Experts and Doctors on mice in Denver, Colorado, United States


Locale: Denver, Colorado, United States
Topic: mice

Top Publications

  1. Gordon D, Haugen B, Sarapura V, Nelson A, Wood W, Ridgway E. Analysis of Pit-1 in regulating mouse TSH beta promoter activity in thyrotropes. Mol Cell Endocrinol. 1993;96:75-84 pubmed
    ..These studies suggest that Pit-1 is not limiting for cell-specific expression of the TSH beta gene in thyrotrope-derived cells and implies that additional thyrotropic factors are likely required. ..
  2. Drake C, Rozzo S, Vyse T, Kotzin B. Absence of coding sequence polymorphism in the serum amyloid P component gene (Sap) in autoimmune New Zealand black mice. Mamm Genome. 1996;7:466-7 pubmed
  3. Bazenet C, Gelderloos J, Kazlauskas A. Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol Cell Biol. 1996;16:6926-36 pubmed
    ..In addition, these findings reveal that while SHP-2 binds to both of the receptors, it binds in different locations: to the carboxy terminus of the betaPDGFR but to the kinase insert of the alphaPDGFR. ..
  4. Kabrun N, Buhring H, Choi K, Ullrich A, Risau W, Keller G. Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development. 1997;124:2039-48 pubmed
    ..Together these findings indicate that Flk-1 is expressed on an early population of hematopoietic precursors that may represent the onset of embryonic hematopoiesis. ..
  5. Wang W, Falk S, Jittikanont S, Gengaro P, Edelstein C, Schrier R. Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice. Am J Physiol Renal Physiol. 2002;283:F583-7 pubmed
  6. Robinson A, Keely S, Karhausen J, Gerich M, Furuta G, Colgan S. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology. 2008;134:145-55 pubmed publisher
    ..Taken together these findings emphasize the role of epithelial HIF-1alpha during inflammatory diseases in the colon and may provide the basis for a therapeutic use of PHD inhibitors in inflammatory mucosal disease. ..
  7. Eckle T, Grenz A, Laucher S, Eltzschig H. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest. 2008;118:3301-15 pubmed publisher
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury. ..
  8. Humann J, Lenz L. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 2010;184:5172-8 pubmed publisher
    ..These data suggest that the activation of NK cells during L. monocytogenes infection requires both secreted cytokines and ligation of NK activating receptors during direct contact with infected DCs. ..
  9. Suram S, Gangelhoff T, Taylor P, Rosas M, Brown G, Bonventre J, et al. Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans. J Biol Chem. 2010;285:30676-85 pubmed publisher
    ..The results demonstrate that C. albicans engages both β-glucan and mannan-binding receptors on macrophages that act with MyD88 to regulate the activation of cPLA(2)α and eicosanoid production. ..

More Information

Publications534 found, 100 shown here

  1. Rubtsov A, Rubtsova K, Fischer A, Meehan R, Gillis J, Kappler J, et al. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. Blood. 2011;118:1305-15 pubmed publisher
    ..We were able to detect a similar population of B cells in the peripheral blood of some elderly women with autoimmune disease, suggesting that there may be parallels between the creation of ABC-like cells between mice and humans. ..
  2. Fotiadis C, Kilpatrick D, Lipton H. Comparison of the binding characteristics to BHK-21 cells of viruses representing the two Theiler's virus neurovirulence groups. Virology. 1991;182:365-70 pubmed
    ..These results suggest members of the two TMEV virulence groups share a common receptor but bind it differently. ..
  3. Sikela J, Law M, Kao F, Hartz J, Wei Q, Hahn W. Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV. Genomics. 1989;4:21-7 pubmed
    ..Hybridization of cDNA probes to metaphase spreads of human chromosomes indicates that the gene is most likely located within the region of bands q21 to q23 of chromosome 5. ..
