Genomes and Genes
Experts and Doctors on signal transduction in Berkeley, California, United States
Locale: Berkeley, California, United States
Topic: signal transduction
Publications241 found, 100 shown here
- Maxwell C, Fleisch M, Costes S, Erickson A, Boissiere A, Gupta R, et al. Targeted and nontargeted effects of ionizing radiation that impact genomic instability. Cancer Res. 2008;68:8304-11 pubmed publisher..Together, these studies show that radiation deregulates centrosome stability, which underlies genomic instability in normal human epithelial cells, and that this can be opposed by radiation-induced TGFbeta signaling. ..
- Pandey G, Grant J, Cheong Y, Kim B, Li L, Luan S. Calcineurin-B-like protein CBL9 interacts with target kinase CIPK3 in the regulation of ABA response in seed germination. Mol Plant. 2008;1:238-48 pubmed publisher..Based on these findings, we conclude that CBL9 and CIPK3 act together in the same pathway for regulating ABA responses. ..
- Bijlsma M, Spek C. The Hedgehog morphogen in myocardial ischemia-reperfusion injury. Exp Biol Med (Maywood). 2010;235:447-54 pubmed publisher..Hh function in pathophysiology as well as recent findings concerning Hh signaling in ischemia models, especially in light of cardiovascular disease, is discussed in more detail and future perspectives are proposed. ..
- Wang N, Sanborn Z, Arnett K, Bayston L, Liao W, Proby C, et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011;108:17761-6 pubmed publisher..The bifunctional role of Notch in human cancer thus emphasizes the context dependency of signaling outcomes and suggests that targeted inhibition of the Notch pathway may induce squamous epithelial malignancies. ..
- Hafezi Y, Bosch J, Hariharan I. Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol. 2012;368:358-69 pubmed publisher..Thus, Crb may be part of a "surveillance mechanism" that is responsible for the cell death that is observed at the boundaries of mutant clones in these cases. ..
- Feng X, Zilberman D, Dickinson H. A conversation across generations: soma-germ cell crosstalk in plants. Dev Cell. 2013;24:215-25 pubmed publisher..Later, the egg cell plays a central role in specifying accessory cells, whereas in both gametophytes, companion cells contribute non-cell-autonomously to the epigenetic landscape of the gamete genomes. ..
- Howlett I, Rusan Z, Parker L, Tanouye M. Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies. G3 (Bethesda). 2013;3:1399-407 pubmed publisher..The gish gene normally encodes the Drosophila ortholog of casein kinase CK1g3, a member of the CK1 family of serine-threonine kinases. We suggest that CK1g3 is an unexpected but promising new target for seizure therapeutics. ..
- Peters T, Miller A, Tourette C, Agren H, Hubbard A, Hughes R. Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae. G3 (Bethesda). 2015;6:161-70 pubmed publisher..These results will facilitate analysis of ATP efflux mechanisms in higher eukaryotes. ..
- Taylor R, Berendzen K, Dillin A. Systemic stress signalling: understanding the cell non-autonomous control of proteostasis. Nat Rev Mol Cell Biol. 2014;15:211-7 pubmed publisher..These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications. ..
- McBride M, Kohler T, Zusman D. Methylation of FrzCD, a methyl-accepting taxis protein of Myxococcus xanthus, is correlated with factors affecting cell behavior. J Bacteriol. 1992;174:4246-57 pubmed..On the basis of the data presented, we propose a model for the frz signal transduction pathway in M. xanthus. ..
- Montell C, Rubin G. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron. 1989;2:1313-23 pubmed..Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells. ..
- Therrien M, Chang H, Solomon N, Karim F, Wassarman D, Rubin G. KSR, a novel protein kinase required for RAS signal transduction. Cell. 1995;83:879-88 pubmed..Our results suggest that KSR is a general and evolutionarily conserved component of the RAS signaling pathway that acts between RAS and RAF...
