Experts and Doctors on mutation in Irvine, California, United States


Locale: Irvine, California, United States
Topic: mutation

Top Publications

  1. Middlebrooks J, Nick H, Subramony S, Advincula J, Rosales R, Lee L, et al. Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms. PLoS ONE. 2013;8:e76749 pubmed publisher
  2. Gach J, Quendler H, Tong T, Narayan K, Du S, Whalen R, et al. A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1. PLoS ONE. 2013;8:e72054 pubmed publisher
  3. Sontag E, Lotz G, Agrawal N, Tran A, Aron R, Yang G, et al. Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. J Neurosci. 2012;32:11109-19 pubmed
    ..Furthermore, MB treatment also promoted an increase in levels of BDNF RNA and protein in vivo. Thus, MB, which is well tolerated and used in humans, has therapeutic potential for HD. ..
  4. Ma C, Tran J, Li C, Ganesan L, Wood D, Morrissette N. Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations. Genetics. 2008;180:845-56 pubmed publisher
    ..These lines have reduced dinitroaniline resistance but most perform better than parental lines in competition assays, indicating that there is a trade-off between resistance and replication fitness. ..
  5. Javidpour P, Das A, Khosla C, Tsai S. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 2011;50:7426-39 pubmed publisher
    ..The molecular features of hedKR important for regio- and stereospecificities can potentially be applied to biosynthesize new polyketides via protein engineering that rationally controls polyketide ketoreduction. ..
  6. Chien R, Zeng W, Kawauchi S, Bender M, Santos R, Gregson H, et al. Cohesin mediates chromatin interactions that regulate mammalian ?-globin expression. J Biol Chem. 2011;286:17870-8 pubmed publisher
    ..Our results reveal that dynamic Nipbl/cohesin binding is critical for developmental chromatin organization and the gene activation function of the LCR in mammalian cells. ..
  7. Dioumaev A, Petrovskaya L, Wang J, Balashov S, Dolgikh D, Kirpichnikov M, et al. Photocycle of Exiguobacterium sibiricum rhodopsin characterized by low-temperature trapping in the IR and time-resolved studies in the visible. J Phys Chem B. 2013;117:7235-53 pubmed publisher
    ..The assignment of photocycle intermediates enables reevaluation of the photocycle; its specific features are discussed in relation to the general mechanism of proton transport in retinal proteins. ..
  8. Hicar M, Chen X, Kalams S, Sojar H, Landucci G, Forthal D, et al. Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations. Mol Immunol. 2016;70:94-103 pubmed publisher
    ..The analysis suggests that large numbers of somatic mutations occur in Ab genes encoding HIV Abs in chronically infected individuals in a non-directed, stochastic, manner. ..
  9. Ladokhin A, Isas J, Haigler H, White S. Determining the membrane topology of proteins: insertion pathway of a transmembrane helix of annexin 12. Biochemistry. 2002;41:13617-26 pubmed
    ..2001) J. Biol. Chem. 276, 32395-32398]. ..

More Information


  1. Dimitrijevic A, Starr A, Bhatt S, Michalewski H, Zeng F, Pratt H. Auditory cortical N100 in pre- and post-synaptic auditory neuropathy to frequency or intensity changes of continuous tones. Clin Neurophysiol. 2011;122:594-604 pubmed publisher
    ..Auditory N100 latency to the low frequency provides an objective measure of the degree of impaired speech perception in AN. ..
  2. Spampanato J, Escayg A, Meisler M, Goldin A. Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. J Neurosci. 2001;21:7481-90 pubmed
  3. Schutte S, Schutte R, Barragan E, O Dowd D. Model systems for studying cellular mechanisms of SCN1A-related epilepsy. J Neurophysiol. 2016;115:1755-66 pubmed publisher
  4. Hu Y, Fay A, Schmid B, Makar B, Ribbe M. Molecular insights into nitrogenase FeMoco insertion: TRP-444 of MoFe protein alpha-subunit locks FeMoco in its binding site. J Biol Chem. 2006;281:30534-41 pubmed
    ..Our results provide some of the initial molecular insights into the FeMoco insertion process and, moreover, have useful implications for the overall scheme of nitrogenase assembly. ..
