Experts and Doctors on animals in Manchester, England, United Kingdom

Summary

Locale: Manchester, England, United Kingdom
Topic: animals

Top Publications

  1. Merry C, Wilson V. Role of heparan sulfate-2-O-sulfotransferase in the mouse. Biochim Biophys Acta. 2002;1573:319-27 pubmed
    ..The implications that altered HS structure may have on growth factor/receptor signalling in vivo will be discussed. ..
  2. Ashcroft G, Mills S, Flanders K, Lyakh L, Anzano M, Gilliver S, et al. Role of Smad3 in the hormonal modulation of in vivo wound healing responses. Wound Repair Regen. 2003;11:468-73 pubmed
    ..These data suggest that Smad3 plays a role in mediating androgen signaling during the normal wound healing response and implicate Smad3 in the modulation of inflammatory cell activity by androgens. ..
  3. Gandillet A, Serrano A, Pearson S, Lie A Ling M, Lacaud G, Kouskoff V. Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification. Blood. 2009;114:4813-22 pubmed publisher
    ..Furthermore, our data demonstrate that the mere sustained expression of Sox7 is sufficient to completely alter the balance between proliferation and differentiation at the onset of hematopoiesis. ..
  4. Chang S, Jobling S, Brennan K, Headon D. Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands. PLoS ONE. 2009;4:e7591 pubmed publisher
  5. Allen A, Cameron M, Brown T, Vugler A, Lucas R. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS ONE. 2010;5:e15063 pubmed publisher
    ..This anomalous rod opsin-based vision should be considered in experiments relying upon Gnat1 knockout to silence rod phototransduction. ..
  6. Jeanes A, Maya Mendoza A, Streuli C. Cellular microenvironment influences the ability of mammary epithelia to undergo cell cycle. PLoS ONE. 2011;6:e18144 pubmed publisher
    ..Moreover, manipulating the cellular environment using this novel method can maintain the proliferative potential of primary MECs, thus enabling cell cycle to be studied as an endpoint after gene transfer or gene deletion experiments. ..
  7. Westerhoff H. Systems biology left and right. Methods Enzymol. 2011;500:3-11 pubmed publisher
    ..This chapter attempts to organize these methodologies from the perspectives of the unique aims of systems biology, and by comparing with one of its parents, molecular biology. ..
  8. Wright E, Farrell K, Malik N, Kassem M, Lewis A, Wallrapp C, et al. Encapsulated glucagon-like peptide-1-producing mesenchymal stem cells have a beneficial effect on failing pig hearts. Stem Cells Transl Med. 2012;1:759-69 pubmed publisher
    ..Combined benefits of paracrine stem cell factors and GLP-1 were superior to those of stem cells alone. These results suggest that encapsulated genetically modified MSCs would be beneficial for recovery following MI. ..
  9. Harno E, Cottrell E, Keevil B, Deschoolmeester J, Bohlooly Y M, Andersén H, et al. 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11?-HSD1 is knocked out in livers of male mice. Endocrinology. 2013;154:3599-609 pubmed publisher

More Information

Publications144 found, 100 shown here

  1. van Casteren A, Sellers W, Thorpe S, Coward S, Crompton R, Ennos A. Factors affecting the compliance and sway properties of tree branches used by the Sumatran orangutan (Pongo abelii). PLoS ONE. 2013;8:e67877 pubmed publisher
    ..The results of this study validate previous field research, which related locomotory modes to local branch diameter, while suggesting how arboreal animals themselves sense their mechanical environment. ..
  2. Worthington J, Klementowicz J, Rahman S, Czajkowska B, Smedley C, Waldmann H, et al. Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity. PLoS Pathog. 2013;9:e1003675 pubmed publisher
    ..Our results therefore provide novel insights into how type 2 immunity is controlled in the intestine, and may help contribute to development of new therapies aimed at promoting expulsion of gut helminths. ..