- Boyartchuk V, Ashby M, Rine J. Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science. 1997;275:1796-800 pubmed..Disruption of RCE1 led to defects in Ras localization and signaling and suppressed the activated phenotype associated with the allele RAS2val19. ..
- Wagner D, Hoecker U, Quail P. RED1 is necessary for phytochrome B-mediated red light-specific signal transduction in Arabidopsis. Plant Cell. 1997;9:731-43 pubmed..Together with complementation analysis, the data show that red1 is a novel photomorphogenic mutant. The evidence suggests that red1 represents a putative phytochrome signal transduction mutant potentially specific to the phyB pathway. ..
- Wang W, Mariani F, Harland R, Luo K. Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Proc Natl Acad Sci U S A. 2000;97:14394-9 pubmed..Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-beta family members. ..
- Lee M, Hadi M, Hallden G, Aponte G. Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity. J Biol Chem. 2005;280:125-36 pubmed
- Liu K, Harland R. Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein. Development. 2005;132:1511-23 pubmed..SRp38 may mediate one component of this control by maintaining splicing and translational silencing in undifferentiated neural cells. ..
- Ballon D, Flanary P, Gladue D, Konopka J, Dohlman H, Thorner J. DEP-domain-mediated regulation of GPCR signaling responses. Cell. 2006;126:1079-93 pubmed..DEP-domain-mediated targeting of effectors and regulators to specific GPCRs provides a means to dictate the nature, duration, and specificity of the response. ..
- Buchholz K, Stephens R. The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection. Infect Immun. 2008;76:3150-5 pubmed publisher..Since ERK is not activated through this pathway, a concomitant interaction between the host and bacteria is additionally required for full activation of the endogenous IL-8 response. ..
- Papatsenko D. Stripe formation in the early fly embryo: principles, models, and networks. Bioessays. 2009;31:1172-80 pubmed publisher..The current model analysis emphasizes the role of spatial information flow in development. Discussion is given on frequent network motifs, pointing to spatial stripe formation solutions...
- Chen X, Hsueh H, Werblin F. Amacrine-to-amacrine cell inhibition: Spatiotemporal properties of GABA and glycine pathways. Vis Neurosci. 2011;28:193-204 pubmed publisher..Surprisingly, neither of these amacrine cell classes received sustained local GABAergic inhibition, commonly found in an earlier study of ganglion cells. ..
- Sun Y, Miao Y, Yamane Y, Zhang C, Shokat K, Takematsu H, et al. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell. 2012;23:2388-98 pubmed publisher..We propose that this mechanism serves as the basis for how Orm phosphoregulation controls sphingolipid biosynthesis in response to stress in a kinetically coupled manner. ..
- Pena J, Harris E. Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway. PLoS ONE. 2012;7:e38202 pubmed publisher..This work paves the way for further study of virally-induced membrane rearrangements and formation of cubic membranes. ..
- Lee S, Meier R, Furuta S, Lenburg M, Kenny P, Xu R, et al. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J Clin Invest. 2012;122:3211-20 pubmed publisher..We found that FAM83A interacted with and caused phosphorylation of c-RAF and PI3K p85, upstream of MAPK and downstream of EGFR. These data provide an additional mechanism by which tumor cells can become EGFR-TKI resistant. ..
- Jahchan N, Ouyang G, Luo K. Expression profiles of SnoN in normal and cancerous human tissues support its tumor suppressor role in human cancer. PLoS ONE. 2013;8:e55794 pubmed publisher..These data strongly suggest that SnoN can function as a tumor suppressor at early stages of tumorigenesis in human cancer tissues. ..
- Berendzen K, Durieux J, Shao L, Tian Y, Kim H, Wolff S, et al. Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis. Cell. 2016;166:1553-1563.e10 pubmed publisher..Collectively, these data suggest the commandeering of a nutrient sensing network to allow for cell-to-cell communication between mitochondria in response to protein folding stress in the nervous system. ..
