Experts and Doctors on protein binding in San Diego, California, United States


Locale: San Diego, California, United States
Topic: protein binding

Top Publications

  1. Tome J, Ozer A, Pagano J, Gheba D, Schroth G, Lis J. Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling. Nat Methods. 2014;11:683-8 pubmed publisher
    ..Mutations additively affected the affinity of the NELF-E-binding aptamer, whose interaction depended mainly on a single-stranded RNA motif, but not that of the GFP aptamer, whose interaction depended primarily on secondary structure. ..
  2. Baughman G, Wiederrecht G, Campbell N, Martin M, Bourgeois S. FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. Mol Cell Biol. 1995;15:4395-402 pubmed
  3. Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, et al. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem. 2003;278:50754-64 pubmed
    ..The identification of relaxin-3 as the ligand for GPCR135 provides the framework for the discovery of a new brainstem/hypothalamus circuitry. ..
  4. Ahn S, Eraly S, Tsigelny I, Nigam S. Interaction of organic cations with organic anion transporters. J Biol Chem. 2009;284:31422-30 pubmed publisher
  5. Hetrick B, Lee K, Joseph S. Kinetics of stop codon recognition by release factor 1. Biochemistry. 2009;48:11178-84 pubmed publisher
    ..These results suggest that sense codons inhibit conformational changes necessary for RF1 to stably bind to the ribosome and catalyze peptide release. ..
  6. Chrovian C, Soyode Johnson A, Ao H, Bacani G, Carruthers N, Lord B, et al. Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain. ACS Chem Neurosci. 2016;7:490-7 pubmed publisher
    ..Structure-activity relationships within this series are described, as well as in vitro ADME results. In vivo pharmacokinetic data for key compounds is also included. ..
  7. Qiu W, Zhuang S, von Lintig F, Boss G, Pilz R. Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins. J Biol Chem. 2000;275:31921-9 pubmed
    ..Our data suggest that 14-3-3 bound to B-Raf protects the enzyme from protein kinase A-mediated inhibition; the amount of 14-3-3 associated with B-Raf may explain the tissue-specific effects of cAMP on B-Raf kinase activity. ..
  8. Straiker A, Borden C, Sullivan J. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. J Neurosci. 2002;22:2460-8 pubmed
    ..Differential coupling of G-protein alpha subunits may be a means of achieving specificity between different GPCRs and their molecular targets for mediating presynaptic inhibition. ..
  9. Dorner A, Xiong D, Couch K, Yajima T, Knowlton K. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004;279:18497-503 pubmed

More Information

Publications130 found, 100 shown here

  1. Guan X, Juarez J, Qi X, Shipulina N, Shaw D, Morgan W, et al. Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 2004;92:403-12 pubmed
    ..These results suggest that HPRG binds to endothelial cell surface tropomyosin which at least partially mediates the antiangiogenic effects of HPRG. ..
  2. Zhao M, Wimmer A, Trieu K, DiScipio R, Schraufstatter I. Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2. J Biol Chem. 2004;279:49259-67 pubmed
    ..These results indicate a novel function for arrestin, which is protection from an excessive oxidative burst, resulting from the sustained stimulation of G-protein-coupled receptors that cause Rac translocation. ..
  3. Hosfield D, Wu Y, Skene R, Hilgers M, Jennings A, Snell G, et al. Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. J Biol Chem. 2005;280:4639-48 pubmed
    ..Together, the crystallographic and biophysical data provide a structural framework for understanding 11beta-HSD1 activities and will ultimately facilitate the development of specific inhibitors. ..
  4. Chen S, Operaña T, Bonzo J, Nguyen N, Tukey R. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005;280:4350-9 pubmed
  5. Grewal P, Uchiyama S, Ditto D, Varki N, Le D, Nizet V, et al. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008;14:648-55 pubmed publisher
    ..Hemostatic adaptation by the Ashwell receptor moderates the onset and severity of disseminated intravascular coagulation during sepsis and improves the probability of host survival. ..
