Experts and Doctors on apoptosis regulatory proteins in Oxford, England, United Kingdom


Locale: Oxford, England, United Kingdom
Topic: apoptosis regulatory proteins

Top Publications

  1. Mongkolsapaya J, Cowper A, Xu X, Morris G, McMichael A, Bell J, et al. Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL. J Immunol. 1998;160:3-6 pubmed
    ..LIT is expressed predominantly on PBL, where it can competitively inhibit TRAIL-induced apoptosis through DR4/TRICK2, and may function to modulate lymphocyte sensitivity to TRAIL. ..
  2. Liang M, Russell G, Hulley P. Bim, Bak, and Bax regulate osteoblast survival. J Bone Miner Res. 2008;23:610-20 pubmed publisher
    ..Our data indicate that Bim, Bak, and Bax actively mediate osteoblast apoptosis induced by trophic factor withdrawal. The complex upstream regulation of Bim may provide targets for therapeutic enhancement of osteoblast viability. ..
  3. Robinson R, Lu X, Jones E, Siebold C. Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure. 2008;16:259-68 pubmed publisher
    ..These results suggest that the binding properties of iASPP render it a target for antitumor therapeutics and provide a peptide-based template for compound design. ..