Genomes and Genes
Experts and Doctors on animals in Southampton, England, United Kingdom
Locale: Southampton, England, United Kingdom
Publications277 found, 100 shown here
- Eccles D. Development of genetic testing for breast, ovarian and colorectal cancer predisposition: a step closer to targeted cancer prevention. Curr Drug Targets. 2011;12:1974-82 pubmed..Robust evidence supporting medical approaches to cancer prevention in particular will require well designed large international collaborative clinical trials. ..
- Gates A, Jones D. Recovery of benthic megafauna from anthropogenic disturbance at a hydrocarbon drilling well (380 m depth in the Norwegian Sea). PLoS ONE. 2012;7:e44114 pubmed publisher..However, elevated Barium concentration and reduced sediment grain size suggest persistence of disturbance for three years, with unclear consequences for other components of the benthic fauna. ..
- Siskova Z, Reynolds R, O Connor V, Perry V. Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease. PLoS ONE. 2013;8:e55004 pubmed publisher..These observations demonstrate that neuronal vulnerability to pathological protein misfolding is strongly dependent on the structure and function of the target neurons. ..
- Mall S, Broadbridge R, Harrison S, Gore M, Lee A, East J. The presence of sarcolipin results in increased heat production by Ca(2+)-ATPase. J Biol Chem. 2006;281:36597-602 pubmed..9 x 10(-4) +/- 2.9 x 10(-4) in units of mol fraction per monolayer. It is suggested that the interaction between Ca(2+)-ATPase and SLN in the sarcoplasmic reticulum could be important in thermogenesis by the sarcoplasmic reticulum. ..
- Howe C, Garstka M, Al Balushi M, Ghanem E, Antoniou A, Fritzsche S, et al. Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. EMBO J. 2009;28:3730-44 pubmed publisher..Our study, to the best of our knowledge, demonstrates for the first time a functional role of intracellular transport in the optimal loading of MHC class I molecules with antigenic peptide. ..
- Liu W, Niranjan M. Gaussian process modelling for bicoid mRNA regulation in spatio-temporal Bicoid profile. Bioinformatics. 2012;28:366-72 pubmed publisher..firstname.lastname@example.org Supplementary data are available at Bioinformatics online. ..
- Sinadinos C, Quraishe S, Sealey M, Samson P, Mudher A, Wyttenbach A. Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease. J Alzheimers Dis. 2013;33:1117-33 pubmed publisher..Forthcoming studies investigating the effects of HSP induction on tau-mediated dysfunction/toxicity in such models will require more robust, non-pharmacological (perhaps genetic) means of manipulating the hsp90 pathway. ..
- Marchbanks R, Reid A. Cochlear and cerebrospinal fluid pressure: their inter-relationship and control mechanisms. Br J Audiol. 1990;24:179-87 pubmed..The tympanic membrane displacement measurement technique has been used to provide reliable measures of perilymphatic pressure and CSF-perilymphatic pressure transfer on an individual subject basis.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Hanson M, Gluckman P. Developmental origins of health and disease: new insights. Basic Clin Pharmacol Toxicol. 2008;102:90-3 pubmed publisher..Appropriate interventions may have long-term multigenerational effects to reduce the risk of chronic disease. ..
- Walker V. Ammonia toxicity and its prevention in inherited defects of the urea cycle. Diabetes Obes Metab. 2009;11:823-35 pubmed publisher..Long-term correction is achieved by liver transplantation. Gene therapy for OTC deficiency is effective in animals, and work is ongoing to improve persistence and safety. ..
- Hoile S, Lillycrop K, Grenfell L, Hanson M, Burdge G. Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats. Br J Nutr. 2012;108:852-7 pubmed publisher..Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis. ..
- Garland P, Broom L, Quraishe S, Dalton P, Skipp P, Newman T, et al. Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. PLoS ONE. 2012;7:e47552 pubmed publisher..These findings highlight a previously unexplored area of axon biology, which may open novel avenues to prevent axon degeneration. Our method for isolating CNS axoplasm also represents a new tool to study axon biology. ..
- Crooks I, Dillon D, Scott J, Ballantyne M, Meredith C. The effect of long term storage on tobacco smoke particulate matter in in vitro genotoxicity and cytotoxicity assays. Regul Toxicol Pharmacol. 2013;65:196-200 pubmed publisher..Some minor but statistically significant differences were observed for stored versus freshly prepared PM, but the magnitude of changes were within the variability observed for repeat testing. ..