  3. Charnock J, Dilworth M, Aplin J, Sibley C, Westwood M, Crocker I. The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. Am J Physiol Endocrinol Metab. 2016;310:E24-31 pubmed publisher
    ..5 in the untreated group). The observed reduction in FGR pup numbers in both C57 and eNOS(-/-) litters suggests the use of this analog as a means of standardizing and rescuing fetal growth, preferentially in the smallest offspring. ..
  4. Edwards Z, Trotter E, Torres Ayuso P, Chapman P, Wood H, Nyswaner K, et al. Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53. Cancer Res. 2017;77:4961-4972 pubmed publisher
    ..Our results establish LZK as critical for maintaining expression of mutant stabilized p53. Cancer Res; 77(18); 4961-72. ©2017 AACR. ..
  5. Little M, Bell L, Cliffe L, Else K. The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris. J Immunol. 2005;175:6713-22 pubmed
    ..Furthermore, we demonstrate the organogenesis of these structures in response to T. muris infection...
  6. Blance R, Sims A, Anderson E, Howell A, Clarke R. Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer Prev Res (Phila). 2009;2:257-64 pubmed publisher
  7. Simpson A, Tan V, Winn J, Svensén M, Bishop C, Heckerman D, et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med. 2010;181:1200-6 pubmed publisher
    ..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy...
  8. Hope W, Petraitis V, Petraitiene R, Aghamolla T, Bacher J, Walsh T. The initial 96 hours of invasive pulmonary aspergillosis: histopathology, comparative kinetics of galactomannan and (1->3) ?-d-glucan and consequences of delayed antifungal therapy. Antimicrob Agents Chemother. 2010;54:4879-86 pubmed publisher
    ..Galactomannan and (1?3)-?-d-glucan have similar kinetics and are comparable biomarkers of early invasive pulmonary aspergillosis. Antifungal treatment at ?48 h postinoculation is associated with suboptimal therapeutic outcomes. ..
  9. Wareing S, Mazan A, Pearson S, Göttgens B, Lacaud G, Kouskoff V. The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development. Stem Cells. 2012;30:1521-31 pubmed publisher
  10. Adebakin A, Bradley J, Gumusgoz S, Waters E, Lawrence C. Impaired satiation and increased feeding behaviour in the triple-transgenic Alzheimer's disease mouse model. PLoS ONE. 2012;7:e45179 pubmed publisher
    ..These data demonstrate that 3×TgAD mice show increased feeding behaviour and insensitivity to satiation, which is possibly due to defective gut-brain signalling in response to endogenous satiety factors released by food ingestion. ..
  11. Pierce A, Lyon M, Hampson I, Cowling G, Gallagher J. Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver. J Biol Chem. 1992;267:3894-900 pubmed
  12. Trainer P. Corticosteroids and pregnancy. Semin Reprod Med. 2002;20:375-80 pubmed
    ..Hypoadrenalism can be difficult to diagnose during pregnancy but, once the diagnosis is made, with careful monitoring, dose adjustment as indicated, and parenteral cover for labor, a successful pregnancy should result. ..
  13. Barrow K, Ward C, Rutter J, Ali S, Stern P. Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev Dyn. 2005;233:1535-45 pubmed
    ..Our data demonstrate a limited 5T4 expression profile during embryogenesis associated with actively cycling, undifferentiated epithelial progenitor cells that may contribute to their migration. ..
  14. Bellingham J, Chaurasia S, Melyan Z, Liu C, Cameron M, Tarttelin E, et al. Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biol. 2006;4:e254 pubmed
  15. Turner N, Murphy M, Kielty C, Shuttleworth C, Black R, Humphries M, et al. Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study. Circulation. 2006;114:820-9 pubmed
  16. Adlam D, Dabbous M, Woolley D. Electrochemical monitoring of rat mammary adenocarcinoma cells: an in vitro assay for anticancer drug selection. Assay Drug Dev Technol. 2008;6:795-802 pubmed publisher
  17. Thomason H, Zhou H, Kouwenhoven E, Dotto G, Restivo G, Nguyen B, et al. Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. J Clin Invest. 2010;120:1561-9 pubmed publisher
    ..Our findings therefore identify p63 as a key regulatory molecule during palate development and provide a mechanism for the cooperative role of p63 and IRF6 in orofacial development in mice and humans. ..