  5. Palsbøll P, Berube M, Jørgensen H. Multiple levels of single-strand slippage at cetacean tri- and tetranucleotide repeat microsatellite loci. Genetics. 1999;151:285-96 pubmed
    ..Partial-repeat mutations introduce imperfections in the repeat array, which subsequently could reduce the rate of single-strand slippage. Limited computer simulations confirmed this predicted effect of partial-repeat mutations. ..
  6. Dioumaev A, Wang J, Balint Z, Váró G, Lanyi J. Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic. Biochemistry. 2003;42:6582-7 pubmed
    ..Instead, proton transport activity followed the titration curve for Asp-97, with an apparent pK(a) of 7.1, and became zero at the pH where Asp-97 is fully protonated. ..
  7. Shahrestani P, Leung H, Le P, Pak W, Tse S, Ocorr K, et al. Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner. PLoS ONE. 2009;4:e6867 pubmed publisher
    ..Our results suggest that heterozygous mutation of dOpa1 shows organ-specific pathogenesis and is associated with multiple organ abnormalities in an age-dependent and organ-specific manner. ..
  8. Stevenson J, Liu H. Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans. Eukaryot Cell. 2013;12:591-603 pubmed publisher
    ..Our data suggest an overlapping function of CAF-1 and HIR in epigenetic regulation of cell fate determination in an H3K56 acetylation-associated manner. ..
  9. Kitazawa M, Cheng D, LaFerla F. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 2009;108:1550-60 pubmed publisher
    ..Taken together, our data suggest that chronic copper exposure accelerates not only amyloid pathology but also tau pathology in a mouse model of AD. ..
  10. Chen K, Jung Y, Bonagura C, Tilley G, Prasad G, Sridhar V, et al. Azotobacter vinelandii ferredoxin I: a sequence and structure comparison approach to alteration of [4Fe-4S]2+/+ reduction potential. J Biol Chem. 2002;277:5603-10 pubmed
  11. Vardo Zalik A, Zhou G, Zhong D, Afrane Y, Githeko A, Yan G. Alterations in Plasmodium falciparum genetic structure two years after increased malaria control efforts in western Kenya. Am J Trop Med Hyg. 2013;88:29-36 pubmed publisher
    ..In addition, the high level of genetic diversity observed after intervention suggests transmission is still high in each population. ..
  12. Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs D, et al. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci. 2008;28:12163-75 pubmed publisher
    ..These data highlight the critical role CHIP plays as a link between Abeta and tau and identify CHIP as a new potential target not only for AD but for other neurodegenerative disorders characterized by tau accumulation. ..
  13. Wang Z, Shah J, Chen Z, Sun C, Berns M. Fluorescence correlation spectroscopy investigation of a GFP mutant-enhanced cyan fluorescent protein and its tubulin fusion in living cells with two-photon excitation. J Biomed Opt. 2004;9:395-403 pubmed
    ..We conclude that ECFP is a useful genetic fluorescent probe for FCS studies of various cellular processes when in fusion to other biomolecules of interest. ..
  14. Intskirveli I, Metherate R, Cramer K. Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex. PLoS ONE. 2011;6:e26192 pubmed publisher
    ..These results demonstrate that EphB receptors influence auditory cortical responses, and suggest that EphB signaling has multiple functions in auditory system development. ..
  15. Nalbandian A, Nguyen C, Katheria V, Llewellyn K, Badadani M, CAIOZZO V, et al. Exercise training reverses skeletal muscle atrophy in an experimental model of VCP disease. PLoS ONE. 2013;8:e76187 pubmed publisher
    ..Collectively, our data highlights that uphill exercise training in VCP(R155H/+) mice did not have any detrimental value to the function of muscle, and may offer effective therapeutic options for patients with VCP-associated diseases. ..
