Experts and Doctors on molecular sequence data in Denver, Colorado, United States

Summary

Locale: Denver, Colorado, United States
Topic: molecular sequence data

Top Publications

  1. Mahalingam R, Smith D, Wellish M, Wolf W, Dueland A, Cohrs R, et al. Simian varicella virus DNA in dorsal root ganglia. Proc Natl Acad Sci U S A. 1991;88:2750-2 pubmed
    ..Our results suggest that SVV becomes latent in monkey ganglia and that latency can develop in the absence of clinical varicella (chickenpox). These studies provide an animal model system to study varicella virus latency. ..
  2. Schechter I, Conrad D, Hart I, Berger R, McKenzie T, Bleskan J, et al. Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1. Genomics. 1994;20:116-8 pubmed
    ..Use of a somatic cell hybrid regional mapping panel dividing chromosome 8 into several fragments localized the gene to 8p21-pter. Fractional length analysis of the FISH mapping placed the signal generated with this YAC at 8p22-p23.1. ..
  3. Carter J, Franden M, Aebersold R, McHenry C. Identification, isolation, and characterization of the structural gene encoding the delta' subunit of Escherichia coli DNA polymerase III holoenzyme. J Bacteriol. 1993;175:3812-22 pubmed
    ..The gene, when placed into a tac promoter-based expression plasmid, directed expression of two proteins of similar size. By immunodetection with anti-holoenzyme immunoglobulin G, both proteins are judged to be products of holB. ..
  4. Gordon D, Wagner J, Atkinson B, Chiono M, Berry R, Sikela J, et al. Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA. DNA Cell Biol. 1996;15:531-41 pubmed
    ..Taken together, these data indicate that Cart-1 may also influence cervix development, identify a putative DNA binding site for Cart-1, and, begin to define its functional role as modulator of gene expression. ..
  5. Tresnan D, Levis R, Holmes K. Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I. J Virol. 1996;70:8669-74 pubmed
    ..Therefore, host factors in addition to receptor specificity apparently affect the virulence and transmissibility of nonfeline serogroup I coronaviruses in the cat. ..
  6. Nordeen S, Ogden C, Taraseviciene L, Lieberman B. Extreme position dependence of a canonical hormone response element. Mol Endocrinol. 1998;12:891-8 pubmed
    ..This may be indicative of cell type-specific interactions between steroid receptors and adapter/coactivator proteins or cell type-specific activities such as acetylases or deacetylases participating in the steroid response. ..
  7. Schwab M, Roberts B, Gross S, Tunquist B, Taieb F, Lewellyn A, et al. Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation. Curr Biol. 2001;11:141-50 pubmed
  8. Kim S, Azam T, Novick D, Yoon D, Reznikov L, Bufler P, et al. Identification of amino acid residues critical for biological activity in human interleukin-18. J Biol Chem. 2002;277:10998-1003 pubmed
    ..The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP. ..
  9. Kieft J, Batey R. A general method for rapid and nondenaturing purification of RNAs. RNA. 2004;10:988-95 pubmed
    ..To demonstrate that this method rapidly generates high-quality RNA, we have transcribed, purified, and generated diffraction-quality crystals of a mutant form of the Tetrahymena thermophila P4-P6 domain in a 48-h time period. ..

More Information

Publications242 found, 100 shown here

  1. Kim S, Han S, Azam T, Yoon D, Dinarello C. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 2005;22:131-42 pubmed
  2. Pritchard A, Seilhamer J, Mahalingam R, Sable C, Venuti S, Cummings D. Nucleotide sequence of the mitochondrial genome of Paramecium. Nucleic Acids Res. 1990;18:173-80 pubmed
    ..Based on sequence comparisons with known tRNAs, only those for phe, trp, and tyr are encoded in Paramecium mt DNA. ..