  4. Fournier T, Riches D, Winston B, Rose D, Young S, Noble P, et al. Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-alpha and prostaglandin E2. J Immunol. 1995;155:2123-33 pubmed
    ..Collectively, these data suggest that TNF-alpha and PGE2 stimulate IGF-I synthesis in macrophages by two separate pathways, and that PGE2 acts as a positive stimulus for IGF-I synthesis through a cyclic AMP/PKA pathway. ..
  5. Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen T. Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem. 1996;271:28727-30 pubmed
    ..These findings suggest several possible regulatory roles of Eps15 during the formation of coated pits...
  6. Clancy K, Berger R, Cox M, Bleskan J, Walton K, Hart I, et al. Localization of the L-glutamine synthetase gene to chromosome 1q23. Genomics. 1996;38:418-20 pubmed
    ..The glutamine synthetase gene was mapped to five CEPH megaYACs between the polymorphic PCR markers D1S117 and D1S466 by analysis of the Whitehead Institute's recently described chromosome 1 contig map. ..
  7. Tebar F, Confalonieri S, Carter R, Di Fiore P, Sorkin A. Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. J Biol Chem. 1997;272:15413-8 pubmed
    ..The possibility that hetero-oligomeric complexes of Eps15 dimers and AP-2 function during the recruitment of proteins into coated pits is discussed. ..
  8. Gordon D, Lewis S, Haugen B, James R, McDermott M, Wood W, et al. Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter. J Biol Chem. 1997;272:24339-47 pubmed
    ..In summary, these data demonstrate functional synergy and physical interaction between homeobox and zinc finger factors and provide insights into the transcriptional mechanisms of thyrotrope-specific gene expression. ..
  9. Allen M, Zeng C, Schneider K, Xiong X, Meintzer M, Bellosta P, et al. Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt. Mol Endocrinol. 1999;13:191-201 pubmed
    ..These data support an important role for Gas6/Ark signaling via the ERK and PI3-K (via Akt) pathways in the protection of GnRH neurons from programmed cell death across neuronal migration. ..
  10. Schaefer B, Mitchell T, Kappler J, Marrack P. A novel family of retroviral vectors for the rapid production of complex stable cell lines. Anal Biochem. 2001;297:86-93 pubmed
    ..The use of these vectors will thus dramatically accelerate the production of complex stable cell lines. ..
  11. Pelanda R, Hobeika E, Kurokawa T, Zhang Y, Kuppig S, Reth M. Cre recombinase-controlled expression of the mb-1 allele. Genesis. 2002;32:154-7 pubmed
  12. Bonavia A, Zelus B, Wentworth D, Talbot P, Holmes K. Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E. J Virol. 2003;77:2530-8 pubmed
    ..Thus, the data suggest that the domain of the spike protein between amino acids 417 and 547 is required for the binding of HCoV-229E to its hAPN receptor. ..
  13. Meyer A, Dwyer Nield L, Hurteau G, Keith R, Ouyang Y, Freed B, et al. Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1260-6 pubmed
  14. Lu L, Oh D, Dursun B, He Z, Hoke T, Faubel S, et al. Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice. J Pharmacol Exp Ther. 2008;324:111-7 pubmed
    ..However, inhibition of macrophage infiltration in the kidney or CX(3)CR1 blockade is not sufficient to prevent CisARF. ..
  15. Oberley R, Goss K, Hoffmann D, Ault K, Neff T, Ramsey K, et al. Regulation of surfactant protein D in the mouse female reproductive tract in vivo. Mol Hum Reprod. 2007;13:863-8 pubmed
    ..These data are suggestive that SP-D may play a role in innate immunity in the female reproductive tract in vivo. ..
  16. Roy S, Singh R, Agarwal C, Siriwardana S, Sclafani R, Agarwal R. Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. Cell Cycle. 2008;7:1828-35 pubmed
  17. Baqir M, Chen C, Martin R, Thaikoottathil J, Case S, Minor M, et al. Cigarette smoke decreases MARCO expression in macrophages: implication in Mycoplasma pneumoniae infection. Respir Med. 2008;102:1604-10 pubmed publisher
    ..Our results indicate that cigarette smoke exposure down-regulates MARCO expression in macrophages, which may be in part responsible for impaired bacterial (e.g., Mp) clearance. ..
