Genomes and Genes
Experts and Doctors on animals in Boulder, Colorado, United States
Locale: Boulder, Colorado, United States
Publications377 found, 100 shown here
- Ventura N, Rea S. Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Biotechnol J. 2007;2:584-95 pubmed..In the present report, we describe our progress in using the Mit mutants as an investigative tool to study some of the processes potentially employed by human cells to offset pathological mitochondrial dysfunction. ..
- Jaklevic B, Uyetake L, Wichmann A, Bilak A, English C, Su T. Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. Dev Biol. 2008;320:122-30 pubmed publisher..miRNAs have been shown previously to be induced by radiation but this is the first report that a miRNA is functionally important for radiation responses. ..
- Sauther M, Cuozzo F. The impact of fallback foods on wild ring-tailed lemur biology: a comparison of intact and anthropogenically disturbed habitats. Am J Phys Anthropol. 2009;140:671-86 pubmed publisher..Such dental pathologies at Beza Mahafaly, resulting from the use or overemphasis of fallback foods for which they are not biologically adapted, indicate that anthropogenic factors must be considered when examining fallback foods...
- Mapes J, Chen Y, Kim A, Mitani S, Kang B, Xue D. CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol. 2012;22:1267-75 pubmed publisher..In addition, some living cells such as macrophages also express exPS...
- Moore S, Borer E. The influence of host diversity and composition on epidemiological patterns at multiple spatial scales. Ecology. 2012;93:1095-105 pubmed..These results highlight the importance of local host community composition, mediated by landscape characteristics such as meadow aspect, as a determinant of the spatial pattern of infection of a multi-host pathogen. ..
- Frank M, Barrientos R, Thompson B, Weber M, Watkins L, Maier S. IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses. J Neuroimmunol. 2012;252:33-9 pubmed publisher..IL-1RA might be administered prophylactically to prevent the neuroinflammatory effects of trauma. ..
- Smorodinsky Atias K, Goshen Lago T, Goldberg Carp A, Melamed D, Shir A, Mooshayef N, et al. Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation. Mol Biol Cell. 2016;27:1026-39 pubmed publisher..Thus this study shows that Erk1 can be considered a proto-oncogene and that Erk molecules possess unusual autoregulatory properties, some of them independent of TEY phosphorylation. ..
- Carroll S, DiNardo S, O Farrell P, White R, Scott M. Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins. Genes Dev. 1988;2:350-60 pubmed..Finally, some cells contain a single homeotic product, whereas other cells simultaneously contain several, suggesting that certain cells may be determined by the combinatorial action of homeotic genes. ..
- Rosenzweig B, Imamura T, Okadome T, Cox G, Yamashita H, ten Dijke P, et al. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A. 1995;92:7632-6 pubmed..Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by BMPR-II in the presence of type I receptors after stimulation by OP-1/BMP-7. ..
- Horvath M, Schultz S. DNA G-quartets in a 1.86 A resolution structure of an Oxytricha nova telomeric protein-DNA complex. J Mol Biol. 2001;310:367-77 pubmed
- Johnson J, O Connor K, Watkins L, Maier S. The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses. Neuroscience. 2004;127:569-77 pubmed
- Mooney K, Linhart Y. Contrasting cascades: insectivorous birds increase pine but not parasitic mistletoe growth. J Anim Ecol. 2006;75:350-7 pubmed..Our study shows that this variation in food web structure occurred between sympatric plants and within plants between differing herbivore guilds...
- Bock C, Jones Z, Bock J. Relationships between species richness, evenness, and abundance in a southwestern savanna. Ecology. 2007;88:1322-7 pubmed
- Fonte V, Kipp D, Yerg J, Merin D, Forrestal M, Wagner E, et al. Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein. J Biol Chem. 2008;283:784-91 pubmed
- Zhang L, Ding L, Cheung T, Dong M, Chen J, Sewell A, et al. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell. 2007;28:598-613 pubmed..Our results demonstrate an effective biochemical approach to systematically identify miRNA targets and provide valuable insights regarding the properties of miRNA effector complexes. ..
