Experts and Doctors on mice in South San Francisco, California, United States

Summary

Locale: South San Francisco, California, United States
Topic: mice

Top Publications

  1. Riedel H. Epidermal growth factor (EGF) modulation of feline sarcoma virus fms tyrosine kinase activity, internalization, degradation, and transforming potential in an EGF receptor/v-fms chimera. J Virol. 1994;68:411-24 pubmed
    ..Despite its ligand-inducible kinase activity, EFR was partly EGF independent in mediating mitogenesis and cell transformation, while ESR appeared biologically inactive...
  2. Westlund B, Parry D, Clover R, Basson M, Johnson C. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Proc Natl Acad Sci U S A. 1999;96:2497-502 pubmed
    ..Thus SEL-12 and HOP-1 appear to function redundantly in promoting Notch-pathway signaling. Phenotypic analyses of hop-1 and sel-12 single and double mutant animals suggest that sel-12 provides more presenilin function than does hop-1. ..
  3. Grewal I, Foellmer H, Grewal K, Wang H, Lee W, Tumas D, et al. CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis. Immunity. 2001;14:291-302 pubmed
  4. Sun L, Liang C, Shirazian S, Zhou Y, Miller T, Cui J, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor t. J Med Chem. 2003;46:1116-9 pubmed
    ..12b is currently in phase I clinical trials for the treatment of cancers. ..
  5. Kong Beltran M, Seshagiri S, Zha J, Zhu W, Bhawe K, Mendoza N, et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 2006;66:283-9 pubmed
  6. Tejada M, Yu L, Dong J, Jung K, Meng G, Peale F, et al. Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Clin Cancer Res. 2006;12:2676-88 pubmed
    ..We propose that therapies targeting this stromal cell type may be effective in treating certain types of solid tumors. ..
  7. Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006;319:998-1008 pubmed
    ..Collectively, the results show R406 potential for modulating Syk activity in human disease...
  8. Choo E, Driscoll J, Feng J, Liederer B, Plise E, Randolph N, et al. Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species. Xenobiotica. 2009;39:700-9 pubmed publisher
    ..5. Based on assessment in dogs, the absorption of GDC-0879 appeared to be sensitive to changes in gut pH, food and salt form (solubililty), with approximately three- to four-fold change in areas under the curve (AUCs) observed. ..
  9. COLLARINI E, Lee F, Foord O, Park M, Sperinde G, Wu H, et al. Potent high-affinity antibodies for treatment and prophylaxis of respiratory syncytial virus derived from B cells of infected patients. J Immunol. 2009;183:6338-45 pubmed publisher
    ..The combination of activity in mouse models for both prophylaxis and treatment makes these high-affinity human-derived Abs promising candidates for human clinical testing. ..