  6. Al Shamma H, Anderson C, Chuang E, Luthringer R, Grottick A, Hauser E, et al. Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. J Pharmacol Exp Ther. 2010;332:281-90 pubmed publisher
    ..These studies point to an efficacy and safety profile for nelotanserin that might be ideally suited for the treatment of sleep maintenance insomnias. ..
  7. Dong L, Marakovits J, Hou X, Guo C, Greasley S, Dagostino E, et al. Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010;20:2210-4 pubmed publisher
  8. Humphrey R, Newcomb C, Yu S, Hao E, Yu D, Krajewski S, et al. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem. 2010;285:22426-36 pubmed publisher
    ..We conclude that MLKs compromise mitochondrial integrity and suppress cellular survival mechanisms via TRB3-dependent inhibition of Akt. ..
  9. Xiao J, Worby C, Mattoo S, Sankaran B, Dixon J. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010;17:1004-10 pubmed publisher
    ..We also show that the nucleotide-binding mechanism is conserved among Fic proteins and propose a catalytic mechanism for this recently discovered family of enzymes...
  10. Gay S, Roberts A, Maekawa K, Talakad J, Hong W, Zhang Q, et al. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 2010;49:8709-20 pubmed publisher
    ..Adjusting both protein conformation and ligand orientation in the active site gives 2B4 the flexibility to bind to the widest range of molecules, while also being energetically favorable. ..
  11. Kim C, Ye F, Ginsberg M. Regulation of integrin activation. Annu Rev Cell Dev Biol. 2011;27:321-45 pubmed publisher
    ..Here, we review recent progress in understanding how the membrane environment can, in cooperation with integrin-binding proteins, regulate integrin activation. ..
  12. Hirve N, Levytskyy R, Rigaud S, Guimond D, Zal T, Sauer K, et al. A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions. PLoS ONE. 2012;7:e45158 pubmed publisher
    ..Thus, the FYF mutation uncouples PIP(3)-mediated ITK membrane recruitment from the interactions of the kinase with key components of the TCR signalosome and abrogates ITK function in T cells. ..
  13. Cardoso R, Love R, Nilsson C, Bergqvist S, Nowlin D, Yan J, et al. Identification of Cys255 in HIF-1? as a novel site for development of covalent inhibitors of HIF-1?/ARNT PasB domain protein-protein interaction. Protein Sci. 2012;21:1885-96 pubmed publisher
    ..Our screening strategy could be applied to other targets to identify pockets surrounding reactive cysteines suitable for development of small molecule modulators of protein function. ..
  14. Cao J, Burke J, Dennis E. Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem. 2013;288:1806-13 pubmed publisher
    ..Its theory, practical considerations, and application to understanding PLA(2)/membrane interactions are addressed...
  15. Falivelli G, Lisabeth E, Rubio de la Torre E, Pérez Tenorio G, Tosato G, Salvucci O, et al. Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS ONE. 2013;8:e81445 pubmed publisher
    ..These results suggest a novel mechanism that may contribute to cancer pathogenesis by attenuating the tumor suppressing effects of Eph receptor signaling pathways activated by ephrins in trans. ..
  16. Dyer D, SALANGA C, Johns S, Valdambrini E, Fuster M, Milner C, et al. The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions. J Biol Chem. 2016;291:12627-40 pubmed publisher
  17. Jaremko M, Lee D, Patel A, Winslow V, Opella S, McCammon J, et al. Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins. Biochemistry. 2017;56:5269-5273 pubmed publisher
    ..Mutational studies supported the role of loop 1 in molecular recognition, as mutations to this region of the peptidyl carrier proteins significantly modulated their activities...
  18. Stofega M, Sanders L, Gardiner E, Bokoch G. Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell. 2004;15:2965-77 pubmed
    ..Abnormal regulation of PAK localization and activity may contribute to the tumorigenic properties of certain breast cancer cells. ..
  19. Johnson K, Terkeltaub R. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. J Biol Chem. 2005;280:15004-12 pubmed
  20. Pines J, Hunter T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell. 1989;58:833-46 pubmed
    ..In G2/M phase, cyclin is associated with p34cdc2, the human homolog of the fission yeast gene cdc2+, and this complex has histone H1 kinase activity. ..