- Monty J, Dogan E, Hanson R, Scardino A, Ganapathisubramani B, Hutchins N. An assessment of the ship drag penalty arising from light calcareous tubeworm fouling. Biofouling. 2016;32:451-64 pubmed publisher..A similarly fouled very large crude carrier would experience a 34% increase in total resistance at cruise. ..
- Herbert R, Collins K, Mallinson J, Hall A, Pegg J, Ross K, et al. Epibenthic and mobile species colonisation of a geotextile artificial surf reef on the south coast of England. PLoS ONE. 2017;12:e0184100 pubmed publisher..Provided no negative invasive impacts are detected on nearby protected reefs the creation of novel yet diverse habitats may be considered a beneficial outcome. ..
- Holt R, Simpson H, Sonksen P. The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis. Diabet Med. 2003;20:3-15 pubmed..IGF-I 'replacement' in diabetes is under investigation and new methods of delivering IGF-I as a complex with IGFBP-3 offer exciting new prospects. ..
- Grainge C, Lau L, Ward J, Dulay V, Lahiff G, Wilson S, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med. 2011;364:2006-15 pubmed publisher..Bronchoconstriction without additional inflammation induces airway remodeling in patients with asthma. These findings have potential implications for management. ..
- Kraft P, Schuhmann M, Garz C, Jandke S, Urlaub D, Mencl S, et al. Hypercholesterolemia induced cerebral small vessel disease. PLoS ONE. 2017;12:e0182822 pubmed publisher..Our data demonstrate a relationship between hypercholesterolemia and the development of CSVD. Ldlr-/- mice appear to be an adequate animal model for research into CSVD. ..
- Lloyd A, Shoolingin Jordan P. Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis. Biochemistry. 2001;40:2455-67 pubmed..The possible structural basis for this catalytic asymmetry and its mechanistic implications are discussed. ..
- Jaffar Z, Wan K, Roberts K. A key role for prostaglandin I2 in limiting lung mucosal Th2, but not Th1, responses to inhaled allergen. J Immunol. 2002;169:5997-6004 pubmed..These results indicate an important role for prostanoids generated during inflammation in regulating mucosal T cell responses and highlight a potential risk in the use of cyclooxygenase-2-specific inhibitors by allergic asthmatics. ..
- Skilton R, Cutcliffen L, Barlow D, Wang Y, Salim O, Lambden P, et al. Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle. PLoS ONE. 2009;4:e7723 pubmed publisher..Removal of penicillin allows recovery of the normal developmental cycle by 10-20 hrs and the process occurs by budding from aberrant RBs. ..
- Robinson S, Dixon S, August S, Diffey B, Wakamatsu K, Ito S, et al. Protection against UVR involves MC1R-mediated non-pigmentary and pigmentary mechanisms in vivo. J Invest Dermatol. 2010;130:1904-13 pubmed publisher..The results indicate that MC1R protects by a combination of pigmentary and non-pigmentary effects in vivo and that when MC1R function is compromised the melanin type in skin is still protective against UVR. ..
- Girling R, Stewart Jones A, Dherbecourt J, Staley J, Wright D, Poppy G. Parasitoids select plants more heavily infested with their caterpillar hosts: a new approach to aid interpretation of plant headspace volatiles. Proc Biol Sci. 2011;278:2646-53 pubmed publisher..Analyses revealed a number of compounds whose emission increased significantly with herbivore load, and these VOCs may be particularly good indicators of herbivore number, as the parasitoid processes cues from its external environment. ..
- Boden S, Asadollahbaik A, Rutt H, Bagnall D. Helium ion microscopy of Lepidoptera scales. Scanning. 2012;34:107-20 pubmed publisher..Furthermore, the extraction of quantitative height information which matches well with cross-sectional transmission electron microscopy measurements from the literature is demonstrated...
- Buchan S, Taraban V, Slebioda T, James S, Cunningham A, Al Shamkhani A. Death receptor 3 is essential for generating optimal protective CD4? T-cell immunity against Salmonella. Eur J Immunol. 2012;42:580-8 pubmed publisher..These data establish for the first time a role for DR3 in a host defence response. ..
- Holloway J, Savarimuthu Francis S, Fong K, Yang I. Genomics and the respiratory effects of air pollution exposure. Respirology. 2012;17:590-600 pubmed publisher..Careful study of genomic responses will improve our understanding of mechanisms of lung injury from air pollution and enable future clinical testing of interventions against the toxic effects of air pollutants. ..
