Genomes and Genes
Experts and Doctors on oxidative stress in Novato, California, United States
Locale: Novato, California, United States
Topic: oxidative stress
- Flynn J, Czerwieniec G, Choi S, Day N, Gibson B, Hubbard A, et al. Proteogenomics of synaptosomal mitochondrial oxidative stress. Free Radic Biol Med. 2012;53:1048-60 pubmed publisher..As a result of using these approaches, we report for the first time an activation of the mTOR pathway in synaptosomes isolated from Sod2 null mice, confirmed by an upregulation of the phosphorylation of 4E-BP1. ..
- Siddiqui A, Mallajosyula J, Rane A, Andersen J. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiol Dis. 2010;40:444-8 pubmed publisher..This has implications for early intervention therapies. ..
- Chinta S, Rane A, Yadava N, Andersen J, Nicholls D, Polster B. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med. 2009;46:939-47 pubmed..These findings raise the important possibility that complex I contributes less to physiological ROS production by brain mitochondria than previously suggested. ..
- Benz C, Yau C. Ageing, oxidative stress and cancer: paradigms in parallax. Nat Rev Cancer. 2008;8:875-9 pubmed publisher..gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer development? ..
- Galvan V, Banwait S, Spilman P, Gorostiza O, Peel A, Ataie M, et al. Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis. 2007;28:65-75 pubmed..Thus, ASK1 may be the apical MAPKKK in a signaling complex assembled with APP as a response to stress. ..
- Siddiqui A, Chinta S, Mallajosyula J, Rajagopolan S, Hanson I, Rane A, et al. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. 2012;53:993-1003 pubmed publisher..This represents a novel role for alpha-synuclein as it relates to mitochondrial dysfunction in PD. ..
- Golden T, Hubbard A, Morten K, Hinerfeld D, Melov S. Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. Free Radic Biol Med. 2005;39:152-63 pubmed..The normalization of expression of some of these pathways by antioxidant treatment suggests approaches to treating disease in which endogenous oxidative stress plays a role. ..
- Ristow M. Interview with Michael Ristow. Aging (Albany NY). 2012;4:2 pubmed..At the time of the interview it was 125 times so it is ranked as number 5 among 100,000 papers on aging in 2009. ..
- Choi S, Gerencser A, Lee D, Rajagopalan S, Nicholls D, Andersen J, et al. Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. J Neurosci. 2011;31:4524-34 pubmed publisher..We conclude that the intrinsic bioenergetic capacities of dopaminergic and nondopaminergic presynaptic synaptosomes from mice do not differ...
- Melov S, Doctrow S, Schneider J, Haberson J, Patel M, Coskun P, et al. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci. 2001;21:8348-53 pubmed
- Chen D, Pan K, Palter J, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell. 2007;6:525-33 pubmed..We have isolated novel lifespan-extension genes, which may help understand the intrinsic link between organism development and adult lifespan. ..
- Velarde M, Flynn J, Day N, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4:3-12 pubmed..Our results support the idea that mitochondrial oxidative stress and cellular senescence contribute to aging skin phenotypes in vivo. ..
- Lucanic M, Lithgow G, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013;12:445-58 pubmed publisher..Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies. ..
- Samper E, Morgado L, Estrada J, Bernad A, Hubbard A, Cadenas S, et al. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med. 2009;46:387-96 pubmed publisher..Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type. ..
- Benedetti M, Foster A, Vantipalli M, White M, Sampayo J, Gill M, et al. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol. 2008;43:882-91 pubmed publisher..Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging. ..
- Melov S, Adlard P, Morten K, Johnson F, Golden T, Hinerfeld D, et al. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS ONE. 2007;2:e536 pubmed..These findings mechanistically link mitochondrial oxidative stress with the pathological features of AD. ..
- Johnson Cadwell L, Jekabsons M, Wang A, Polster B, Nicholls D. 'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress. J Neurochem. 2007;101:1619-31 pubmed..It is concluded that the 'mild uncoupling' hypothesis is not supported by this model. ..
- Morten K, Ackrell B, Melov S. Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment. J Biol Chem. 2006;281:3354-9 pubmed..Increased production of O2* resulting from complex II normalization had no effect on steady state levels due to the rapid conversion to H2O2, a process presumably aided by the presence of the EUK189, an SOD mimetic...
- Boonplueang R, Akopian G, Stevenson F, Kuhlenkamp J, Lu S, Walsh J, et al. Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death. Exp Neurol. 2005;192:203-14 pubmed..This could be due to alterations in the redox state of the glutathione system resulting in elevated glutathione disulfide (GSSG) levels which, in turn, may directly activate NMDA receptors or enhanced response of the NMDA receptor. ..
- Hinerfeld D, Traini M, Weinberger R, Cochran B, Doctrow S, Harry J, et al. Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 2004;88:657-67 pubmed..In addition, we observed a striking pattern of neuronal cell death as a result of mitochondrial oxidative stress, and were able to significantly reduce the loss of neurons via antioxidant treatment. ..
- Kumar M, Nicholls D, Andersen J. Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease. J Biol Chem. 2003;278:46432-9 pubmed..Our data suggest that H2O2 production via subtle elevations in MAO-B levels can result in oxidative effects on KGDH that can compromise the ability of dopaminergic neurons to cope with increased energetic stress. ..