biol Chem. 2009;284:13660-8 pubmed publisher
    ..We suggest that GTPCH expression is the primary regulator of BH4 levels, and changes in GTPCH or BH4 are not necessarily accompanied by changes in GFRP expression. ..
  2. Irani S, Pettingill P, Kleopa K, Schiza N, Waters P, Mazia C, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol. 2012;72:241-55 pubmed publisher
  3. Cottee M, Muschalik N, Wong Y, Johnson C, Johnson S, Andreeva A, et al. Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly. elife. 2013;2:e01071 pubmed publisher