Experts and Doctors on molecular sequence data in Irvine, California, United States

Summary

Locale: Irvine, California, United States
Topic: molecular sequence data

Top Publications

  1. Krishnamani V, Lanyi J. Molecular dynamics simulation of the unfolding of individual bacteriorhodopsin helices in sodium dodecyl sulfate micelles. Biochemistry. 2012;51:1061-9 pubmed publisher
    ..The reason may be either that the sampling time was not sufficiently long or, more interestingly, that interhelix residue interactions play a role in the unfolding of the helices...
  2. Geib T, Hertel K. Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs. PLoS ONE. 2009;4:e8204 pubmed publisher
  3. Nabokina S, Ramos M, Said H. Mechanism(S) Involved in the Colon-Specific Expression of the Thiamine Pyrophosphate (Tpp) Transporter. PLoS ONE. 2016;11:e0149255 pubmed publisher
    ..These studies show, for the first time, epigenetic mechanisms (histone modifications) play a role in determining the tissue-specific pattern of expression of TPPT in the GI tract. ..
  4. Hu Y, Ribbe M. Decoding the nitrogenase mechanism: the homologue approach. Acc Chem Res. 2010;43:475-84 pubmed publisher
  5. Yieh L, Kassavetis G, Geiduschek E, Sandmeyer S. The Brf and TATA-binding protein subunits of the RNA polymerase III transcription factor IIIB mediate position-specific integration of the gypsy-like element, Ty3. J Biol Chem. 2000;275:29800-7 pubmed
    ..These findings suggest that the minimal requirements for pol III transcription and Ty3 integration are very similar. ..
  6. Reissner K, Boyle H, Ye X, Carew T. Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker-type potassium channels. J Neurochem. 2008;105:1006-18 pubmed publisher
  7. Mastroianni J, Ouellette A. Alpha-defensins in enteric innate immunity: functional Paneth cell alpha-defensins in mouse colonic lumen. J Biol Chem. 2009;284:27848-56 pubmed publisher
  8. Meierhofer D, Wang X, Huang L, Kaiser P. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. J Proteome Res. 2008;7:4566-76 pubmed publisher
  9. Tripathi S, O Neill M, Wilks A, Poulos T. Crystal structure of the Pseudomonas aeruginosa cytoplasmic heme binding protein, Apo-PhuS. J Inorg Biochem. 2013;128:131-6 pubmed publisher
    ..98Å resolution which shows a unique heme binding pocket and oligomeric structure compared to other known cytoplasmic heme transporter and accounts for some of the unusual biochemical properties of PhuS. ..

More Information

Publications81

  1. Schuller D, Wilks A, Ortiz de Montellano P, Poulos T. Crystal structure of human heme oxygenase-1. Nat Struct Biol. 1999;6:860-7 pubmed
    ..Regioselective oxygenation of the alpha-meso heme carbon is due primarily to steric influence of the distal helix. ..
  2. Gao Sheridan H, Kemper M, Khayat R, Tilley G, Armstrong F, Sridhar V, et al. A T14C variant of Azotobacter vinelandii ferredoxin I undergoes facile [3Fe-4S]0 to [4Fe-4S]2+ conversion in vitro but not in vivo. J Biol Chem. 1998;273:33692-701 pubmed
    ..However, unlike native FdI which does not undergo facile cluster conversion, the 7Fe form T14C FdI quickly converts to the 8Fe form with a high efficiency under reducing conditions. ..
  3. Houmani J, Ruf I. Clusters of basic amino acids contribute to RNA binding and nucleolar localization of ribosomal protein L22. PLoS ONE. 2009;4:e5306 pubmed publisher
    ..Our data support the growing consensus that the nucleolar accumulation of ribosomal proteins may not be mediated by a defined localization signal, but rather by specific interaction with established nucleolar components such as rRNA. ..
  4. Rosenfeld J, Osborne T. HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph. J Biol Chem. 1998;273:16112-21 pubmed
    ..This is notable, since insects are reportedly incapable of de novo sterol biosynthesis. ..
  5. Neilson L, Schneider P, Van Deerlin P, Kiriakidou M, Driscoll D, Pellegrini M, et al. cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus. Genomics. 1999;60:272-80 pubmed
    ..The cloning of the human homologue of the Chlamydomonas PF16 locus provides a new avenue to explore the role of the axoneme central pair in human sperm function. ..
  6. Lalo D, Steffan J, Dodd J, Nomura M. RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I. J Biol Chem. 1996;271:21062-7 pubmed
    ..No significant similarity was detected between two sets of the proteins. Similarity as well as differences between CF and SL1 are discussed. ..
