Genomes and Genes
Experts and Doctors on animals in Leeds, England, United Kingdom
Locale: Leeds, England, United Kingdom
Publications373 found, 100 shown here
- Rodgers R, Harvest H, Hassall C, Kaddour L. D-cycloserine enhances memory consolidation in the plus-maze retest paradigm. Behav Neurosci. 2011;125:106-16 pubmed publisher..These data strongly suggest that the EPM retest effect involves glycineB/NMDA receptor-dependent neuroplasticity. Further studies will be required to identify the neural circuitry involved. ..
- Holmes A, Rodgers R. Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine. Eur J Pharmacol. 2003;459:221-30 pubmed..Present findings provide further evidence demonstrating that prior test history is a critical consideration in mouse studies of anxiety-related behavior. ..
- Dunn S, Morrison E, Liverpool T, Molina París C, Cross R, Alonso M, et al. Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells. J Cell Sci. 2008;121:1085-95 pubmed publisher..These data suggest that kinesin-1 preferentially binds to and trafficks on detyrosinated microtubules in vivo, providing a potential basis for the spatial targeting of kinesin-1-based cargo transport. ..
- Miller D, Paradowska A. Evaluating the localization and DNA binding complexity of histones in mature sperm. Methods Mol Biol. 2013;927:459-75 pubmed..However, similar methods may be applicable to the sperm of other mammalian and even non-mammalian classes. ..
- Picton H, Harris S, Muruvi W, Chambers E. The in vitro growth and maturation of follicles. Reproduction. 2008;136:703-15 pubmed publisher..Finally, cytoplasmic and nuclear maturation will be induced in the in vitro derived oocytes with the production of fertile metaphase II gametes. ..
- Xu S, Beech D. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. Circ Res. 2001;88:84-7 pubmed..The antibody is a powerful new tool for the study of mammalian trp1 gene product. The study shows that TrpC1 is a novel physiological Ca(2+) channel subunit in arterial smooth muscle cells. ..
- Musa H, Lei M, Honjo H, Jones S, Dobrzynski H, Lancaster M, et al. Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node. J Histochem Cytochem. 2002;50:311-24 pubmed
- Mary D, Stoker J. The activity of single vasoconstrictor nerve units in hypertension. Acta Physiol Scand. 2003;177:367-76 pubmed..Target organ damage may in turn lead to an increase in overall sympathetic output (excessive MSNA increase) through the operation of peripheral reflex mechanisms. ..
- Cunningham M, Davies C, Buhl E, Kopell N, Whittington M. Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro. J Neurosci. 2003;23:9761-9 pubmed..We propose that similar cellular and network mechanisms to those seen in the hippocampus generate and modulate persistent gamma oscillations in the entorhinal cortex. ..
- Bentley G, Jones A, Oliveros Parra W, Agnew A. ShAR1alpha and ShAR1beta: novel putative nicotinic acetylcholine receptor subunits from the platyhelminth blood fluke Schistosoma. Gene. 2004;329:27-38 pubmed..We discuss our findings in the context of the proposed role for surface nAChRs in the regulation of glucose uptake in the parasite, and the potential exploitation of these receptors as targets for cholinergic schistosomicides. ..
- Fowler M, Cooper G, Hunter M. Regulation and identity of intracellular calcium stores involved in membrane cross talk in the early distal tubule of the frog kidney. Am J Physiol Renal Physiol. 2004;286:F1219-25 pubmed..A second pool, sensitive to ionomycin but not IP(3), may overlap with the IP(3)-sensitve pool. The data also rule out any contribution by mitochondria to EDT Ca(2+) cycling. ..
- Hope I, Stevens J, Garner A, Hayes J, Cheo D, Brasch M, et al. Feasibility of genome-scale construction of promoter::reporter gene fusions for expression in Caenorhabditis elegans using a multisite gateway recombination system. Genome Res. 2004;14:2070-5 pubmed..The recombinational cloning involved in the Gateway system, which permits the highly efficient and precise transfer of DNA segments between plasmid vectors, makes this technology ideal for genomics research programs. ..
- Whitaker I, Cheung C, Chahal C, Karoo R, Gulati A, Foo I. By what mechanism do leeches help to salvage ischaemic tissues? A review. Br J Oral Maxillofac Surg. 2005;43:155-60 pubmed..We aim to summarise the anatomy, physiology, and pharmacological mechanisms of action of leeches to provide reconstructive surgeons with a theoretical basis for their use. ..
