Genomes and Genes
Experts and Doctors on nuclear proteins in San Diego, California, United States
Locale: San Diego, California, United States
Topic: nuclear proteins
- Shaw P, Tononi G, Greenspan R, Robinson D. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 2002;417:287-91 pubmed..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat. ..
- Crotti A, Benner C, Kerman B, Gosselin D, Lagier Tourenne C, Zuccato C, et al. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014;17:513-21 pubmed publisher..These findings suggest a cell-autonomous basis for enhanced microglia reactivity that may influence non-cell-autonomous HD pathogenesis. ..
- Kraus W, Manning E, Kadonaga J. Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. Mol Cell Biol. 1999;19:8123-35 pubmed..These data exemplify a situation in which a network of multiple activation functions is required to achieve gene transcription. ..
- Deckert M, Tartare Deckert S, Couture C, Mustelin T, Altman A. Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity. 1996;5:591-604 pubmed..These results indicate that the interaction between Syk family kinases and Vav plays an important role in coupling immune recognition receptors to signaling pathways involved in lymphokine production. ..
- Zhang T, Johnson E, Gu Y, Morissette M, Sah V, Gigena M, et al. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem. 2002;277:1261-7 pubmed..Our findings are the first to demonstrate that CaMKII can induce hypertrophy and dilation in vivo and indicate that compensatory increases in phosphatase activity contribute to the resultant phenotype. ..
- Lancaster M, Gopal D, Kim J, Saleem S, Silhavy J, Louie C, et al. Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med. 2011;17:726-31 pubmed publisher..Our findings implicate a defect in Wnt signaling in the cerebellar midline phenotype seen in Joubert syndrome that can be overcome with Wnt stimulation. ..
- Darsow T, Katzmann D, Cowles C, Emr S. Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Mol Biol Cell. 2001;12:37-51 pubmed..These data indicate that a homo-oligomeric form of Vps41p is required for the formation of ALP containing vesicles at the Golgi complex via interactions with AP-3. ..
- Shao G, Heyman R, Schulman I. Three amino acids specify coactivator choice by retinoid X receptors. Mol Endocrinol. 2000;14:1198-209 pubmed..The ability of an optimized seven-amino acid nuclear receptor box to specifically interact with RXR and function as a selective inhibitor suggests the coactivator-binding pocket may serve as a new target for drug discovery. ..
- Liu F, Usui I, Evans L, Austin D, Mellon P, Olefsky J, et al. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002;277:32099-108 pubmed..Taken together, these results indicate that the GnRH receptor activates both G(q) and G(s) signaling to regulate gene expression in L beta T2 cells. ..
- Her L, Goldstein L. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008;28:13662-72 pubmed publisher..These data suggest that a loss of wild-type huntingtin function in fast axonal transport plays important roles in the development of cell-type-specific defects in HD. ..
- Lin S, Coutinho Mansfield G, Wang D, Pandit S, Fu X. The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol. 2008;15:819-26 pubmed publisher..Recombinant SC35 is sufficient to rescue this defect in nuclear run-on experiments. These findings suggest a reciprocal functional relationship between the transcription and splicing machineries during gene expression. ..
- Sanchez V, McElroy A, Spector D. Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus. J Virol. 2003;77:13214-24 pubmed
- Zhang Y, Kim Y, Genoud N, Gao J, Kelly J, Pfaff S, et al. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006;24:759-770 pubmed publisher..Ser5 of the CTD heptad repeat. Moreover, these results provide a template for the design of specific inhibitors of Scp1 for the study of neuronal stem cell development. ..
- Finley K, Edeen P, Foss M, Gross E, Ghbeish N, Palmer R, et al. Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior. Neuron. 1998;21:1363-74 pubmed..Expression of a female transformer cDNA under the control of a dsf enhancer in males leads to dsf-like bisexual behavior. ..
- Ollendorff V, Donoghue D. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. J Biol Chem. 1997;272:32011-8 pubmed..The direct interaction of PP5 with CDC16 and CDC27, as well as its overlapping spindle localization in mitosis, suggests that PP5 may be involved in the regulation of the activity of the anaphase-promoting complex. ..