  18. Fernandez Boyanapalli R, McPhillips K, Frasch S, Janssen W, Dinauer M, Riches D, et al. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010;185:4030-41 pubmed publisher
    ..These data support the hypothesis that in addition to correcting immunodeficiency in CGD, IFN-? priming of Ms restores clearance of apoptotic cells and may thereby contribute to resolution of exaggerated CGD inflammation. ..
  19. Bjordahl R, Gapin L, Marrack P, Refaeli Y. iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. PLoS ONE. 2012;7:e42635 pubmed publisher
    ..This study reveals a tumor-promoting role for iNKT cells and suggests their capacity to inhibit the CD8(+) T cell response to B cell lymphoma by opposing the effects of type II NKT cells. ..
  20. Olincy A, Stevens K. Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men. Biochem Pharmacol. 2007;74:1192-201 pubmed
    ..These data suggest that therapeutic agents selected for alpha7 nicotinic activity may have utility in treating certain symptoms of schizophrenia. ..
  21. Marrack P, McKee A, Munks M. Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol. 2009;9:287-93 pubmed publisher
    ..We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work. ..
  22. Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013;140:3731-42 pubmed publisher
    ..Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation. ..
  23. Fagan K, Tyler R, Sato K, Fouty B, Morris K, Huang P, et al. Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation. Am J Physiol. 1999;277:L472-8 pubmed
  24. Seeds N, Basham M, Haffke S. Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene. Proc Natl Acad Sci U S A. 1999;96:14118-23 pubmed
    ..These findings establish a direct role for tPA in facilitating neuronal migration, and they raise the possibility that late arriving neurons may have altered synaptic interactions. ..
  25. Capasso J, Rivard C, Enomoto L, Berl T. Adaptation of murine inner medullary collecting duct (IMCD3) cell cultures to hypertonicity. Ann N Y Acad Sci. 2003;986:410-5 pubmed
    ..Failure to upregulate the expression of the gamma subunit was associated with a marked decrease in cell viability upon stress. ..
  26. Gardai S, Hildeman D, Frankel S, Whitlock B, Frasch S, Borregaard N, et al. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem. 2004;279:21085-95 pubmed
  27. Boackle S, Culhane K, Brown J, Haas M, Bao L, Quigg R, et al. CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE. Autoimmunity. 2004;37:111-23 pubmed
    ..Together these data support the concept that alterations in CR1/CR2 expression or function affect the regulation of autoantibody production and/or clearance and may have clinical consequences. ..
  28. Meng X, Ao L, Song Y, Raeburn C, Fullerton D, Harken A. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol. 2005;288:R600-6 pubmed
    ..Thus TLR4 and the p55 TNF-alpha receptor represent therapeutic targets for preservation of cardiac mechanical function during hemorrhagic shock. ..
  29. Wang W, Faubel S, Ljubanovic D, Mitra A, Falk S, Kim J, et al. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol. 2005;288:F997-1004 pubmed
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study. ..
  30. Eyers P, Liu J, Hayashi N, Lewellyn A, Gautier J, Maller J. Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem. 2005;280:24339-46 pubmed
    ..The identification of substrates for PKAc that maintain cell cycle arrest in G(2) remains an important goal for future work. ..
  31. Lewis E, Dinarello C. Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor. Proc Natl Acad Sci U S A. 2006;103:16852-7 pubmed
    ..Importantly, discrepancies between IL-18- and IL-18R-deficient cells suggest that IL-18Ralpha chain is used by an inflammation-suppressing signal. ..
  32. Wu Q, Martin R, Lafasto S, Efaw B, Rino J, Harbeck R, et al. Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance. Am J Respir Crit Care Med. 2008;177:720-9 pubmed publisher
    ..This could offer novel therapeutic strategies to reinstate TLR2 activation by using TLR2 ligands and/or blocking IL-4 and IL-13 to ameliorate persisting respiratory bacterial infections in allergic lungs. ..