  21. Yoshikawa S, McKinnon R, Kokel M, Thomas J. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature. 2003;422:583-8 pubmed
    ..Our results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events. ..
  22. Larder R, Mellon P. Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem. 2009;284:16966-78 pubmed publisher
    ..Taken together, these data show that Otx2 is important for GnRH expression and that direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons. ..
  23. Hoare S, Sullivan S, Schwarz D, Ling N, Vale W, Crowe P, et al. Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. Biochemistry. 2004;43:3996-4011 pubmed
    ..2) Agonist-J-domain interaction is allosterically enhanced by receptor-G-protein interaction and inhibited by nonpeptide antagonist. ..
  24. Clemm D, Sherman L, Boonyaratanakornkit V, Schrader W, Weigel N, Edwards D. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Mol Endocrinol. 2000;14:52-65 pubmed
    ..That Ser 294 lies within an inhibitory domain that mediates the unique repressive functions of PR-A raises the possibility that differential phosphorylation of Ser 294 is involved in the distinct functional properties of PR-A and PR-B. ..
  25. Kast Woelbern H, Dana S, Cesario R, Sun L, de Grandpre L, Brooks M, et al. Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis. J Biol Chem. 2004;279:23908-15 pubmed
    ..These findings suggest that the regulation of Insig-1 by PPARgamma agonists could in turn regulate SREBP processing and thus couple insulin sensitizers with the regulation of lipid homeostasis. ..
  26. Macheboeuf P, Buffalo C, Fu C, Zinkernagel A, Cole J, Johnson J, et al. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature. 2011;472:64-8 pubmed publisher
    ..Disruption of this network into other supramolecular assemblies was not tolerated. These results have bearing on the pathophysiology of streptococcal toxic shock. ..
  27. Talukdar I, Sen S, Urbano R, Thompson J, Yates J, Webster N. hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. PLoS ONE. 2011;6:e27869 pubmed publisher
    ..Lastly, our data point to a functional interaction between hnRNP F and SRSF1 as a mutant that eliminates SRSF1 binding to exon 11, or a SRSF1 knockdown, which prevents the stimulatory effect of hnRNP F over expression. ..
  28. Hsu Y, Burke J, Li S, Woods V, Dennis E. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem. 2009;284:23652-61 pubmed publisher
    ..Our model combined with the deuterium exchange results in the presence of lipid substrate have allowed us to propose the first structural model of GVIA-2 iPLA(2) as well as the interfacial lipid binding region. ..
  29. Fanchiang S, Cojocaru R, Othman M, Khanna R, Brooks M, Smith T, et al. Global expression profiling of peripheral Qa-1-restricted CD8??+TCR??+ regulatory T cells reveals innate-like features: implications for immune-regulatory repertoire. Hum Immunol. 2012;73:214-22 pubmed publisher
    ..These studies have important implications for the regulatory mechanisms mediated by the CD8(+) Treg population in general. ..
  30. Schwarz D, Barry G, Eliasof S, Petroski R, Conlon P, Maki R. Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor. J Biol Chem. 2000;275:32174-81 pubmed
    ..Despite this strong interaction, GABA(B(1e)) fails to disrupt G-protein coupled inwardly rectifying potassium activation by the full-length heterodimer pair of GABA(B(1a))/GABA(B(2)). ..
  31. Vigil D, Blumenthal D, Taylor S, Trewhella J. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. J Biol Chem. 2005;280:35521-7 pubmed
  32. Osburn D, Shao G, Seidel H, Schulman I. Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions. Mol Cell Biol. 2001;21:4909-18 pubmed
    ..Taken together, the data suggest a model for targeted destruction of transcription factors based on structural or conformational signals as opposed to functional coupling with gene transcription. ..