  16. Sahar S, Sassone Corsi P. Metabolism and cancer: the circadian clock connection. Nat Rev Cancer. 2009;9:886-96 pubmed publisher
    ..Therefore, a comprehensive understanding of the molecular links that connect the circadian clock to the cell cycle and metabolism could provide therapeutic benefit against certain human neoplasias. ..
  17. Shahriyari L, Komarova N. Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer?. PLoS ONE. 2013;8:e76195 pubmed publisher
    ..Our work provides a hypothesis to explain the observation that in mammalian cells, symmetric patterns of stem cell division seem to be very common. ..
  18. Lin S, Lee K, Nikitin A, Hilsenbeck S, Cardiff R, Li A, et al. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004;64:3525-32 pubmed
    ..Thus, this tumor system reproduces many important features of human breast cancer and provides tools for the study of the origins of ERalpha-positive and -negative breast tumors in mice. ..
  19. Subramanian V, Marchant J, Said H. Targeting and trafficking of the human thiamine transporter-2 in epithelial cells. J Biol Chem. 2006;281:5233-45 pubmed
    ..Finally, we compared the behavior of hTHTR2 with that of hTHTR1 and the human reduced folate carrier (SLC19A1) to underscore commonalities in the cell surface targeting mechanisms of the entire SLC19A gene family. ..
  20. Kawauchi S, Calof A, Santos R, Lopez Burks M, Young C, Hoang M, et al. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet. 2009;5:e1000650 pubmed publisher
    ..In addition, evidence is presented that reduced expression of genes involved in adipogenic differentiation may underlie the low amounts of body fat observed both in Nipbl+/- mice and in individuals with CdLS...
  21. Yeromin A, Zhang S, Jiang W, Yu Y, Safrina O, Cahalan M. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature. 2006;443:226-9 pubmed
    ..These results indicate that Orai itself forms the Ca2+-selectivity filter of the CRAC channel. ..
  22. Xiao J, Ghosn C, Hinchman C, Forbes C, Wang J, Snider N, et al. Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem. 2003;278:29954-62 pubmed
    ..These results suggest a potential role for RXR and its agonists in the regulation of beta-catenin turnover and related biological events. ..
  23. El Fiky A, Pioli P, Azam A, Yoo K, Nastiuk K, Krolewski J. Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9. Cell Signal. 2008;20:1400-8 pubmed publisher
    ..Overall, the data suggest that liberation of the IFNaR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor Stat2 to the nucleus. ..
  24. Zan H, Zhang J, Al Qahtani A, Pone E, White C, Lee D, et al. Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions. Mol Immunol. 2011;48:610-22 pubmed publisher
    ..Rather, it was associated with significantly reduced frequency of DSBs. Thus, our findings determine a role for EndoG in the generation of S region DSBs and CSR. ..
  25. Shakkottai V, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001;276:43145-51 pubmed
    ..Lei-Dab(7) will be a useful tool to investigate the functional role of SKCa2 in mammalian tissues. ..
  26. Zan H, Casali P. AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID. Mol Immunol. 2008;46:45-61 pubmed publisher
    ..Thus, AID and Ung generate staggered DSBs not only by cleaving intact double-strand DNA, but also by processing blunt DSB ends, whose generation is AID- and Ung-independent, thereby outlining a post-cleavage role for AID in CSR. ..
  27. Anzalone A, Lizardi Ortiz J, Ramos M, De Mei C, Hopf F, Iaccarino C, et al. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012;32:9023-34 pubmed publisher
    ..This study reveals previously unappreciated control of DA signaling, shedding new light on region-specific regulation of DA-mediated effects. ..
  28. Guo X, Chen C, Wang D, Modrek A, Phan V, Lee W, et al. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem. 2011;286:38783-94 pubmed publisher
    ..These results indicate a direct role of SUV3 in maintaining mitochondrial genome stability that is independent of intron turnover but requires the intact ATPase activity and the CC conserved region. ..