- Torrens C, Ethirajan P, Bruce K, Cagampang F, Siow R, Hanson M, et al. Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. PLoS ONE. 2012;7:e50671 pubmed publisher..Further, this disadvantageous vascular phenotype is exacerbated by age to influence the risk of developing obesity, raised blood pressure and endothelial dysfunction in adult life. ..
- Naish D, Simpson M, Dyke G. A new small-bodied azhdarchoid pterosaur from the lower cretaceous of England and its implications for pterosaur anatomy, diversity and phylogeny. PLoS ONE. 2013;8:e58451 pubmed publisher..The western Europe pterodactyloid record may therefore be artificially low in diversity due to preservational factors. ..
- Semkova I, Kociok N, Karagiannis D, Nischt R, Smyth N, Paulsson M, et al. Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization. Exp Eye Res. 2014;118:80-8 pubmed publisher..In this sense nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels. ..
- Morris A, Sharp M, Albargothy N, Fernandes R, Hawkes C, Verma A, et al. Vascular basement membranes as pathways for the passage of fluid into and out of the brain. Acta Neuropathol. 2016;131:725-36 pubmed publisher..The significance of these findings for neuroimmunology, Alzheimer's disease, drug delivery to the brain and the concept of the Virchow-Robin space are discussed. ..
- Giannogonas P, Apostolou A, Manousopoulou A, Theocharis S, Macari S, Psarras S, et al. Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy. Sci Rep. 2016;6:23342 pubmed publisher..These data suggest the intriguing possibility that targeting Crh stimulation in the intestine may provide a novel therapeutic approach to support the integrity of the epithelial barrier and to protect from chronic colitis. ..
- Gall T, Ioannidis J, Maniadis Z. The credibility crisis in research: Can economics tools help?. PLoS Biol. 2017;15:e2001846 pubmed publisher..Here, we review these methods and show their potential. Prominent among them are mathematical modeling and laboratory experiments that constitute affordable ways to approximate the effects of policies with wide-ranging implications. ..
- Gollner S, Kaiser S, Menzel L, Jones D, Brown A, Mestre N, et al. Resilience of benthic deep-sea fauna to mining activities. Mar Environ Res. 2017;129:76-101 pubmed publisher..The loss of hard substrata or alteration of substrata composition may cause substantial community shifts that persist over geological timescales at mined sites. ..
- Behrsing H, Hill E, Raabe H, Tice R, Fitzpatrick S, Devlin R, et al. In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use. Altern Lab Anim. 2017;45:117-158 pubmed
- Green D, Walsh D, Mann S, Oreffo R. The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons. Bone. 2002;30:810-5 pubmed
- Brown N, Rachwal P, Brown T, Fox K. Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeat. Org Biomol Chem. 2005;3:4153-7 pubmed..The association reaction has a half-life of a few seconds at 37 degrees C, but becomes slower at elevated temperatures consistent with the suggestion that association occurs by a nucleation-zipper mechanism...
- Willis C, Baalham T, Greenwood M, Presland F. Evaluation of a new chromogenic agar for the detection of Listeria in food. J Appl Microbiol. 2006;101:711-7 pubmed..The commercial availability of more than one medium will facilitate the more widespread use of the method, thus increasing confidence in the ability to detect L. monocytogenes in food in the presence of other Listeria spp. ..
- Smart D, Green K, Oakley F, Weitzman J, Yaniv M, Reynolds G, et al. JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. Hepatology. 2006;44:1432-40 pubmed..In conclusion, a signaling pathway for the development of fibrosis involves the regulation of TIMP-1 expression by phosphorylated JunD. ..
- Zubkov M, Tarran G. High bacterivory by the smallest phytoplankton in the North Atlantic Ocean. Nature. 2008;455:224-6 pubmed publisher..This has important implications for how we perceive nutrient acquisition and limitation of carbon-fixing protists as well as control of bacterioplankton in the ocean...
- James E, Yeh A, King C, Korangy F, Bailey I, Boulanger D, et al. Differential suppression of tumor-specific CD8+ T cells by regulatory T cells. J Immunol. 2010;185:5048-55 pubmed publisher..This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes...
- Whitby R, Stec J, Blind R, Dixon S, Leesnitzer L, Orband Miller L, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011;54:2266-81 pubmed publisher..Initial studies on the regulation of gene expression in human cell lines showed excellent, reproducible activity at endogenous target genes. ..
