Experts and Doctors on chromosome deletion in Southampton, England, United Kingdom
Locale: Southampton, England, United Kingdom
Topic: chromosome deletion
Parker H, Rose Zerilli M, Parker A, Chaplin T, Wade R, Gardiner A, et al
. 13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia. Leukemia. 2011;25:489-97 pubmed publisher
..Deletion of a 1?Mb gene cluster (48.2-49.2?Mb), including SETDB2, PHF11 and RCBTB1, was significantly associated (P<0.01) with disease progression. Here, we show that the deletion of genes outside MDRs can influence clinical outcome. ..
Mercer C, Lachlan K, Karcanias A, Affara N, Huang S, Jacobs P, et al
. Detailed clinical and molecular study of 20 females with Xq deletions with special reference to menstruation and fertility. Eur J Med Genet. 2013;56:1-6 pubmed publisher
..In conjunction with patient data from the literature, our study suggests that loss of Xq26-Xq28 has the most significant effect on ovarian function. ..
Moorman A, Harrison C, Buck G, Richards S, Secker Walker L, Martineau M, et al
. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood. 2007;109:3189-97 pubmed
Ashraf T, Collinson M, Fairhurst J, Wang R, Wilson L, Foulds N. Two further patients with the 1q24 deletion syndrome expand the phenotype: A possible role for the miR199-214 cluster in the skeletal features of the condition. Am J Med Genet A. 2015;167A:3153-60 pubmed publisher
..The deletion in the second patient spans the previously reported critical region and indicates that the cognitive impairment may not always be as severe as previous reports suggest. ..