  29. Spencer R, Hochbaum A. The Phe-Ile Zipper: A Specific Interaction Motif Drives Antiparallel Coiled-Coil Hexamer Formation. Biochemistry. 2017;56:5300-5308 pubmed publisher
    ..Finally, we expanded on the generality of the Phe-Ile zipper, creating a unique sequence that forms an antiparallel hexamer that is topologically similar to ACC-Hex but atomistically unique...
  30. Sun L, Gilligan J, Staber C, Schutte R, Nguyen V, O Dowd D, et al. A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J Neurosci. 2012;32:14145-55 pubmed publisher
    ..Furthermore, our data indicate a natural temperature-dependent shift in sodium current deactivation (exacerbated by mutation) may contribute to febrile seizures in GEFS+ and perhaps normal individuals. ..
  31. Qi X, Sandmeyer S. In vitro targeting of strand transfer by the Ty3 retroelement integrase. J Biol Chem. 2012;287:18589-95 pubmed publisher
    ..Surprisingly, in the presence of MnCl(2), strand transfer was TFIIIB-independent and targeted sequences resembling the Ty3 terminal inverted repeat. ..
  32. McCall G, Haddad F, Roy R, Zhong H, Edgerton V, Baldwin K. Transcriptional regulation of the myosin heavy chain IIb gene in inactive rat soleus. Muscle Nerve. 2009;40:411-9 pubmed publisher
  33. Zaragoza M, Fass J, Diegoli M, Lin D, Arbustini E. Mitochondrial DNA variant discovery and evaluation in human Cardiomyopathies through next-generation sequencing. PLoS ONE. 2010;5:e12295 pubmed publisher
    ..We hope that this will assist in the identification of mtDNA mutations and key genetic determinants for cardiomyopathy and mitochondrial disease. ..
  34. Kong X, Stephens J, Ball A, Heale J, Newkirk D, Berns M, et al. Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. PLoS ONE. 2011;6:e23548 pubmed publisher
    ..We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I. ..
  35. Chen P, Kuraguchi M, Velasquez J, Wang Y, Yang K, Edwards R, et al. Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PLoS Genet. 2008;4:e1000092 pubmed publisher
  36. Lee D, O Dowd D. cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: alterations in the memory mutant dunce. J Neurosci. 2000;20:2104-11 pubmed
    ..In addition, the alterations in dunce neurons suggest that cAMP-dependent plasticity at cholinergic synapses could mediate changes in neuronal communication that contribute to memory formation. ..
  37. Torres Vazquez J, Warrior R, Arora K. schnurri is required for dpp-dependent patterning of the Drosophila wing. Dev Biol. 2000;227:388-402 pubmed
    ..Our data are consistent with a model in which Shn acts as a cofactor for Mad. ..
  38. Fuja T, Lin F, Osann K, Bryant P. Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res. 2004;64:942-51 pubmed
    ..They also justify additional studies of the functional significance of the changes, as well as a search for additional changes in these and other genes identified from studies on model systems. ..
  39. Jang G, Leong L, Hoang L, Wang P, Gutman G, Semler B. Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA. J Biol Chem. 2004;279:47419-30 pubmed
    ..Therefore, these findings indicate that Kv1.4 expression is mediated through a complex interplay between many distinct RNA regions. ..
  40. Zhang S, Yu Y, Roos J, Kozak J, Deerinck T, Ellisman M, et al. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 2005;437:902-5 pubmed
    ..We propose that STIM1 functions as the missing link between Ca2+ store depletion and SOC influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels. ..
  41. Li L, Johnson L, Dai Ju J, Sandri Goldin R. Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27. PLoS ONE. 2008;3:e1491 pubmed publisher
    ..We propose that one function of the Hsc70 nuclear foci may be to serve to facilitate the process of clearing stalled RNAP II complexes from viral genomes during times of highly active transcription. ..