- Eckert J, Porter R, Watkins A, Burt E, Brooks S, Leese H, et al. Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health. PLoS ONE. 2012;7:e52791 pubmed publisher..Moreover, this induction step associates with changes in extra-embryonic trophectoderm behaviour occurring as early compensatory responses leading to later nutrient recovery. ..
- Humbert M, Awanye A, Lian L, Derrick J, Christodoulides M. Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor. PLoS Pathog. 2017;13:e1006448 pubmed publisher..Thus, ACP represents a dual target for developing Neisseria vaccines and drugs to inhibit host-pathogen interactions. ..
- Thong B, Hourihane J. Monitoring of IgE-mediated food allergy in childhood. Acta Paediatr. 2004;93:759-64 pubmed..Prospective studies of non-selected children, optimally from birth cohorts, are needed to evaluate the effects of such management programmes regarding FA in childhood. ..
- Burdge G, Slater Jefferies J, Torrens C, Phillips E, Hanson M, Lillycrop K. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr. 2007;97:435-9 pubmed..This may represent a mechanism for the transmission of induced phenotypes between generations ..
- Gray B, Siskova Z, Perry V, O Connor V. Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology. Neurobiol Dis. 2009;35:63-74 pubmed publisher..This synaptic pathology or "synaptopathy" may represent the earliest neuronal dysfunction in this and other protein misfolding induced neurodegenerative diseases. ..
- Sampson A. FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Investig Drugs. 2009;10:1163-72 pubmed
- Watkins A, Lucas E, Wilkins A, Cagampang F, Fleming T. Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PLoS ONE. 2011;6:e28745 pubmed publisher..These adverse outcomes further exemplify the criticality of dietary behaviour around the time of conception on long-term offspring health. ..
- Dyke G, Vremir M, Kaiser G, Naish D. A drowned Mesozoic bird breeding colony from the Late Cretaceous of Transylvania. Naturwissenschaften. 2012;99:435-42 pubmed publisher..Such a large concentration of breeding birds suggests aquatic feeding in this species, augments our understanding of enantiornithine biology and shows that colonial nesting was not unique to crown birds. ..
- Smith K, Thatje S. The secret to successful deep-sea invasion: does low temperature hold the key?. PLoS ONE. 2012;7:e51219 pubmed publisher..Such knowledge is instrumental to understand better how changes in climate envelopes affect the distribution and radiation of species along latitudinal as well as bathymetric temperature gradients. ..
- Sanderson J, Brennan P, Mansour S, Matulis G, Patel O, Lissin N, et al. CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. Eur J Immunol. 2013;43:815-25 pubmed publisher..Mutation of the human residue, Trp153, to the mouse ortholog, Gly155, therefore allowed iGb3-hCD1d to stimulate human iNKT cells. In conclusion, our data indicate that iGb3 is unlikely to be a major antigen in human iNKT-cell biology. ..
- Bressloff N, Ragkousis G, Curzen N. Design Optimisation of Coronary Artery Stent Systems. Ann Biomed Eng. 2016;44:357-67 pubmed publisher..Nonetheless, the potential for future, carefully posed, optimisation strategies has been suitably demonstrated, as described in this review. ..
- Jubrail J, Morris P, Bewley M, Stoneham S, Johnston S, Foster S, et al. Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages. Cell Microbiol. 2016;18:80-96 pubmed publisher..We show that cycles of lysis and reuptake maintain a pool of viable intracellular bacteria over time when killing is overwhelmed and demonstrate intracellular persistence in alveolar macrophages in the lungs in a murine model. ..
- Batten L, Parnell A, Wells N, Murch A, Oyston P, Roach P. Biochemical and structural characterization of polyphosphate kinase 2 from the intracellular pathogen Francisella tularensis. Biosci Rep. 2015;36:e00294 pubmed publisher..This combination of biochemical, structural and microbiological data provide a sound foundation for future studies targeting the development of PPK2 small molecule inhibitors. ..
- Watson R, SzathmÃ¡ry E. How Can Evolution Learn?. Trends Ecol Evol. 2016;31:147-157 pubmed publisher..If so, the ability for evolution to learn might explain how it produces such apparently intelligent designs. ..