  18. Lopez Castejon G, Theaker J, Pelegrin P, Clifton A, Braddock M, Surprenant A. P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases. J Immunol. 2010;185:2611-9 pubmed publisher
    ..Our results suggest P2X(7)R activation may play a novel and direct role in tissue damage through release of cathepsins independently of its proinflammatory actions via IL-1 cytokines...
  19. Mohamet L, Lea M, Ward C. Abrogation of E-cadherin-mediated cellular aggregation allows proliferation of pluripotent mouse embryonic stem cells in shake flask bioreactors. PLoS ONE. 2010;5:e12921 pubmed publisher
    ..Whilst this proof-of-principle method would be useful for the culture of human ES and iPS cells, further steps are necessary to increase cell viability of hES cells in suspension. ..
  20. Davidson A, Millar I, Burgess Mullan R, Maher G, Urquhart J, Brown P, et al. Functional characterization of bestrophin-1 missense mutations associated with autosomal recessive bestrophinopathy. Invest Ophthalmol Vis Sci. 2011;52:3730-6 pubmed publisher
  21. Powis K, MacDougall L. The localisation of PtdIns3P in Drosophila fat responds to nutrients but not insulin: a role for Class III but not Class II phosphoinositide 3-kinases. Cell Signal. 2011;23:1153-61 pubmed publisher
    ..We find that both Class II and Class III PI3Ks are capable of generating PtdIns3P in vivo but the source of PtdIns3P in the fat body and the response to nutritional status can be exclusively accounted for by Class III PI3K activity. ..
  22. Testerink J, Degens H, Rittweger J, Shiraishi A, Jaspers R, de Haan A. Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats. J Physiol Pharmacol. 2011;62:111-8 pubmed
    ..Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels. ..
  23. Ackermann J, Ashton G, Lyons S, James D, Hornung J, Jones N, et al. Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development. PLoS ONE. 2011;6:e19090 pubmed publisher
    ..It also confirms that ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS. ..
  24. Li J, Lu W, Beesley S, Loudon A, Meng Q. Lithium impacts on the amplitude and period of the molecular circadian clockwork. PLoS ONE. 2012;7:e33292 pubmed publisher
    ..These findings may advance our understanding of the therapeutic actions of lithium in Bipolar Disorder or other psychiatric diseases that involve circadian rhythm disruptions. ..
  25. Girard S, Brough D, Lopez Castejon G, Giles J, Rothwell N, Allan S. Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia. 2013;61:813-24 pubmed publisher
    ..These data suggest that macrophages infiltrating the brain from the periphery after an injury may be cytotoxic, independently of their phenotype, while microglia may be protective. ..
  26. Kümper S, Mardakheh F, McCarthy A, Yeo M, Stamp G, Paul A, et al. Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. elife. 2016;5:e12994 pubmed publisher
    ..Our results reveal an indispensable role for ROCK, yet redundant role for isoforms 1 and 2, in cell cycle progression and tumorigenesis, possibly through the maintenance of cellular contractility. ..
  27. Pereira S, Williams S, Murray P, Taylor A. MS-1 magA: Revisiting Its Efficacy as a Reporter Gene for MRI. Mol Imaging. 2016;15: pubmed publisher
    ..We suggest that the use of magA for stem cells should be approached with caution, and its efficacy as a reporter gene requires a careful assessment on a cell-by-cell basis. ..
  28. Storchi R, Bale M, Biella G, Petersen R. Comparison of latency and rate coding for the direction of whisker deflection in the subcortical somatosensory pathway. J Neurophysiol. 2012;108:1810-21 pubmed publisher
    ..Spike timing decreases the population size necessary for reliable information transmission and may thereby bring significant advantages in both wiring and metabolic efficiency. ..