  7. Sokolchik I, Tanabe T, Baldi P, Sze J. Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins. J Neurosci. 2005;25:1015-23 pubmed
    ..Thus, different sensory functions of OCR-2 arise from separable intrinsic determinants, and specific functional properties of TRPV channel proteins may be selectively conserved across phyla. ..
  8. Zhong D, Lo E, Hu R, Metzger M, CUMMINGS R, Bonizzoni M, et al. Genetic analysis of invasive Aedes albopictus populations in Los Angeles County, California and its potential public health impact. PLoS ONE. 2013;8:e68586 pubmed publisher
    ..There remains an imperative need for improved surveillance and control strategies for this species. ..
  9. Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein E, et al. Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem. 1999;274:22563-8 pubmed
  10. Weeks C, Tanabe H, Cummings J, Crampton S, Sheynis T, Jelinek R, et al. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006;281:28932-42 pubmed
  11. Ball A, Schmiesing J, Zhou C, Gregson H, Okada Y, Doi T, et al. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. Mol Cell Biol. 2002;22:5769-81 pubmed
    ..Thus, the CNAP1 C-terminal region defines a novel histone-binding domain that is responsible for targeting CNAP1, and possibly condensin, to mitotic chromosomes. ..
  12. Spampanato J, Kearney J, de Haan G, McEwen D, Escayg A, Aradi I, et al. A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci. 2004;24:10022-34 pubmed
    ..The D1866Y mutation weakens this interaction, demonstrating a novel molecular mechanism leading to seizure susceptibility. ..
  13. Kudryavtseva E, Sugihara T, Wang N, Lasso R, Gudnason J, Lipkin S, et al. Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor. Dev Dyn. 2003;226:604-17 pubmed
    ..These data suggest that GET-1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals. ..
  14. Biswas A, Elmatari D, Rothman J, LaMunyon C, Said H. Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2. PLoS ONE. 2013;8:e58190 pubmed publisher
    ..elegans and demonstrate their expression and importance to metabolic function in worms. Absence of transporter function renders worms sterile, making them useful in understanding human disease associated with mutations in hRFVT3. ..
  15. Ouellette A, Darmoul D, Tran D, Huttner K, Yuan J, Selsted M. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. Infect Immun. 1999;67:6643-51 pubmed
    ..We speculate that this unique duplicated element may have a cis-acting regulatory role in the positional specificity of cryptdin 4 gene expression...
  16. Nguyen T, Fujioka H, Kang A, Rogers W, Fidock D, James A. Stage-dependent localization of a novel gene product of the malaria parasite, Plasmodium falciparum. J Biol Chem. 2001;276:26724-31 pubmed
    ..This differential localization provides multiple opportunities to exploit the MB2 gene product as a vaccine or therapeutic target. ..
  17. Li M, Bullock C, Knauer D, Ehlert F, Zhou Q. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Mol Pharmacol. 2001;59:692-8 pubmed
    ..The availability of recombinant prokineticins should provide novel therapeutic agents for disorders involving impaired gastrointestinal motility. ..
  18. Carlson M, Komine Y, Bryant S, Gardiner D. Expression of Hoxb13 and Hoxc10 in developing and regenerating Axolotl limbs and tails. Dev Biol. 2001;229:396-406 pubmed
  19. Li M, Bermak J, Wang Z, Zhou Q. Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280). Mol Pharmacol. 2000;57:446-52 pubmed
    ..Our results suggest a new molecular mechanism of modulating D(2) receptor signaling by cytoskeletal protein interaction. ..
  20. Steele R, Dana C. Evolutionary history of the HAP2/GCS1 gene and sexual reproduction in metazoans. PLoS ONE. 2009;4:e7680 pubmed publisher
  21. Brummel T, Abdollah S, Haerry T, Shimell M, Merriam J, Raftery L, et al. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 1999;13:98-111 pubmed
    ..Our results define a novel Drosophila Activin/TGF-beta pathway that is analogous to its vertebrate counterpart and show that this pathway functions to promote cellular growth with minimal effects on patterning. ..
  22. Hoshino Y, Kodama T, Okahata Y, Shea K. Peptide imprinted polymer nanoparticles: a plastic antibody. J Am Chem Soc. 2008;130:15242-3 pubmed publisher
    ..These NPs are of interest as inert and stable substitutes for antibodies. Extension of this approach to other targets of biological importance and the applications of these materials are currently being evaluated. ..
  23. Torres R, Swift R, Chim N, Wheatley N, Lan B, Atwood B, et al. Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. PLoS ONE. 2011;6:e25084 pubmed publisher
    ..Thus, the results of this molecular study of Y. pestis RipA provide a structural platform for rational inhibitor design, which may lead to a greater understanding of the role of RipA in this unique virulence pathway...