- Page A, Lagnado J. Ultrastructural analysis of Phytomonas species from Euphorbia pinea reveals trans-cytoplasmic filaments 10 nm in diameter. Parasitol Res. 2000;86:843-50 pubmed
- Winsloe C, Earl S, Dennison E, Cooper C, Harvey N. Early life factors in the pathogenesis of osteoporosis. Curr Osteoporos Rep. 2009;7:140-4 pubmed
- van Hateren A, James E, Bailey A, Phillips A, Dalchau N, Elliott T. The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding. Tissue Antigens. 2010;76:259-75 pubmed publisher..Lastly we discuss how these processes culminate to influence immune responses. ..
- Postle A, Henderson N, Koster G, Clark H, Hunt A. Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes. Chem Phys Lipids. 2011;164:549-55 pubmed publisher..Finally, PC molecular species analysis suggested that a proportion of newly synthesised PC is secreted rapidly into the lung air spaces in both control and SP-D(-/-) mice before significant PC acyl remodelling occurs. ..
- Xiao C, Puddicombe S, Field S, Haywood J, Broughton Head V, Puxeddu I, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol. 2011;128:549-56.e1-12 pubmed publisher..This defect may facilitate the passage of allergens and other agents into the airway tissue, leading to immune activation and may thus contribute to the end organ expression of asthma. ..
- Godfrey K, Inskip H, Hanson M. The long-term effects of prenatal development on growth and metabolism. Semin Reprod Med. 2011;29:257-65 pubmed publisher..This mismatch may arise through unbalanced diet or body composition of the mother or a change in lifestyle factors between generations. These insights offer new possibilities for the early diagnosis and prevention of chronic disease. ..
- Holden Dye L, Crisford A, Welz C, von Samson Himmelstjerna G, Walker R, O Connor V. Worms take to the slo lane: a perspective on the mode of action of emodepside. Invert Neurosci. 2012;12:29-36 pubmed publisher..Therefore, we rationalise this possibility by suggesting a model that speculates on the nature of the emodepside pharmacophore within the calcium-activated potassium channels. ..
- Lillycrop K, Burdge G. Epigenetic mechanisms linking early nutrition to long term health. Best Pract Res Clin Endocrinol Metab. 2012;26:667-76 pubmed publisher..This review will focus on how nutritional cues in early life can alter the epigenome, producing different phenotypes and altered disease susceptibilities. ..
- Hosseini A, Hirota J, Hackett T, McNagny K, Wilson S, Carlsten C. Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects. Part Fibre Toxicol. 2016;13:2 pubmed publisher..URL: http://www.clinicaltrials.gov. Unique identifier: NCT01792232. ..
- Shi Y, Lai S, Chen Q, Mu D, Li Y, Li X, et al. [Analysis on the epidemiological features of human brucellosis in northern and southern areas of China, 2015-2016]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:435-440 pubmed publisher..6%??????????????2.2?1?2.7?1???m?48?????????38~58?????????????86.8%????62.7%????????????????3?7?? ??? ?????????????????????????????????????????????????????????????????????????????????. ..
- Loxham M, Davies D. Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients. J Allergy Clin Immunol. 2017;139:1736-1751 pubmed publisher..We postulate that such abnormalities play a causal role in immune dysregulation in the airways by translating gene-environment interactions that underpin disease pathogenesis and exacerbation. ..
- Trueman C, MacKenzie K, Palmer M. Identifying migrations in marine fishes through stable-isotope analysis. J Fish Biol. 2012;81:826-47 pubmed publisher..Here, the theoretical background underpinning the use of stable isotopes of C, N and O in otolith, scale and muscle tissues as geolocation tools in the marine environment is reviewed, and examples of their applications are provided. ..
- Pecl G, Araujo M, Bell J, Blanchard J, Bonebrake T, Chen I, et al. Biodiversity redistribution under climate change: Impacts on ecosystems and human well-being. Science. 2017;355: pubmed publisher..Consideration of these effects of biodiversity redistribution is critical yet lacking in most mitigation and adaptation strategies, including the United Nation's Sustainable Development Goals. ..
- Hauton C, Hawkins L, Hutchinson S. Response of haemocyte lysosomes to bacterial inoculation in the oysters Ostrea edulis L. and Crassostrea gigas (Thunberg) and the scallop Pecten maximus (L). Fish Shellfish Immunol. 2001;11:143-53 pubmed..Using appropriate controls, the NRR assay was demonstrated to have great potential as a tool with which to make rapid initial assessments of the immune status of bivalve molluscs...
- Elliott T, Williams A. The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex. Immunol Rev. 2005;207:89-99 pubmed..We provide a framework model for how this may operate at the molecular level and draw parallels with the proposed mechanism of action of human leukocyte antigen-DM for MHC class II complex optimization. ..