  29. Cossarizza A, Chang H, Radbruch A, Akdis M, Andrä I, Annunziato F, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol. 2017;47:1584-1797 pubmed publisher
  30. Lopez Castejon G, Corbett D, Goldrick M, Roberts I, Brough D. Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes. PLoS ONE. 2012;7:e35936 pubmed publisher
    ..These data indicate that L. monocytogenes co-opts host calpain to facilitate its escape from the phagosome, and more generally, that calpain may represent a cellular Achilles heel exploited by pathogens. ..
  31. Felton T, Troke P, Hope W. Tissue penetration of antifungal agents. Clin Microbiol Rev. 2014;27:68-88 pubmed publisher
    ..This review explores these issues and provides a summary of tissue concentrations of 11 currently licensed systemic antifungal agents. It also explores the therapeutic implications of their distribution at various sites of infection. ..
  32. Tassabehji M, Fang Z, Hilton E, McGaughran J, Zhao Z, de Bock C, et al. Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome. Hum Mutat. 2008;29:1017-27 pubmed publisher
  33. Booton R, Lindsay M. Emerging role of MicroRNAs and long noncoding RNAs in respiratory disease. Chest. 2014;146:193-204 pubmed publisher
    ..However, in the short term, changes in miRNA and long noncoding RNA expression are likely to be of use as biomarkers for disease stratification and/or assessment of drug action. ..
  34. Kamjoo M, Brison D, Kimber S. Apoptosis in the preimplantation mouse embryo: effect of strain difference and in vitro culture. Mol Reprod Dev. 2002;61:67-77 pubmed
    ..0005 M16; P = 0.002 kSOM) and than C57BL6/CBA x C57BL6/CBA in M16 (P = 0.019). Our data suggest that genetic make-up and the chemical composition of simple medium are equally important in determining the level of apoptosis. ..
  35. Papadopoulos N, Megremis S, Kitsioulis N, Vangelatou O, West P, Xepapadaki P. Promising approaches for the treatment and prevention of viral respiratory illnesses. J Allergy Clin Immunol. 2017;140:921-932 pubmed publisher
  36. Harlow C, Wu X, van Deemter M, Gardiner F, Poland C, Green R, et al. Targeting lysyl oxidase reduces peritoneal fibrosis. PLoS ONE. 2017;12:e0183013 pubmed publisher
    ..Progesterone significantly inhibited IL-1α induced Lox expression by PMC in vitro. Our results provide proof-of-concept that targeting peritoneal Lox could be an effective approach in ameliorating fibrosis and adhesion development. ..
  37. Andre R, Moggs J, Kimber I, Rothwell N, Pinteaux E. Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia. 2006;53:477-83 pubmed
    ..These results show that IL-1beta exclusively downregulates alpha-syntrophin expression independently of IL-1R1, and suggest the expression of additional functional IL-1 receptors in the CNS. ..
  38. Humphreys N, Xu D, Hepworth M, Liew F, Grencis R. IL-33, a potent inducer of adaptive immunity to intestinal nematodes. J Immunol. 2008;180:2443-9 pubmed
    ..Thus, the ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection, particularly during the initiation of the response. ..
  39. O Connor J, Jayson G. Do imaging biomarkers relate to outcome in patients treated with VEGF inhibitors?. Clin Cancer Res. 2012;18:6588-98 pubmed publisher
    ..However, lack of control data with other therapies prevents assessment of the predictive nature of these biomarkers, and such studies are urgently required...
  40. Thomason H, Dixon M, Dixon J. Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling. Dev Biol. 2008;321:273-82 pubmed publisher
    ..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting. ..
  41. Li Q, O Neill S, Tao T, Li Y, Eisner D, Zhang H. Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study. Biophys J. 2012;102:1471-82 pubmed publisher
    ..This study provides what to our knowledge are new insights into the genesis of Ca(2+) alternans and spontaneous second Ca(2+) release in cardiac myocytes that lack t-tubules. ..
