Experts and Doctors on amino acid sequence in London, England, United Kingdom


Locale: London, England, United Kingdom
Topic: amino acid sequence

Top Publications

  1. Haley J, Waterfield M. Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis. J Biol Chem. 1991;266:1746-53 pubmed
  2. Toker A, Ellis C, Sellers L, Aitken A. Protein kinase C inhibitor proteins. Purification from sheep brain and sequence similarity to lipocortins and 14-3-3 protein. Eur J Biochem. 1990;191:421-9 pubmed
  3. Alexander D, Goris J, Marais R, Rothbard J, Merlevede W, Crumpton M. Dephosphorylation of the human T lymphocyte CD3 antigen. Eur J Biochem. 1989;181:55-65 pubmed
    ..The data point to an important role for polycation-stimulated phosphatases in regulating the phosphorylation state, and so function(s), of the CD3 antigen. ..
  4. Hurley J, Gardiner J, Jones P, Bloom S. Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis. Endocrinology. 1995;136:550-7 pubmed
  5. Sali A, Blundell T. Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol. 1993;234:779-815 pubmed
    ..The method is automated and is illustrated by the modelling of trypsin from two other serine proteinases. ..
  6. Craighead M, Bowden S, Watson R, Armstrong J. Function of the ypt2 gene in the exocytic pathway of Schizosaccharomyces pombe. Mol Biol Cell. 1993;4:1069-76 pubmed
    ..Thus the ypt2 protein, and by inference rab8, appear to function in the last stage of the secretory pathway. ..
  7. Tailor C, Takeuchi Y, O HARA B, Johann S, Weiss R, Collins M. Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections. J Virol. 1993;67:6737-41 pubmed
    ..Substitution of human GLVR1 amino acids in the critical region of rat GLVR1 identified three amino acids as responsible for resistance to FeLV-B infection; two of these affect SSAV infection, but none affects GALV infection...
  8. Chambers J, Solomon E. Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. Genomics. 1996;38:305-13 pubmed
    ..Analysis of the murine Nbr1 genomic clones indicates that it maps less than 1 kb from the Brca1 gene and that, unlike that in human, this region is not duplicated. ..
  9. Hong Y, Cole T, Brasier C, Buck K. Evolutionary relationships among putative RNA-dependent RNA polymerases encoded by a mitochondrial virus-like RNA in the Dutch elm disease fungus, Ophiostoma novo-ulmi, by other viruses and virus-like RNAs and by the Arabidopsis mitochondrial genome. Virology. 1998;246:158-69 pubmed publisher

More Information

Publications133 found, 100 shown here

  1. Stanier P, Abu Hayyeh S, Murdoch J, Eddleston J, Copp A. Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. Genomics. 1998;51:144-7 pubmed
  2. Llevadot R, Marques G, Pritchard M, Estivill X, Ferrus A, Scambler P. Cloning, chromosome mapping and expression analysis of the HIRA gene from Drosophila melanogaster. Biochem Biophys Res Commun. 1998;249:486-91 pubmed
    ..The expression of dhira is dramatically increased in early embryos and in females, suggesting that the dhira mRNA could be maternally deposited in the embryos. ..
  3. Srinivasan R, Benton E, McCormick F, Thomas H, Gullick W. Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Clin Cancer Res. 1999;5:2877-83 pubmed
    ..These results suggest that signaling through the c-erbB-3 and c-erbB-4 receptors and the ligands neuregulin alpha, neuregulin beta, and betacellulin are important in endometrial carcinogenesis. ..
  4. Perry J, Short K, Romer J, Swift S, Cox T, Ashworth A. FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules. Genomics. 1999;62:385-94 pubmed
    ..The FXY/MID1 protein has previously been shown to colocalize with microtubules, and here we show that the FXY2 protein similarly associates with microtubules in a manner that is dependent on the carboxy-terminal B30.2 domain. ..
  5. Morgan M, Whawell S. The structure of the human LIM protein ACT gene and its expression in tumor cell lines. Biochem Biophys Res Commun. 2000;273:776-83 pubmed
    ..Interestingly, FHL1, FHL2, and FHL3 were also found to be expressed in some of these cell lines and the results suggest an important role for FHLs in tumor biology. ..