- Harding F, McArthur J, Gross J, Raulet D, Allison J. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356:607-9 pubmed..7; J.A.G. et al., manuscript in preparation) can provide a co-stimulatory signal to naive CD4+ T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones. ..
- Blumer K, Thorner J. Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling. Proc Natl Acad Sci U S A. 1990;87:4363-7 pubmed
- Hoecker U, Tepperman J, Quail P. SPA1, a WD-repeat protein specific to phytochrome A signal transduction. Science. 1999;284:496-9 pubmed..SPA1 can localize to the nucleus, suggesting a possible function in phytochrome A-specific regulation of gene expression. ..
- Ashe H, Mannervik M, Levine M. Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo. Development. 2000;127:3305-12 pubmed..We also present evidence that the activation of Dpp/Scw target genes depends on the Drosophila homolog of the CBP histone acetyltransferase. ..
- Zhu Y, Tepperman J, Fairchild C, Quail P. Phytochrome B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3. Proc Natl Acad Sci U S A. 2000;97:13419-24 pubmed
- Wang J, Bongianni J, Napoli J. The N-terminus of retinol dehydrogenase type 1 signals cytosolic orientation in the microsomal membrane. Biochemistry. 2001;40:12533-40 pubmed..The latter suggests that the SDR core of RoDH1 has marked external hydrophobicity that causes nonspecific membrane association. ..
- Stroschein S, Bonni S, Wrana J, Luo K. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev. 2001;15:2822-36 pubmed..Our studies elucidate an important mechanism and pathway for the degradation of SnoN and more importantly, reveal a novel role of the APC in the regulation of TGF-beta signaling. ..
- Huq E, Al Sady B, Quail P. Nuclear translocation of the photoreceptor phytochrome B is necessary for its biological function in seedling photomorphogenesis. Plant J. 2003;35:660-4 pubmed
- Raulet D. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003;3:781-90 pubmed
- Monte E, Tepperman J, Al Sady B, Kaczorowski K, Alonso J, Ecker J, et al. The phytochrome-interacting transcription factor, PIF3, acts early, selectively, and positively in light-induced chloroplast development. Proc Natl Acad Sci U S A. 2004;101:16091-8 pubmed..These data suggest that PIF3 may function in early phy signaling at the dark-to-light transition, not only during initial seedling deetiolation, but daily at dawn under diurnal light-dark cycles. ..
- Nelson C, Bissell M. Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2006;22:287-309 pubmed
- Herskovits A, Auerbuch V, Portnoy D. Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog. 2007;3:e51 pubmed..This study supports the hypothesis that in activated macrophages, cytosolic innate immune receptors are activated by bacterial ligands generated in the phagosome and transported to the cytosol. ..
- Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo M. LKB1/STRAD promotes axon initiation during neuronal polarization. Cell. 2007;129:565-77 pubmed..Thus local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation. ..
- Lim B, Matsuda N, Poo M. Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivo. Nat Neurosci. 2008;11:160-9 pubmed publisher..This ephrin-B-dependent synapse maturation supports the notion that the ephrin/Eph protein families have multiple functions in neural development. ..
- Lee S, Lan W, Buchanan B, Luan S. A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A. 2009;106:21419-24 pubmed publisher..The findings are in keeping with a paradigm in which a protein kinase-phosphatase pair interacts physically with a target protein to couple a signal with a specific response. ..
- Osborn S, Diehl G, Han S, Xue L, Kurd N, Hsieh K, et al. Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A. 2010;107:13034-9 pubmed publisher..We conclude that FADD constitutes a mechanism to keep TCR-induced programmed necrotic signaling in check during early phases of T-cell clonal expansion. ..
- Ratnam K, Feng X, Chuang P, Verma V, Lu T, Wang J, et al. Role of the retinoic acid receptor-? in HIV-associated nephropathy. Kidney Int. 2011;79:624-634 pubmed publisher..Thus, a defect in the endogenous synthesis of retinoic acid contributes to loss of the protection by retinoic acid in HIVAN. Hence, RAR? agonists may be potential agents for the treatment of HIVAN. ..