  33. Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz L. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med. 2010;207:327-37 pubmed publisher
    ..Such cross talk permits prioritization of IFN-alphabeta-type immune responses and may contribute to the beneficial effects of IFN-beta in treatment of inflammatory diseases such as multiple sclerosis. ..
  34. Lang J, Weiss N, Freed B, Torres R, Pelanda R. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2r?null mouse model: a multivariable optimization approach. Clin Immunol. 2011;140:102-16 pubmed publisher
    ..Thus, hematopoietic humanized mice generated on a BALB/c immunodeficient background represent a useful model to study the human immune system. ..
  35. Zemans R, Briones N, Campbell M, McClendon J, Young S, Suzuki T, et al. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011;108:15990-5 pubmed publisher
    ..This pathway represents a potential therapeutic target to accelerate physiological recovery in inflammatory lung diseases. ..
  36. Teodorovic L, Riccardi C, Torres R, Pelanda R. Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS ONE. 2012;7:e31632 pubmed publisher
    ..Overall, our data indicate that GITR does not play a significant role in B cell development and antibody responses to T-dependent and independent model antigens within the context of a GITR-deficient genetic background. ..
  37. Pujanauski L, Janoff E, McCarter M, Pelanda R, Torres R. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2013;110:1422-7 pubmed publisher
  38. Kratzer A, Chu H, Salys J, Moumen Z, Leberl M, Bowler R, et al. Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD. J Pathol. 2013;230:388-98 pubmed publisher
    ..Our study indicates that loss of CD146 function damages pulmonary endothelial integrity. This damage may represent part of the pathophysiological processes that are involved in the basic aetiology of COPD/emphysema. ..
  39. Hu J, Oda S, Shotts K, Donovan E, Strauch P, Pujanauski L, et al. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014;193:85-95 pubmed publisher
    ..Our findings extend the influence of lysophospholipids on immune function and suggest that alterations in LPA levels likely influence adaptive humoral immunity. ..
  40. D Ambrosio D, Hippen K, Minskoff S, Mellman I, Pani G, Siminovitch K, et al. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science. 1995;268:293-7 pubmed
    ..Inhibitory signaling mediated by Fc gamma RIIB1 is deficient in motheaten mice which do not express functional PTP1C. Thus, PTP1C is an effector of BCR-Fc gamma RIIB1 negative signal cooperativity. ..
  41. Vyse T, Drake C, Rozzo S, Roper E, Izui S, Kotzin B. Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J Clin Invest. 1996;98:1762-72 pubmed
    ..Interestingly, a distal chromosome 4 locus, Nba1, was linked with nephritis but not with any of the autoantibodies measured, suggesting that it contributes to renal disease at a checkpoint distal to autoantibody production. ..
  42. Widmann C, Gerwins P, Johnson N, Jarpe M, Johnson G. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol Cell Biol. 1998;18:2416-29 pubmed
    ..MEKK1 and caspases are predicted to be part of an amplification loop to increase caspase activity during apoptosis. ..
  43. Orlicky D, Lieber J, Morin C, Evans R. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. J Lipid Res. 1998;39:1152-61 pubmed
    ..Transient expression of an FPRP cDNA in undifferentiated 3T3-L1 cells was insufficient to induce lipid droplet accumulation. ..
  44. Malkinson A, Koski K, Dwyer Nield L, Rice P, Rioux N, Castonguay A, et al. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone). Carcinogenesis. 1998;19:1353-6 pubmed
  45. Ling H, Edelstein C, Gengaro P, Meng X, Lucia S, Knotek M, et al. Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice. Am J Physiol. 1999;277:F383-90 pubmed
    ..In conclusion, kidneys of iNOS knockout mice were protected against ischemic acute renal failure. This protective effect may be related to a compensatory upregulation of heat shock protein 72. ..
  46. Taube C, Duez C, Cui Z, Takeda K, Rha Y, Park J, et al. The role of IL-13 in established allergic airway disease. J Immunol. 2002;169:6482-9 pubmed
  47. Lin W, Arellano J, Slotnick B, Restrepo D. Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system. J Neurosci. 2004;24:3703-10 pubmed
    ..These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors. ..