- Smith P, Oakley F, Fernandez M, Mann D, Lemoine N, Whitehouse A. Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging. Gene Ther. 2005;12:1465-76 pubmed
- Wilcox R. The biomechanical effect of vertebroplasty on the adjacent vertebral body: a finite element study. Proc Inst Mech Eng H. 2006;220:565-72 pubmed..The model results suggest that clinicians should be wary of using standard vertebroplasty cements to treat compression fractures in patients with highly osteoporotic bone. ..
- Bentley G, Jones A, Agnew A. ShAR2beta, a divergent nicotinic acetylcholine receptor subunit from the blood fluke Schistosoma. Parasitology. 2007;134:833-40 pubmed..We discuss our findings in the context of potentially exploiting this receptor as a target for controlling schistosome parasites. ..
- Crowley D, Kanakaris N, Giannoudis P. Irrigation of the wounds in open fractures. J Bone Joint Surg Br. 2007;89:580-5 pubmed..New systems for debridement are currently being investigated, and an ideal method has yet to be determined...
- Bartie K, Devine D, Wilson M, Lewis M. In vitro susceptibility of the Streptococcus milleri group to antimicrobial peptides. Int Endod J. 2008;41:586-92 pubmed publisher..To determine the susceptibility of strains of the Streptococcus milleri group (SMG) to commercially available antimicrobial peptides...
- Roberts N, Magee D, Song Y, Brabazon K, Shires M, Crellin D, et al. Toward routine use of 3D histopathology as a research tool. Am J Pathol. 2012;180:1835-42 pubmed publisher..Both 3D tissue volumes and generated 3D models are presented for four demonstrator cases. ..
- Wang Y, Wang J, Ou Yang G, Li X, Henderson Z, Lu C. Co-activation of nAChR and mGluR induces ? oscillation in rat medial septum diagonal band of Broca slices. Acta Pharmacol Sin. 2014;35:175-84 pubmed publisher..Activation of mGluR1 and nAChR is able to program slow or fast network oscillation by altering the intensity of receptor activation, which may provide a mechanism for modulation of learning and memory. ..
- Mannion C, Graham A, Shepherd K, Greenberg D. Dog bites and maxillofacial surgery: what can we do?. Br J Oral Maxillofac Surg. 2015;53:522-5 pubmed publisher..Educational strategies should aim to reduce the incidence of all dog bites, particularly in young children, as their needs after initial treatment are complex. We propose specific strategies to reduce the number of these injuries. ..
- Clausen M, Ralet M, Willats W, McCartney L, Marcus S, Thibault J, et al. A monoclonal antibody to feruloylated-(1-->4)-beta-D-galactan. Planta. 2004;219:1036-41 pubmed..LM9 is therefore a useful antibody probe for the analysis of phenolic substitution of cell wall pectic polymers and of cell wall structure in the Amaranthaceae including sugar beet (Beta vulgaris L.) and spinach (Spinacia oleracea L.). ..
- Ardley H, Scott G, Rose S, Tan N, Robinson P. UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease. J Neurochem. 2004;90:379-91 pubmed..Furthermore, UCH-L1 accumulation is likely to play a pathological role in inclusion formation in Parkinson's disease. ..
- Turner A, Nalivaeva N. Proteinase dysbalance in pathology: the neprilysin (NEP) and angiotensin-converting enzyme (ACE) families. Cell Mol Biol (Noisy-le-grand). 2006;52:40-8 pubmed..Finally, the serendipitous discovery of ACE2 as the SARS virus receptor illustrates the surprises always in store from nature. ..
- Fountain S, Cheong A, Li J, Dondas N, Zeng F, Wood I, et al. K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress. Am J Physiol Heart Circ Physiol. 2007;293:H2719-25 pubmed..5 channel expression in physiological or pathological conditions. ..
- Kanakaris N, Giannoudis P. Clinical applications of bone morphogenetic proteins: current evidence. J Surg Orthop Adv. 2008;17:133-46 pubmed
- Grant C, Brockwell D, Radford S, Thomson N. Tuning the elastic modulus of hydrated collagen fibrils. Biophys J. 2009;97:2985-92 pubmed publisher..These include hydration forces and hydrogen bonding, ion pairs, and possibly the hydrophobic effect. Tuning of the relative strengths of these forces allows rational tuning of the elastic modulus of the fibrils. ..
