Park S, Link C, Johnson T. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 2010;24:383-92 pubmed publisher
..We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans. ..
Buchan J, Kolaitis R, Taylor J, Parker R. Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell. 2013;153:1461-74 pubmed publisher
Johnson T. Genetic influences on aging. Exp Gerontol. 1997;32:11-22 pubmed
Schoeniger Skinner D, Ledeboer A, Frank M, Milligan E, Poole S, Martin D, et al
. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun. 2007;21:660-7 pubmed
..These results would suggest that IL-6 induces pain facilitation, and may do so in part by stimulating the production and release of other pro-inflammatory cytokines. ..
Vigers G, Dripps D, Edwards C, Brandhuber B. X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. J Biol Chem. 2000;275:36927-33 pubmed
..ligand structures. The structure shows an unexpected binding mode for the peptide and may contribute to the design of smaller IL-1R antagonists. ..
Guzelian J, Barwick J, Hunter L, Phang T, Quattrochi L, Guzelian P. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006;94:379-87 pubmed
..Our results support the idea that the domain of PXR-controlled gene networks may be even more extensive than currently thought and may extend to functions apart from xenobiotic metabolism. ..
Wehner J, Keller J, Keller A, Picciotto M, Paylor R, Booker T, et al
. Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience. 2004;129:11-24 pubmed
..A new role for alpha7 nAChRs in regulating sensitivity to the cognitive disrupting effects of ethanol is proposed. ..
Wang W, Ungermannova D, Jin J, Harper J, Liu X. Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene. 2004;23:1064-75 pubmed
Ginsberg A, Campeau S, Day H, Spencer R. Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular . J Neuroendocrinol. 2003;15:1075-83 pubmed
Hamady M, Peden E, Knight R, Singh R. Fast-Find: a novel computational approach to analyzing combinatorial motifs. BMC Bioinformatics. 2006;7:1 pubmed
..We have used it to generate hypotheses about interactions between specific polyadenylation factors, which we will test experimentally. ..
Downing C, Balderrama Durbin C, Hayes J, Johnson T, Gilliam D. No effect of prenatal alcohol exposure on activity in three inbred strains of mice. Alcohol Alcohol. 2009;44:25-33 pubmed publisher
..The present study investigated the effects of prenatal ethanol exposure on activity in mice from three inbred strains: C57BL/6 (B6), Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS)...
Mariner P, Walters R, Espinoza C, Drullinger L, Wagner S, Kugel J, et al
. Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock. Mol Cell. 2008;29:499-509 pubmed publisher
..These studies provide an explanation for why mouse cells harbor two major classes of SINEs, whereas human cells contain only one. ..
Allen D, Sartorius C, Sycuro L, Leinwand L. Different pathways regulate expression of the skeletal myosin heavy chain genes. J Biol Chem. 2001;276:43524-33 pubmed
..Thus, we have found specific regulatory pathways that are distinct for the three adult fast MyHC genes. These elements are logical candidates for fiber-specific control of skeletal muscle gene expression in vivo. ..
Hullinger T, Montgomery R, Seto A, Dickinson B, Semus H, Lynch J, et al
. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res. 2012;110:71-81 pubmed publisher
Tata B, Chung W, Brooks L, Kavanaugh S, Tsai P. Fibroblast growth factor signaling deficiencies impact female reproduction and kisspeptin neurons in mice. Biol Reprod. 2012;86:119 pubmed publisher
..Further, these deficiencies led to changes in the AVPV/PeV KP-ir neurons that may have contributed to the accelerated VO in the compound hypomorphs. ..
Newmark P, Mohr S, Gong L, Boswell R. mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila. Development. 1997;124:3197-207 pubmed
..In the absence of mago+ function during oogenesis, the anteroposterior and dorsoventral coordinates of the oocyte are not specified and the germ plasm fails to assemble. ..
Hicke B, Watson S, Koenig A, Lynott C, Bargatze R, Chang Y, et al
. DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice. J Clin Invest. 1996;98:2688-92 pubmed
..These aptamers also block L-selectin-dependent lymphocyte trafficking in vivo, indicating their potential utility as therapeutics. ..