  42. Wallace D. Mitochondria as chi. Genetics. 2008;179:727-35 pubmed publisher
  43. Su N, Ouni I, Papagiannis C, Kaiser P. A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32. J Biol Chem. 2008;283:11615-24 pubmed publisher
    ..These results suggest a regulatory role of Met32 as part of the Cbf1-Met4 complex and provide molecular insight into coordination of cell cycle response and modulation of gene expression programs. ..
  44. Zhang S, Kozak J, Jiang W, Yeromin A, Chen J, Yu Y, et al. Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem. 2008;283:17662-71 pubmed publisher
    ..The Orai3 current induced by 2-APB may reflect a store-independent mode of CRAC channel activation that opens a relatively nonselective cation pore. ..
  45. Cheng M, Bullock C, Li C, Lee A, Bermak J, Belluzzi J, et al. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002;417:405-10 pubmed
    ..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output. ..
  46. Greene D, Kang S, Hoshi N. XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. J Pharmacol Exp Ther. 2017;362:177-185 pubmed publisher
    ..Instead, they were well explained by binding to a single activated subunit. The characteristics of XE991 and linopirdine should be taken into account when these M-channel inhibitors are used in experiments. ..
  47. Tabb M, Tongaonkar P, Vu L, Nomura M. Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation. Mol Cell Biol. 2000;20:6062-73 pubmed
    ..These results suggest a role for Srp1p in regulation of protein degradation separate from its well-established role as the NLS receptor...
  48. Rollins B, Martin M, Sequeira P, Moon E, Morgan L, Watson S, et al. Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS ONE. 2009;4:e4913 pubmed publisher
    ..Focusing on haplogroup and individual susceptibility factors in psychiatric disorders by considering mtDNA variants may lead to innovative treatments to improve mitochondrial health and brain function...
  49. Hoverter N, Ting J, Sundaresh S, Baldi P, Waterman M. A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Mol Cell Biol. 2012;32:3648-62 pubmed publisher
    ..The C-clamp-RCCG interaction was critical for TCF1E-mediated transcriptional control of p21-connected target gene promoters. Our results indicate that a rapid-response WNT/p21 circuit is driven by C-clamp target gene selection. ..
  50. Morrell P, Toleno D, Lundy K, Clegg M. Estimating the contribution of mutation, recombination and gene conversion in the generation of haplotypic diversity. Genetics. 2006;173:1705-23 pubmed publisher
    ..simulans, and Zea mays. In total, 13 of 27 loci show evidence of gene conversion. For these loci, gene conversion is estimated to contribute an average of twice as much as crossing over to total recombination...
  51. Drapeau M, Radovic A, Wittkopp P, Long A. A gene necessary for normal male courtship, yellow, acts downstream of fruitless in the Drosophila melanogaster larval brain. J Neurobiol. 2003;55:53-72 pubmed
    ..Overall, these data suggest that y is a downstream member of the fru branch of the D. melanogaster sex determination hierarchy, where it plays a currently unknown role in the development of adult male wing extension during courtship. ..
  52. Ravikumar A, Arrieta A, Liu C. An orthogonal DNA replication system in yeast. Nat Chem Biol. 2014;10:175-7 pubmed publisher
    ..Orthogonal replication serves as a platform for in vivo continuous evolution and as a system whose replicative properties can be manipulated independently of the host's. ..
  53. Clinton L, Blurton Jones M, Myczek K, Trojanowski J, LaFerla F. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010;30:7281-9 pubmed publisher
    ..Together, our data support the notion that Abeta, tau, and alpha-synuclein interact in vivo to promote the aggregation and accumulation of each other and accelerate cognitive dysfunction. ..
  54. Dolezal T, Dolezelova E, Zurovec M, Bryant P. A role for adenosine deaminase in Drosophila larval development. PLoS Biol. 2005;3:e201 pubmed
    ..The existence of such an independent mechanism has also been suggested in mammals. ..