  42. Wilkinson F, Holley R, Langford Smith K, Badrinath S, Liao A, Langford Smith A, et al. Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB. PLoS ONE. 2012;7:e35787 pubmed publisher
    ..These data lend novel insight to MPS neuropathology, suggesting that MPSIIIA and IIIB have more pronounced neuropathology than MPSI, yet all are still progressive, at least in some aspects of neuropathology, from 4-9 months. ..
  43. Bezard E, Dovero S, Prunier C, Ravenscroft P, Chalon S, Guilloteau D, et al. Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J Neurosci. 2001;21:6853-61 pubmed
  44. Baldock C, Koster A, Ziese U, Rock M, Sherratt M, Kadler K, et al. The supramolecular organization of fibrillin-rich microfibrils. J Cell Biol. 2001;152:1045-56 pubmed
  45. Rogers H, Griffiths Jones S. Mitochondrial pseudogenes in the nuclear genomes of Drosophila. PLoS ONE. 2012;7:e32593 pubmed publisher
    ..We estimate genus average rates of insertion of 0.75 per million years, and a duplication rate of 0.010 duplications per numt per million years. ..
  46. Cunliffe P, Reed V, Boyd Y. Intragenic deletions at Atp7a in mouse models for Menkes disease. Genomics. 2001;74:155-62 pubmed
    ..This contrasts with the mutation spectrum associated with MD, emphasizing the need for caution when mottled mice are used as models for the clinical disorder. ..
  47. Yamanushi T, Shui Z, Leach R, Dobrzynski H, Claydon T, Boyett M. Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart. Am J Physiol Heart Circ Physiol. 2007;292:H1737-46 pubmed
    ..It is concluded that a G protein-receptor kinase 2- and beta-arrestin 2-dependent internalization of the M(2) receptor into clathrin-coated vesicles could play a major role in I(K,ACh) desensitization. ..
  48. Taylor S, Al Youha S, Van Agtmael T, Lu Y, Wong J, McGrouther D, et al. Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE. 2011;6:e16337 pubmed publisher
    ..The Col4a1(+/Svc) mouse is an effective animal model for studying adhesion formation because of the presence of a structurally-defective collagen type IV-containing BM. ..
  49. Nicolaou N, Xu Y, Goodacre R. Fourier transform infrared and Raman spectroscopies for the rapid detection, enumeration, and growth interaction of the bacteria Staphylococcus aureus and Lactococcus lactis ssp. cremoris in milk. Anal Chem. 2011;83:5681-7 pubmed publisher
    ..In addition, it has been demonstrated that the L. cremoris metabolic effect in milk dominates that of S. aureus even though there was no growth antagonism observed. ..
  50. Kelly A, Houston S, Sherwood E, Casulli J, Travis M. Regulation of Innate and Adaptive Immunity by TGFβ. Adv Immunol. 2017;134:137-233 pubmed publisher
    ..Here, we review our current knowledge of how TGFβ regulates the immune system, highlighting the multifunctional nature of TGFβ and how its function can change depending on location and context of action. ..
  51. Pelegrin P, Barroso Gutierrez C, Surprenant A. P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol. 2008;180:7147-57 pubmed
    ..None of these release responses were associated with cell damage or cytolytic effects. This provides the first direct demonstration of a distinct signaling mechanism responsible for ATP-induced release of pro-IL-1beta. ..
  52. Rodriguez J, Jones V, Tabuchi M, Allan S, Knight E, LaFerla F, et al. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS ONE. 2008;3:e2935 pubmed publisher
    ..Thus it is conceivable to speculate that a recovery in neurogenesis rates in AD could help to rescue cognitive impairment. ..
  53. Stewart G, Thistlethwaite A, Lees H, Cooper G, Smith C. Vasopressin regulation of the renal UT-A3 urea transporter. Am J Physiol Renal Physiol. 2009;296:F642-8 pubmed publisher
    ..In conclusion, this study details the effects of vasopressin on UT-A3 urea transporter function and hence its role in regulating urea permeability within the renal inner medullary collecting duct. ..