Preston D, Henderson J, Johnson P. Community ecology of invasions: direct and indirect effects of multiple invasive species on aquatic communities. Ecology. 2012;93:1254-61 pubmed
..Our results highlight how the net effects of multiple nonnative species depend on the trophic level of each invader, the form and magnitude of invader interactions, and the traits of native community members. ..
Klymkowsky M, Parr B. The body language of cells: the intimate connection between cell adhesion and behavior. Cell. 1995;83:5-8 pubmed
AghaKouchak A, Feldman D, Hoerling M, Huxman T, Lund J. Water and climate: Recognize anthropogenic drought. Nature. 2015;524:409-11 pubmed publisher
Yakovchuk P, Goodrich J, Kugel J. B2 RNA represses TFIIH phosphorylation of RNA polymerase II. Transcription. 2011;2:45-9 pubmed publisher
..Biochemical assays revealed that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH. ..
Franks T, Lykke Andersen J. The control of mRNA decapping and P-body formation. Mol Cell. 2008;32:605-15 pubmed publisher
..Here, we discuss the regulation of decapping machinery recruitment to specific mRNPs and how their assembly into PBs is governed by the relative rates of translational repression, mRNP multimerization, and mRNA decay. ..
Frank M, Barrientos R, Hein A, Biedenkapp J, Watkins L, Maier S. IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats. Brain Behav Immun. 2010;24:254-62 pubmed publisher
..The present results suggest that central pro-inflammatory cytokines play a salient role in the suppression of Arc and impairments of LTM by a peripheral immune challenge in older animals. ..
Bouchet Marquis C, Hoenger A. Cryo-electron tomography on vitrified sections: a critical analysis of benefits and limitations for structural cell biology. Micron. 2011;42:152-62 pubmed publisher
..Here we critically compare the benefits and limitations of vitrified sectioning for its application to modern structural cell biology. ..
Wilkins M, Seddon N, Safran R. Evolutionary divergence in acoustic signals: causes and consequences. Trends Ecol Evol. 2013;28:156-66 pubmed publisher
Poss Z, Ebmeier C, Taatjes D. The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol. 2013;48:575-608 pubmed publisher
..We also describe factors that influence Mediator structure and activity, including TFs, non-coding RNAs and the CDK8 module. ..
Ortiz N, O Neill H, Marks M, Grady S. Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo. Nicotine Tob Res. 2012;14:711-9 pubmed publisher
..Varenicline acts as a functional antagonist of β2*-nAChRs, blocking certain effects of nicotine. At higher doses, varenicline is an agonist of β4*-nAChRs producing physiological changes in mice. ..
Metcalf J, Love Stowell S, Kennedy C, Rogers K, McDonald D, Epp J, et al
. Historical stocking data and 19th century DNA reveal human-induced changes to native diversity and distribution of cutthroat trout. Mol Ecol. 2012;21:5194-207 pubmed publisher
Golumbeski G, Bardsley A, Tax F, Boswell R. tudor, a posterior-group gene of Drosophila melanogaster, encodes a novel protein and an mRNA localized during mid-oogenesis. Genes Dev. 1991;5:2060-70 pubmed
..Taken together, these results indicate that the tud product is a novel protein required during oogenesis for establishment of a functional center of morphogenetic activity in the posterior tip of the Drosophila embryo. ..
Kemp B, Judd K, Monroe C, Eerkens J, Hilldorfer L, Cordray C, et al
. Prehistoric mitochondrial DNA of domesticate animals supports a 13th century exodus from the northern US southwest. PLoS ONE. 2017;12:e0178882 pubmed publisher
..These results support scenarios that suggest contemporary Pueblo peoples of the Northern Rio Grande are biological and cultural descendants of Four Corners populations. ..
Engel P, Kwong W, McFrederick Q, Anderson K, Barribeau S, Chandler J, et al
. The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions. MBio. 2016;7:e02164-15 pubmed publisher
Grogan K, McGinnis G, Sauther M, Cuozzo F, Drea C. Next-generation genotyping of hypervariable loci in many individuals of a non-model species: technical and theoretical implications. BMC Genomics. 2016;17:204 pubmed publisher
..Owing to MHC-DRB diversity and copy number, ring-tailed lemurs may serve as an ideal model for estimating the interaction between genetic diversity, fitness, and environment, especially regarding endangered species. ..