- Pearson C, Giddings T, Winey M. Basal body components exhibit differential protein dynamics during nascent basal body assembly. Mol Biol Cell. 2009;20:904-14 pubmed publisher..The bimodal dynamics found for centrin and Sas6a reveal unique protein assembly mechanisms at basal bodies that may reflect novel functions for these important basal body and centriolar proteins. ..
- Arthur C, Dean C, Pagratis M, Chapman E, Stowell M. Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons. Neuroscience. 2010;167:135-42 pubmed publisher..The proportion of docked vesicles in syt IV -/- boutons was further reduced, 5-fold, following depolarization. ..
- Allen D, Cleary A, Lindsay S, Loh A, Reed J. Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice. J Appl Physiol (1985). 2010;109:692-701 pubmed publisher..Our data are consistent with the hypothesis that MSTN is dispensable for the initial atrophy occurring in response to FD but attenuates the decrease in fast-twitch muscle mass during prolonged FD. ..
- Su T. The effect of a DNA damaging agent on embryonic cell cycles of the cnidarian Hydractinia echinata. PLoS ONE. 2010;5:e11760 pubmed publisher..This represents the first study of DNA damage responses in the phylum Cnidaria. ..
- Montgomery R, van Rooij E. Therapeutic advances in MicroRNA targeting. J Cardiovasc Pharmacol. 2011;57:1-7 pubmed publisher..We summarize the various therapeutic tools that are currently being investigated to manipulate miRNAs with a special focus on cardiovascular disease and speculate on the future developments of miRNA therapeutics. ..
- Shi J, Severson C, Yang J, Wedlich D, Klymkowsky M. Snail2 controls mesodermal BMP/Wnt induction of neural crest. Development. 2011;138:3135-45 pubmed publisher..Taken together, these results identify Snail2 as a key regulator of the signals involved in mesodermal induction of neural crest...
- Donner N, Montoya C, Lukkes J, Lowry C. Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. Psychoneuroendocrinology. 2012;37:645-61 pubmed publisher..Our data demonstrate that chronic elevation of corticosterone creates a vulnerability to a depression-like syndrome that is associated with increased tph2 expression, similar to that observed in depressed patients. ..
- Rozeske R, Evans A, Frank M, Watkins L, Lowry C, Maier S. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci. 2011;31:14107-15 pubmed publisher..These data suggest that uncontrollable stressors produce a desensitization of DRN 5-HT(1A) autoreceptors and that this desensitization is responsible for the behavioral consequences of uncontrollable stress. ..
- Ungermannova D, Parker S, Nasveschuk C, Wang W, Quade B, Zhang G, et al. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). PLoS ONE. 2012;7:e29208 pubmed publisher..Thus, Largazole and select analogs are a novel class of ubiquitin E1 inhibitors and valuable tools for studying ubiquitination in vitro. This class of compounds could be further developed and potentially be a useful tool in cells. ..
- Barlow C, Lievense L, Gross S, Ronk C, Paustenbach D. The role of genotoxicity in asbestos-induced mesothelioma: an explanation for the differences in carcinogenic potential among fiber types. Inhal Toxicol. 2013;25:553-67 pubmed publisher..This review discusses the existing literature on asbestos-induced genotoxicity and explains why these studies may or may not likely help characterize the dose-response curve at low dose...
- Yoder J, Chong H, Guan K, Han M. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 2004;23:111-9 pubmed..Genetic analysis also indicates that PP2A phosphatase and PAR-1 kinase act downstream of Raf to positively and negatively regulate KSR activity, respectively...
- Wu D, Cypser J, Yashin A, Johnson T. The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality?. J Gerontol A Biol Sci Med Sci. 2008;63:660-8 pubmed..The dose of heat shock that coincided with this benefit in initial mortality did not affect the rate of increase in mortality. ..