  3. Schaller K, Krzemien D, Yarowsky P, Krueger B, Caldwell J. A novel, abundant sodium channel expressed in neurons and glia. J Neurosci. 1995;15:3231-42 pubmed
    ..RT-PCR and/or in situ hybridization showed that astrocytes and Schwann cells express NaCh6. Thus, this sodium channel is broadly distributed throughout the nervous system and is shown to be expressed in both neurons and glial cells. ..
  4. Terada N, Patel H, Takase K, Kohno K, Nairn A, Gelfand E. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci U S A. 1994;91:11477-81 pubmed
    ..Specific inhibition of ribosomal protein synthesis likely explains the differential antiproliferative effect of RAP on proliferating and mitogen-activated quiescent cells. ..
  5. Choi K, Wall C, Hanratty R, Keller G. Isolation of a gene encoding a novel receptor tyrosine kinase from differentiated embryonic stem cells. Oncogene. 1994;9:1261-6 pubmed
    ..On the basis of sequence homology, EmRK2 is likely to be the mouse homologue of human flt, a receptor for vascular endothelial growth factor, and as such, could encode an endothelial cell specific receptor tyrosine kinase. ..
  6. Wadzinski B, Wheat W, Jaspers S, Peruski L, Lickteig R, Johnson G, et al. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol Cell Biol. 1993;13:2822-34 pubmed
    ..Nuclear PP2A appears to be the primary phosphatase that dephosphorylates PKA-phosphorylated CREB. ..
  7. Pleiman C, Clark M, Gauen L, Winitz S, Coggeshall K, Johnson G, et al. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-ki. Mol Cell Biol. 1993;13:5877-87 pubmed
    ..Fast protein liquid chromatography Mono Q column-fractionated MAPK maintains the ability to bind bacterially expressed Lyn, suggesting that the two kinases may interact directly. ..
  8. Haugen B, Wood W, Gordon D, Ridgway E. A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin beta promoter. J Biol Chem. 1993;268:20818-24 pubmed
    ..These data suggest that Pit-1T is a thyrotrope-specific splice variant of Pit-1 that is required for TSH beta promoter stimulation; furthermore, both Pit-1 and Pit-1T are required for TSH beta promoter activity in thyrotrope cells. ..
  9. Hunger S, Li S, Fall M, Naumovski L, Cleary M. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. Blood. 1996;87:4607-17 pubmed
    ..Thus, TEF and HLF share indistinguishable DNA-binding and transcriptional regulatory properties, whose alteration in leukemia may be pathogenetically important. ..
  10. Frasch S, Henson P, Kailey J, Richter D, Janes M, Fadok V, et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J Biol Chem. 2000;275:23065-73 pubmed
    ..Furthermore, reconstitution of PKCdelta and scramblase, but not scramblase or PKCdelta alone in Chinese hamster ovary cells demonstrated enhanced scramblase activity. ..
  11. Umenishi F, Schrier R. Induction of human aquaporin-1 gene by retinoic acid in human erythroleukemia HEL cells. Biochem Biophys Res Commun. 2002;293:913-7 pubmed
    ..These results indicate that RAs strongly stimulate the human AQP1 gene expression through the RARE and define a novel role in the regulation of erythropoiesis. ..
  12. Bin L, Xu L, Shu H. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003;278:24526-32 pubmed
    ..Our findings suggest that TIRP is involved in IL-1-triggered NF-kappaB activation and functions upstream of IRAK, IRAK-2, TRAF6, and IKKbeta ..
  13. Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, et al. Ligand-receptor binding revealed by the TNF family member TALL-1. Nature. 2003;423:49-56 pubmed
  14. Howell M, Jones J, Kisich K, Streib J, Gallo R, Leung D. Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J Immunol. 2004;172:1763-7 pubmed
    ..01). These data support a role for cathelicidins in the inhibition of orthopox virus (vaccinia) replication both in vitro and in vivo. Susceptibility of patients with AD to eczema vaccinatum may be due to a deficiency of cathelicidin...