  33. Bain G, Lorrain D, Stebbins K, Broadhead A, Santini A, Prodanovich P, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011;338:290-301 pubmed publisher
    ..AM211 represents a potent and selective antagonist of DP2 that may be used clinically to evaluate the role of DP2 in T helper 2-driven allergic inflammatory diseases. ..
  34. Xiao J, Jin R, Yu X, Shen M, Wagner J, Pai A, et al. Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Nat Genet. 2017;49:1546-1552 pubmed publisher
    ..Thus PRC2 recruitment in Arabidopsis relies in large part on binding of trans-acting factors to cis-localized DNA sequence motifs. ..
  35. Yang Z, Kollman J, Pandi L, Doolittle R. Crystal structure of native chicken fibrinogen at 2.7 A resolution. Biochemistry. 2001;40:12515-23 pubmed
    ..It is concluded that structural flexibility is an inherent feature of fibrinogen that plays a key role in both its conversion to fibrin and its subsequent destruction by plasmin. ..
  36. Donate F, Juarez J, Guan X, Shipulina N, Plunkett M, Tel Tsur Z, et al. Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 2004;64:5812-7 pubmed
  37. Bazirgan O, Hampton R. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem. 2008;283:12797-810 pubmed publisher
    ..Moreover, it suggests a previously unappreciated mode for regulation of E2s by Cue1p-like interacting partners. ..
  38. Li S, Tsalkova T, White M, Mei F, Liu T, Wang D, et al. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem. 2011;286:17889-97 pubmed publisher
  39. Oku S, van der Meulen T, Copp J, Glenn G, van der Geer P. Engineering NGF receptors to bind Grb2 directly uncovers differences in signaling ability between Grb2- and ShcA-binding sites. FEBS Lett. 2012;586:3658-64 pubmed publisher
    ..Our results show that the Grb2- and ShcA-binding sites have similar abilities to activate the Ras-Erk and PI 3-kinase-Akt pathways. In contrast, they displayed dramatic differences in their ability to activate DNA synthesis. ..
  40. Mikolajczyk S, Millar L, Marker K, Rittenhouse H, Wolfert R, Marks L, et al. Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue. Cancer Res. 1999;59:3927-30 pubmed
    ..The physiological role of PI-6 in the prostate and its relationship to hK2 and prostate cancer are under investigation. ..
  41. Lesley J, English N, Gal I, Mikecz K, Day A, Hyman R. Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6. J Biol Chem. 2002;277:26600-8 pubmed
    ..Instead, they stuck and remained "tethered" to the substrate under fluid flow. This result argues that the low affinity of CD44 for its ligand is important for rolling, an early phase of leukocyte extravasation from the blood. ..
  42. Smyth S, Sciorra V, Sigal Y, Pamuklar Z, Wang Z, Xu Y, et al. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. J Biol Chem. 2003;278:43214-23 pubmed
  43. Operaña T, Tukey R. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007;282:4821-9 pubmed
    ..These preliminary studies suggest that the UGT1A family of proteins form oligomerized complexes in the membrane, a property that may influence function and substrate selectivity. ..
  44. Sadeque A, Palamar S, Usmani K, Chen C, Cerny M, Chen W. Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation. Drug Metab Dispos. 2016;44:570-5 pubmed publisher
  45. Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE. 2017;12:e0184843 pubmed publisher
    ..Our results demonstrate its druggability, provide a high affinity tool compound, and establish a high throughput assay for the identification of next generation cGAS inhibitors...
  46. Ito T, Tyler J, Bulger M, Kobayashi R, Kadonaga J. ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem. 1996;271:25041-8 pubmed
    ..These and other data collectively suggest that dNLP may participate in parallel with other histone-binding proteins such as dNAP-1 in the assembly of chromatin. ..
  47. Andersen C, Wan Y, Chang J, Riggs B, Lee C, Liu Y, et al. Discovery of selective aminothiazole aurora kinase inhibitors. ACS Chem Biol. 2008;3:180-92 pubmed publisher
    ..The compounds recapitulate the hallmarks of Aurora kinase inhibition, including decreased histone H3 serine 10 phosphorylation, failure to complete cytokinesis, and endoreduplication. ..