- McConkey E, Menon R, Williams G, Baker E, Sutherland G. Assignment of the gene for beta-casein (CSN2) to 4q13 --> q21 in humans and 3p13 --> p12 in chimpanzees. Cytogenet Cell Genet. 1996;72:60-2 pubmed..This confirms the presence of a pericentric inversion that distinguishes the two species, as first observed by chromosomal banding studies. ..
- Goehler L, Gaykema R, Hammack S, Maier S, Watkins L. Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res. 1998;804:306-10 pubmed..IL-1beta, but not vehicle, induced c-Fos expression, demonstrating that IL-1beta is likely an important signal from the immune system to the vagus nerve, and thus the brain. ..
- Parrish J, Metters H, Chen L, Xue D. Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc Natl Acad Sci U S A. 2000;97:11916-21 pubmed..The structure-based design of second-site suppressors via homology modeling should be widely applicable for probing important molecular interactions that are implicated in fundamental biological processes. ..
- Prescott D, Dizick S. A unique pattern of intrastrand anomalies in base composition of the DNA in hypotrichs. Nucleic Acids Res. 2000;28:4679-88 pubmed..These islands may serve as signals for the excision of macronuclear molecules during macronuclear development. We have found no published reports of coding or non-coding native DNA with such anomalous base composition...
- Pak T, Lynch G, Tsai P. Testosterone and estrogen act via different pathways to inhibit puberty in the male Siberian hamster (Phodopus sungorus). Endocrinology. 2001;142:3309-16 pubmed..5 +/- 0.98 ng/ml) yet significantly lower pituitary FSH concentration (0.09 +/- 0.04 ng/microg protein). These results showed that the pathways of T and E2 action on the hypothalamo-pituitary-gonadal axis are distinct...
- Murakami S, Johnson T. The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Curr Biol. 2001;11:1517-23 pubmed..This study reveals a new system for specifying longevity and stress resistance and suggests possible mechanisms for mediating life extension by dietary restriction and hormesis. ..
- Carey G. Cholesky problems. Behav Genet. 2005;35:653-65 pubmed..If followed, the proposed interim remedy will develop a body of empirical data to assess the extent to which Cholesky problems are important substantive issues versus statistical curiosities. ..
- Hicke B, Stephens A, Gould T, Chang Y, Lynott C, Heil J, et al. Tumor targeting by an aptamer. J Nucl Med. 2006;47:668-78 pubmed..As synthetic molecules, aptamers are readily modified in a site-specific manner. A variety of aptamer conjugates accumulate in tumors, suggesting imaging and potentially therapeutic applications. ..
- Wichmann A, Jaklevic B, Su T. Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2006;103:9952-7 pubmed..This work establishes Drosophila as a model for p53-independent apoptosis, which is of potential therapeutic importance for inducing cell death in p53-deficient cancer cells. ..
- Grishchuk E, Spiridonov I, Volkov V, Efremov A, Westermann S, Drubin D, et al. Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms. Proc Natl Acad Sci U S A. 2008;105:6918-23 pubmed publisher..The coupling properties of these two assemblies are, however, quite different, so each may make a distinct contribution to chromosome motility. ..
- Cui M, Allen M, Larsen A, MacMorris M, Han M, Blumenthal T. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Proc Natl Acad Sci U S A. 2008;105:16665-70 pubmed publisher..Furthermore, our results implicate a serine/arginine-rich (SR) protein, SRp20, in events following 3'-end cleavage, leading to termination of transcription. ..
- Woessner R, Tunquist B, Lemieux C, Chlipala E, Jackinsky S, DeWolf W, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009;29:4373-80 pubmed..ARRY-520 was also active in several taxane resistant models. The data provide a rationale for clinical evaluation of the activity of ARRY-520 in hematological carcinomas and taxane-resistant tumors. ..
- Robida M, Sridharan V, Morgan S, Rao T, Singh R. Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization. Proc Natl Acad Sci U S A. 2010;107:12570-5 pubmed publisher..This represents a cytological defect resulting from PTB loss. We discuss the basis for functional differences between mammalian and Drosophila PTB orthologs. ..