  48. Snyder C, Aviszus K, Heiser R, Tonkin D, Guth A, Wysocki L. Activation and tolerance in CD4(+) T cells reactive to an immunoglobulin variable region. J Exp Med. 2004;200:1-11 pubmed
    ..They suggest that nondeletional forms of T tolerance in BCR-reactive T cells may be insufficient to preclude helper activity for chromatin-reactive B cells. ..
  49. Redente E, Orlicky D, Bouchard R, Malkinson A. Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am J Pathol. 2007;170:693-708 pubmed
    ..These biochemical markers of macrophage activation states would have diagnostic and/or therapeutic value if analogous systemic shifts occur in humans...
  50. Kim B, Leung D, Boguniewicz M, Howell M. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol. 2008;126:332-7 pubmed publisher
    ..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism. ..
  51. McWilliams J, Sullivan R, Jordan K, McMahan R, Kemmler C, McDuffie M, et al. Age-dependent tolerance to an endogenous tumor-associated antigen. Vaccine. 2008;26:1863-1873 pubmed publisher
    ..We conclude that immunosurveillance may decline with age due to increased or de novo peripheral expression of endogenous TAAs. ..
  52. Gally F, Hartney J, Janssen W, Perraud A. CD38 plays a dual role in allergen-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2009;40:433-42 pubmed publisher
    ..These studies demonstrate that CD38 not only acts as a key modulator of the immune response, but also plays an equally important role as an intrinsic pulmonary component. ..
  53. Macleod M, David A, McKee A, Crawford F, Kappler J, Marrack P. Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol. 2011;186:2889-96 pubmed publisher
  54. De Arras L, Yang I, Lackford B, Riches D, Prekeris R, Freedman J, et al. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J Immunol. 2012;188:2905-13 pubmed publisher
    ..The identification of a novel spatiotemporal regulator of innate immunity signaling validates the comparative genomics approach for innate immunity gene discovery. ..
  55. Chen L, Martino V, Dombkowski A, Williams T, WEST MAYS J, Gage P. AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development. Invest Ophthalmol Vis Sci. 2016;57:1072-81 pubmed publisher
    ..Therefore, additional PITX2-dependent factors likely regulate these latter processes during embryonic development. These results extend our understanding of the genetic mechanisms regulating cornea development. ..
  56. White J, Cross E, Burchill M, Danhorn T, McCarter M, Rosen H, et al. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. Nat Commun. 2016;7:11291 pubmed publisher
    ..These data identify developmental and functional attributes of VM cells, including their likely role in protective immunity. ..
  57. Miller Y, Kao B. Monoclonal antibody based immunoassay for human aminoacylase-1. J Immunoassay. 1989;10:129-52 pubmed
    ..We have produced mouse monoclonal antibodies and rabbit antisera which recognize human aminoacylase-1. A sandwich ELISA has been developed which allows the measurement of human aminoacylase-1. ..
  58. Littler C, Morris K, Fagan K, McMurtry I, Messing R, Dempsey E. Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2003;284:H1321-31 pubmed
    ..Instead, the absence of PKC-epsilon allows increased expression of K(V) channels (like Kv3.1b) to occur in PASMC, which likely contributes to decreased HPV. ..
  59. Gally F, Di Y, Smith S, Minor M, Liu Y, Bratton D, et al. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol. 2011;178:2159-67 pubmed publisher
  60. Desch A, Randolph G, Murphy K, Gautier E, Kedl R, Lahoud M, et al. CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med. 2011;208:1789-97 pubmed publisher
  61. Vazquez Torres A, Jones Carson J, Wagner R, Warner T, Balish E. Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infect Immun. 1999;67:670-4 pubmed
  62. Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, et al. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. Am J Respir Cell Mol Biol. 2000;23:327-34 pubmed
  63. Bowler R, Nicks M, Warnick K, Crapo J. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2002;282:L719-26 pubmed
    ..We conclude that EC-SOD plays an important role in reducing the magnitude of lung injury from extracellular free radicals after bleomycin administration. ..