- Tatterton M, Wilshaw S, Ingham E, Homer Vanniasinkam S. The use of antithrombotic therapies in reducing synthetic small-diameter vascular graft thrombosis. Vasc Endovascular Surg. 2012;46:212-22 pubmed publisher..Very few antithrombotic therapies have translated into clinical use. More human in vivo studies are required to assess the efficacy and safety of such therapies. ..
- Greaves E, Copeland N, Coverley D, Ainscough J. Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells. J Cell Sci. 2012;125:2466-77 pubmed publisher..Together, the data imply post-replicative roles for CIZ1 in germ cell differentiation that might include meiotic recombination - a process intrinsic to genome stability and diversification. ..
- Abdelhamed Z, Wheway G, Szymanska K, Natarajan S, Toomes C, Inglehearn C, et al. Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects. Hum Mol Genet. 2013;22:1358-72 pubmed publisher..The Tmem67(tm1(Dgen/H)) line is unique in modelling the variable expressivity of phenotypes in these two ciliopathies. ..
- Ooi L, Gigout S, Pettinger L, Gamper N. Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. J Neurosci. 2013;33:6041-6 pubmed publisher..This sensor may play an important role in mediating excitatory effects of NO in such trigeminal disorders as headache and migraine. ..
- Guy J, Lambert D, Warner F, Hooper N, Turner A. Membrane-associated zinc peptidase families: comparing ACE and ACE2. Biochim Biophys Acta. 2005;1751:2-8 pubmed..As the complexity of this crucial pathway is unravelled, there is a growing interest in the therapeutic potential of agents that modulate the activity of ACE2. ..
- Hordon L, Itoda M, Shore P, Shore R, Heald M, Brown M, et al. Preservation of thoracic spine microarchitecture by alendronate: comparison of histology and microCT. Bone. 2006;38:444-9 pubmed..Added to this is now suggested the preservation of several aspects of vertebral cancellous architecture, with microscopy the most sensitive method of analysis. ..
- Tomlinson D, Lamont F, Shnyder S, Knowles M. Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer. Cancer Res. 2009;69:4613-20 pubmed publisher..Our results indicate that FGFR1 has significant effects on urothelial cell phenotype and may represent a useful therapeutic target in some cases of urothelial carcinoma. ..
- Xue W, Hellewell A, Hewitt E, Radford S. Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters. Prion. 2010;4:20-5 pubmed..Controlling fibril length and stability toward fracturing, and thereby the biological availability of fibril material, may provide a new target for future therapeutic strategies towards combating amyloid disease. ..
- Kolokotroni K, Rodgers R, Harrison A. Acute nicotine increases both impulsive choice and behavioural disinhibition in rats. Psychopharmacology (Berl). 2011;217:455-73 pubmed publisher..As such, drug-induced changes in impulsivity may play a critical role in the transition to and maintenance of nicotine dependence. ..
- Groves D, Fisher J, Williams S. An in vitro simulation method for the tribological assessment of complete natural hip joints. PLoS ONE. 2017;12:e0184226 pubmed publisher..It is envisaged that this methodology will be used to investigate morphological risk factors for developing hip osteoarthritis, as well as the effectiveness of early interventional treatments for degenerative hip disease. ..
- Andrew E, Newton D, Dalton J, Egan C, Goodwin S, Tramonti D, et al. Delineation of the function of a major gamma delta T cell subset during infection. J Immunol. 2005;175:1741-50 pubmed
- Luo Z, Seedhom B. Light and low-frequency pulsatile hydrostatic pressure enhances extracellular matrix formation by bone marrow mesenchymal cells: an in-vitro study with special reference to cartilage repair. Proc Inst Mech Eng H. 2007;221:499-507 pubmed..05). The results suggest that a light PHP applied at a low frequency has a cumulative stimulatory effect on the BMMCs' metabolic activities including cell proliferation and synthesis of the extracellular matrix. ..
- Kozera L, White E, Calaghan S. Caveolae act as membrane reserves which limit mechanosensitive I(Cl,swell) channel activation during swelling in the rat ventricular myocyte. PLoS ONE. 2009;4:e8312 pubmed publisher..They illustrate a general principle whereby caveolae as a membrane reserve limit increases in membrane tension during stretch/swelling thereby restricting mechanosensitive channel activation. ..