  48. Agrawal A, de Oliveira C, Cheng Y, Jacobsen J, McCammon J, Cohen S. Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor. J Med Chem. 2009;52:1063-74 pubmed publisher
    ..29-0.54 kcal mol(-1) per heavy atom were achieved. The results highlight the need for a better understanding to optimize the interplay between the ZBG, linker, and backbone to get improved LFi. ..
  49. Li D, Sewer M. RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking. Endocrinology. 2010;151:4313-23 pubmed publisher
    ..We conclude that ACTH regulates cortisol production by facilitating interorganelle substrate transfer via a process that is mediated by RhoA and DIAPH1, which act to coordinate the dynamic trafficking of mitochondria. ..
  50. Heinz S, Romanoski C, Benner C, Allison K, Kaikkonen M, Orozco L, et al. Effect of natural genetic variation on enhancer selection and function. Nature. 2013;503:487-92 pubmed publisher
  51. Levenstein M, Kadonaga J. Biochemical analysis of chromatin containing recombinant Drosophila core histones. J Biol Chem. 2002;277:8749-54 pubmed
    ..Thus, chromatin assembly and remodeling by ACF can occur in the absence of histone modifications. ..
  52. Zent R, Bush K, Pohl M, Quaranta V, Koshikawa N, Wang Z, et al. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol. 2001;238:289-302 pubmed
    ..These data may help to partially explain the renal phenotype seen in integrin alpha3 and alpha3/alpha6 subunit-deficient animals. ..
  53. Hutchinson J, Li Y, Arruda J, Baccei C, Bain G, Chapman C, et al. 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). J Med Chem. 2009;52:5803-15 pubmed publisher
    ..Compound 11j was selected for clinical development and has successfully completed phase 1 trials in healthy volunteers. ..
  54. Casteel D, Turner S, Schwappacher R, Rangaswami H, Su Yuo J, Zhuang S, et al. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012;287:38367-78 pubmed publisher
    ..We conclude that IQGAP1 acts both upstream of RhoA/C, regulating their activation state, and downstream of RhoA/C, mediating their effects on breast cancer cell proliferation and migration, respectively. ..
  55. Kurdi Haidar B, Heath D, Aebi S, Howell S. Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I). J Biol Chem. 1998;273:22173-6 pubmed
    ..The results indicate that hASNA-I is a distinct human arsenite-stimulated ATPase belonging to the same superfamily of ATPases represented by the E. coli ArsA protein. ..
  56. Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm M, Fritz L, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003;425:407-10 pubmed
    ..These results suggest that tumour cells contain Hsp90 complexes in an activated, high-affinity conformation that facilitates malignant progression, and that may represent a unique target for cancer therapeutics. ..
  57. Li F, Templeton T, Popov V, Comer J, Tsuboi T, Torii M, et al. Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission. J Biol Chem. 2004;279:26635-44 pubmed
    ..gallinaceum for A. aegypti. These results support the concept that ookinete micronemal proteins may constitute a general class of malaria transmission-blocking vaccine candidates. ..
  58. Trelle M, Ramsey K, Lee T, Zheng W, Lamboy J, Wolynes P, et al. Binding of NFκB Appears to Twist the Ankyrin Repeat Domain of IκBα. Biophys J. 2016;110:887-95 pubmed publisher
  59. Ziff J, Rudolph D, Stenne B, Koudriakova T, Lord B, Bonaventure P, et al. Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists. ACS Chem Neurosci. 2016;7:498-504 pubmed publisher
    ..Overall, 20 has suitable druglike properties and pharmacokinetics in rat and dog. This molecule and others disclosed herein will serve as additional tools to elucidate the role of the P2X7 receptor in neuropsychiatric disorders. ..
  60. Yang J, Reddy T, Truong K, Suhasini M, Wong Staal F. Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002;21:7187-94 pubmed
    ..We propose that the direct interaction of Sam68 and hnRNP K adversely affect the activities of both proteins in signal transduction pathways of both transcriptional and post-transcriptional events. ..