- Crow A, Webster K, Hohlfeld E, Ng W, Geissler P, Fletcher D. Contractile equilibration of single cells to step changes in extracellular stiffness. Biophys J. 2012;102:443-51 pubmed publisher..We therefore propose that an initial event in stiffness sensing is establishment of a mechanical equilibrium that balances contraction of the viscoelastic cytoskeleton with deformation of the extracellular matrix. ..
- Davalos A, Kawahara M, Malhotra G, Schaum N, Huang J, Ved U, et al. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol. 2013;201:613-29 pubmed publisher..Our findings identify senescence as a novel biological setting in which HMGB1 functions and link HMGB1 redistribution to p53 activity and senescence-associated inflammation. ..
- Stjepanovic G, Baskaran S, Lin M, Hurley J. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex. Mol Cell. 2017;67:528-534.e3 pubmed publisher..This pinpoints the dislodging and tethering of the VPS34 catalytic domain, and its regulation by VPS15, as a master allosteric switch in autophagy induction. ..
- Simon M, Carthew R, Fortini M, Gaul U, Mardon G, Rubin G. Signal transduction pathway initiated by activation of the sevenless tyrosine kinase receptor. Cold Spring Harb Symp Quant Biol. 1992;57:375-80 pubmed
- McBride M, Weinberg R, Zusman D. "Frizzy" aggregation genes of the gliding bacterium Myxococcus xanthus show sequence similarities to the chemotaxis genes of enteric bacteria. Proc Natl Acad Sci U S A. 1989;86:424-8 pubmed
- Hecht P, Anderson K. Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo. Genetics. 1993;135:405-17 pubmed..We discuss the phenotypes of tube-pelle double mutants in the context of whether the two proteins interact directly. ..
- Neufeld T, Tang A, Rubin G. A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. Genetics. 1998;148:277-86 pubmed
- Hsu D, Economides A, Wang X, Eimon P, Harland R. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell. 1998;1:673-83 pubmed..Therefore, we propose that Gremlin, Cerberus, and DAN control diverse processes in growth and development by selectively antagonizing the activities of different subsets of the TGF beta ligands. ..
- Eby J, Holly S, van Drogen F, Grishin A, Peter M, Drubin D, et al. Actin cytoskeleton organization regulated by the PAK family of protein kinases. Curr Biol. 1998;8:967-70 pubmed..Thus, PAKs are effectors of Cdc42 in pathways that regulate the organization of the cortical actin cytoskeleton. ..
- Yalovsky S, Kulukian A, Rodríguez Concepción M, Young C, Gruissem W. Functional requirement of plant farnesyltransferase during development in Arabidopsis. Plant Cell. 2000;12:1267-78 pubmed..Together, these results provide a basis for future studies on the involvement of FTase in specific developmental processes and for structure-function analysis of FTase in vivo. ..
- Wolven A, Belmont L, Mahoney N, Almo S, Drubin D. In vivo importance of actin nucleotide exchange catalyzed by profilin. J Cell Biol. 2000;150:895-904 pubmed..Based on the results of these studies, we conclude that in living cells profilin promotes rapid actin dynamics by regenerating ATP actin from ADP actin-cofilin generated during filament disassembly. ..
- Diefenbach A, Tomasello E, Lucas M, Jamieson A, Hsia J, Vivier E, et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002;3:1142-9 pubmed..This strategy suggests a rationale for the multisubunit structure of stimulatory immunoreceptors. ..
- Newman K, Almeida R, Purcell A, Lindow S. Cell-cell signaling controls Xylella fastidiosa interactions with both insects and plants. Proc Natl Acad Sci U S A. 2004;101:1737-42 pubmed..This article reports a cell-cell signaling requirement for vector transmission. Identification of the genes regulated by rpfF should elucidate bacterial factors involved in transmission and biofilm formation in the insect...