- Dallas M, Boyle J, Milligan C, Sayer R, Kerrigan T, McKinstry C, et al. Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1. FASEB J. 2011;25:1519-30 pubmed publisher..Our results provide a novel mechanism to account for the neuroprotective effects of CO against oxidative apoptosis, which has potential for therapeutic exploitation to provide neuronal protection in situations of oxidative stress. ..
- Nowak A, Mathieson H, Chapman R, Janzso G, Yanagawa Y, Obata K, et al. Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones. J Chem Neuroanat. 2011;42:30-8 pubmed publisher..These data suggest that whilst both GAD65-GFP and GAD67-GFP +ve neurones express Kv3.1b and therefore may share certain biophysical traits, their responses to peripheral noxious stimulation are distinct. ..
- Brüning Richardson A, Langford K, Ruane P, Lee T, Askham J, Morrison E. EB1 is required for spindle symmetry in mammalian mitosis. PLoS ONE. 2011;6:e28884 pubmed publisher..Our work confirms that EB1 and APC have important mitotic roles, the loss of which could contribute to CIN in colorectal tumour cells. ..
- Hogarth A, Dobson L, Tayebjee M. During ablation for atrial fibrillation, is simultaneous renal artery ablation appropriate?. J Hum Hypertens. 2013;27:707-14 pubmed publisher..The aim of this review is to explore the link between hypertension and AF, the synergistic effect of renal artery ablation on AF ablation, explain how this may work and address unanswered questions. ..
- Proffitt J, Crabtree G, Grove M, Daubersies P, Bailleul B, Wright E, et al. An ATF/CREB-binding site is essential for cell-specific and inducible transcription of the murine MIP-1 beta cytokine gene. Gene. 1995;152:173-9 pubmed
- Altringham J, Block B. Why do tuna maintain elevated slow muscle temperatures? Power output of muscle isolated from endothermic and ectothermic fish. J Exp Biol. 1997;200:2617-27 pubmed..This reserve should be sufficient to power significantly higher sustainable swimming speeds, presumably at lower energetic cost than if intrinsically less efficient fast fibres were recruited. ..
- Atkinson L, Batten T, Corbett E, Sinfield J, Deuchars J. Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs. Neuroscience. 2003;118:115-22 pubmed..The lack of nNOS in vagal afferent terminals in the NTS, yet the presence in some vagal afferent cell bodies, suggests it is selectively targeted to specific regions of the same neurones. ..
- Simpson R, Wilding C, Grahame J. Intron analyses reveal multiple calmodulin copies in Littorina. J Mol Evol. 2005;60:505-12 pubmed..This suggests a higher number of, and more ancient, gene duplications than previously detected in a single genus. ..
- Dalton J, Cruickshank S, Egan C, Mears R, Newton D, Andrew E, et al. Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection. Gastroenterology. 2006;131:818-29 pubmed
- Rodgers R. More haste, considerably less speed. J Psychopharmacol. 2007;21:141-3 pubmed
- Lee T, Langford K, Askham J, Brüning Richardson A, Morrison E. MCAK associates with EB1. Oncogene. 2008;27:2494-500 pubmed
- Liu X, Ma W, Surprenant A, Jiang L. Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH. Br J Pharmacol. 2009;156:135-42 pubmed publisher..Functional inhibition of rat P2X(7) receptors by acidic pH was variably affected by the extra-cellular His(85), Lys(110), Lys(137), Asp(197) and His(219) residues, with the Asp(197) residue being most critical for this inhibition. ..
- Mucha M, Ooi L, Linley J, Mordaka P, Dalle C, Robertson B, et al. Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability. J Neurosci. 2010;30:13235-45 pubmed publisher..We propose that these mechanisms are important in the control of excitability of neurons and may have implications in seizure activity and pain. ..
- Abbas A, Imrie H, Viswambharan H, Sukumar P, Rajwani A, Cubbon R, et al. The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes. 2011;60:2169-78 pubmed publisher..These data demonstrate that IGF-1R is a critical negative regulator of insulin sensitivity and NO bioavailability in the endothelium. ..
- Nishiyama H, Gill J, Pitt E, Kennedy W, Knowles M. Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. Oncogene. 2001;20:2956-64 pubmed..The levels of apoptosis were not altered. These results demonstrate a role for DBCCR1 in cell cycle control, thereby supporting the hypothesis that this is the tumour suppressor gene targeted by 9q32-33 deletion in bladder cancer. ..
