Experts and Doctors on anopheles gambiae in Liverpool, England, United Kingdom
Locale: Liverpool, England, United Kingdom
Topic: anopheles gambiae
M ller P, Warr E, Stevenson B, Pignatelli P, Morgan J, Steven A, et al
. Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids. PLoS Genet. 2008;4:e1000286 pubmed publisher
..This is the first study to demonstrate the capacity of a P450 identified in wild A. gambiae to metabolise insecticides. The findings add to the understanding of the genetic basis of insecticide resistance in wild mosquito populations...
Lynd A, Weetman D, Barbosa S, Egyir Yawson A, Mitchell S, Pinto J, et al
. Field, genetic, and modeling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s. Mol Biol Evol. 2010;27:1117-25 pubmed publisher
..16 and a dominance coefficient of 0.25. Our data show that strong, recent positive selective events, such as those caused by insecticide resistance, can be identified in wild insect populations. ..
Lian L, Widdowson P, McLaughlin L, Paine M. Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits. PLoS ONE. 2011;6:e20574 pubmed publisher
Weetman D, Wilding C, Steen K, Pinto J, Donnelly M. Gene flow-dependent genomic divergence between Anopheles gambiae M and S forms. Mol Biol Evol. 2012;29:279-91 pubmed publisher
..This highlights the potential for islands comprising a relatively small fraction of the genome to play an important role in early-stage speciation when reproductive isolation is limited. ..
Stevenson B, Pignatelli P, Nikou D, Paine M. Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance. PLoS Negl Trop Dis. 2012;6:e1595 pubmed publisher
..P450s have been identified with the potential to confer pyrethroid resistance in Ae.aegypti. It is recommended that over expression of these enzymes should be monitored as indicators of resistance where pyrethroids are used. ..