- Stein B, Yang M. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol. 1995;15:4971-9 pubmed..Therefore, drugs that separate the transactivation and transrepression functions of ER will be very helpful for treatment of osteoporosis without causing undesirable side effects. ..
- Li C, Zhu J, Wang J. Ectopic expression of p73alpha, but not p73beta, suppresses myogenic differentiation. J Biol Chem. 2005;280:2159-64 pubmed..These results demonstrated a functional diversity between the two C-terminal variants of p73 and suggested that p73alpha can regulate cellular differentiation in addition to its role in stimulating cell death. ..
- Sandberg M, Sutton S, Pletcher M, Wiltshire T, Tarantino L, Hogenesch J, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-66 pubmed..Cell cycle analyses show that twice as many HSCs from c-Myb(M303V/M303V) animals are actively cycling. Thus c-Myb, through interaction with p300, controls the proliferation and differentiation of hematopoietic stem and progenitor cells. ..
- Huang S, Lavine J, Boland P, Newbury R, Kolodner R, Pham T, et al. Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. J Pediatr. 2001;138:629-35 pubmed..Genetic screening of other suspected HNPCC families with unusually young members with cancer might reveal certain genotypes with particularly virulent forms of this disease. ..
- Pines J, Hunter T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol. 1991;115:1-17 pubmed
- Mulvihill M, Guttman M, Komives E. Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein. Biochemistry. 2011;50:6208-16 pubmed publisher..Fe65 PID1 thus provides a link between the Dab-like class and the IRS-like class of PIDs and is the first Dab-like family member to show phosphorylation-dependent binding. ..
- Saxena M, Williams S, Gilman J, Mustelin T. Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP). J Biol Chem. 1998;273:15340-4 pubmed..Together these findings suggest that HePTP plays an active negative role in TCR signaling by dephosphorylating one or several signaling molecules between the receptor and the mitogen-activated protein kinase pathway. ..
- Kuo H, Chen J, Ruiz Lozano P, Zou Y, Nemer M, Chien K. Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development. 1999;126:4223-34 pubmed..5 and GATA-4. We have shown that this cooperative regulation is dependent on binding of GATA-4 to its cognate DNA sequence in the promoter, which suggests that Nkx2.5 controls CARP expression, at least in part, through GATA-4. ..
- Lawson M, Whyte D, Mellon P. GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol. 1996;16:3596-605 pubmed
- Pines J, Hunter T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell. 1989;58:833-46 pubmed..In G2/M phase, cyclin is associated with p34cdc2, the human homolog of the fission yeast gene cdc2+, and this complex has histone H1 kinase activity. ..
- Aubol B, Ungs L, Lukasiewicz R, Ghosh G, Adams J. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. J Biol Chem. 2004;279:30182-8 pubmed..The chemical clamping mechanism offers an efficient means whereby a protein kinase can simultaneously achieve both high turnover and good substrate binding properties. ..
- Deckert M, Tartare Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity. 1998;9:595-605 pubmed..Thus, 3BP2 is an important adaptor that may couple activated Zap-70/Syk to a LAT-containing signaling complex involved in TCR-mediated gene transcription. ..
- Lin S, Xiao R, Sun P, Xu X, Fu X. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell. 2005;20:413-25 pubmed..We further showed that this process is regulated by differential dephosphorylation of the RS domain, thus revealing a sorting mechanism for mRNP transition from splicing to export. ..
- Lee N, Lira M, Pavlicek A, Ye J, Buckman D, Bagrodia S, et al. A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation. PLoS ONE. 2012;7:e39653 pubmed publisher..Our results suggest that combination of a c-Met tyrosine kinase inhibitor with a BRAF or a MEK inhibitor may be effective in treating resistant tumors that use activated BRAF to escape suppression of c-Met signaling. ..