  24. Bybee S, Yuan F, Ramstetter M, Llorente Bousquets J, Reed R, Osorio D, et al. UV photoreceptors and UV-yellow wing pigments in Heliconius butterflies allow a color signal to serve both mimicry and intraspecific communication. Am Nat. 2012;179:38-51 pubmed publisher
    ..Our results are the best available evidence for the correlated evolution of a color signal and color vision. They also suggest that predator visual systems are error prone in the context of mimicry. ..
  25. Kalman K, Nguyen A, Tseng Crank J, Dukes I, Chandy G, Hustad C, et al. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem. 1998;273:5851-7 pubmed
    ..In situ hybridization demonstrates the presence of Kv1.7 in mouse pancreatic islet cells. Kv1.7 was also isolated from mouse brain and hamster insulinoma cells by polymerase chain reaction. ..
  26. Gach J, Quendler H, Tong T, Narayan K, Du S, Whalen R, et al. A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1. PLoS ONE. 2013;8:e72054 pubmed publisher
  27. Kasravi A, Walter M, Brand S, Mason J, Biessmann H. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. Genetics. 1999;152:1025-35 pubmed
    ..The MU2 protein may be involved in controlling chromatin structure and thus may influence the processing of DNA DSBs. ..
  28. Owens C, Chim N, Graves A, Harmston C, Iniguez A, Contreras H, et al. The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. J Biol Chem. 2013;288:21714-28 pubmed publisher
    ..This work elucidates a key step in the mycobacterial uptake of heme, and it may be useful in the development of anti-tuberculosis drugs targeting this pathway...
  29. Chikova A, Grando S. Naturally occurring variants of human ?9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. PLoS ONE. 2011;6:e27978 pubmed publisher
    ..The biologic activities of ?9 nAChR may be regulated at the splicing level, and genetic polymorphisms in CHRNA9 affecting protein levels, amino acid sequence and RNA splicing may influence the risk for lung cancer. ..
  30. Lee M, Ames B, Tsai S. Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 2012;51:3079-91 pubmed publisher
    ..A unified ARO/CYC-mediated cyclization mechanism is proposed on the basis of these structural and functional results. ..
  31. Hovanes K, Li T, Munguia J, Truong T, Milovanovic T, Lawrence Marsh J, et al. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet. 2001;28:53-7 pubmed
  32. Sahar S, Zocchi L, Kinoshita C, Borrelli E, Sassone Corsi P. Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS ONE. 2010;5:e8561 pubmed publisher
    ..BMAL1 phosphorylation appears to be an important regulatory step in maintaining the robustness of the circadian clock. ..
  33. Palmarini M, Sharp J, De las Heras M, Fan H. Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer in sheep. J Virol. 1999;73:6964-72 pubmed
    ..The resulting tumors were positive for JSRV DNA and protein. Thus, JSRV21 is an infectious and pathogenic molecular clone and is necessary and sufficient to induce sheep pulmonary adenomatosis...
  34. Grigorian A, Demetriou M. Manipulating cell surface glycoproteins by targeting N-glycan-galectin interactions. Methods Enzymol. 2010;480:245-66 pubmed publisher
    ..In this chapter, we describe methods used to analyze N-glycan-galectin interactions in controlling the distribution and organization of cell surface receptors and transporters. ..
  35. Rangaraju S, Khoo K, Feng Z, Crossley G, Nugent D, Khaytin I, et al. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010;285:9124-36 pubmed publisher
    ..Evolutionary pressure to maintain a channel-modulatory function may contribute to the conservation of this domain throughout the plant and animal kingdoms. ..
  36. Hoffman T, Javier A, Campeau S, Knight R, Schilling T. Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. J Exp Zool B Mol Dev Evol. 2007;308:679-91 pubmed
  37. Fanger C, Ghanshani S, Logsdon N, Rauer H, Kalman K, Zhou J, et al. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem. 1999;274:5746-54 pubmed
    ..Taken together, our results suggest that Ca2+-calmodulin-induced conformational changes in all four subunits are necessary for the channel to open. ..
  38. Daijogo S, Semler B. Mechanistic intersections between picornavirus translation and RNA replication. Adv Virus Res. 2011;80:1-24 pubmed publisher
  39. Keener J, Josaitis C, Dodd J, Nomura M. Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem. 1998;273:33795-802 pubmed
    ..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription. ..