Starr D, Hermann G, Malone C, Fixsen W, Priess J, Horvitz H, et al
. unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development. 2001;128:5039-50 pubmed
..We favor a model in which UNC-84 directly recruits UNC-83 to the nuclear envelope where they help transfer force between the cytoskeleton and the nucleus...
Starr D, Han M. ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci. 2003;116:211-6 pubmed
..Syne/ANC-1 anchors nuclei by directly tethering the nuclear envelope to the actin cytoskeleton, and UNC-84/SUN functions at the nuclear envelope to recruit Syne/ANC-1. ..
Butt C, Hutton S, Stitzel J, Balogh S, Owens J, Collins A. A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol. Alcohol Clin Exp Res. 2003;27:733-42 pubmed
..However, the possibility of the polymorphism modulating the effects of ethanol on the 86Rb+ efflux response has not been investigated...
Yu H, Lai H, Lin T, Lo S. Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Biosci Rep. 2015;35: pubmed publisher
..Collectively, we demonstrate that the ToLFP method can be used to differentiate the locations of blastomeres where DNase II acts autonomously or non-autonomously in degrading apoptotic DNA. ..
Dynan W, Gilman M. Transcriptional control and signal transduction: of soap-operas and reductionism. Trends Genet. 1993;9:154-6 pubmed
Bardsley A, McDonald K, Boswell R. Distribution of tudor protein in the Drosophila embryo suggests separation of functions based on site of localization. Development. 1993;119:207-19 pubmed
..Our results suggest that tudor protein localized in the germ plasm is instrumental in germ cell determination, whereas nuclear-associated tudor protein is involved in determination of segmental pattern in the abdomen. ..
Prescott D. Cutting, splicing, reordering, and elimination of DNA sequences in hypotrichous ciliates. Bioessays. 1992;14:317-24 pubmed
..nova. Telomeric sequences are added to the excised gene-sized DNA molecules. Finally, the gene-sized molecules are replicated several times to form the macronucleus of the organism...
Chapman T, Barrientos R, Ahrendsen J, Hoover J, Maier S, Patterson S. Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus. Neurobiol Aging. 2012;33:832.e1-14 pubmed publisher
..Effects in dentate were minimal. Northern blot analysis confirmed an aging-associated loss of total BDNF mRNA in areas CA1 and CA3, and revealed a parallel, preferential loss of BDNF mRNA transcripts with long 3' UTRs. ..
Nufio C, McGuire C, Bowers M, Guralnick R. Grasshopper community response to climatic change: variation along an elevational gradient. PLoS ONE. 2010;5:e12977 pubmed publisher
..Using grasshopper communities found along an elevational gradient, we present an ideal system along the Front Range of Colorado USA that provides a mechanistic link between climate and phenology...
Chung W, Tsai P. Role of fibroblast growth factor signaling in gonadotropin-releasing hormone neuronal system development. Front Horm Res. 2010;39:37-50 pubmed publisher
Mason M, Mahoney M. Inhibition of gamma-secretase activity promotes differentiation of embryonic pancreatic precursor cells into functional islet-like clusters in poly(ethylene glycol) hydrogel culture. Tissue Eng Part A. 2010;16:2593-603 pubmed publisher
Bhattacharya A, Mahajan R. Temperature dependence of thermal conductivity of biological tissues. Physiol Meas. 2003;24:769-83 pubmed
..The degree of enhancement is different in different organs and shows a direct dependence on the blood flow rate. ..
White A, Khuu J, Dang C, Hu J, Tran K, Liu A, et al
. Stem cell quiescence acts as a tumour suppressor in squamous tumours. Nat Cell Biol. 2014;16:99-107 pubmed publisher
..These data demonstrate that stem cell quiescence is a form of tumour suppression in HFSCs, and that Pten plays a role in maintaining quiescence in the presence of tumorigenic stimuli. ..
Johnson J, Campisi J, Sharkey C, Kennedy S, Nickerson M, Fleshner M. Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72. J Appl Physiol (1985). 2005;99:1789-95 pubmed
..Understanding the signals involved in elevating extracellular Hsp72 could facilitate the use of extracellular Hsp72 to bolster immunity and perhaps prevent exacerbation of inflammatory diseases during stress. ..