  54. Garwood R, Ross A, Sotty D, Chabard D, Charbonnier S, Sutton M, et al. Tomographic reconstruction of neopterous carboniferous insect nymphs. PLoS ONE. 2012;7:e45779 pubmed publisher
    ..The study of juvenile Palaeozoic insects is currently a neglected field, yet these fossils provide direct evidence on the evolution of insect development. It is hoped this study will stimulate a renewed interest in such work. ..
  55. Kabat A, Harrison O, Riffelmacher T, Moghaddam A, Pearson C, Laing A, et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. elife. 2016;5:e12444 pubmed publisher
    ..These findings provide new insights into the reciprocal control of distinct intestinal TH cell responses by autophagy, with important implications for understanding and treatment of chronic inflammatory disorders. ..
  56. Oliver J, Roderick H, Llewellyn D, High S. ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin. Mol Biol Cell. 1999;10:2573-82 pubmed
    ..We conclude that ERp57 forms complexes with both calnexin and calreticulin and propose that it is these complexes that can specifically modulate glycoprotein folding within the ER lumen. ..
  57. Nühse T, Yu K, Salomon A. Isolation of phosphopeptides by immobilized metal ion affinity chromatography. Curr Protoc Mol Biol. 2007;Chapter 18:Unit 18.13 pubmed publisher
  58. Ma W, Hui H, Pelegrin P, Surprenant A. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther. 2009;328:409-18 pubmed publisher
  59. Keramari M, Razavi J, Ingman K, Patsch C, Edenhofer F, Ward C, et al. Sox2 is essential for formation of trophectoderm in the preimplantation embryo. PLoS ONE. 2010;5:e13952 pubmed publisher
    ..Our findings provide a novel insight into the first differentiation event within the preimplantation embryo, namely the segregation of the ICM and TE lineages. ..
  60. Helmby H, Grencis R. IFN-gamma-independent effects of IL-12 during intestinal nematode infection. J Immunol. 2003;171:3691-6 pubmed
    ..Hence, IL-12 may play a significant biological role as a direct negative regulator of intestinal Th2 responses and may act to promote the survival of intestinal parasites in vivo also in the absence of IFN-gamma. ..
  61. Wang Q, Kumar S, Mitsios N, Slevin M, Kumar P. Investigation of downstream target genes of PAX3c, PAX3e and PAX3g isoforms in melanocytes by microarray analysis. Int J Cancer. 2007;120:1223-31 pubmed
    ..Thus, our data reveal that PAX3 isoforms regulate distinct but overlapping sets of genes in melanocytes in vitro. ..
  62. Begum T, Farrelly P, Craigie R. Non-cross-linked porcine acellular dermal matrix (Strattice Tissue Matrix) in pediatric reconstructive surgery. J Pediatr Surg. 2016;51:461-4 pubmed publisher
    ..In our study, children have a favorable risk profile as compared to published adult series. ..
  63. Cash F, Vernon S, Phelan P, Goodchild J, Baines R. Central cholinergic synaptic vesicle loading obeys the set-point model in Drosophila. J Neurophysiol. 2016;115:843-50 pubmed publisher
    ..This effect spotlights the poly-glutamine domain as potentially being important for sensing the level of neurotransmitter in cholinergic SVs. ..
  64. Price S, Hounsom L, Purves Tyson T, Fernyhough P, Tomlinson D. Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro. Ann N Y Acad Sci. 2003;1010:95-9 pubmed
  65. Stelmashenko O, Lalo U, Yang Y, Bragg L, North R, Compan V. Activation of trimeric P2X2 receptors by fewer than three ATP molecules. Mol Pharmacol. 2012;82:760-6 pubmed
    ..Currents through KKA and KAK receptors were larger than those observed for AKK receptors. The results indicate that trimeric P2X receptors containing only two intact binding sites can be readily activated by ATP. ..
  66. Heighway J, Betticher D, Hoban P, Altermatt H, Cowen R. Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG. Genomics. 1996;35:207-14 pubmed
    ..Multiplex PCR confirmed the inclusion of both genes in the KRAS2 amplicon in human malignancy, suggesting that either may contribute to the malignant phenotype. ..
