Experts and Doctors on neisseria meningitidis in Irvine, California, United States
Locale: Irvine, California, United States
Topic: neisseria meningitidis
- Schuller D, Zhu W, Stojiljkovic I, Wilks A, Poulos T. Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1. Biochemistry. 2001;40:11552-8 pubmed..Key glycine residues provide the flexibility for the helical kink, allow close contact of the helix backbone with the heme, and may interact directly with heme ligands...
- Friedman J, Lad L, Deshmukh R, Li H, Wilks A, Poulos T. Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation. J Biol Chem. 2003;278:34654-9 pubmed..Although the active site residues differ between nm-HO and human HO-1, the close similarity in the H-bonded water network suggests a common mechanism shared by all heme oxygenases. ..
- Friedman J, Lad L, Li H, Wilks A, Poulos T. Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa. Biochemistry. 2004;43:5239-45 pubmed