- Papaioannou S, Holden Dye L, Walker R. Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegans. Invert Neurosci. 2008;8:91-100 pubmed publisher..Overall, the data support a role for cAMP in modulating the excitatory action of both FLP17A and 5-HT on C. elegans pharyngeal pumping and furthermore implicate an EGL-30 dependent pathway in the regulation of the response to FLP17A. ..
- Asuni A, Cunningham C, Vigneswaran P, Perry V, O Connor V. Unaltered SNARE complex formation in an in vivo model of prion disease. Brain Res. 2008;1233:1-7 pubmed publisher..Thus the accumulation of PrP(Sc) although deleterious to synaptic function in vivo, does not exert its synaptic effects by disrupting the formation of SNARE complexes that are core to transmitter release. ..
- Hands S, Proud C, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy?. Aging (Albany NY). 2009;1:586-97 pubmed..In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways. ..
- Stevenson F, Ottensmeier C, Rice J. DNA vaccines against cancer come of age. Curr Opin Immunol. 2010;22:264-70 pubmed publisher..Prolongation of remission is the goal and an activated immune system should achieve this. ..
- Poore K, Boullin J, Cleal J, Newman J, Noakes D, Hanson M, et al. Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep. J Physiol. 2010;588:2219-37 pubmed publisher..With altered glucose tolerance previously reported in this model, this may have long-term detrimental effects on metabolic homeostasis and cardiovascular function...
- Williams E, Tutt A, French R, Chan H, Lau B, Penfold C, et al. Development and characterisation of monoclonal antibodies specific for the murine inhibitory Fc?RIIB (CD32B). Eur J Immunol. 2012;42:2109-20 pubmed publisher..These two types of mAb exhibit different characteristics in a range of biochemical, cellular, and functional assays relevant to Fc?RIIB activity and mAb therapy. ..
- Sun D, Newman T, Perry V, Weller R. Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis. Neuropathol Appl Neurobiol. 2004;30:374-84 pubmed..local changes in the release of pro-inflammatory cytokines within the brain in EAE results in the widespread enhancement of autoimmune inflammation within the brain and cord, and exacerbation of clinical symptoms. ..
- Goodwin D, Levine M, McGreevy P. Preliminary investigation of morphological differences between ten breeds of horses suggests selection for paedomorphosis. J Appl Anim Welf Sci. 2008;11:204-12 pubmed publisher..This preliminary study suggests that morphological, behavioral, and physiological differences between the breeds-plus morphometric comparisons of extant breeds and faunal remains of predomestication horses-warrant further study. ..
- Wilson J, Dixon D, Dixon L. Numerical chromosomal aberrations in the early life-history stages of a marine tubeworm, Pomatoceros lamarckii (Polychaeta: Serpulidae). Aquat Toxicol. 2002;59:163-75 pubmed..In keeping with the severely debilitating effects of this class of agent, an inverse correlation was observed between the induced levels of NCAs and larval fitness based on the results of a standard 48-h larval bioassay. ..
- MacDonald T, Frankel G, Dougan G, Goncalves N, Simmons C. Host defences to Citrobacter rodentium. Int J Med Microbiol. 2003;293:87-93 pubmed..Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut. ..
- Coleman R, Underwood A, Benedetti Cecchi L, Aberg P, Arenas F, Arrontes J, et al. A continental scale evaluation of the role of limpet grazing on rocky shores. Oecologia. 2006;147:556-64 pubmed..Here we show a clear trophic control of an ecosystem in that grazing by limpets not only determines macroalgal abundance overall but also modifies ecosystem stability via variability in cover of algae. ..
- Kwong W, Miller D, Wilkins A, Dear M, Wright J, Osmond C, et al. Maternal low protein diet restricted to the preimplantation period induces a gender-specific change on hepatic gene expression in rat fetuses. Mol Reprod Dev. 2007;74:48-56 pubmed..The present findings show that the long term potential of the preimplantation embryo is sensitive to maternal LPD such that basal levels of hepatic gene expression in day 20 fetuses are altered in a gender-specific manner. ..
- Kretzmann M, Mentzer L, DiGiovanni R, Leslie M, Amato G. Microsatellite diversity and fitness in stranded juvenile harp seals (Phoca groenlandica). J Hered. 2006;97:555-60 pubmed..Under these circumstances, mean d(2) may provide a powerful measure for assessing diversity-fitness correlations. ..