  40. Nagpal S, Patel S, Jacobe H, DiSepio D, Ghosn C, Malhotra M, et al. Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. J Invest Dermatol. 1997;109:91-5 pubmed
  41. Carter W, Aswad D. Formation, localization, and repair of L-isoaspartyl sites in histones H2A and H2B in nucleosomes from rat liver and chicken erythrocytes. Biochemistry. 2008;47:10757-64 pubmed publisher
  42. Sun L, Gilligan J, Staber C, Schutte R, Nguyen V, O Dowd D, et al. A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J Neurosci. 2012;32:14145-55 pubmed publisher
    ..Furthermore, our data indicate a natural temperature-dependent shift in sodium current deactivation (exacerbated by mutation) may contribute to febrile seizures in GEFS+ and perhaps normal individuals. ..
  43. Wang W, Chan J. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem. 2006;281:19676-87 pubmed
    ..These results suggest that Nrf1 is normally targeted to the endoplasmic reticulum membrane and that endoplasmic reticulum stress may play a role in modulating Nrf1 function as a transcriptional activator. ..
  44. Kemper M, Stout C, Lloyd S, Prasad G, Fawcett S, Armstrong F, et al. Y13C Azotobacter vinelandii ferredoxin I. A designed [Fe-S] ligand motif contains a cysteine persulfide. J Biol Chem. 1997;272:15620-7 pubmed
    ..It is interesting to note that neither of the two free cysteines present in FdI was modified. Thus, if NifS is involved in modifying the introduced cysteine there must be specificity to the reaction. ..
  45. Milnes M, Garcia A, Grossman E, Gr n F, Shiotsugu J, Tabb M, et al. Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species. Environ Health Perspect. 2008;116:880-5 pubmed publisher
  46. Bettahi I, Nesburn A, Yoon S, Zhang X, Mohebbi A, Sue V, et al. Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines. Invest Ophthalmol Vis Sci. 2007;48:4643-53 pubmed
    ..The strength of protective immunity induced by these lipopeptides together with their safety provide a molecularly defined vaccine formulation that could combat ocular herpes infection and disease in humans. ..
  47. Fuja T, Lin F, Osann K, Bryant P. Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res. 2004;64:942-51 pubmed
    ..They also justify additional studies of the functional significance of the changes, as well as a search for additional changes in these and other genes identified from studies on model systems. ..
  48. Balakirev E, Ayala F. Nucleotide variation of the Est-6 gene region in natural populations of Drosophila melanogaster. Genetics. 2003;165:1901-14 pubmed
    ..melanogaster, creates an excess of very similar sequences (RsaI- and S allelic lineages, in the promoter and coding regions, respectively) in the non-African samples. ..
  49. Grens A, Shimizu H, Hoffmeister S, Bode H, Fujisawa T. The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra. Development. 1999;126:517-24 pubmed
    ..These results suggest that peptides play signaling roles in patterning processes in cnidaria and, plausibly, in more complex metazoans as well...
  50. Tang Y, Yuan J, Miller C, Selsted M. Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes. Infect Immun. 1999;67:6139-44 pubmed
    ..This study is the first to characterize the sequences and activities of alpha-defensins from nonhuman primates, data that should aid in delineating the role of these peptides in rhesus macaque host defense. ..
  51. Nothacker H, Wang Z, Zhu Y, Reinscheid R, Lin S, Civelli O. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000;58:1601-8 pubmed
    ..Moreover, we have identified BAY u9773 as a CysLT(2) selective agonist, which could prove to be of immediate use in understanding the functional roles of the CysLT(2) receptor. ..
  52. Tran D, Tran P, Tang Y, Yuan J, Cole T, Selsted M. Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem. 2002;277:3079-84 pubmed publisher
    ..Equal amounts of each theta-defensin bound to E. coli cells, indicating that the differences in antibacterial activities are the result of post-binding processes...
  53. Qi X, Sandmeyer S. In vitro targeting of strand transfer by the Ty3 retroelement integrase. J Biol Chem. 2012;287:18589-95 pubmed publisher
    ..Surprisingly, in the presence of MnCl(2), strand transfer was TFIIIB-independent and targeted sequences resembling the Ty3 terminal inverted repeat. ..
  54. Ayabe T, Satchell D, Pesendorfer P, Tanabe H, Wilson C, Hagen S, et al. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002;277:5219-28 pubmed
    ..MMP-7-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen. ..