  15. Oram D, Avdalovic A, Holmes R. Analysis of genes that encode DtxR-like transcriptional regulators in pathogenic and saprophytic corynebacterial species. Infect Immun. 2004;72:1885-95 pubmed
  16. Shoureshi P, Baron A, Szynskie L, Dores R. Analyzing the evolution of beta-endorphin post-translational processing events: studies on reptiles. Gen Comp Endocrinol. 2007;153:148-54 pubmed
  17. Leon R, Tecklenburg M, Sclafani R. Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae. Genetics. 2008;179:1757-68 pubmed publisher
    ..Therefore, in addition to its known regulatory role, Mcm5 protein has a positive role in origin binding, which requires coordination by all six Mcm2-7 subunits in the hexamer. ..
  18. Mueller N, Walters M, Marcus R, Graf L, Prenni J, Gilden D, et al. Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63. J Gen Virol. 2010;91:1133-7 pubmed publisher
  19. Huang T, Kuersten S, Deshpande A, Spieth J, MacMorris M, Blumenthal T. Intercistronic region required for polycistronic pre-mRNA processing in Caenorhabditis elegans. Mol Cell Biol. 2001;21:1111-20 pubmed
    ..Furthermore, when the downstream gene was replaced by a gene from another organism, no loss of trans-splicing specificity was observed, suggesting that the Ur element may be the primary signal required for downstream mRNA processing. ..
  20. Kruse S, Zhao R, Smith D, Jones D. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat Struct Biol. 2003;10:694-700 pubmed
    ..Further, these sequences are found in regions of ion channels that are known to confer alcohol sensitivity. We suggest that the alcohol-binding site in LUSH represents a general model for alcohol-binding sites in proteins. ..
  21. Alvarez E, Zhou W, Witta S, Freed C. Characterization of the Bex gene family in humans, mice, and rats. Gene. 2005;357:18-28 pubmed
    ..We conclude that the Bex gene family members are highly homologous but differ in their expression patterns, subcellular localization, and degradation by the proteasome. ..
  22. Capodagli G, McKercher M, Baker E, Masters E, Brunzelle J, Pegan S. Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. J Virol. 2011;85:3621-30 pubmed publisher
  23. Jin L, Xu L, Yang I, Davidson E, Schwartz D, Wurfel M, et al. Identification and characterization of a loss-of-function human MPYS variant. Genes Immun. 2011;12:263-9 pubmed publisher
    ..Lastly, we find that the loss of IFN? activity is due primarily to the R71H and R293Q SNPs in HAQ. We hypothesize that individuals carrying HAQ may exhibit heightened susceptibility to viral infection and respond poorly to DNA vaccines. ..
  24. Winston B, Lange Carter C, Gardner A, Johnson G, Riches D. Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc Natl Acad Sci U S A. 1995;92:1614-8 pubmed
    ..These data suggest that the activation of the MAPK cascade in response to TNF alpha is mediated by the sequential activation of a MEKK and a MEK in a c-Raf-1- and Raf-B-independent fashion. ..
  25. Gill R, Karlok M, Benton D. Myxococcus xanthus encodes an ATP-dependent protease which is required for developmental gene transcription and intercellular signaling. J Bacteriol. 1993;175:4538-44 pubmed
    ..coli, and the BsgA protein was partially purified and found, like its E. coli homolog, to be an ATP-dependent protease. Thus, the basis for the phenotype of bsgA mutants is likely to be a defect in intracellular proteolysis. ..
  26. Gemmill R, West J, Boldog F, Tanaka N, Robinson L, Smith D, et al. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A. 1998;95:9572-7 pubmed
    ..By analogy to patched, TRC8 might function as a signaling receptor and other pathway members, to be defined, are mutation candidates in malignant diseases involving the kidney and thyroid. ..
  27. Roberts B, Ying C, Gautier J, Maller J. DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase. Proc Natl Acad Sci U S A. 1999;96:2800-4 pubmed
  28. Gordon D, Woodmansee W, Lewis S, James R, Wood W, Ridgway E. Cloning of the mouse somatostatin receptor subtype 5 gene: promoter structure and function. Endocrinology. 1999;140:5598-608 pubmed
    ..Cloning of the sst5 gene will facilitate the mapping of basal and regulated responses at the transcriptional level. ..