- Wagner B, Valledor A, Shao G, Daige C, Bischoff E, Petrowski M, et al. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol. 2003;23:5780-9 pubmed
- Kioussi C, Briata P, Baek S, Wynshaw Boris A, Rose D, Rosenfeld M. Pitx genes during cardiovascular development. Cold Spring Harb Symp Quant Biol. 2002;67:81-7 pubmed
- Brockdorff J, Williams S, Couture C, Mustelin T. Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1. Eur J Immunol. 1999;29:2539-50 pubmed..Instead, we propose that ligation of a distinct inhibitory receptor leads to the recruitment of SHP1 via its SH2 domains, activation of SHP1 and subsequently inhibition of TCR signals if the inhibitory receptor is juxtaposed to the TCR. ..
- Bower K, Zeller R, Wachsman W, Martinez T, McGuire K. Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. J Biol Chem. 2002;277:34967-77 pubmed..The data suggest that p21(SNFT) may repress transcriptional activity by inducing a unique conformation in the transcription factor complex. ..
- You Z, Harvey K, Kong L, Newport J. Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication. Genes Dev. 2002;16:1182-94 pubmed..These observations demonstrate that a direct link exists between DNA replication and CKI degradation. ..
- Tang Y, Wallace M, Sanchez Gurmaches J, Hsiao W, Li H, Lee P, et al. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016;7:11365 pubmed publisher..These data suggest mTORC2 functions in WAT as part of an extra-hepatic nutrient-sensing mechanism to control glucose homeostasis. ..
- Lee C, Smith B, Bandyopadhyay K, Gjerset R. DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF. Cancer Res. 2005;65:9834-42 pubmed..The results implicate the nucleolus and nucleolar interactions of the ARF, including potentially novel interactions involving its COOH terminus as sites for early DNA damage and stress-mediated cellular events. ..
- Kapasi A, Clark C, Tran K, Spector D. Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription. J Virol. 2009;83:5904-17 pubmed publisher..Exogenous expression of additional cdk9 mutants indicates that binding of Brd4 to the cdk9 complex is not required but that efficient binding to cyclin T1 is essential. ..
- Pepper A, Delaney T, Washburn T, Poole D, Chory J. DET1, a negative regulator of light-mediated development and gene expression in arabidopsis, encodes a novel nuclear-localized protein. Cell. 1994;78:109-16 pubmed..These results suggest that DET1 acts in the nucleus to control the cell type-specific expression of light-regulated promoters. ..
- Ito T, Tyler J, Bulger M, Kobayashi R, Kadonaga J. ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem. 1996;271:25041-8 pubmed..These and other data collectively suggest that dNLP may participate in parallel with other histone-binding proteins such as dNAP-1 in the assembly of chromatin. ..
- Zhang W, Shao Y, Fang D, Huang J, Jeon M, Liu Y. Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. J Biol Chem. 2003;278:23978-83 pubmed..Thus, Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells. ..
- Kaminuma O, Deckert M, Elly C, Liu Y, Altman A. Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. Mol Cell Biol. 2001;21:3126-36 pubmed..These findings indicate that a Rac1-dependent JNK/c-Jun/AP-1 pathway, rather than the Ca(2+)/NFAT pathway, plays the predominant role in NFAT-IL-2 activation by Vav. ..
- Sugihara T, Kudryavtseva E, Kumar V, Horridge J, Andersen B. The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300. J Biol Chem. 2001;276:33036-44 pubmed
- Houglum K, Buck M, Adir V, Chojkier M. LAP (NF-IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region. J Clin Invest. 1994;94:808-14 pubmed..These experiments suggest that LAP may be important in the expression of collagen in differentiated hepatocytes through both the promoter and a newly described upstream element. ..
- Ethayathulla A, Nguyen H, Viadiu H. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements. J Biol Chem. 2013;288:4744-54 pubmed publisher..Sequence variations in the RE elicit a p73 conformational response that might explain target gene specificity. ..
- Zhang Z, Elly C, Altman A, Liu Y. Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z. J Biol Chem. 1999;274:4883-9 pubmed
- Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, et al. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene. 1999;18:1147-56 pubmed..The Crk-L-binding sites were further determined to be Y655DVP and Y709KIP, with the latter being the primary binding site. Taken together, these results implicate that Cbl-b is involved in TCR-mediated intracellular signaling pathways. ..