  55. Moore M, Dietz L, Tirtorahardjo B, Cotter P. A multiplex methylation PCR assay for identification of uniparental disomy of chromosome 7. Hum Mutat. 2003;21:645-8 pubmed
  56. Kolski Andreaco A, Tomita H, Shakkottai V, Gutman G, Cahalan M, Gargus J, et al. SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem. 2004;279:6893-904 pubmed
  57. Moody C, Tretyachenko Ladokhina V, Laue T, Senear D, Cocco M. Multiple conformations of the cytidine repressor DNA-binding domain coalesce to one upon recognition of a specific DNA surface. Biochemistry. 2011;50:6622-32 pubmed publisher
    ..Aspects of CytR activity are unique among repressors; we identify here structural properties that are also distinct and that might underlie the different functional properties. ..
  58. Reissner K, Paranandi M, Luc T, Doyle H, Mamula M, Lowenson J, et al. Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain. J Biol Chem. 2006;281:8389-98 pubmed
  59. Yu H, Kibler D, Tan M. In silico prediction and functional validation of sigma28-regulated genes in Chlamydia and Escherichia coli. J Bacteriol. 2006;188:8206-12 pubmed
    ..coli. ..
  60. McCall G, Haddad F, Roy R, Zhong H, Edgerton V, Baldwin K. Transcriptional regulation of the myosin heavy chain IIb gene in inactive rat soleus. Muscle Nerve. 2009;40:411-9 pubmed publisher
  61. Balakirev E, Anisimova M, Ayala F. Complex interplay of evolutionary forces in the ladybird homeobox genes of Drosophila melanogaster. PLoS ONE. 2011;6:e22613 pubmed publisher
  62. Zan H, Casali P. AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID. Mol Immunol. 2008;46:45-61 pubmed publisher
    ..Thus, AID and Ung generate staggered DSBs not only by cleaving intact double-strand DNA, but also by processing blunt DSB ends, whose generation is AID- and Ung-independent, thereby outlining a post-cleavage role for AID in CSR. ..
  63. Zan H, Zhang J, Al Qahtani A, Pone E, White C, Lee D, et al. Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions. Mol Immunol. 2011;48:610-22 pubmed publisher
    ..Rather, it was associated with significantly reduced frequency of DSBs. Thus, our findings determine a role for EndoG in the generation of S region DSBs and CSR. ..
  64. Ring C, Ogata S, Meek L, Song J, Ohta T, Miyazono K, et al. The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 2002;16:820-35 pubmed
  65. Tanabe H, Yuan J, Zaragoza M, Dandekar S, Henschen Edman A, Selsted M, et al. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004;72:1470-8 pubmed
    ..These studies should facilitate further analyses of the role of alpha-defensins in primate enteric immunity...
  66. Balakirev E, Ayala F. Nucleotide variation in the tinman and bagpipe homeobox genes of Drosophila melanogaster. Genetics. 2004;166:1845-56 pubmed
    ..We suggest that negative selection and demographic history are the major factors shaping the pattern of nucleotide polymorphism in the tin and bap genes; moreover, there are clear indications of positive selection in the bap gene...
  67. Greene D, Kang S, Kosenko A, Hoshi N. Adrenergic regulation of HCN4 channel requires protein association with ?2-adrenergic receptor. J Biol Chem. 2012;287:23690-7 pubmed publisher
    ..These results suggest that the ion channel-receptor complex is a critical mechanism in ion channel regulation. ..
  68. Shakkottai V, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001;276:43145-51 pubmed
    ..Lei-Dab(7) will be a useful tool to investigate the functional role of SKCa2 in mammalian tissues. ..
  69. Jung Y, Bonagura C, Tilley G, Gao Sheridan H, Armstrong F, Stout C, et al. Structure of C42D Azotobacter vinelandii FdI. A Cys-X-X-Asp-X-X-Cys motif ligates an air-stable [4Fe-4S]2+/+ cluster. J Biol Chem. 2000;275:36974-83 pubmed
    ..The cluster conversion was ultimately accomplished using a new electrochemical method. Hydrophobic and electrostatic interaction and the lack of Gly residues adjacent to the Asp ligand explain the remarkable stability of this cluster. ..
  70. Wang X, Chen C, Baker P, Chen P, Kaiser P, Huang L. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry. 2007;46:3553-65 pubmed
    ..The detailed proteomic profiling obtained here is significant to future studies aiming at a complete understanding of the structure-function relationship of the human 26S proteasome complex. ..
  71. Hofacre A, Nitta T, Fan H. Jaagsiekte sheep retrovirus encodes a regulatory factor, Rej, required for synthesis of Gag protein. J Virol. 2009;83:12483-98 pubmed publisher
    ..Thus, in most cell lines, the predominant function of Rej is to facilitate translation of unspliced viral mRNA...
  72. He S, Ni D, Ma B, Lee J, Zhang T, Ghozalli I, et al. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat Cell Biol. 2013;15:1206-1219 pubmed publisher