- Johnson P, Rohr J, Hoverman J, Kellermanns E, Bowerman J, Lunde K. Living fast and dying of infection: host life history drives interspecific variation in infection and disease risk. Ecol Lett. 2012;15:235-42 pubmed publisher..Broader integration between life history theory and disease ecology can aid in identifying both reservoir hosts and species at risk of disease-driven declines...
- Comeault A, Sommers M, Schwander T, Buerkle C, Farkas T, Nosil P, et al. De novo characterization of the Timema cristinae transcriptome facilitates marker discovery and inference of genetic divergence. Mol Ecol Resour. 2012;12:549-61 pubmed publisher..The results suggest variable levels of genetic divergence and gene flow among taxon pairs and genes and illustrate a first step towards future genomic work in Timema. ..
- Dobelis P, Staley K, Cooper D. Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PLoS ONE. 2012;7:e41108 pubmed publisher..Our results indicate that under our experimental conditions, which produced complete KYNA-mediated blockade of sEPSCs, claims of KYNA effects on choline-evoked ?7* nAChR function should be made with caution. ..
- Dean K, Palmer A. Advances in fluorescence labeling strategies for dynamic cellular imaging. Nat Chem Biol. 2014;10:512-23 pubmed publisher..Important attributes that contribute to the success of each technique are emphasized, providing a guideline for future advances in dynamic live-cell imaging. ..
- Chang S, Smedley E, Stansfield K, Stott J, Smith K. Optogenetic Inhibition of Ventral Pallidum Neurons Impairs Context-Driven Salt Seeking. J Neurosci. 2017;37:5670-5680 pubmed publisher..These results highlight the importance of the VP in context-driven reward-seeking behavior. ..
- Haubold K, Allen D, Capetanaki Y, Leinwand L. Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance. J Appl Physiol (1985). 2003;95:1617-22 pubmed
- O Connor K, Holguin A, Hansen M, Maier S, Watkins L. A method for measuring multiple cytokines from small samples. Brain Behav Immun. 2004;18:274-80 pubmed..In many cases, assaying for one cytokine does not interfere with subsequent assay for another cytokine in the same sample. Moreover, when interference is observed, the interfering factor can be identified and its effect minimized. ..
- Beylkin D, Allen D, Leinwand L. MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes. Dev Biol. 2006;294:541-53 pubmed..Some common features are shared between the promoters of these two genes; however, the mechanisms of their regulation appear distinct. ..
- Wise S, Stock D. bmp2b and bmp4 are dispensable for zebrafish tooth development. Dev Dyn. 2010;239:2534-46 pubmed publisher..The mostly likely explanation for this result is functional redundancy with other Bmp ligands, which may differ between the zebrafish and the mouse. ..
- Ren L, Wenglowsky S, Miknis G, Rast B, Buckmelter A, Ely R, et al. Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg Med Chem Lett. 2011;21:1243-7 pubmed publisher..Exposure was improved by incorporating more metabolically stable groups such as indazole and tricyclic pyrazole, while indazole could also be optimized for good cellular activity. ..
- Erickson K, Bouchet Marquis C, Heiser K, Szomolanyi Tsuda E, Mishra R, Lamothe B, et al. Virion assembly factories in the nucleus of polyomavirus-infected cells. PLoS Pathog. 2012;8:e1002630 pubmed publisher..The ultrastructure of the tubes suggests a new model for the encapsidation of small DNA viruses...
- Geng X, Harry B, Zhou Q, Skeen Gaar R, Ge X, Lee E, et al. Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012;109:18465-70 pubmed publisher..Our results suggest that C. elegans could serve as an animal model for identifying crucial host factors and signaling pathways of HBx and aid in development of strategies to treat HBV-induced liver disorders. ..
- Nordwald E, Kaar J. Mediating electrostatic binding of 1-butyl-3-methylimidazolium chloride to enzyme surfaces improves conformational stability. J Phys Chem B. 2013;117:8977-86 pubmed publisher..Accordingly, these results more broadly provide insight into the mechanism of stabilization in ILs via charge modification. ..