Donovan E, Gleeson T. Metabolic support of moderate activity differs from patterns seen after extreme behavior in the desert iguana Dipsosaurus dorsalis. Physiol Biochem Zool. 2006;79:370-88 pubmed
..The findings presented here indicate that the metabolic consequences of the behaviorally relevant activity studied are less severe than has been suggested by studies using more extreme activity patterns...
Ehrenfeucht A, Prescott D, Rozenberg G. A model for the origin of internal eliminated segments (IESs) and gene rearrangement in stichotrichous ciliates. J Theor Biol. 2007;244:108-14 pubmed
..All experimentally demonstrated as well as theoretical MIC gene patterns can be produced in this way...
Matus Amat P, Higgins E, Sprunger D, Wright Hardesty K, Rudy J. The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories. Behav Neurosci. 2007;121:721-31 pubmed
..However, both DL-AP5 and L-AP5 reduced the expression of fear when they were injected into the amygdala prior to testing for contextual fear. ..
Rocha L, Aleixo A, Allen G, Almeda F, Baldwin C, Barclay M, et al
. Specimen collection: an essential tool. Science. 2014;344:814-5 pubmed publisher
Junge H. Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In. Neuron. 2017;95:983-985 pubmed publisher
..In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor complexes. ..
Hiester B, Galati D, Salinas P, Jones K. Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation. Mol Cell Neurosci. 2013;56:115-27 pubmed publisher
..Together, these data suggest that BDNF and Wnt signaling cooperatively regulate dendritic spine formation. ..
Donner N, Johnson P, Fitz S, Kellen K, Shekhar A, Lowry C. Elevated tph2 mRNA expression in a rat model of chronic anxiety. Depress Anxiety. 2012;29:307-19 pubmed publisher
..Tph2 mRNA expression in the DRVL/VLPAG was correlated with increased anxiety-related behavior. Our data support the hypothesis that chronic anxiety states are associated with dysregulated tph2 expression. ..
Quintero C, Bowers M. Plant induced defenses depend more on plant age than previous history of damage: implications for plant-herbivore interactions. J Chem Ecol. 2011;37:992-1001 pubmed publisher
..lanceolata and perhaps other systems, ontogenetic trajectories in plant growth and defenses leading to strong age-dependent induced responses may prevail over herbivore-induced indirect interactions. ..
Hassan W, Merin D, Fonte V, Link C. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hum Mol Genet. 2009;18:2739-47 pubmed publisher
..Our results implicate AIP-1 in the regulation of protein turnover and protection against Abeta toxicity and point at AIRAPL as the functional mammalian homologue of AIP-1. ..
Barrientos R, Frank M, Hein A, Higgins E, Watkins L, Rudy J, et al
. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun. 2009;23:46-54 pubmed publisher
..These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection. ..
Kell A, Ventura N, Kahn N, Johnson T. Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007;43:1560-6 pubmed
..Inhibition of two of these kinases results in shorter life span and increased sensitivity to stress. ..
Wang X, Wang J, Gengyo Ando K, Gu L, Sun C, Yang C, et al
. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol. 2007;9:541-9 pubmed
..Thus WAH-1, after its release from mitochondria during apoptosis, promotes plasma membrane phosphatidylserine externalization through its downstream effector, SCRM-1. ..
Holguin A, O Connor K, Biedenkapp J, Campisi J, Wieseler Frank J, Milligan E, et al
. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 2004;110:517-30 pubmed
..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines. ..
Parr B, Cornish V, Cybulsky M, McMahon A. Wnt7b regulates placental development in mice. Dev Biol. 2001;237:324-32 pubmed
..Wnt7b also is required for normal organization of cells in the chorionic plate. Thus, Wnt7b signaling is central to the early stages of placental development in mammals. ..
Van Auken K, Weaver D, Edgar L, Wood W. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes. Proc Natl Acad Sci U S A. 2000;97:4499-503 pubmed
..K.) 126, 1537-1546]. Therefore, essential embryonic patterning in C. elegans requires only Hox genes of the anterior and posterior paralog groups, raising interesting questions about evolution of the medial-group genes. ..
Yochem J, Tuck S, Greenwald I, Han M. A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development. 1999;126:597-606 pubmed
..These observations indicate that LRP-1 is related to megalin not only structurally but also functionally. ..