Genomes and Genes
Experts and Doctors on rna precursors in Boulder, Colorado, United States
Locale: Boulder, Colorado, United States
Topic: rna precursors
- Ishikawa F, Matunis M, Dreyfuss G, Cech T. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. 1993;13:4301-10 pubmed..These studies establish the binding specificities of these D and E hnRNPs. Furthermore, they suggest the possibility that these hnRNPs could perhaps bind to chromosome telomeres, in addition to having a role in pre-mRNA metabolism. ..
- Tanner M, Cech T. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus. RNA. 1996;2:74-83 pubmed..Thus, even superficially similar group I introns from the same structural subgroup can differ significantly in activity and stability. ..
- Tanner M, Anderson E, Gutell R, Cech T. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997;3:1037-51 pubmed..Repositioning of the base triple to form a new set of interactions may be required for the second step of splicing. ..
- Cui M, Allen M, Larsen A, MacMorris M, Han M, Blumenthal T. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Proc Natl Acad Sci U S A. 2008;105:16665-70 pubmed publisher..Furthermore, our results implicate a serine/arginine-rich (SR) protein, SRp20, in events following 3'-end cleavage, leading to termination of transcription. ..