- Fonken L, Weber M, Daut R, Kitt M, Frank M, Watkins L, et al. Stress-induced neuroinflammatory priming is time of day dependent. Psychoneuroendocrinology. 2016;66:82-90 pubmed publisher..This work highlights the importance of studying circadian rhythms to elucidate biological mechanisms of stress. ..
- Campisi J, Leem T, Greenwood B, Hansen M, Moraska A, Higgins K, et al. Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues. Am J Physiol Regul Integr Comp Physiol. 2003;284:R520-30 pubmed..Facilitated induction of HSP72 may contribute to the increased stress resistance previously reported in physically active organisms. ..
- Link C, Taft A, Kapulkin V, Duke K, Kim S, Fei Q, et al. Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging. 2003;24:397-413 pubmed..elegans model. Both CRYAB and TNFAIP1 show increased transcript levels in AD brains, supporting the validity of this approach. ..
- Day H, Masini C, Campeau S. The pattern of brain c-fos mRNA induced by a component of fox odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), in rats, suggests both systemic and processive stress characteristics. Brain Res. 2004;1025:139-51 pubmed..These results suggest that TMT elicits stress responses through a relatively unique and complex mix of brain regions associated with both processive and systemic neural pathways, unlike those seen in response to cat odors. ..
- Lai H, Lo S, Kage Nakadai E, Mitani S, Xue D. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. PLoS ONE. 2009;4:e7348 pubmed publisher..Our study illustrates how multiple DNase II nucleases play differential roles in apoptotic DNA degradation and development and reveals an unexpected mode of DNase II action in mediating DNA degradation. ..
- Tardiff J, Krauter K. Divergent expression of alpha1-protease inhibitor genes in mouse and human. Nucleic Acids Res. 1998;26:3794-9 pubmed..This difference between the species appears to result from an absence of a functional macrophage-specific promoter in mice. ..
- Skop A, Bergmann D, Mohler W, White J. Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex. Curr Biol. 2001;11:735-46 pubmed
- Sauther M, Sussman R, Cuozzo F. Dental and general health in a population of wild ring-tailed lemurs: a life history approach. Am J Phys Anthropol. 2002;117:122-32 pubmed..Males exhibit more evidence of past trauma, including scars and chipped teeth. These results indicate that environmental as well as social factors, such as female dominance, may lead to sex differences in health patterns among lemurs. ..
- Mohr S, Boswell R. Genetic analysis of Drosophila melanogaster polytene chromosome region 44D-45F: loci required for viability and fertility. Genetics. 2002;160:1503-10 pubmed..Mutations in sine prole disrupt spermatogenesis at or before individualization of spermatozoa and cause multiple defects in oogenesis, including inappropriate division of the germline cyst and arrest of oogenesis at stage 4. ..
- Fawcett S, Klymkowsky M. Embryonic expression of Xenopus laevis SOX7. Gene Expr Patterns. 2004;4:29-33 pubmed..XSOX7 expression continues within the hindbrain in 3-day old ( approximately stage 40) larvae. Given its widespread expression, XSOX7 is likely to be involved in a number of developmental processes. ..
- Campisi J, Leem T, Fleshner M. Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones. 2003;8:272-86 pubmed..Thus, these results lend support to the hypothesis that intense stressor exposure increases eHsp72, which acts as a danger signal to potentiate the NO response to bacterial challenge and facilitate recovery from bacterial inflammation. ..
- Whiteaker P, Cooper J, Salminen O, Marks M, McClure Begley T, Brown R, et al. Immunolabeling demonstrates the interdependence of mouse brain alpha4 and beta2 nicotinic acetylcholine receptor subunit expression. J Comp Neurol. 2006;499:1016-38 pubmed..Consequently, it seems that the two subunits' effects on each other's expression are mediated at the protein, rather than gene expression level. ..