  6. Meyer P, Prodromou C, Hu B, Vaughan C, Roe S, Panaretou B, et al. Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Mol Cell. 2003;11:647-58 pubmed
  7. Andrawiss M, Takeuchi Y, Hewlett L, Collins M. Murine leukemia virus particle assembly quantitated by fluorescence microscopy: role of Gag-Gag interactions and membrane association. J Virol. 2003;77:11651-60 pubmed
    ..These data suggest that two independent mechanisms, CA interactions and membrane association following myristylation, cooperate in MLV Gag assembly and budding...
  8. Dromey J, Weenink S, Peters G, Endl J, Tighe P, Todd I, et al. Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants. J Immunol. 2004;172:4084-90 pubmed
    ..This study identifies a region commonly recognized by autoantibodies in type 1 diabetes that overlaps with dominant T cell determinants. ..
  9. Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld F, Smith G. A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathog. 2007;3:e17 pubmed
    ..This study identifies a new regulator of cell death that is highly conserved in evolution from plants to insects, amphibians, mammals, and poxviruses...
  10. Mercer P, Johns R, Scotton C, Krupiczojc M, Konigshoff M, Howell D, et al. Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Am J Respir Crit Care Med. 2009;179:414-25 pubmed publisher
  11. Leen E, Baeza G, Curry S. Structure of a murine norovirus NS6 protease-product complex revealed by adventitious crystallisation. PLoS ONE. 2012;7:e38723 pubmed publisher
    ..The observed mode of binding of the C-terminal product peptide yields new insights into the structural basis of NS6(pro) specificity. ..
  12. Elphick M, Achhala S, Martynyuk N. The evolution and diversity of SALMFamide neuropeptides. PLoS ONE. 2013;8:e59076 pubmed publisher
    ..Thus, the SALMFamides would be a good model system for experimental analysis of the physiological significance of neuropeptide "cocktails" derived from the same precursor protein. ..
  13. Autore F, Pfuhl M, Quan X, Williams A, Roberts R, Shanahan C, et al. Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins. PLoS ONE. 2013;8:e63633 pubmed publisher
    ..Molecular Dynamics simulations have been performed to study the structural and elastic properties of consecutive SRs, revealing insights in the mechanical properties adopted by these modules in the cell. ..
  14. Minneci F, Piovesan D, Cozzetto D, Jones D. FFPred 2.0: improved homology-independent prediction of gene ontology terms for eukaryotic protein sequences. PLoS ONE. 2013;8:e63754 pubmed publisher
    ..We illustrate all these points through the use of both precision-recall plots and of the COGIC scores, which we recently proposed as an alternative numerical evaluation measure of function prediction accuracy. ..
  15. Wheeler G, Parker A, Thomas C, Ataliotis P, Poynter D, Arnemann J, et al. Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. Proc Natl Acad Sci U S A. 1991;88:4796-800 pubmed
    ..As in the cadherins, the extracellular domain contains possible Ca2(+)-binding sequences and a potential protease processing site. The cell adhesion recognition region (His-Ala-Val) of the cadherins is modified to Arg-Ala-Leu. ..
  16. Chazot P, Coleman S, Cik M, Stephenson F. Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J Biol Chem. 1994;269:24403-9 pubmed
    ..These results show that the three NMDA receptor subunit types can co-assemble following their co-expression in mammalian cells with a pharmacological profile that is similar to that found for adult cerebellar NMDA receptors. ..
  17. Townsend P, Farza H, MacGeoch C, Spurr N, Wade R, Gahlmann R, et al. Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q. Genomics. 1994;21:311-6 pubmed
    ..Hybridization of the cloned cDNAs to genomic DNA identifies a single-copy gene, and using somatic cell hybrid analysis, we have mapped the corresponding gene locus (designated TNNT2) to the long arm of chromosome 1 (1cen-qter). ..
  18. Carr M, Bauer C, Gradwell M, Feeney J. Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein. Proc Natl Acad Sci U S A. 1994;91:2206-10 pubmed
    ..The two patches are located at the far ends of the protein molecule, and we propose that these residues form at least part of the receptor binding site, or sites, on pSP. ..
  19. Sowden J, Morrison K, Schofield J, Putt W, Edwards Y. A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l). Genomics. 1995;29:145-51 pubmed
    ..These observations are consistent with Tceb1l being an RNA polymerase II elongation factor and suggest that Tceb1l/p15-like peptides may be a new family of proteins that influence RNA elongation. ..
  20. Johnston C, Cox H, Gomm J, Coombes R. Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus. J Biol Chem. 1995;270:30643-50 pubmed
    ..We conclude that two forms of FGFR-3 are present in breast epithelial cells; a full-length 135-kDa receptor, which has a conventional membrane localization, and a novel soluble form of 110 kDa. ..