  67. Friswell M, Gika H, Stratford I, Theodoridis G, Telfer B, Wilson I, et al. Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice. PLoS ONE. 2010;5:e8584 pubmed publisher
    ..However, relocation studies and uterine implantation demonstrated the dominance of environmental influences on the GTM. This was manifested in large variations between isogenic adult mice reared in different research institutions. ..
  68. Gieling R, Babur M, Mamnani L, Burrows N, Telfer B, Carta F, et al. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem. 2012;55:5591-600 pubmed publisher
    ..CA inhibitors of the sulfamate class specifically targeting the tumor-associated isoforms are potential candidates in antimetastatic therapy. ..
  69. Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, et al. Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques. PLoS ONE. 2017;12:e0181677 pubmed publisher
  70. Kielty C, Raghunath M, Siracusa L, Sherratt M, Peters R, Shuttleworth C, et al. The Tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils. J Cell Biol. 1998;140:1159-66 pubmed
    ..These data indicate that Tsk fibrillin-1 polymerizes and becomes incorporated into a discrete population of beaded microfibrils with altered molecular organization. ..
  71. Henry B, Fox S, Crossman A, Brotchie J. Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp Neurol. 2001;171:139-46 pubmed
    ..These data suggest that specific mu- or delta-opioid receptor antagonists might be applicable clinically in the treatment of levodopa-induced dyskinesia in Parkinson's disease...
  72. Bolton Maggs P. Factor XI deficiency--resolving the enigma?. Hematology Am Soc Hematol Educ Program. 2009;:97-105 pubmed publisher
    ..These factors (or enigmas) contribute to the variable management of patients with this coagulation factor deficiency, but recent research is helping to clarify some of these areas. ..
  73. Finegan K, Tournier C. The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer. Cancer Res. 2010;70:5797-806 pubmed publisher
    ..Together, our results provide the first genetic demonstration that MKK4 is essential to mediate the oncogenic effect of Ras in vivo, thereby validating MKK4 as a potential drug target for cancer therapy. ..
  74. Flasza M, Shering A, Smith K, Andrews P, Talley P, Johnson P. Reprogramming in inter-species embryonal carcinoma-somatic cell hybrids induces expression of pluripotency and differentiation markers. Cloning Stem Cells. 2003;5:339-54 pubmed
  75. Beare A, Krane S, Ferguson M. Variable impairment of wound healing in the heterozygous collagenase-resistant mouse. Wound Repair Regen. 2005;13:27-40 pubmed
  76. Cotterill S, Jackson G, Leighton M, Wagener R, Makitie O, Cole W, et al. Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3. Hum Mutat. 2005;26:557-65 pubmed
    ..In summary, the data presented in this paper suggest that MED caused by MATN3 mutations is the result of an intracellular retention of the mutant protein...
  77. Tsakiri N, Kimber I, Rothwell N, Pinteaux E. Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones. Mol Cell Neurosci. 2008;38:259-65 pubmed publisher
  78. Chavas L, Ihara K, Kawasaki M, Kato R, Izumi T, Wakatsuki S. Purification, crystallization and preliminary X-ray crystallographic analysis of Rab27a GTPase in complex with exophilin4/Slp2-a effector. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:599-601 pubmed publisher
    ..8 A. Eventually, the structural characterization of the Rab27a-exophilin4/Slp2-a complex will clarify Rab27 recognition by its effectors prior to vesicle tethering and docking. ..
  79. Soncin F, Mohamet L, Eckardt D, Ritson S, Eastham A, Bobola N, et al. Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal. Stem Cells. 2009;27:2069-80 pubmed publisher
    ..We conclude that transhomodimerization of E-cadherin protein is required for LIF-dependent ES cell self-renewal and that multiple self-renewal signaling networks subsist in ES cells, with activity dependent upon the cellular context. ..