  61. Kinderman F, Kim C, von Daake S, Ma Y, Pham B, Spraggon G, et al. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell. 2006;24:397-408 pubmed
    ..RIalpha, with a cavity in the groove, can accept a bulky tryptophan, whereas RIIalpha requires valine. ..
  62. Dias P, Giannoni F, Lee L, Han D, Yoon S, Yagita H, et al. CD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions. J Virol. 2010;84:8241-9 pubmed publisher
    ..These data suggest that CD4 T-cell help programs a change in CD8 T-cell function mediated by altered PD-1 expression, which enables effective long-term control of MHV-68. ..
  63. Ollendorff V, Donoghue D. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. J Biol Chem. 1997;272:32011-8 pubmed
    ..The direct interaction of PP5 with CDC16 and CDC27, as well as its overlapping spindle localization in mitosis, suggests that PP5 may be involved in the regulation of the activity of the anaphase-promoting complex. ..
  64. Verdecia M, Bowman M, Lu K, Hunter T, Noel J. Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol. 2000;7:639-43 pubmed
    ..Ser. The lack of widespread conservation of the Arg and Ser residues responsible for P.Ser recognition in the WW domain family suggests that only a subset of WW domains can bind P.Ser-Pro in a similar fashion to that of Pin1. ..
  65. Moore M, Kanter J, Jones K, Taylor S. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem. 2002;277:47878-84 pubmed
  66. Givens M, Rave Harel N, Goonewardena V, Kurotani R, Berdy S, Swan C, et al. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005;280:19156-65 pubmed
    ..These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development. ..
  67. Shah M, Wilderman P, Pascual J, Zhang Q, Stout C, Halpert J. Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 2012;51:7225-38 pubmed publisher
    ..In addition, the structures exhibit the versatility that can be exploited via in silico studies with other P450 2B6 ligands as large as raloxifene and itraconazole. ..
  68. Darsow T, Katzmann D, Cowles C, Emr S. Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Mol Biol Cell. 2001;12:37-51 pubmed
    ..These data indicate that a homo-oligomeric form of Vps41p is required for the formation of ALP containing vesicles at the Golgi complex via interactions with AP-3. ..
  69. Wong K, Kassavetis G, Leonetti J, Geiduschek E. Mutational and functional analysis of a segment of the sigma family bacteriophage T4 late promoter recognition protein gp55. J Biol Chem. 2003;278:7073-80 pubmed
    ..2 and the recently determined structures of the Thermus thermophilus and Thermus aquaticus sigma(70)-RNA polymerase holoenzymes. ..
  70. Miller B, Nyitrai M, Bernstein S, Geeves M. Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical coupling. J Biol Chem. 2003;278:50293-300 pubmed
    ..As a result, the attachment rate and completion of the power stroke or the equilibrium between actin.myosin.ADP states may define actin filament velocity for these myosin isoforms. ..
  71. Abresch E, Paddock M, Villalobos M, Chang C, Okamura M. Interaction between cytochrome c2 and the photosynthetic reaction center from Rhodobacter sphaeroides: role of interprotein hydrogen bonds in binding and electron transfer. Biochemistry. 2008;47:13318-25 pubmed publisher
    ..The close packing contributes to fast electron transfer by increasing the rate of electronic coupling and contributes to the binding energy holding the cyt in position for times sufficient for electron transfer to occur. ..
  72. Cook P, Ju B, Telese F, Wang X, Glass C, Rosenfeld M. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009;458:591-6 pubmed publisher
  73. Stanford K, Wang L, Castagnola J, Song D, Bishop J, Brown J, et al. Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem. 2010;285:286-94 pubmed publisher
    ..Our findings show that plasma lipoprotein clearance depends on specific subclasses of sulfate groups and not on overall charge of the chains. ..
  74. Yao W, Sung L. Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain. J Biol Chem. 2010;285:31408-17 pubmed publisher
    ..E-Tmod29 may thus modulate the availability of TM5 and G-actin for E-Tmod41 to construct the protofilament-based membrane skeletal network for circulating erythrocytes. ..
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