  21. Armes N, Fried M. Surfeit locus gene homologs are widely distributed in invertebrate genomes. Mol Cell Biol. 1996;16:5591-6 pubmed
  22. Hui N, Nakamura N, Sönnichsen B, Shima D, Nilsson T, Warren G. An isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic reticulum retrieval signal. Mol Biol Cell. 1997;8:1777-87 pubmed
    ..The predicted absence of the long form in budding yeast points to a function unique to higher organisms. ..
  23. Lawson D, Harrison M, Shapland C. Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines. Cell Motil Cytoskeleton. 1997;38:250-7 pubmed
    ..Tg down-regulation may therefore be an early and sensitive marker for the onset of transformation. A functional role for Tg is unlikely to directly involve Ca2+ since it neither contains a functional EF hand nor binds 45Ca2+. ..
  24. Katsanis N, Fisher E. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. Genomics. 1998;51:128-31 pubmed
    ..9 and 7.0 kb in all tissues. In addition, we have mapped UBC7 to human chromosome 21q22.3 close to 21qtel. ..
  25. Hohenester E, Tisi D, Talts J, Timpl R. The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin. Mol Cell. 1999;4:783-92 pubmed
    ..A calcium-coordinated sulfate ion is suggested to mimic the binding of anionic oligosaccharides. The structure demonstrates a conserved function of the LG module in calcium-dependent lectin-like alpha-DG binding. ..
  26. Chambers D, Medhurst A, Walsh F, Price J, Mason I. Differential display of genes expressed at the midbrain - hindbrain junction identifies sprouty2: an FGF8-inducible member of a family of intracellular FGF antagonists. Mol Cell Neurosci. 2000;15:22-35 pubmed
    ..These data suggest that sprouty2 participates in a negative feedback regulatory loop to modulate the patterning activity of FGF8 at the isthmus. ..
  27. Cox B, Hadjantonakis A, Collins J, Magee A. Cloning and expression throughout mouse development of mfat1, a homologue of the Drosophila tumour suppressor gene fat. Dev Dyn. 2000;217:233-40 pubmed
    ..RT-PCR detects widespread expression in the adult suggesting a role in proliferation and differentiation of many tissues and cell types. ..
  28. Marinaki A, Escuredo E, Duley J, Simmonds H, Amici A, Naponelli V, et al. Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency. Blood. 2001;97:3327-32 pubmed
    ..This study is the first description of the structure and location of the P5'N-1 gene, and 3 mutations have been identified in affected patients from separate kindreds. (Blood. 2001;97:3327-3332) ..
  29. Kemp T, Sadusky T, Simon M, Brown R, Eastwood M, Sassoon D, et al. Identification of a novel stretch-responsive skeletal muscle gene (Smpx). Genomics. 2001;72:260-71 pubmed
    ..This gene has been called "small muscle protein (X chromosome)" (Smpx; HGMW-approved human gene symbol SMPX) and we hypothesize that it plays a role in skeletal muscle hypertrophy. ..
  30. Diez S, Gomez B, Restrepo A, Hay R, Hamilton A. Paracoccidioides brasiliensis 87-kilodalton antigen, a heat shock protein useful in diagnosis: characterization, purification, and detection in biopsy material via immunohistochemistry. J Clin Microbiol. 2002;40:359-65 pubmed
    ..brasiliensis confirmed in vivo expression of the 87-kDa antigen by yeasts, and identification of this antigen via this method appears to be a useful adjunct to other methods used to diagnose paracoccidioidomycosis. ..
  31. Kerkar N, Choudhuri K, Ma Y, Mahmoud A, Bogdanos D, Muratori L, et al. Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease. J Immunol. 2003;170:1481-9 pubmed
    ..The demonstrated similarity and cross-reactivity between CYP2D6(193-212) and two unrelated viruses suggests that multiple exposure to viruses mimicking self may represent an important pathway to the development of autoimmunity. ..
  32. Clout N, Hohenester E. A model of FAS1 domain 4 of the corneal protein beta(ig)-h3 gives a clearer view on corneal dystrophies. Mol Vis. 2003;9:440-8 pubmed
    ..The integrin binding properties of beta(ig)-h3, described in several recent studies, have been analysed with respect to the beta(ig)-h3 structure...