  29. Lefkowitz J, Haver T, Clarke S, Jacobson L, Weller A, Nuss R, et al. The prothrombin Denver patient has two different prothrombin point mutations resulting in Glu-300-->Lys and Glu-309-->Lys substitutions. Br J Haematol. 2000;108:182-7 pubmed
    ..Assays of plasma from the prothrombin Denver proband suggested that the functional defect was in the activation of zymogen to enzyme. ..
  30. Wentworth D, Holmes K. Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. J Virol. 2001;75:9741-52 pubmed
    ..Thus, certain differences in glycosylation between coronavirus receptors from different species are critical determinants in the species specificity of infection. ..
  31. Fletcher R, Bishop B, Leon R, Sclafani R, Ogata C, Chen X. The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat Struct Biol. 2003;10:160-7 pubmed
    ..Yeast bypass experiments using MCM5 mutant proteins support the hypothesis for the bypass mechanism. ..
  32. Matsumoto Y, Maller J. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science. 2004;306:885-8 pubmed
    ..These results suggest that cyclin E has a modular centrosomal-targeting domain essential for promoting S phase entry in a Cdk2-independent manner. ..
  33. Frank D, Manigart O, Leroy V, Meda N, Valea D, Zhang W, et al. Altered vaginal microbiota are associated with perinatal mother-to-child transmission of HIV in African women from Burkina Faso. J Acquir Immune Defic Syndr. 2012;60:299-306 pubmed publisher
    ..Therefore, determining the mucosal features associated with alterations in vaginal microbial communities may guide efforts to modulate the risk for HIV MTCT. ..
  34. Deason Towne F, Perraud A, Schmitz C. Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C ?2 (PLC?2) using TRPM7-kinase. Cell Signal. 2012;24:2070-5 pubmed publisher
    ..These results suggest that Mg(2+)-sensitivity of the BCR signaling pathway may be regulated by Ser/Thr phosphorylation of PLC?2. ..
  35. Pujanauski L, Janoff E, McCarter M, Pelanda R, Torres R. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2013;110:1422-7 pubmed publisher
  36. Reardon C, Lefrancois L, Farr A, Kubo R, O Brien R, Born W. Expression of gamma/delta T cell receptors on lymphocytes from the lactating mammary gland. J Exp Med. 1990;172:1263-6 pubmed
  37. de Franchis R, Kozich V, McInnes R, Kraus J. Identical genotypes in siblings with different homocystinuric phenotypes: identification of three mutations in cystathionine beta-synthase using an improved bacterial expression system. Hum Mol Genet. 1994;3:1103-8 pubmed
  38. Gordon D, Haugen B, Sarapura V, Nelson A, Wood W, Ridgway E. Analysis of Pit-1 in regulating mouse TSH beta promoter activity in thyrotropes. Mol Cell Endocrinol. 1993;96:75-84 pubmed
    ..These studies suggest that Pit-1 is not limiting for cell-specific expression of the TSH beta gene in thyrotrope-derived cells and implies that additional thyrotropic factors are likely required. ..
  39. Matsuguchi T, Zhao Y, Lilly M, Kraft A. The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation. J Biol Chem. 1997;272:17450-9 pubmed
    ..While the activation of JAK2, Shc, Erk, and STAT5 proteins correlated with hGM-CSF-mediated cell growth, cellular differentiation occurred in the absence of activation of these signal transduction pathways...
  40. Rahmani Z, Maunoury C, Siddiqui A. Isolation of a novel human voltage-dependent anion channel gene. Eur J Hum Genet. 1998;6:337-40 pubmed
    ..The expression of this gene in various tissues and its chromosomal localization by polymerase chain reaction (PCR) using a human/rodent somatic cell mapping panel and by fluorescence in situ hybridization is also presented. ..
