Experts and Doctors on viral proteins in Fort Collins, Colorado, United States


Locale: Fort Collins, Colorado, United States
Topic: viral proteins

Top Publications

  1. Akkina R, Raisch K. Intracellular virus-induced polypeptides of pestivirus border disease virus. Virus Res. 1990;16:95-105 pubmed
    ..Peptide mapping analysis of homologous polypeptides from BVDV and BDV confirmed their structural relatedness. ..
  2. Sholders A, Peersen O. Distinct conformations of a putative translocation element in poliovirus polymerase. J Mol Biol. 2014;426:1407-19 pubmed publisher
    ..The loop structure and key residues surrounding it are highly conserved, suggesting that the structural dynamics we observe in poliovirus 3D(pol) are a common feature of viral RNA-dependent RNA polymerases. ..
  3. Lanciotti R, Lewis J, Gubler D, Trent D. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol. 1994;75 ( Pt 1):65-75 pubmed
    ..Phylogenetic analysis has also contributed to our understanding of the molecular epidemiology and worldwide distribution of DEN-3 viruses. ..
  4. Paterson A, Robinson E, Suchman E, Afanasiev B, Carlson J. Mosquito densonucleosis viruses cause dramatically different infection phenotypes in the C6/36 Aedes albopictus cell line. Virology. 2005;337:253-61 pubmed
    ..C6/36 cells persistently infected with AeDNV were not protected from superinfection with HeDNV. Thus, there does not seem to be an antiviral state induced by AeDNV persistent infection. ..
  5. Fiscus S, Rivoire B, Teramoto Y. Humoral immune response of cats to virulent and avirulent feline infectious peritonitis virus isolates. Adv Exp Med Biol. 1987;218:559-68 pubmed
    ..However, all cats except uninoculated controls developed neutralizing titers to FIPV-UCD-2. Competition ELISAs were used to analyze the specific humoral immune responses of cats to structural polypeptides of the viruses. ..
  6. Blair C, Adelman Z, Olson K. Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoes. Clin Microbiol Rev. 2000;13:651-61 pubmed
    ..Prospects for application of molecular strategies to control arbovirus diseases are briefly reviewed. ..
  7. Quackenbush S, Linton A, Brewster C, Rovnak J. Walleye dermal sarcoma virus rv-cyclin inhibits NF-kappaB-dependent transcription. Virology. 2009;386:55-60 pubmed publisher
    ..Furthermore, interference with NF-kappaB is dependent upon an intact TAF9-binding motif in rv-cyclin. The outcome of this NF-kappaB down regulation is likely to be important in the control of virus replication and tumorigenesis...
  8. Davis A, Gordy P, Bowen R. Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus). Arch Virol. 2013;158:809-20 pubmed publisher
    ..Our study demonstrates that RV variants obtained from the same species of bat from similar geographical areas may result in a diverse clinical progression of disease...
  9. Rovnak J, Brewster C, Quackenbush S. Retroviral cyclin enhances cyclin-dependent kinase-8 activity. J Virol. 2012;86:5742-51 pubmed publisher

More Information


  1. Kinney R, Tsuchiya K, Sneider J, Trent D. Genetic evidence that epizootic Venezuelan equine encephalitis (VEE) viruses may have evolved from enzootic VEE subtype I-D virus. Virology. 1992;191:569-80 pubmed
  2. Daniels C, Rovnak J, Quackenbush S. Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C. Virology. 2008;375:550-60 pubmed publisher
    ..Orf B associates with PKCalpha, which is constitutively activated and localized at the membrane. Activated PKC promoted cell survival, proliferation, and increased cell viability in Orf B-expressing cells...
  3. Kuno G, Chang G. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses. Arch Virol. 2007;152:687-96 pubmed publisher
    ..In the non-coding regions, it was found that a particular organizational pattern of conserved sequences in the 3' terminal region generally correlated with the current virus grouping...
  4. Brewster C, Birkenheuer C, Vogt M, Quackenbush S, Rovnak J. The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8. Virology. 2011;409:299-307 pubmed publisher
    ..Co-IP and pulldowns demonstrate direct rv-cyclin binding to cdk3 as well. The rv-cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins...
  5. Gong P, Peersen O. Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc Natl Acad Sci U S A. 2010;107:22505-10 pubmed publisher
    ..The data also suggest that translocation by RDRPs may not be directly linked to the conformational changes responsible for active site closure and reopening...
  6. Henderson B, Saeedi B, Campagnola G, Geiss B. Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme. PLoS ONE. 2011;6:e25795 pubmed publisher
    ..The mode of RNA binding appears similar to that found with other methyltransferase enzymes, and a discussion of diphosphorylated RNA binding is presented. ..
  7. Crabtree M, Sang R, Stollar V, Dunster L, Miller B. Genetic and phenotypic characterization of the newly described insect flavivirus, Kamiti River virus. Arch Virol. 2003;148:1095-118 pubmed publisher
    ..Additionally, this virus will be an important tool in future studies to determine markers associated with flavivirus host specificity...
  8. Brown T, Mitchell C, Nasci R, Smith G, Roehrig J. Detection of eastern equine encephalitis virus in infected mosquitoes using a monoclonal antibody-based antigen-capture enzyme-linked immunosorbent assay. Am J Trop Med Hyg. 2001;65:208-13 pubmed
    ..The conversion of this ELISA to a monoclonal antibody-based format should result in a readily standardizable and transferable assay that will permit laboratories lacking virus isolation facilities to conduct EEE virus surveillance...
  9. Geiss B, Stahla H, Hannah A, Gari A, Keenan S. Focus on flaviviruses: current and future drug targets. Future Med Chem. 2009;1:327-44 pubmed publisher
    ..As our molecular and biochemical understanding of the flavivirus life cycle increases, the number of targets for antiviral therapeutic discovery grows and the possibility for novel drug discovery continues to strengthen. ..
  10. Soboll Hussey G, Hussey S, Wagner B, Horohov D, Van De Walle G, Osterrieder N, et al. Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant. Vet Res. 2011;42:23 pubmed publisher
  11. Campbell C, Lehmann C, Gill S, Dunn W, James A, Foy B. A role for endosomal proteins in alphavirus dissemination in mosquitoes. Insect Mol Biol. 2011;20:429-36 pubmed publisher
    ..Common CREs at the 5'-end genomic regions of a subset of enriched transcripts support the hypothesis that UNC93A transcription may be co-regulated with that of other ion transport and endosomal trafficking proteins. ..
  12. Rovnak J, Quackenbush S. Walleye dermal sarcoma virus retroviral cyclin directly contacts TAF9. J Virol. 2006;80:12041-8 pubmed publisher
    ..A similar motif is present in the rv-cyclin AD, and point mutations within this motif affect rv-cyclin function and protein-protein interactions. The results support a model of transcription regulation by direct interaction with TAF9...
  13. Achenbach J, Bowen R. Effect of oseltamivir carboxylate consumption on emergence of drug-resistant H5N2 avian influenza virus in Mallard ducks. Antimicrob Agents Chemother. 2013;57:2171-81 pubmed publisher
    ..These results indicate that consumption by wild waterfowl of OC in drinking water may promote selection of the E119V resistance mutation in some strains of H5N2 AIV that could contribute to viruses infecting human populations...
  14. Schmitt K, Mohan Kumar D, Curlin J, Remling Mulder L, Stenglein M, O Connor S, et al. Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice. Virology. 2017;510:175-184 pubmed publisher
    ..These data demonstrated the utility of hu-mice in modeling the SIVsm transmission to the human and to evaluate its potential sequential evolution into a human pathogen of HIV-2 lineage. ..