  33. Nair M, Adinolfi S, Pastore C, Kelly G, Temussi P, Pastore A. Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites. Structure. 2004;12:2037-48 pubmed
    ..The presence of secondary binding sites on CyaY, but not on frataxin, hints at a possible polymerization mechanism. We suggest mutations that may provide further insights into the frataxin function. ..
  34. Schmidt C, Otto A, Luke G, Valasek P, Otto W, Patel K. Expression and regulation of Nkd-1, an intracellular component of Wnt signalling pathway in the chick embryo. Anat Embryol (Berl). 2006;211:525-34 pubmed
    ..Lastly, we show that the expression of cNkd-1 is regulated by Wnt expression originating from the neural tube. This study provides evidence that non-canonical Wnt signalling plays a part in somite development. ..
  35. McGarvey M, Iqbal M, Nastos T, Karayiannis P. Restricted quasispecies variation following infection with the GB virus B. Virus Res. 2008;135:181-6 pubmed publisher
    ..This restricted sequence variation of GBV-B during acute hepatitis may explain the infrequent progression of the infection to a chronic stage...
  36. Druce M, Minnion J, Field B, Patel S, Shillito J, Tilby M, et al. Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs. Endocrinology. 2009;150:1712-22 pubmed publisher
    ..An Oxm analog was developed with enhanced pharmaceutical characteristics, with greater potency and longevity with respect to effects on food intake. These studies suggest that Oxm is a potential target for antiobesity drug design. ..
  37. Köhler K, Xiong S, Brzostek J, Mehrabi M, Eissmann P, Harrison A, et al. Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells. PLoS ONE. 2010;5:e15374 pubmed publisher
  38. Jones T, Ogunkolade B, Szary J, Aarum J, Mumin M, Patel S, et al. Widespread expression of BORIS/CTCFL in normal and cancer cells. PLoS ONE. 2011;6:e22399 pubmed publisher
    ..While BORIS transcript levels are low compared to CTCF, its protein levels are readily detectable. These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function...
  39. de Groot R, Lane D, Crawley J. The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis. Blood. 2015;125:1968-75 pubmed publisher
  40. Papaioannou D, Geibel S, Kunze M, Kay C, Waksman G. Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci. 2016;25:627-37 pubmed publisher
    ..This suggests that TrpEF1 is not the determining factor for the conformation of the phosphopeptide. ..
  41. Huxley C, Fried M. The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. Mol Cell Biol. 1990;10:605-14 pubmed
    ..The neighboring CpG-rich islands have been located 500 and 100 kb distant on either side of the surfeit cluster, indicating that the end of the cluster of islands has been reached. ..
  42. Sekiya K, Ghatei M, Minamino N, Bretherton Watt D, Matsuo H, Bloom S. Isolation of human pancreastatin fragment containing the active sequence from a glucagonoma. FEBS Lett. 1988;228:153-6 pubmed
    ..Several forms of pancreastatin-like immunoreactivity were found in human endocrine tumors of which the purified peptide was the smallest and contained the active sequence of pancreastatin...
  43. White H, Totty N, Panayotou G. Haemonectin, a granulocytic-cell-binding protein, is related to the plasma glycoprotein fetuin. Eur J Biochem. 1993;213:523-8 pubmed
    ..Also, antihaemonectin antibodies cross react with human fetuin. These data imply that the rabbit haemonectin molecule is closely related to fetuin, but do not rule out the possibility that these molecules are functionally distinct. ..
  44. Aitken A, Howell S, Jones D, Madrazo J, Patel Y. 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. J Biol Chem. 1995;270:5706-9 pubmed
  45. Carucci D, Witney A, Muhia D, Warhurst D, Schaap P, Meima M, et al. Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. J Biol Chem. 2000;275:22147-56 pubmed
    ..The profound structural differences identified between mammalian and parasite guanylyl cyclases suggest that aspects of this signaling pathway may be mechanistically distinct. ..
  46. Malaspina A, Kaushik N, de Belleroche J. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. J Neurochem. 2000;75:2511-20 pubmed
    ..X57347). These results show the marked up-regulation of the 14-3-3 isoform (YWHAQ) in ALS spinal cord and indicate the involvement of a potential 14-3-3-mediated survival pathway in the pathogenesis of ALS. ..