  41. Robitaille J, Izzi L, Daniels E, Zelus B, Holmes K, Beauchemin N. Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bbgp1 and Bbgp2. Eur J Biochem. 1999;264:534-44 pubmed
  42. Fontenot A, Maier L, Canavera S, Hendry Hofer T, Boguniewicz M, Barker E, et al. Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung. J Immunol. 2002;168:3627-34 pubmed
    ..These studies using skin patch testing provide new insight into the dynamics of T cell influx and mobilization during granulomatous inflammation...
  43. Wynes M, Riches D. Transcription of macrophage IGF-I exon 1 is positively regulated by the 5'-untranslated region and negatively regulated by the 5'-flanking region. Am J Physiol Lung Cell Mol Physiol. 2005;288:L1089-98 pubmed
    ..These data support the view that macrophage IGF-I expression is positively regulated by elements located in the 5'-untranslated region and negatively regulated by elements in the 5'-flanking region of the IGF-I gene. ..
  44. Fontenot A, Keizer T, McCleskey M, Mack D, Meza Romero R, Huan J, et al. Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells. J Immunol. 2006;177:3874-83 pubmed
    ..Thus, the rHLA-DP2 molecules described herein provide a template for engineering variants that retain the ability to tolerize pathogenic CD4+ T cells, but do so in the absence of the beryllium Ag...
  45. Berger R, Mezey E, Clancy K, Harta G, Wright R, Repine J, et al. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Somat Cell Mol Genet. 1995;21:121-31 pubmed
    ..Neither of these XDH genes appears to be highly expressed in human spinal cord. This evidence suggests that AO may be a candidate gene for FALS-AR. ..
  46. Lu J, Pei H, Kaeck M, Thompson H. Gene expression changes associated with chemically induced rat mammary carcinogenesis. Mol Carcinog. 1997;20:204-15 pubmed
    ..The genes identified in this study may therefore represent mammary carcinoma-specific molecular markers that may be helpful in investigations of mammary carcinogenesis and its prevention. ..
  47. Takimoto G, Tung L, Abdel Hafiz H, Abel M, Sartorius C, Richer J, et al. Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure. J Steroid Biochem Mol Biol. 2003;85:209-19 pubmed
    ..This would explain why PR-B are stronger transactivators than PR-A. ..
  48. Stearman R, Grady M, Nana Sinkam P, Varella Garcia M, Geraci M. Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines. Mol Cancer Res. 2007;5:295-308 pubmed
    ..These results show that an individual's PGIS promoter haplotype can play an important role in the predisposition for lung cancer and CpG methylation provides an epigenetic mechanism for the down-regulated PGIS expression. ..
  49. Marchitti S, Orlicky D, Vasiliou V. Expression and initial characterization of human ALDH3B1. Biochem Biophys Res Commun. 2007;356:792-8 pubmed
    ..This study shows for the first time the functionality, expression and protective role of ALDH3B1 and indicates a potential physiological role of ALDH3B1 against oxidative stress. ..
  50. Yin L, Crawford F, Marrack P, Kappler J, Dai S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc Natl Acad Sci U S A. 2012;109:18517-22 pubmed publisher
    ..We suggest that the mimotope p7 lysine mimics Ni(++) in the natural TCR ligand and that MHCII ?-chain flexibility in the area around the peptide p7 position forms a common site for cation binding in metal allergies. ..
  51. Duval N, Luhrs K, Wilkinson T, Baresova V, Skopova V, Kmoch S, et al. Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders. Mol Genet Metab. 2013;108:178-189 pubmed publisher
  52. Bandyopadhyay P, Wang C, Lipton H. Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus. J Virol. 1992;66:6249-56 pubmed
    ..Analysis of luciferase translation in a rabbit reticulocyte lysate suggests that the 3' end of the translation initiation signal lies between nucleotides 1043 and 1053. ..