- Marks M, Meinerz N, Drago J, Collins A. Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine. Neuropharmacology. 2007;53:390-405 pubmed..These effects are very similar to those following deletion of beta2. Thus, alpha4beta2*-nAChRs mediate a significant fraction of both phases of ACh stimulated 86Rb+ efflux. ..
- Arum O, Johnson T. Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity. J Gerontol A Biol Sci Med Sci. 2007;62:951-9 pubmed..This study clarifies the inverse relationship between cep-1 expression and C. elegans life span, and, by extrapolation, that between p53 expression and mammalian life span. ..
- Cushing M, Mariner P, Liao J, Sims E, Anseth K. Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells. FASEB J. 2008;22:1769-77 pubmed publisher..Furthermore, FGF-2 treatment of VICs blocks the development of pathological contractile and calcifying phenotypes, suggesting that these pathways may be utilized in the engineering of effective treatments for valvular disease. ..
- Argast G, Croy C, Couts K, Zhang Z, Litman E, Chan D, et al. Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells. Oncogene. 2009;28:2697-709 pubmed publisher..Our findings suggest that B-Raf/MKK/ERK provides a permissive environment for melanoma genesis by modulating plexin B1. ..
- Geng X, Zhou Q, Kage Nakadai E, Shi Y, Yan N, Mitani S, et al. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death Differ. 2009;16:1385-94 pubmed publisher..elegans caspase homologs use the same mechanism to prevent caspase autoactivation and apoptosis in different tissues, suggesting that this could be a generally applicable strategy for regulating caspase activation and apoptosis. ..
- Barrientos R, Hein A, Frank M, Watkins L, Maier S. Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci. 2012;32:14641-8 pubmed publisher..Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes. ..
- O Neill H, Laverty D, Patzlaff N, Cohen B, Fonck C, McKinney S, et al. Mice expressing the ADNFLE valine 287 leucine mutation of the ?2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function. Pharmacol Biochem Behav. 2013;103:603-21 pubmed publisher..Data indicate decreases in maximal response for certain measures are larger than expected given the decrease in receptor expression...
- Gupta S, Hirota M, Waugh S, Murakami I, Suzuki T, Muraguchi M, et al. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem. 2014;289:8706-19 pubmed publisher..This new class of IL-6 inhibitor may be an effective therapeutic alternative for patients suffering from inflammatory diseases. ..
- Weaver B, Weaver Y, Mitani S, Han M. Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development. Dev Cell. 2017;41:665-673.e6 pubmed publisher..The interdependence of these proteolytic activities provides a paradigm for non-apoptotic caspase-mediated protein inactivation. ..
- Dobelis P, Marks M, Whiteaker P, Balogh S, Collins A, Stitzel J. A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. Mol Pharmacol. 2002;62:334-42 pubmed
- Pak T, Lynch G, Tsai P. Differential alteration of the reproductive axis by testosterone and estrogen in peripubertal and adult male Siberian hamsters (Phodopus sungorus). Biol Reprod. 2002;67:706-11 pubmed
- Milligan E, Twining C, Chacur M, Biedenkapp J, O CONNOR K, Poole S, et al. Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci. 2003;23:1026-40 pubmed..These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions. ..
- Park S, Tedesco P, Johnson T. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell. 2009;8:258-69 pubmed publisher..These findings showed that a transcriptional shift from growth and maintenance towards the activation of cellular defense mechanisms was caused by the oxidative stress; many of these transcriptional alterations are SKN-1 dependent. ..
- Hoenger A, Bouchet Marquis C. Cellular tomography. Adv Protein Chem Struct Biol. 2011;82:67-90 pubmed publisher..Without extending to molecular tomography, which is described elsewhere in this book, this chapter leads the reader through cellular tomography by following the specifications outlined above. ..
- Reuter R, Panganiban G, Hoffmann F, Scott M. Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos. Development. 1990;110:1031-40 pubmed..The two growth factor genes therefore are excellent candidates for target genes that are directly regulated by the homeotic genes. ..