  55. Vogel Ciernia A, Kramár E, Matheos D, Havekes R, Hemstedt T, Magnan C, et al. Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling. Learn Mem. 2017;24:199-209 pubmed publisher
  56. Sevrioukova I. High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry. 2017;56:3058-3067 pubmed publisher
  57. Pentek J, Parker L, Wu A, Arora K. Follistatin preferentially antagonizes activin rather than BMP signaling in Drosophila. Genesis. 2009;47:261-73 pubmed publisher
    ..In assays targeting endogenous BMP signaling, we find no evidence that fs can antagonize BMP activity. We conclude that fs functions primarily as an inhibitor of activin rather than BMP ligands. ..
  58. Rodr guez Trelles F, Tarr o R, Ayala F. Switch in codon bias and increased rates of amino acid substitution in the Drosophila saltans species group. Genetics. 1999;153:339-50 pubmed
    ..Previous observations suggesting that GC content evolution is very limited in Drosophila may have been distorted due to the restricted number of genes and species (mostly D. melanogaster) investigated...
  59. Fitzgerald K, Semler B. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus. PLoS Pathog. 2011;7:e1002127 pubmed publisher
  60. Tsai C, Ngo B, Tapadia A, Hsu P, Wu G, Lee W. Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly. J Biol Chem. 2011;286:30097-106 pubmed publisher
    ..Taken together, these results suggest that Aurora-A modulates the microtubule binding activity of Hice1 in a spatiotemporal manner for proper bipolar spindle assembly. ..
  61. Katouli A, Komarova N. Optimizing combination therapies with existing and future CML drugs. PLoS ONE. 2010;5:e12300 pubmed publisher
    ..For illustration, we apply this algorithm to the mutation data obtained in [1], [2]. ..
  62. Hsieh C, Nakamura P, Luk S, MIKO I, Henkemeyer M, Cramer K. Ephrin-B reverse signaling is required for formation of strictly contralateral auditory brainstem pathways. J Neurosci. 2010;30:9840-9 pubmed publisher
    ..Together, these data suggest that EphB2-ephrin-B2 reverse signaling is required to prevent the formation of ipsilateral VCN-MNTB projections and that this signaling operates non-cell autonomously. ..
  63. Hilgenberg L, Pham B, Ortega M, Walid S, Kemmerly T, O Dowd D, et al. Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction. J Biol Chem. 2009;284:16956-65 pubmed publisher
    ..These data demonstrate that the basal frequency of myocyte contraction depends on endogenous agrin-alpha3 Na,K-ATPase interaction and suggest that agrin modulation of the alpha3 Na,K-ATPase is important in regulating heart function. ..
  64. Chen K, Tilley G, Sridhar V, Prasad G, Stout C, Armstrong F, et al. Alteration of the reduction potential of the [4Fe-4S](2+/+) cluster of Azotobacter vinelandii ferredoxin I. J Biol Chem. 1999;274:36479-87 pubmed
    ..Subsequent Protein Dipole Langevin Dipole calculations (using the actual I40N x-ray structures) did quite accurately predict the observed change in E(0'). ..
  65. Lander A, Selleck S. The elusive functions of proteoglycans: in vivo veritas. J Cell Biol. 2000;148:227-32 pubmed
  66. Gruber J, Long A. Cis-regulatory variation is typically polyallelic in Drosophila. Genetics. 2009;181:661-70 pubmed publisher
    ..If standing cis-regulatory variation is actually slightly deleterious, the true mutational target size is larger. ..
  67. Subramanian V, Marchant J, Said H. Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia. Am J Physiol Cell Physiol. 2008;294:C233-40 pubmed
    ..For the first time, our data present information regarding structure-function and membrane targeting of the hPCFT polypeptide, as well as the mechanisms that control its steady-state expression in polarized cells. ..