- Radisky D, Bissell M. Cancer. Respect thy neighbor!. Science. 2004;303:775-7 pubmed
- Pitera D, Paddon C, Newman J, Keasling J. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng. 2007;9:193-207 pubmed..These results demonstrate that balancing carbon flux through the heterologous pathway is a key determinant in optimizing isoprenoid biosynthesis in microbial hosts. ..
- Le Clainche C, Pauly B, Zhang C, Engqvist Goldstein A, Cunningham K, Drubin D. A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. EMBO J. 2007;26:1199-210 pubmed..Finally, we showed that Hip1R inhibits actin assembly by forming a complex with cortactin that blocks actin filament barbed end elongation. ..
- Bates J, Cado D, Nolla H, Schlissel M. Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination. J Exp Med. 2007;204:3247-56 pubmed..These data suggest that locus contraction, mimicked by proximal targeting, can override any regulation imposed by DNA sequences immediately surrounding V(H) gene segments. ..
- Almeida R, Killiny N, Newman K, Chatterjee S, Ionescu M, Lindow S. Contribution of rpfB to cell-to-cell signal synthesis, virulence, and vector transmission of Xylella fastidiosa. Mol Plant Microbe Interact. 2012;25:453-62 pubmed publisher..It is possible that Xylella fastidiosa coordinates host vector and plant colonization by varying the proportions of different forms of DSF signals via RpfB. ..
- Fiume E, Fletcher J. Regulation of Arabidopsis embryo and endosperm development by the polypeptide signaling molecule CLE8. Plant Cell. 2012;24:1000-12 pubmed publisher..These results demonstrate that seed development is coordinated by a secreted peptide ligand that plays a key early role in orchestrating cell patterning and proliferation in the embryo and endosperm. ..
- Fischer B, Ledford H, Wakao S, Huang S, Casero D, Pellegrini M, et al. SINGLET OXYGEN RESISTANT 1 links reactive electrophile signaling to singlet oxygen acclimation in Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A. 2012;109:E1302-11 pubmed publisher..RES can be formed after singlet oxygen-induced lipid peroxidation, indicating that RES-stimulated and SOR1-mediated responses of detoxification genes are part of the singlet oxygen-induced acclimation process in C. reinhardtii...
- Wang N, Li J, Lindow S. RpfF-dependent regulon of Xylella fastidiosa. Phytopathology. 2012;102:1045-53 pubmed publisher..A large number of other RpfF-dependent genes that might contribute to virulence or insect colonization were also identified such as those encoding hemolysin and colicin V, as well as genes with unknown functions. ..
- Burdette D, Vance R. STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol. 2013;14:19-26 pubmed publisher..Here we discuss advances in the understanding of STING and highlight the many unresolved issues in the field...
- Koshland D, Sanders D, Weis R. Roles of methylation and phosphorylation in the bacterial sensing system. Cold Spring Harb Symp Quant Biol. 1988;53 Pt 1:11-7 pubmed..It wishes to keep swimming in the positive direction as long as the signals indicate that the direction is favorable. Hence, the feedback between the phosphorylation and methylation system involves further fine tuning. ..
- Rebay I, Rubin G. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell. 1995;81:857-66 pubmed
- Heberlein U, Hariharan I, Rubin G. Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Dev Biol. 1993;160:51-63 pubmed
- Sefton L, Timmer J, Zhang Y, Beranger F, Cline T. An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element. Nature. 2000;405:970-3 pubmed..Unlike sex signals for other organisms, sisC has acquired its sex-specific function while maintaining non-sex-specific roles in development, a characteristic that it shares with all other Drosophila XSEs. ..
- Harland R. Neural induction. Curr Opin Genet Dev. 2000;10:357-62 pubmed..Recent work has employed zebrafish, chick and mouse in addition to amphibians as models. Genetics has supplemented experimental embryology in enriching the understanding of the mechanism of neural induction and in posing new questions...