- Kimura Y, Schmitt A, Fukushima N, Ishii I, Kimura H, Nebreda A, et al. Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J Biol Chem. 2001;276:15208-15 pubmed..These results indicate that XLP(A1)-1 and XLP(A1)-2 are functional Xenopus LPA receptors and demonstrate the evolutionary conservation of LPA signaling over a range of vertebrate phylogeny. ..
- Charvet C, Canonigo A, Billadeau D, Altman A. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. J Biol Chem. 2005;280:15289-99 pubmed..Altogether, our data show that TCR-induced association of Vav3 with SLP-76 is required for its membrane/IS localization and function. ..
- Lakshmana M, Yoon I, Chen E, Bianchi E, Koo E, Kang D. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. J Biol Chem. 2009;284:11863-72 pubmed publisher..These findings not only implicate RanBP9 as a novel and potent regulator of APP processing but also as a potential therapeutic target for Alzheimer disease. ..
- Tyler J, Collins K, Prasad Sinha J, Amiott E, Bulger M, Harte P, et al. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Mol Cell Biol. 2001;21:6574-84 pubmed..This interaction between dCAF-1 and dASF1 may be a key component of the functional synergy observed between RCAF and dCAF-1 during the assembly of newly synthesized DNA into chromatin. ..
- Hermanson O, Jepsen K, Rosenfeld M. N-CoR controls differentiation of neural stem cells into astrocytes. Nature. 2002;419:934-9 pubmed..We propose that repression by N-CoR, modulated by opposing enzymatic activities, is a critical mechanism in neural stem cells that underlies the inhibition of glial differentiation. ..
- Nievergelt C, Kripke D, Barrett T, Burg E, Remick R, Sadovnick A, et al. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:234-41 pubmed..However, the trends for ARNTL and PER3 are suggestive of their involvement in bipolar disorder and warrant further study in a larger sample. ..
- Bailey J, Rave Harel N, McGillivray S, Coss D, Mellon P. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol. 2004;18:1158-70 pubmed..Our studies provide a basis for understanding activin regulation of FSHbeta gene expression and identify Pbx1 and Prep1 as Smad partners and novel mediators of activin action. ..
- Lusser A, Urwin D, Kadonaga J. Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly. Nat Struct Mol Biol. 2005;12:160-6 pubmed..These results suggest a role for CHD1 in the assembly of active chromatin and a function of ACF in the assembly of repressive chromatin. ..
- Yang J, Tang H, Reddy T, Wong Staal F. Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. J Biol Chem. 2001;276:30694-700 pubmed..Taken together, these data support the proposal that HAP95 specifically facilitates CTE-mediated gene expression by directly binding to RHA. ..
- Westberg C, Yang J, Tang H, Reddy T, Wong Staal F. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. J Biol Chem. 2000;275:21396-401 pubmed..Overexpression of HAP95 significantly increases CTE-dependent gene expression but has no effect on general gene expression or that mediated by the Rev/Rev response element of human immunodeficiency virus type 1. ..
- Rehling P, Darsow T, Katzmann D, Emr S. Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol. 1999;1:346-53 pubmed..Vps41 binds to the AP-3 delta-adaptin subunit, suggesting that they function together in the formation of ALP pathway transport intermediates at the late Golgi. ..
- Lukasiewicz R, Velazquez Dones A, Huynh N, Hagopian J, Fu X, Adams J, et al. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007;282:23036-43 pubmed..Thus, there are physical attributes of SR and SR-like substrates that dictate the mechanism of phosphorylation, whereas the ability to processively phosphorylate substrates is inherent to SR protein kinases. ..
- Chappell P, White R, Mellon P. Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci. 2003;23:11202-13 pubmed..This effect persists in normal light/dark (LD) cycles, suggesting that a suprachiasmatic nucleus-independent endogenous clock in GnRH neurons is required for eliciting normal pulsatile patterns of GnRH secretion. ..
- Gjerset R, Bandyopadhyay K. Regulation of p14ARF through subnuclear compartmentalization. Cell Cycle. 2006;5:686-90 pubmed..The results also have therapeutic implications for therapies based on exploiting p53 and other cellular stress response pathways to suppress cancer. ..