  80. Oceandy D, Pickard A, Prehar S, Zi M, Mohamed T, Stanley P, et al. Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy. Circulation. 2009;120:607-16 pubmed publisher
    ..Our data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway. ..
  81. Woodcock S, Jones R, Edmondson R, Malliri A. A modified tandem affinity purification technique identifies that 14-3-3 proteins interact with Tiam1, an interaction which controls Tiam1 stability. J Proteome Res. 2009;8:5629-41 pubmed publisher
    ..Thus, we have established and proven methodology that allows the identification of additional protein-protein interactions in mammalian cells, resulting in the discovery of a novel mechanism of regulating Tiam1 stability. ..
  82. Hasnain S, Wang H, Ghia J, Haq N, Deng Y, Velcich A, et al. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology. 2010;138:1763-71 pubmed publisher
    ..Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection...
  83. Faroni A, Mantovani C, Shawcross S, Motta M, Terenghi G, Magnaghi V. Schwann-like adult stem cells derived from bone marrow and adipose tissue express ?-aminobutyric acid type B receptors. J Neurosci Res. 2011;89:1351-62 pubmed publisher
    ..The presence of functional GABA-B receptors on differentiated stem cells opens new opportunities for a possible pharmacological modulation of their physiology and phenotype. ..
  84. Kung L, Rajpar M, Briggs M, Boot Handford R. Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response. J Histochem Cytochem. 2012;60:734-48 pubmed
  85. Anderson M, Amin S, Luise F, Zeef L, Bobola N. Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2. PLoS ONE. 2013;8:e63160 pubmed publisher
    ..We further show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch. Hoxa2 is also sufficient to induce Pcp4 expression in anterior first arch cells, which are Pcp4-negative. ..
  86. Tabatabaeifar M, Wlodkowski T, Simić I, Denc H, Mollet G, Weber S, et al. An inducible mouse model of podocin-mutation-related nephrotic syndrome. PLoS ONE. 2017;12:e0186574 pubmed publisher
    ..This model constitutes a valuable tool to test the efficacy of novel pharmacological interventions aimed to improve podocyte function and viability and attenuate proteinuria, glomerulosclerosis and progressive renal failure. ..
  87. Lyon M, Deakin J, Mizuno K, Nakamura T, Gallagher J. Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants. J Biol Chem. 1994;269:11216-23 pubmed
    ..The structural specificity of the HGF-HS interaction is thus shown to be radically different from that previously described for the basic fibroblast growth factor-HS interaction. ..
  88. Norton J, Atherton G. Coupling of cell growth control and apoptosis functions of Id proteins. Mol Cell Biol. 1998;18:2371-81 pubmed
    ..These findings highlight the close coupling between the G1 progression and apoptosis functions of Id proteins and hint at a common mechanism for this family of transcriptional regulators in cell determination. ..
  89. Borrow R, Goldblatt D, Finn A, Southern J, Ashton L, Andrews N, et al. Immunogenicity of, and immunologic memory to, a reduced primary schedule of meningococcal C-tetanus toxoid conjugate vaccine in infants in the United kingdom. Infect Immun. 2003;71:5549-55 pubmed
    ..This study provides the first evidence that the number of doses of MCC-TT used in infant immunization schedules could be decreased. ..
  90. Hubbard S, Grafham D, Beattie K, Overton I, McLaren S, Croning M, et al. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Genome Res. 2005;15:174-83 pubmed
  91. Findlow J, Taylor S, Aase A, Horton R, Heyderman R, Southern J, et al. Comparison and correlation of neisseria meningitidis serogroup B immunologic assay results and human antibody responses following three doses of the Norwegian meningococcal outer membrane vesicle vaccine MenBvac. Infect Immun. 2006;74:4557-65 pubmed
    ..These results emphasize the need for standardized methodologies that would allow a more robust comparison of assays between laboratories and promote their further evaluation as correlates of protection against MenB disease...
  92. deSchoolmeester M, Manku H, Else K. The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response. Infect Immun. 2006;74:6280-6 pubmed