- Cowden J, Levine M. The Snail repressor positions Notch signaling in the Drosophila embryo. Development. 2002;129:1785-93 pubmed..We suggest that these dual activities of Snail, repression of Notch target genes and stimulation of Notch signaling, help define precise lines of sim expression within the neurogenic ectoderm. ..
- Eimon P, Harland R. Effects of heterodimerization and proteolytic processing on Derrière and Nodal activity: implications for mesoderm induction in Xenopus. Development. 2002;129:3089-103 pubmed..Taken together, these findings indicate that Derrière and Nodal proteins probably work cooperatively to induce mesoderm throughout the marginal zone during early Xenopus development. ..
- Hudson M, Lisch D, Quail P. The FHY3 and FAR1 genes encode transposase-related proteins involved in regulation of gene expression by the phytochrome A-signaling pathway. Plant J. 2003;34:453-71 pubmed..We propose that FAR1 and FHY3 control the expression of their target genes by a mechanism that has evolved directly from the way that an ancestral, MuDRA-like transposase bound to the TIRs of mobile elements. ..
- Tepperman J, Hudson M, Khanna R, Zhu T, Chang S, Wang X, et al. Expression profiling of phyB mutant demonstrates substantial contribution of other phytochromes to red-light-regulated gene expression during seedling de-etiolation. Plant J. 2004;38:725-39 pubmed
- Hawkins N, Ellis G, Bowerman B, Garriga G. MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions. Dev Biol. 2005;284:246-59 pubmed..Although all neurons in C. elegans are produced by an invariant pattern of cell divisions, our results indicate that cell signaling may contribute to asymmetric neuroblast division during embryogenesis. ..
- Westfall P, Thorner J. Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele. Eukaryot Cell. 2006;5:1215-28 pubmed..Finally, our results demonstrate a role for active Hog1 in maintaining signaling specificity under conditions of persistently high external osmolarity. ..
- Hekmat Scafe D, Lundy M, Ranga R, Tanouye M. Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. J Neurosci. 2006;26:8943-54 pubmed..The kcc mutants provide an excellent model system in which to investigate how modulation of GABAergic signaling influences neuronal excitability and epileptogenesis. ..
- Christiaen L, Davidson B, Kawashima T, Powell W, Nolla H, Vranizan K, et al. The transcription/migration interface in heart precursors of Ciona intestinalis. Science. 2008;320:1349-52 pubmed publisher..We propose that transcription regulation of specific effector genes determines the coordinated deployment of discrete cellular modules underlying migration. ..
- Xu R, Boudreau A, Bissell M. Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev. 2009;28:167-76 pubmed publisher..Cancer occurs when these dynamic interactions go awry for an extended time. ..
- Cacheaux L, Ivens S, David Y, Lakhter A, Bar Klein G, Shapira M, et al. Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. J Neurosci. 2009;29:8927-35 pubmed publisher..Our present data identifies the TGF-beta pathway as a novel putative epileptogenic signaling cascade and therapeutic target for the prevention of injury-induced epilepsy. ..
- Chen R, Thorner J. Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics. 2010;185:855-70 pubmed publisher..Thus, although there are similarities between haploids and diploids, cell type-specific differences clearly alter the balance of the signaling inputs required to elicit the various nutrient limitation-evoked cellular behaviors. ..
- Murphy M, Holmgren A, Larsson N, Halliwell B, Chang C, Kalyanaraman B, et al. Unraveling the biological roles of reactive oxygen species. Cell Metab. 2011;13:361-366 pubmed publisher..Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area. ..
- Logue E, Bakkour S, Murphy M, Nolla H, Sha W. ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9. J Immunol. 2006;177:2356-64 pubmed..These data define shedding of B7h as a novel mechanism for controlling costimulatory signaling by B7-CD28 family members that is regulated on B cells by TLR signaling. ..
- Mitchell D, Morton S, Fernhoff N, Marletta M. Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. Proc Natl Acad Sci U S A. 2007;104:11609-14 pubmed