- Green K, Peers C. Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB. J Neurochem. 2002;81:1043-51 pubmed
- Hilton K, Bateson A, King A. A model of organotypic rat spinal slice culture and biolistic transfection to elucidate factors that drive the preprotachykinin-A promoter. Brain Res Brain Res Rev. 2004;46:191-203 pubmed..These data demonstrate the usefulness of this model to study physiological and pharmacological factors relevant to nociceptive processing that can modulate PPT-A promoter activity. ..
- Ilett E, Prestwich R, Kottke T, Errington F, Thompson J, Harrington K, et al. Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity. Gene Ther. 2009;16:689-99 pubmed publisher..These findings are therefore of direct translational relevance for the future design of clinical trials. ..
- Spary E, Maqbool A, Batten T. Changes in oestrogen receptor alpha expression in the nucleus of the solitary tract of the rat over the oestrous cycle and following ovariectomy. J Neuroendocrinol. 2010;22:492-502 pubmed publisher..This may have consequences for the regulation of autonomic tone and baroreflex sensitivity when oestrogen levels decline, for example following menopause. ..
- Nalivaeva N, Belyaev N, Lewis D, Pickles A, Makova N, Bagrova D, et al. Effect of sodium valproate administration on brain neprilysin expression and memory in rats. J Mol Neurosci. 2012;46:569-77 pubmed publisher..This suggests that VA and more specific HDAC inhibitors can be considered as potential pharmaceutical agents for up-regulation of NEP activity and improvement of cognitive functions of ageing brain. ..
- McConkey G, Martin H, Bristow G, Webster J. Toxoplasma gondii infection and behaviour - location, location, location?. J Exp Biol. 2013;216:113-9 pubmed publisher..A mechanism is proposed that could explain the behaviour changes due to parasite regulation of dopamine. This could have important implications for T. gondii infections in humans. ..
- Bonthron D, Smith S, Campbell R. Complex patterns of intragenic polymorphism at the PDGFA locus. Hum Genet. 1999;105:452-9 pubmed..The high level of polymorphism demonstrated in this region will also be valuable for disease-association and linkage studies of the PDGFA locus. ..
- Ashcroft A, Cruickshank S, Croucher P, Perry M, Rollinson S, Lippitt J, et al. Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity. 2003;19:849-61 pubmed..This study identifies a common causal link between bone disease and intestinal inflammation and establishes the importance of DC in mediating colonic inflammation in vivo. ..
- Botham M, Kerfoot C, Louca V, Krause J. The effects of different predator species on antipredator behavior in the Trinidadian guppy, Poecilia reticulata. Naturwissenschaften. 2006;93:431-9 pubmed..We discuss these results in the context of multiple predator effects. ..
- Dixon N, Pali T, Kee T, Ball S, Harrison M, Findlay J, et al. Interaction of spin-labeled inhibitors of the vacuolar H+-ATPase with the transmembrane Vo-sector. Biophys J. 2008;94:506-14 pubmed..The INDOL6 derivative, which is closest to the parent INDOL0 inhibitor, displays limited subtype specificity for the osteoclast V-ATPase, with an IC(50) in the 10-nanomolar range. ..
- Mathews R, Sprakes M, McDermott M. NOD-like receptors and inflammation. Arthritis Res Ther. 2008;10:228 pubmed publisher..This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function. ..
- Odell A, Askham J, Whibley C, Hollstein M. How to become immortal: let MEFs count the ways. Aging (Albany NY). 2010;2:160-5 pubmed..Here we consider various routes to p53/ARF disruption in senescence bypass, and dysfunction of other tumour suppressor networks that may contribute to release from tenacious cell cycle arrest in senescent cultures. ..
- Quinnell R, Pritchard D, Raiko A, Brown A, Shaw M. Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection. J Infect Dis. 2004;190:430-8 pubmed..americanus antigen. Resistance to reinfection is associated with the parasite-specific IL-5 response...
- Korossis S, Wilcox H, Watterson K, Kearney J, Ingham E, Fisher J. In-vitro assessment of the functional performance of the decellularized intact porcine aortic root. J Heart Valve Dis. 2005;14:408-21; discussion 422 pubmed..This approach can be used for both allogeneic and xenogeneic tissue matrices. ..
- Freeman J, Baines S, Jabes D, Wilcox M. Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection. J Antimicrob Chemother. 2005;56:717-25 pubmed..Ramoplanin may be more effective than vancomycin at killing spores and preventing spore recrudescence. These findings suggest a potential therapeutic role for ramoplanin in CDI that requires further clinical investigation. ..