  53. Koeller D, DiGiulio K, Angeloni S, Dowler L, Frerman F, White R, et al. Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene. Genomics. 1995;28:508-12 pubmed
    ..Gcdh was mapped by backcross analysis to mouse chromosome 8 within a region that is homologous to a region of human chromosome 19, where the human gene was previously mapped. ..
  54. Erickson P, Robinson M, Owens G, Drabkin H. The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor. Cancer Res. 1994;54:1782-6 pubmed
    ..The relatively high levels of ETO in developing brain suggest that it could be involved in the regulation of some aspect of neural proliferation or differentiation. ..
  55. Holder E, Maeda M, Bies R. Expression and regulation of the dystrophin Purkinje promoter in human skeletal muscle, heart, and brain. Hum Genet. 1996;97:232-9 pubmed
    ..These data show that the P promoter transcript displays a broader scope of expression, regulation, and complexity than previously appreciated. ..
  56. Villard L, Tassone F, Haymowicz M, Welborn R, Gardiner K. Map location, genomic organization and expression patterns of the human RED1 RNA editase. Somat Cell Mol Genet. 1997;23:135-45 pubmed
    ..The difference in transcript size likely results from alternative processing in the 3' UT. Potential relevance of overexpression of RED1 to the development of the Down Syndrome phenotype is discussed. ..
  57. Pederson K, Carlson S, Pierson D. The ClpP protein, a subunit of the Clp protease, modulates ail gene expression in Yersinia enterocolitica. Mol Microbiol. 1997;26:99-107 pubmed
    ..Thus, ClpP has a role in the modulation of ail transcription in Y. enterocolitica. ..
  58. Kawasome H, Papst P, Webb S, Keller G, Johnson G, Gelfand E, et al. Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity. Proc Natl Acad Sci U S A. 1998;95:5033-8 pubmed
    ..This study localizes the function of p70(s6k) to ribosomal biogenesis by regulating ribosomal protein synthesis at the level of mRNA translation. ..
  59. Schwab M, Kim S, Terada N, Edfjall C, Kozma S, Thomas G, et al. p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis. Mol Cell Biol. 1999;19:2485-94 pubmed
    ..These results suggest that changes in p70(S6K) activity during oocyte maturation and early embryogenesis selectively alter the translational capacity available for mRNAs lacking a 5'-TOP region. ..
  60. Geraci M, Gao B, Shepherd D, Moore M, Westcott J, Fagan K, et al. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J Clin Invest. 1999;103:1509-15 pubmed
    ..We conclude that PGIS plays a major role in modifying the pulmonary vascular response to chronic hypoxia. This has important implications for the pathogenesis and treatment of severe pulmonary hypertension. ..
  61. Sun W, Vincent S, Settleman J, Johnson G. MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase. J Biol Chem. 2000;275:24421-8 pubmed
    ..MEKK2 activation of PRK2 is independent of MEKK2 regulation of the c-Jun NH(2)-terminal kinase pathway. MEKK2 activation of PRK2 results in a bifurcation of signaling for the dual control of MAPK pathways and PRK2 regulated responses. ..
  62. Liu Y, Manna A, Li R, Martin W, Murphy R, Cheung A, et al. Crystal structure of the SarR protein from Staphylococcus aureus. Proc Natl Acad Sci U S A. 2001;98:6877-82 pubmed publisher
    ..The structure also demonstrates the molecular basis for the stable dimerization of the SarR monomers and possible motifs for interaction with other proteins...
  63. Murray K, Barton D. Poliovirus CRE-dependent VPg uridylylation is required for positive-strand RNA synthesis but not for negative-strand RNA synthesis. J Virol. 2003;77:4739-50 pubmed
    ..Because these results are inconsistent with existing models of poliovirus RNA replication, we propose a new four-step model that explains the roles of VPg, the CRE, and VPgpUpU(OH) in the asymmetric replication of poliovirus RNA. ..