  68. Furuta S, Wang J, Wei S, Jeng Y, Jiang X, Gu B, et al. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006;10:13-24 pubmed
    ..These results suggest that, besides its role in maintaining genomic stability, BRCA1 directly regulates the expression of angiogenic factors to modulate the tumor microenvironment. ..
  69. Jun H, Liu J, Jeong H, Kim J, Qiao F. Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1. Genes Dev. 2013;27:1917-31 pubmed publisher
    ..Our results suggest critical regulatory roles of Tpz1 in the telomere binary switch. ..
  70. Ni J, Baik L, Holmes T, Montell C. A rhodopsin in the brain functions in circadian photoentrainment in Drosophila. Nature. 2017;545:340-344 pubmed publisher
    ..The demonstration that Rh7 functions in circadian pacemaker neurons represents, to our knowledge, the first role for an opsin in the central brain. ..
  71. Bardwell A, Flatauer L, Matsukuma K, Thorner J, Bardwell L. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem. 2001;276:10374-86 pubmed
    ..Thus, both the MEK-MAPK docking interaction and binding to the Ste5 scaffold make mutually reinforcing contributions to the efficiency of signaling by this MAPK cascade in vivo. ..
  72. Chen K, Bonagura C, Tilley G, McEvoy J, Jung Y, Armstrong F, et al. Crystal structures of ferredoxin variants exhibiting large changes in [Fe-S] reduction potential. Nat Struct Biol. 2002;9:188-92 pubmed
    ..The smaller (50--100 mV) increases observed for the neutral form are proposed to occur by directing a Hdelta+--Ndelta- dipole toward the reduced form of the cluster. ..
  73. Leung L, Kwong M, Hou S, Lee C, Chan J. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem. 2003;278:48021-9 pubmed
    ..Together, these findings indicate that the functions of Nrf1 and Nrf2 overlap during early development and to a large extent in regulating antioxidant gene expression in cells. ..
  74. Knight R, Javidan Y, Nelson S, Zhang T, Schilling T. Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development. Dev Dyn. 2004;229:87-98 pubmed
    ..Developmental Dynamics 229:87-98, 2004. ..
  75. Yarosh W, Monserrate J, Tong J, Tse S, Le P, Nguyen K, et al. The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment. PLoS Genet. 2008;4:e6 pubmed publisher
    ..This study provides novel insights into the pathogenesis of optic atrophy and demonstrates the promise of antioxidants as therapeutic agents for this condition. ..
  76. Marcsisin R, Campeau S, Lopez J, Barbour A. Alp, an arthropod-associated outer membrane protein of Borrelia species that cause relapsing fever. Infect Immun. 2012;80:1881-90 pubmed publisher
    ..hermsii antigens but not detectably to native or recombinant Alp...
  77. Tang S, Le P, Tse S, Wallace D, Huang T. Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production. PLoS ONE. 2009;4:e4492 pubmed publisher
    ..Our results, for the first time, demonstrate the important role of OPA1 in aging and lifespan, which is most likely mediated through augmented ROS production. ..
  78. Vogel Ciernia A, Matheos D, Barrett R, Kramar E, Azzawi S, Chen Y, et al. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013;16:552-61 pubmed publisher
    ..Our results provide new insight into the role of dominant mutations in subunits of BAF complexes in human intellectual and cognitive disorders. ..
  79. Chen D, Lanyi J. Structural changes in the N and N' states of the bacteriorhodopsin photocycle. Biophys J. 2009;96:2779-88 pubmed publisher
    ..The structural changes reverse their directions and decay in the N' state. ..
  80. Owens C, Du J, Dawson J, Goulding C. Characterization of heme ligation properties of Rv0203, a secreted heme binding protein involved in Mycobacterium tuberculosis heme uptake. Biochemistry. 2012;51:1518-31 pubmed publisher
    ..Moreover, the heme affinity of Rv0203-notag is comparable to that of other heme transport proteins, implying that Rv0203 may act as an extracellular heme transporter...