  47. Sweeney M, Dolphin A. Adenosine A1 agonists and the Ca2+ channel agonist bay K 8644 produce a synergistic stimulation of the GTPase activity of Go in rat frontal cortical membranes. J Neurochem. 1995;64:2034-42 pubmed
    ..It appears that a positive cooperative stimulation of G(o) occurs when it is first activated by A1 receptors and subsequently interacts with the L-type Ca2+ channel. ..
  48. Todone F, Brick P, Werner F, Weinzierl R, Onesti S. Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. Mol Cell. 2001;8:1137-43 pubmed
    ..We propose a model for the interaction between RPB4/RPB7 and the core RNA polymerase in which the RNA binding face of RPB7 is positioned to interact with the nascent RNA transcript. ..
  49. Kidd T, Abu Shumays R, Katzen A, Sisson J, Jiménez G, Pinchin S, et al. The epsilon-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions. Genetics. 2005;170:697-708 pubmed
    ..As Sun has been identified as the ligand for the Methuselah receptor that regulates aging, Sun may function both within and outside mitochondria. ..
  50. Ebenezer N, Patel C, Hariprasad S, Chen L, Patel R, Hardcastle A, et al. Clinical and molecular characterization of a family with autosomal recessive cornea plana. Arch Ophthalmol. 2005;123:1248-53 pubmed
    ..Although the vast majority of cases of cornea plana are in individuals of Finnish descent, this report demonstrates the occurrence of the disease in other populations. ..
  51. Galiano M, Agapow P, Thompson C, Platt S, Underwood A, Ellis J, et al. Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK. PLoS ONE. 2011;6:e23779 pubmed publisher
    ..Although some limited antigenic divergence in viruses with four-fold reduction in HI titre might be related to the presence of 203T, additional studies are needed to test this hypothesis. ..
  52. Young J, Trowsdale J. The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript. Immunogenetics. 1990;31:386-8 pubmed
  53. Pratt W, Crawley S, Hicks J, Ho J, Nash M, Kim Y, et al. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Biochem Biophys Res Commun. 2000;275:916-23 pubmed
    ..The introns show around 95% identity. We propose to name this second gene MUC3B, MUC3A being reserved for the first MUC3 gene. MUC3B, like MUC3A, is expressed in intestine and Caco-2 cells. ..
  54. Edgar A, Polak J. Human homologues of yeast vacuolar protein sorting 29 and 35. Biochem Biophys Res Commun. 2000;277:622-30 pubmed
    ..6 kb, 17 exon, VPS35 gene is on chromosome 16. In humans, Vps29p, Vps35p, and Hbeta58, the homologue of Vps26p, may form an inner shell of the retromer coat similar to that found in yeast. ..
  55. Wilson J, Jing C, Walker P, Martin S, Howell S, Blackburn G, et al. Crystal structure and functional analysis of the histone methyltransferase SET7/9. Cell. 2002;111:105-15 pubmed
    ..Furthermore, we show how the cofactor AdoMet binds to this domain and present biochemical data supporting the role of invariant residues in catalysis, binding of AdoMet, and interactions with the peptide substrate. ..
  56. Akopian A, Wood J. Peripheral nervous system-specific genes identified by subtractive cDNA cloning. J Biol Chem. 1995;270:21264-70 pubmed
    ..In addition, the DRG-specific clones provide probes to define the regulatory elements that specify peripheral nervous-system-specific gene expression. ..
  57. Halford S, Mattei M, Daw S, Scambler P. A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4. Genomics. 1995;25:322-3 pubmed
  58. Beck S, Abdulla S, Alderton R, Glynne R, Gut I, Hosking L, et al. Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. J Mol Biol. 1996;255:1-13 pubmed
    ..We also report the finding of a class I-related pseudogene (HLA-ZI) in the middle of the class II region, which provides the first direct evidence for DNA exchange between these two related regions in man. ..
  59. Jackson A, Panayiotidis P, Foroni L. The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21. Genomics. 1998;50:34-43 pubmed
    ..The contributions of this gene to human B-cell leukemia and to brain development are unknown at present. ..
  60. Satoh T, Smith A, Sarde A, Lu H, Mian S, Mian S, et al. B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease. PLoS ONE. 2012;7:e33891 pubmed publisher
    ..Further studies are needed to assess the functional consequences of the germ-line (T599A)B-RAF allele. ..
  61. Martin M, Clare S, Goulding D, Faulds Pain A, Barquist L, Browne H, et al. The agr locus regulates virulence and colonization genes in Clostridium difficile 027. J Bacteriol. 2013;195:3672-81 pubmed publisher
    ..Thus, the agr locus likely plays a contributory role in the fitness and virulence potential of C. difficile strains in the 027/BI/NAP1 lineage. ..