  64. Oram M, Howells A, Maxwell A, Pato M. A biochemical analysis of the interaction of DNA gyrase with the bacteriophage Mu, pSC101 and pBR322 strong gyrase sites: the role of DNA sequence in modulating gyrase supercoiling and biological activity. Mol Microbiol. 2003;50:333-47 pubmed
    ..The results emphasize the importance of the DNA substrate as an active component in modulating the gyrase supercoiling reaction, and in determining the biological roles of specialized gyrase sites. ..
  65. Xu L, Li L, Shu H. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem. 2004;279:17278-82 pubmed
    ..Our studies identified a novel TRAF family member that is involved in MEKK3 signaling and apoptosis. ..
  66. Gault J, Shenkar R, Recksiek P, Awad I. Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion. Stroke. 2005;36:872-4 pubmed
    ..These 2 genetic hits are biallelic. Identification of biallelic CCM1 somatic and germ line truncating mutations strongly support the "two-hit" mechanism in this CCM lesion. ..
  67. Koeppe J, Campbell T, Rapaport E, Wilson C. HIV-1-specific CD4+ T-cell responses are not associated with significant viral epitope variation in persons with persistent plasma viremia. J Acquir Immune Defic Syndr. 2006;41:140-8 pubmed
  68. Ghosh M, Loper R, Gelb M, Leslie C. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. J Biol Chem. 2006;281:16615-24 pubmed
    ..cPLA(2)beta3 is widely expressed in tissues, suggesting that it has a generalized function at these unique sites. ..
  69. Sampey B, Carbone D, Doorn J, Drechsel D, Petersen D. 4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. Mol Pharmacol. 2007;71:871-83 pubmed
    ..These novel results show that the formation of 4-HNE-Erk-1/2 monomer-adducts results in the inhibition of Erk-Elk-AP-1 signaling in hepatocytes and implicates the His 178 residue with the mechanism of inhibition. ..
  70. Roberts E, Shoureshi P, Kozak K, Szynskie L, Baron A, Lecaude S, et al. Tracking the evolution of the proenkephalin gene in tetrapods. Gen Comp Endocrinol. 2007;153:189-97 pubmed
  71. Ortega M, Gaussier H, Catalano C. The DNA maturation domain of gpA, the DNA packaging motor protein of bacteriophage lambda, contains an ATPase site associated with endonuclease activity. J Mol Biol. 2007;373:851-65 pubmed
    ..The implications of these results with respect to the two roles of the terminase holoenzyme, DNA maturation and DNA packaging, are discussed. ..
  72. Jin L, Waterman P, Jonscher K, Short C, Reisdorph N, Cambier J. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol. 2008;28:5014-26 pubmed publisher
    ..Finally, MHC class II-mediated cell death signaling requires MPYS-dependent activation of the extracellular signal-regulated kinase signaling pathway. ..
  73. Stadinski B, Zhang L, Crawford F, Marrack P, Eisenbarth G, Kappler J. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A. 2010;107:10978-83 pubmed publisher
    ..Our findings suggest that the association of autoimmunity with particular MHCII alleles may be do to poorer, rather than more favorable, binding of the critical self-epitopes, allowing T-cell escape from thymic deletion...
  74. Wilson Shaw D, Robinson M, Gambarana C, Siegel R, Sikela J. A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. FEBS Lett. 1991;284:211-5 pubmed
    ..Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits. ..
  75. Su J, Rempel R, Erikson E, Maller J. Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1. Proc Natl Acad Sci U S A. 1995;92:10187-91 pubmed
    ..These results suggest a function for Xic-1 in the control of DNA synthesis by cyclin E/Cdk2. ..
  76. Guan G, Jiang G, Koch R, Shechter I. Molecular cloning and functional analysis of the promoter of the human squalene synthase gene. J Biol Chem. 1995;270:21958-65 pubmed
    ..Kim, J. B., Graves, R. A., and Spiegelman B. M. (1993) Mol. Cell Biol. 13, 4753-4759) by mobility shift assay and footprinting analyses. ..
