Experts and Doctors on mitogen activated protein kinases in Berkeley, California, United States


Locale: Berkeley, California, United States
Topic: mitogen activated protein kinases

Top Publications

  1. Carlson M, Suetta C, Conboy M, Aagaard P, Mackey A, Kjaer M, et al. Molecular aging and rejuvenation of human muscle stem cells. EMBO Mol Med. 2009;1:381-91 pubmed publisher
    ..These findings strongly suggest that aging of human muscle maintenance and repair can be reversed by 'youthful' calibration of specific molecular pathways. ..
  2. Kurpinski K, Jang D, Bhattacharya S, Rydberg B, Chu J, So J, et al. Differential effects of x-rays and high-energy 56Fe ions on human mesenchymal stem cells. Int J Radiat Oncol Biol Phys. 2009;73:869-77 pubmed publisher
    ..Since hMSC are the progenitors of osteoblasts in vivo, this study provides new mechanistic understandings of the relative health risks associated with low- and high-dose X-rays and high-LET space radiation. ..
  3. Shi W, Peyrot S, Munro E, Levine M. FGF3 in the floor plate directs notochord convergent extension in the Ciona tadpole. Development. 2009;136:23-8 pubmed publisher
    ..We propose that FGF signaling coordinates CE movements by regulating PCP pathway components such as Dsh. ..
  4. Sohn S, Sarvis B, Cado D, Winoto A. ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem. 2002;277:43344-51 pubmed
    ..Importantly, ERK5 is required at an earlier developmental stage than p38alpha, and p38alpha does not compensate for ERK5 deficiency. These results demonstrate that ERK5 plays a specific role in the regulation of early angiogenesis. ..
  5. Westfall P, Patterson J, Chen R, Thorner J. Stress resistance and signal fidelity independent of nuclear MAPK function. Proc Natl Acad Sci U S A. 2008;105:12212-7 pubmed publisher
    ..By contrast, enzymes needed for glycerol production were essential for viability. Thus, control of intracellular glycerol formation by Hog1 is critical for maintenance of osmotic balance but not transcriptional induction of any gene. ..
  6. Pincus D, Benjamin K, Burbulis I, Tsong A, Resnekov O. Reagents for investigating MAPK signalling in model yeast species. Yeast. 2010;27:423-30 pubmed publisher
    ..These antibodies are new tools for investigating MAPK signalling in model yeast species and may be useful for studying MAPK signalling in higher eukaryotes. ..
  7. Yu R, Pesce C, Colman Lerner A, Lok L, Pincus D, Serra E, et al. Negative feedback that improves information transmission in yeast signalling. Nature. 2008;456:755-61 pubmed publisher
    ..Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission. ..
  8. Garrenton L, Braunwarth A, Irniger S, Hurt E, Kunzler M, Thorner J. Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol Cell Biol. 2009;29:582-601 pubmed publisher
  9. Cook J, Bardwell L, Kron S, Thorner J. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev. 1996;10:2831-48 pubmed
    ..Collectively, these findings indicate that Dig1, and most likely Dig2, are physiological substrates of Kssl and suggest that they regulate Ste12 function by direct protein-protein interaction. ..

More Information


  1. Westfall P, Thorner J. Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele. Eukaryot Cell. 2006;5:1215-28 pubmed
    ..Finally, our results demonstrate a role for active Hog1 in maintaining signaling specificity under conditions of persistently high external osmolarity. ..
  2. Therrien M, Wong A, Kwan E, Rubin G. Functional analysis of CNK in RAS signaling. Proc Natl Acad Sci U S A. 1999;96:13259-63 pubmed
    ..Our results suggest that CNK functions in more than one pathway downstream of RAS. CNK(c-term) seems to regulate RAF, a component of the MAPK pathway, whereas CNK(N-term) seems to be involved in a MAPK-independent pathway. ..
  3. Bardwell L, Cook J, Zhu Shimoni J, Voora D, Thorner J. Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A. 1998;95:15400-5 pubmed
  4. Bardwell L, Cook J, Voora D, Baggott D, Martinez A, Thorner J. Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev. 1998;12:2887-98 pubmed
  5. Ma D, Cook J, Thorner J. Phosphorylation and localization of Kss1, a MAP kinase of the Saccharomyces cerevisiae pheromone response pathway. Mol Biol Cell. 1995;6:889-909 pubmed
    ..Indirect immunofluorescence demonstrated that Kss1 is concentrated in the nucleus and that its distribution is not altered detectably during signaling. ..
  6. Ziegelbauer J, Wei J, Tjian R. Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth. Proc Natl Acad Sci U S A. 2004;101:458-63 pubmed
    ..Taken together, our studies suggest that MIZ-1 regulates a specific set of genes that includes LDLR and that the ERK pathway plays a role in the activation of target promoters by MIZ-1. ..
  7. Huang A, Rubin G. A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics. 2000;156:1219-30 pubmed
    ..We discuss the utility of gain-of-function screens in identifying new components of signaling pathways in Drosophila. ..
  8. Chen R, Thorner J. Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics. 2010;185:855-70 pubmed publisher
    ..Thus, although there are similarities between haploids and diploids, cell type-specific differences clearly alter the balance of the signaling inputs required to elicit the various nutrient limitation-evoked cellular behaviors. ..
  9. O RIORDAN M, Yi C, Gonzales R, Lee K, Portnoy D. Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc Natl Acad Sci U S A. 2002;99:13861-6 pubmed
    ..Our studies suggest that infection by intracellular bacterial pathogens results in an immune response distinct from that of infection by extracellular bacterial pathogens. ..