  62. van Ham S, Gruneberg U, Malcherek G, Broker I, Melms A, Trowsdale J. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J Exp Med. 1996;184:2019-24 pubmed
    ..Thus, HLA-DM acts as a peptide editor, facilitating selection of peptides that stably bind to class II molecules for eventual presentation to the immune system from the pool of available peptides. ..
  63. Kraus B, Pohlschmidt M, Leung A, Germino G, Snarey A, Schneider M, et al. A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). Genomics. 1994;24:27-33 pubmed
    ..We have characterized the transcript by sequencing, determination of the exon intron boundaries, and Northern blot analysis. Cyclin F is related to A- and B-type cyclins by sequence, but its function is unknown. ..
  64. Naylor C, Eaton J, Howells A, Justin N, Moss D, Titball R, et al. Structure of the key toxin in gas gangrene. Nat Struct Biol. 1998;5:738-46 pubmed
    ..Finally, a possible mechanism for alpha-toxin attack on membrane-packed phospholipid is described, which rationalizes its toxicity when compared to other, non-haemolytic, but homologous phospholipases C...
  65. Turton J, Reynaud R, Mehta A, Torpiano J, Saveanu A, Woods K, et al. Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency. J Clin Endocrinol Metab. 2005;90:4762-70 pubmed
    ..Mutations within the gene encoding the pituitary-specific transcription factor POU1F1 are associated with combined pituitary hormone deficiency (CPHD). Most of the affected individuals manifest GH, prolactin, and TSH deficiency...
  66. Devader C, Webb R, Thomas G, Dale L. Xenopus apyrase (xapy), a secreted nucleotidase that is expressed during early development. Gene. 2006;367:135-41 pubmed
    ..When expressed in HEK 293 cells, XAPY is largely retained in the endoplasmic reticulum, although some is also secreted. XAPY conditioned media hydrolyses UDP and UTP, confirming that it is a functional apyrase. ..
  67. Agromayor M, Carlton J, Phelan J, Matthews D, Carlin L, Ameer Beg S, et al. Essential role of hIST1 in cytokinesis. Mol Biol Cell. 2009;20:1374-87 pubmed publisher
    ..Last, we show that the hIST1 MIM activity is essential for cytokinesis, suggesting possible mechanisms to explain the role of hIST1 in the last step of mammalian cell division. ..
  68. Sharma V, Antonacopoulou A, Tanaka S, Panoutsopoulos A, Bravou V, Kalofonos H, et al. Enhancement of TGF-? signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer. Cancer Res. 2011;71:6438-49 pubmed publisher
    ..Collectively, our findings reveal that Arkadia enhances TGF-? signaling responses and supports its tumor-suppressing properties in CRC. ..
  69. Hewitt J, Clark L, Ivens A, Williamson R. Structure and sequence of the human homeobox gene HOX7. Genomics. 1991;11:670-8 pubmed
  70. Kurtenbach E, Curtis C, Pedder E, Aitken A, Harris A, Hulme E. Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation. J Biol Chem. 1990;265:13702-8 pubmed
  71. Xu Q, Baker B, Tata J. Developmental and hormonal regulation of the Xenopus liver-type arginase gene. Eur J Biochem. 1993;211:891-8 pubmed
    ..They also demonstrate that this gene can be exploited as a target for thyroid hormones in further studies to analyze the mechanisms underlying the establishment of the adult phenotype during amphibian metamorphosis. ..
  72. Timmons P, Chan C, Rigby P, Poirier F. The gene encoding the calcium binding protein calcyclin is expressed at sites of exocytosis in the mouse. J Cell Sci. 1993;104 ( Pt 1):187-96 pubmed
    ..We propose that this S100-like protein may be part of a calcium signalling pathway utilized in the secretion of various products by different cell types. ..
  73. Katsanis N, Fisher E. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. Genomics. 1998;47:294-9 pubmed
    ..We found that CTBP2 is expressed in all tissues tested, with a higher level of expression in the heart, skeletal muscle, and pancreas. We mapped CTBP1 and CTBP2 to human chromosomes 4p16 and 21q21.3, respectively. ..
  74. Harrison S, Houzelstein D, Dunwoodie S, Beddington R. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury. Dev Biol. 2000;227:358-72 pubmed
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