  64. Hall J, Bell M, Finger T. Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae. Dev Biol. 2003;255:263-77 pubmed
  65. Cuevas B, Abell A, Witowsky J, Yujiri T, Johnson N, Kesavan K, et al. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J. 2003;22:3346-55 pubmed
    ..Inhibition of ERK1/2 or calpain, but not of JNK, mimics MEKK1 deficiency. Therefore, MEKK1 regulates calpain-mediated substratum release of migrating fibroblasts. ..
  66. McDaniel S, Rumer K, Biroc S, Metz R, Singh M, Porter W, et al. Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J Pathol. 2006;168:608-20 pubmed
  67. Nemenoff R, Simpson P, Furgeson S, Kaplan Albuquerque N, Crossno J, Garl P, et al. Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha. Circ Res. 2008;102:1036-45 pubmed publisher
  68. Tyagi A, Singh R, Ramasamy K, Raina K, Redente E, Dwyer Nield L, et al. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila). 2009;2:74-83 pubmed publisher
  69. Ge X, Chu H, Minor M, Case S, Bosch D, Martin R. Roflumilast increases Clara cell secretory protein in cigarette smoke-exposed mice. COPD. 2009;6:185-91 pubmed
    ..Our results demonstrate that one of the therapeutic mechanisms of roflumilast is to reverse CS-induced downward trend in CCSP levels of BAL fluid, which may be mediated by down-regulating ERK1/2 activity. ..
  70. Seibold M, Schwartz D. The lung: the natural boundary between nature and nurture. Annu Rev Physiol. 2011;73:457-78 pubmed publisher
    ..Herein we discuss recent advances in knowledge and technology surrounding the role of genetics, the environment, and gene-environment interactions in these common lung diseases. ..
  71. Irvin C, Tu Y, Sheller J, Funk C. 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice. Am J Physiol. 1997;272:L1053-8 pubmed
    ..We conclude that 5-lipoxygenase products are essential for the production of nonspecific airway reactivity in mice and suggest that 5-lipoxygenase products may be important in immunoglobulin formation...
  72. Marschner S, Freiberg B, Kupfer A, Hunig T, Finkel T. Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin. Proc Natl Acad Sci U S A. 1999;96:9763-8 pubmed
  73. Cady C, Lahn M, Vollmer M, Tsuji M, Seo S, Reardon C, et al. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol. 2000;165:1790-8 pubmed
    ..Direct stimulation by ligands resembling pE50Y50 may thus selectively evoke contributions of gamma delta T cells to the host response...
  74. Strickland I, Kisich K, Hauk P, Vottero A, Chrousos G, Klemm D, et al. High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med. 2001;193:585-93 pubmed
    ..Moreover, upregulation of this GR by proinflammatory cytokines such as IL-8 further enhances their survival in the presence of glucocorticoids during inflammation. ..
  75. Vandivier R, Fadok V, Ogden C, Hoffmann P, Brain J, Accurso F, et al. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest. 2002;121:89S pubmed
  76. Gemmill R, Bemis L, Lee J, Sozen M, Baron A, Zeng C, et al. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene. 2002;21:3507-16 pubmed
    ..Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. ..
  77. McDermott N, Gordon D, Kramer C, Liu Q, Linney E, Wood W, et al. Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells. J Biol Chem. 2002;277:36839-44 pubmed
    ..Isolation and characterization of the mouse RXRgamma1 promoter region provides a tool for further investigation focusing on thyrotrope-specific gene expression as well as negative regulation of genes by retinoic acid. ..
  78. Rha Y, Taube C, Haczku A, Joetham A, Takeda K, Duez C, et al. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. J Immunol. 2002;169:5300-7 pubmed
    ..These results indicate selective and distinctive properties among the hsp, and that M. leprae hsp may have a potential therapeutic role in the treatment of allergic airway inflammation and altered airway function. ..
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