- Fisk L, Nalivaeva N, Boyle J, Peers C, Turner A. Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes. Neurochem Res. 2007;32:1741-8 pubmed..On contrary in astrocytes hypoxia increased NEP mRNA expression. ..
- Orsi N, Tribe R. Cytokine networks and the regulation of uterine function in pregnancy and parturition. J Neuroendocrinol. 2008;20:462-9 pubmed publisher..Further insight into the complexity of cytokine networks will be required to develop novel therapeutic strategies for the treatment of cytokine imbalances in pregnancy. ..
- Lever C, Burton S, Jeewajee A, Wills T, Cacucci F, Burgess N, et al. Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum. Hippocampus. 2010;20:229-34 pubmed publisher..Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty-induced plasticity in CA1. ..
- Aydin S, Bas E, Basci O, Filippucci E, Wakefield R, Celikel C, et al. Validation of ultrasound imaging for Achilles entheseal fibrocartilage in bovines and description of changes in humans with spondyloarthritis. Ann Rheum Dis. 2010;69:2165-8 pubmed publisher..6 ± 0.2 vs 0.5 ± 0.1 mm; p=0.009) compared with women. Ultrasound can visualise EF of the AT insertion, which can be abnormal in cases of spondyloarthritis. This has implications for a better understanding of enthesopathy. ..
- Subramanian H, Holstege G. Midbrain and medullary control of postinspiratory activity of the crural and costal diaphragm in vivo. J Neurophysiol. 2011;105:2852-62 pubmed publisher..These data demonstrate that three-phase breathing in the crural diaphragm during eupnea exists in vivo and that postinspiratory neurons have an inhibitory effect on crural diaphragm function. ..
- Blyth K, Carter P, Morrissey B, Chelala C, Jones L, Holen I, et al. SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. Breast Cancer Res Treat. 2016;156:447-452 pubmed publisher..Access to this unique resource is freely available to all academic researchers following registration at https://searchbreast.org. ..
- Durham B, Grigg R, Wood I. Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism. J Neurochem. 2017;143:214-224 pubmed publisher..Taken together, this study supports the idea that inhibitors selective towards HDAC1 or HDAC2, may be therapeutically useful for targeting neuroinflammation in brain injuries and neurodegenerative disease. ..
- Lee A, Machell J, van den Broek A, Nisbet A, Miller H, Isaac R, et al. Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens. Parasite Immunol. 2002;24:413-22 pubmed..The IgE-antibody response to whole mite extract was poor in four of five animals. However, a marked IgE response occurred in the fifth animal, and IgE anti Pso o 1 was detected in the serum...
- Walters M, Hall K, Whitehouse A. The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an at hook required for binding to the ORF 50 response element in delayed-early promoters. J Virol. 2004;78:4936-42 pubmed..In addition, p50GFPDeltaAT-hook is capable of functioning as a trans-dominant mutant, leading to a reduction in virus production of approximately 50% compared to that for wild-type ORF 50. ..
- Brooke R, Moores T, Morris N, Parson S, Deuchars J. Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals. Eur J Neurosci. 2004;20:3313-21 pubmed..05-1 microM. The combined presynaptic localization of Kv3 subunits and pharmacological enhancement of EPP amplitude indicate that Kv3 channels regulate neurotransmitter release from presynaptic terminals at the NMJ. ..
- Derham C, Yow H, Ingram J, Fisher J, Ingham E, Korrosis S, et al. Tissue engineering small-diameter vascular grafts: preparation of a biocompatible porcine ureteric scaffold. Tissue Eng Part A. 2008;14:1871-82 pubmed publisher..This study has demonstrated the potential of acellular porcine ureteric scaffolds in tissue engineering small-diameter living vascular grafts. ..
- Pierce M, Deuchars J, Deuchars S. Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice. Neuroscience. 2010;170:827-38 pubmed publisher..This work questions the assumption that sympathetic rhythms are dependent on supraspinal pacemaker circuits, by highlighting a surprisingly strong rhythmogenic capability of the reduced sympathetic networks of the spinal cord slice. ..
- Hesselink R, Findlay J. Expression, characterization and ligand specificity of lipocalin-1 interacting membrane receptor (LIMR). Mol Membr Biol. 2013;30:327-37 pubmed publisher..No interactions with any of the other putative ligands could be detected, raising doubts about the physiological relevance of the reported binding of BLG and UG to the receptor. ..