Experts and Doctors on neuronal plasticity in Irvine, California, United States


Locale: Irvine, California, United States
Topic: neuronal plasticity

Top Publications

  1. Marinesco S, Carew T. Serotonin release evoked by tail nerve stimulation in the CNS of aplysia: characterization and relationship to heterosynaptic plasticity. J Neurosci. 2002;22:2299-312 pubmed
    ..The development of chronoamperometric techniques in Aplysia now paves the way for a more complete understanding of the contribution of the serotonergic modulatory pathway to memory processing in this system. ..
  2. Bender R, Dube C, Gonzalez Vega R, Mina E, Baram T. Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus. 2003;13:399-412 pubmed
  3. Hsieh C, Cramer K. Deafferentation induces novel axonal projections in the auditory brainstem after hearing onset. J Comp Neurol. 2006;497:589-99 pubmed
    ..Moreover, sensitive periods for changes in individual pathways are independently regulated. ..
  4. Marinesco S, Wickremasinghe N, Carew T. Regulation of behavioral and synaptic plasticity by serotonin release within local modulatory fields in the CNS of Aplysia. J Neurosci. 2006;26:12682-93 pubmed
  5. Tong L, Prieto G, Kramar E, Smith E, Cribbs D, Lynch G, et al. Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1? via p38 mitogen-activated protein kinase. J Neurosci. 2012;32:17714-24 pubmed publisher
    ..The suppressive effect of IL-1? on F-actin and LTP was prevented by inhibiting p38 MAPK. These findings define a new mechanism for the action of IL-1? on LTP and point to a potential therapeutic target to restore synaptic plasticity. ..
  6. Chen K, Neu A, Howard A, Földy C, Echegoyen J, Hilgenberg L, et al. Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. J Neurosci. 2007;27:46-58 pubmed
  7. Reissner K, Pu L, Schaffhausen J, Boyle H, Smith I, Parker I, et al. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. J Neurosci. 2010;30:8797-806 pubmed publisher
    ..Our results support a model in which postsynaptic summation of IP(3) signals from suprathreshold and subthreshold inputs results in molecular coincidence detection that gives rise to a novel form of heterosynaptic plasticity. ..
  8. Bender R, Baram T. Epileptogenesis in the developing brain: what can we learn from animal models?. Epilepsia. 2007;48 Suppl 5:2-6 pubmed
  9. Vogel Ciernia A, Kramár E, Matheos D, Havekes R, Hemstedt T, Magnan C, et al. Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling. Learn Mem. 2017;24:199-209 pubmed publisher

More Information


  1. Beyeler M, DUTT N, Krichmar J. Categorization and decision-making in a neurobiologically plausible spiking network using a STDP-like learning rule. Neural Netw. 2013;48:109-24 pubmed publisher
  2. Pearson Fuhrhop K, Minton B, Acevedo D, Shahbaba B, Cramer S. Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa. PLoS ONE. 2013;8:e61197 pubmed publisher
    ..These findings may have clinical applications in post-stroke rehabilitation or the treatment of Parkinson's disease...
  3. Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, et al. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 2007;27:4697-706 pubmed
    ..These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation. ..
  4. Lynch G, Kramar E, Rex C, Jia Y, Chappas D, Gall C, et al. Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci. 2007;27:4424-34 pubmed
    ..That BDNF rescues LTP in HD knock-in mice suggests the possibility of treating cognitive deficits in asymptomatic HD gene carriers by upregulating production of the neurotrophin. ..
  5. Hsieh C, Hong C, Cramer K. Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. J Comp Neurol. 2007;504:508-18 pubmed
    ..contralateral target choice during deafferentation-induced plasticity. ..
  6. Riegle K, Meyer R. Rapid homeostatic plasticity in the intact adult visual system. J Neurosci. 2007;27:10556-67 pubmed
    ..Thus, tectal neurons exhibit archetypical homeostasis, one of the first robust examples in the intact adult CNS. ..
  7. Kubik S, Miyashita T, Guzowski J. Using immediate-early genes to map hippocampal subregional functions. Learn Mem. 2007;14:758-70 pubmed
    ..In closing, we provide a framework for how cutting-edge IEG imaging and intervention techniques will likely contribute to better understanding of the specific functions of CA3 and other hippocampal subregions. ..
  8. Kramar E, Chen L, Brandon N, Rex C, Liu F, Gall C, et al. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009;29:12982-93 pubmed publisher
  9. Babayan A, Kramar E, Barrett R, Jafari M, Haettig J, Chen L, et al. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012;32:12854-61 pubmed publisher
  10. Weinberger N. Associative representational plasticity in the auditory cortex: a synthesis of two disciplines. Learn Mem. 2007;14:1-16 pubmed
    ..The advantages of studying associative representational plasticity are emphasized, as is the need for greater behavioral sophistication. ..
  11. Vogel Ciernia A, Matheos D, Barrett R, Kramar E, Azzawi S, Chen Y, et al. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013;16:552-61 pubmed publisher
    ..Our results provide new insight into the role of dominant mutations in subunits of BAF complexes in human intellectual and cognitive disorders. ..
  12. Poon W, Carlos A, Aguilar B, Berchtold N, Kawano C, Zograbyan V, et al. β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem. 2013;288:16937-48 pubmed publisher
    ..Further, our results support the idea that in AD, Aβ may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF/TrkB-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival. ..
  13. Reissner K, Shobe J, Carew T. Molecular nodes in memory processing: insights from Aplysia. Cell Mol Life Sci. 2006;63:963-74 pubmed
  14. Weinberger N. Specific long-term memory traces in primary auditory cortex. Nat Rev Neurosci. 2004;5:279-90 pubmed
  15. Britton W, Lindahl J, Cahn B, Davis J, Goldman R. Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness. Ann N Y Acad Sci. 2014;1307:64-81 pubmed publisher
  16. Lee D, O Dowd D. cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: alterations in the memory mutant dunce. J Neurosci. 2000;20:2104-11 pubmed
    ..In addition, the alterations in dunce neurons suggest that cAMP-dependent plasticity at cholinergic synapses could mediate changes in neuronal communication that contribute to memory formation. ..