Experts and Doctors on case control studies in Cambridge, England, United Kingdom
Locale: Cambridge, England, United Kingdom
Topic: case control studies
Maier L, Chapman J, Howson J, Clayton D, Pask R, Strachan D, et al
. No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. Am J Hum Genet. 2005;76:517-21 pubmed
..Additional support from independent samples will be even more important in the study of gene-gene interactions and other subgroup analyses. ..
Vella A, Cooper J, Lowe C, Walker N, Nutland S, Widmer B, et al
. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet. 2005;76:773-9 pubmed
..3x10(-3); combined P=1.3x10(-10)). These results illustrate the utility of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region. ..
Kuschel B, Chenevix Trench G, Spurdle A, Chen X, Hopper J, Giles G, et al
. Common polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2005;14:1828-31 pubmed
..None of the three single nucleotide polymorphisms were significantly associated with the incidence of breast cancer. ..
Ye Z, Song H, Higgins J, Pharoah P, Danesh J. Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies. PLoS Med. 2006;3:e91 pubmed
..As lung cancer has important environmental causes, understanding any genetic contribution to it in general populations will require the conduct of particularly large and comprehensive studies. ..
Song H, Ramus S, Shadforth D, Quaye L, Kjaer S, Dicioccio R, et al
. Common variants in RB1 gene and risk of invasive ovarian cancer. Cancer Res. 2006;66:10220-6 pubmed
..The possible associations of rs2854344 and rs4151620 with ovarian cancer risk warrant confirmation in independent case-control studies before studies on their biological mode of action. ..
Syed Z, Dudbridge F, Kent L. An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:375-8 pubmed
..69, odds ratio (OR) = 1.65, P = 0.05). Although this SNP is located in the 5' pro-NGF sequence and not the mature NGF protein, it may affect intracellular processing and secretion of NGF. ..
Yates J, Sepp T, Matharu B, Khan J, Thurlby D, Shahid H, et al
. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med. 2007;357:553-61 pubmed
..Complement C3 is important in the pathogenesis of age-related macular degeneration. This finding further underscores the influence of the complement pathway in the pathogenesis of this disease. ..
Ramus S, Vierkant R, Johnatty S, Pike M, Van Den Berg D, Wu A, et al
. Consortium analysis of 7 candidate SNPs for ovarian cancer. Int J Cancer. 2008;123:380-388 pubmed publisher
..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach. ..
Toshner M, Voswinckel R, Southwood M, Al Lamki R, Howard L, Marchesan D, et al
. Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2009;180:780-7 pubmed publisher
..These findings provide evidence of the involvement of progenitor cells in the vascular remodeling associated with PAH. Dysfunction of circulating progenitors in PAH may contribute to this process. ..