  77. Rempel R, Sleight S, Maller J. Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase. J Biol Chem. 1995;270:6843-55 pubmed
    ..The data indicate that the Cdk2-cyclin E complex functions during meiotic and embryonic cell cycles in addition to performing its established role during G1 in somatic cells. ..
  78. Ribera A, Nguyen D. Primary sensory neurons express a Shaker-like potassium channel gene. J Neurosci. 1993;13:4988-96 pubmed
    ..abstract truncated at 250 words)..
  79. Pietropaolo M, Castano L, Babu S, Buelow R, Kuo Y, Martin S, et al. Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin Invest. 1993;92:359-71 pubmed
  80. Trotter P, Pedretti J, Voelker D. Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. J Biol Chem. 1993;268:21416-24 pubmed
    ..Analysis of lipid synthesis and enzyme activity in null mutants indicates that there are two PSD genes. ..
  81. Patterson D, Jones C, Hart I, Bleskan J, Berger R, Geyer D, et al. The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region. Genomics. 1993;15:173-6 pubmed
    ..2 by fluorescence in situ hybridization. This site is near the positions of genes for human IL-1 alpha, IL-1 beta, and types I and II IL-1 receptors, as reported by other laboratories. ..
  82. Friedrich R, Campbell K, Cambier J. The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene. J Immunol. 1993;150:2814-22 pubmed
    ..This raises the possibility that it may confer some distinct signaling function on the Ag receptors of these cells. ..
  83. Liu A, Jena P, Wysocki L. Tracing the development of single memory-lineage B cells in a highly defined immune response. J Exp Med. 1996;183:2053-63 pubmed
    ..If germinal centers are the source of memory B cells, our data suggest that B cell memory may be derived from only a small fraction of all germinal centers. ..
  84. Pekarsky Y, Rynditch A, Wieser R, Fonatsch C, Gardiner K. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Cancer Res. 1997;57:3914-9 pubmed
    ..The Ribophorin I-EVI1 fusion in particular may be a common occurrence in t(3;3). ..
  85. Gabay C, Porter B, Fantuzzi G, Arend W. Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo. J Immunol. 1997;159:5905-13 pubmed
    ..Using RPA, primer extension assay and 5' rapid amplification of cDNA ends, we were able to demonstrate the presence of different transcription start sites for murine sIL-1Ra mRNA. ..
  86. Shu H, Hu W, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999;65:680-3 pubmed
    ..Furthermore, TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin. ..
  87. Qian Y, Erikson E, Maller J. Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1. Mol Cell Biol. 1999;19:8625-32 pubmed
  88. Liu Y, Xu L, Opalka N, Kappler J, Shu H, Zhang G. Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell. 2002;108:383-94 pubmed
    ..Finally, we found the virus-like cluster of sTALL-1 exists in physiological condition. We propose that this virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo. ..
  89. Slavov D, Gardiner K. Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns. Gene. 2002;299:83-94 pubmed
    ..Patterns and levels of editing and alternative splicing vary among organisms, and include novel N-terminal exons and splicing events. ..
  90. Lyman M, Demmin G, Banfield B. The attenuated pseudorabies virus strain Bartha fails to package the tegument proteins Us3 and VP22. J Virol. 2003;77:1403-14 pubmed
    ..Furthermore, our data suggest that one or more of the gI, gE, Us9, or Us2 genes influences the localization of the Us3 protein in infected cells, and this effect may be important for the proper incorporation of Us3 into virions. ..
  91. Manzer R, Qamar L, Estey T, Pappa A, Petersen D, Vasiliou V. Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA. DNA Cell Biol. 2003;22:329-38 pubmed publisher
    ..These data suggest that ALDH1A1 may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation...
  92. Matsunaga M, Jaehning J. A mutation in the yeast mitochondrial core RNA polymerase, Rpo41, confers defects in both specificity factor interaction and promoter utilization. J Biol Chem. 2004;279:2012-9 pubmed
    ..The fact that mutation of Rpo41 results in selective transcription defects indicates that the core RNAP, like T7RNAP, plays an important role in promoter utilization. ..