Experts and Doctors on rna binding proteins in San Diego, California, United States

Summary

Locale: San Diego, California, United States
Topic: rna binding proteins

Top Publications

  1. Rehling P, Darsow T, Katzmann D, Emr S. Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol. 1999;1:346-53 pubmed
    ..Vps41 binds to the AP-3 delta-adaptin subunit, suggesting that they function together in the formation of ALP pathway transport intermediates at the late Golgi. ..
  2. Sen S, Talukdar I, Webster N. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol. 2009;29:871-80 pubmed publisher
    ..Thus, we propose that SRp20, SF2/ASF, and CUG-BP1 act antagonistically to regulate IR alternative splicing in vivo and that the relative ratios of SRp20 and SF2/ASF to CUG-BP1 in different cells determine the degree of exon inclusion. ..
  3. Trabucchi M, Briata P, Garcia Mayoral M, Haase A, Filipowicz W, Ramos A, et al. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature. 2009;459:1010-4 pubmed publisher
  4. Ahn K, Gruhler A, Galocha B, Jones T, Wiertz E, Ploegh H, et al. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity. 1997;6:613-21 pubmed
    ..Thus, HCMV targets TAP for immune escape by a molecular mechanism different from that of herpes simplex virus...
  5. Murao K, Terpstra V, Green S, Kondratenko N, Steinberg D, Quehenberger O. Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes. J Biol Chem. 1997;272:17551-7 pubmed
    ..An additional role in recognition of damaged cells is suggested by these studies. ..
  6. Tang H, Wong Staal F. Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus. J Biol Chem. 2000;275:32694-700 pubmed
    ..The nuclear transport domain of RHA also interfered with Tap-mediated transactivation of the CTE function in quail cells, in which the function of CTE is dependent on the expression of a functional human Tap cDNA...
  7. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster N. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010;285:25426-37 pubmed publisher
    ..Collectively, these findings demonstrate a role for Mbnl1 in controlling insulin receptor exon 11 inclusion via binding to a downstream intronic enhancer element. ..
  8. Darsow T, Katzmann D, Cowles C, Emr S. Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Mol Biol Cell. 2001;12:37-51 pubmed
    ..These data indicate that a homo-oligomeric form of Vps41p is required for the formation of ALP containing vesicles at the Golgi complex via interactions with AP-3. ..
  9. Chappell S, Owens G, Mauro V. A 5' Leader of Rbm3, a Cold Stress-induced mRNA, Mediates Internal Initiation of Translation with Increased Efficiency under Conditions of Mild Hypothermia. J Biol Chem. 2001;276:36917-22 pubmed
    ..The results suggest that cap-independent mechanisms may facilitate the translation of particular mRNAs during mild hypothermia. ..
  10. Yang J, Reddy T, Truong K, Suhasini M, Wong Staal F. Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002;21:7187-94 pubmed
    ..We propose that the direct interaction of Sam68 and hnRNP K adversely affect the activities of both proteins in signal transduction pathways of both transcriptional and post-transcriptional events. ..

Scientific Experts

Detail Information

Publications14

  1. Rehling P, Darsow T, Katzmann D, Emr S. Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol. 1999;1:346-53 pubmed
    ..Vps41 binds to the AP-3 delta-adaptin subunit, suggesting that they function together in the formation of ALP pathway transport intermediates at the late Golgi. ..
  2. Sen S, Talukdar I, Webster N. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol. 2009;29:871-80 pubmed publisher
    ..Thus, we propose that SRp20, SF2/ASF, and CUG-BP1 act antagonistically to regulate IR alternative splicing in vivo and that the relative ratios of SRp20 and SF2/ASF to CUG-BP1 in different cells determine the degree of exon inclusion. ..
  3. Trabucchi M, Briata P, Garcia Mayoral M, Haase A, Filipowicz W, Ramos A, et al. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature. 2009;459:1010-4 pubmed publisher
  4. Ahn K, Gruhler A, Galocha B, Jones T, Wiertz E, Ploegh H, et al. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity. 1997;6:613-21 pubmed
    ..Thus, HCMV targets TAP for immune escape by a molecular mechanism different from that of herpes simplex virus...
  5. Murao K, Terpstra V, Green S, Kondratenko N, Steinberg D, Quehenberger O. Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes. J Biol Chem. 1997;272:17551-7 pubmed
    ..An additional role in recognition of damaged cells is suggested by these studies. ..
  6. Tang H, Wong Staal F. Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus. J Biol Chem. 2000;275:32694-700 pubmed
    ..The nuclear transport domain of RHA also interfered with Tap-mediated transactivation of the CTE function in quail cells, in which the function of CTE is dependent on the expression of a functional human Tap cDNA...
  7. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster N. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010;285:25426-37 pubmed publisher
    ..Collectively, these findings demonstrate a role for Mbnl1 in controlling insulin receptor exon 11 inclusion via binding to a downstream intronic enhancer element. ..
  8. Darsow T, Katzmann D, Cowles C, Emr S. Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Mol Biol Cell. 2001;12:37-51 pubmed
    ..These data indicate that a homo-oligomeric form of Vps41p is required for the formation of ALP containing vesicles at the Golgi complex via interactions with AP-3. ..
  9. Chappell S, Owens G, Mauro V. A 5' Leader of Rbm3, a Cold Stress-induced mRNA, Mediates Internal Initiation of Translation with Increased Efficiency under Conditions of Mild Hypothermia. J Biol Chem. 2001;276:36917-22 pubmed
    ..The results suggest that cap-independent mechanisms may facilitate the translation of particular mRNAs during mild hypothermia. ..
  10. Yang J, Reddy T, Truong K, Suhasini M, Wong Staal F. Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002;21:7187-94 pubmed
    ..We propose that the direct interaction of Sam68 and hnRNP K adversely affect the activities of both proteins in signal transduction pathways of both transcriptional and post-transcriptional events. ..
  11. Aubol B, Ungs L, Lukasiewicz R, Ghosh G, Adams J. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. J Biol Chem. 2004;279:30182-8 pubmed
    ..The chemical clamping mechanism offers an efficient means whereby a protein kinase can simultaneously achieve both high turnover and good substrate binding properties. ..
  12. Lukasiewicz R, Velazquez Dones A, Huynh N, Hagopian J, Fu X, Adams J, et al. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007;282:23036-43 pubmed
    ..Thus, there are physical attributes of SR and SR-like substrates that dictate the mechanism of phosphorylation, whereas the ability to processively phosphorylate substrates is inherent to SR protein kinases. ..
  13. Hossain M, Claggett J, Nguyen T, Johnson T. The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA. RNA. 2009;15:1515-27 pubmed publisher
  14. Smith L, Wloch M, Ye M, Reyes L, Boutsaboualoy S, Dunne C, et al. Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin. Vaccine. 2010;28:2565-72 pubmed publisher