More Information

Publications411 found, 100 shown here

  1. Du X, Kim Y, Lai S, Chen X, Lizarzaburu M, Turcotte S, et al. Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes. Bioorg Med Chem Lett. 2012;22:6218-23 pubmed publisher
    ..Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels. ..
  2. Strop P, Liu S, Dorywalska M, Delaria K, Dushin R, Tran T, et al. Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chem Biol. 2013;20:161-7 pubmed publisher
    ..With this method, it is possible to produce homogeneous ADCs and tune their properties to maximize the therapeutic window. ..
  3. Lawrence M, Huber W, Pagès H, Aboyoun P, Carlson M, Gentleman R, et al. Software for computing and annotating genomic ranges. PLoS Comput Biol. 2013;9:e1003118 pubmed publisher
    ..This infrastructure directly supports more than 80 other Bioconductor packages, including those for sequence analysis, differential expression analysis and visualization. ..
  4. Desnoyers L, Arnott D, Pennica D. WISP-1 binds to decorin and biglycan. J Biol Chem. 2001;276:47599-607 pubmed
    ..We propose that this specific interaction plays a role in the regulation of WISP-1 function. ..
  5. Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, et al. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp Cell Res. 2005;306:128-41 pubmed
    ..A therapeutic antibody strategy aimed at B7-H4 could offer an exciting opportunity to inhibit the growth and progression of human ovarian and breast cancers. ..
  6. Li B, Simmons A, Du T, Lin C, Moskalenko M, Gonzalez Edick M, et al. Allogeneic GM-CSF-secreting tumor cell immunotherapies generate potent anti-tumor responses comparable to autologous tumor cell immunotherapies. Clin Immunol. 2009;133:184-97 pubmed publisher
  7. Armstrong S, Campbell C, Richardson C, Vickery R, Tsuruda P, Long D, et al. The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:471-8 pubmed publisher
    ..The data from these studies support the clinical development of TD-1211 as a novel treatment for opioid-induced GI dysfunction. ..
  8. Dowbenko D, Diep A, Taylor B, Lusis A, Lasky L. Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons. Genomics. 1991;9:270-7 pubmed
  9. Carver Moore K, Broxmeyer H, Luoh S, Cooper S, Peng J, Burstein S, et al. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood. 1996;88:803-8 pubmed
    ..Furthermore, the megakaryocytopoietic activity of other cytokines in the absence of a functional TPO or c-mpl gene was shown both in vitro and in vivo. ..
  10. Rothe M, Xiong J, Shu H, Williamson K, Goddard A, Goeddel D. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci U S A. 1996;93:8241-6 pubmed
    ..Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state. ..
  11. Leong K, Wang B, Johnson L, Gao W. Generation of a prostate from a single adult stem cell. Nature. 2008;456:804-8 pubmed publisher
    ..Our data establish that single cells in the adult mouse prostate with multipotent, self-renewal capacity are defined by a Lin(-)Sca-1(+)CD133(+)CD44(+)CD117(+) phenotype. ..
  12. Lewis Phillips G, Li G, Dugger D, Crocker L, Parsons K, Mai E, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 2008;68:9280-90 pubmed publisher
  13. Salphati L, Plise E, Li G. Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513. Eur J Pharm Sci. 2009;37:463-8 pubmed publisher
    ..The ER could be significantly reduced with the addition of inhibitors of P-gp (GF120918), BCRP (FTC), and MRP2 (MK571), confirming the activity of these transporters in the LS513 cells...
  14. Mukherjee A, Badal Y, Nguyen X, Miller J, Chenna A, Tahir H, et al. Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins. PLoS ONE. 2011;6:e16443 pubmed publisher
    ..This assay system is capable of quantitatively measuring therapeutically relevant responses and enables molecular profiling of receptor networks in both preclinical and tumor models. ..
  15. Liu L, Halladay J, Shin Y, Wong S, Coraggio M, La H, et al. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor. Drug Metab Dispos. 2011;39:1840-9 pubmed publisher
    ..In contrast, the Michaelis-Menten constant (K(m)) was comparable among species. Intrinsic clearance (V(max)/K(m)) of GDC-0834 from M1 formation in human was 23- to 169-fold higher than observed in rat, dog, and monkey. ..
  16. Hötzel I, Chiang V, Diao J, Pantua H, Maun H, Kapadia S. Efficient production of antibodies against a mammalian integral membrane protein by phage display. Protein Eng Des Sel. 2011;24:679-89 pubmed publisher
    ..The use of baculovirus particles as a source of mammalian multispan protein facilitates the application of phage display to this difficult class of proteins. ..
  17. French D, Lin B, Wang M, Adams C, Shek T, Hotzel K, et al. Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models. PLoS ONE. 2012;7:e36713 pubmed publisher
    ..These findings suggest a modulatory role for FGFR4 in the development and progression of hepatocellular carcinoma and that FGFR4 may be an important and novel therapeutic target in treating this disease. ..
  18. Lipari M, Li W, Moran P, Kong Beltran M, Sai T, Lai J, et al. Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels. J Biol Chem. 2012;287:43482-91 pubmed publisher
    ..Therapeutic anti-PCSK9 approaches that neutralize both forms should be the most effective in preserving LDL receptors and in lowering plasma LDL cholesterol. ..
  19. Wang X, Magnuson S, Pastor R, Fan E, Hu H, Tsui V, et al. Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. Bioorg Med Chem Lett. 2013;23:3149-53 pubmed publisher
    ..Compound 17 is a novel lead with low picomolar potency on all three Pim kinase isoforms. ..
  20. Fielder P, Gurney A, Stefanich E, Marian M, Moore M, Carver Moore K, et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood. 1996;87:2154-61 pubmed
    ..These data provide evidence that platelets regulate plasma TPO levels via binding to the c-mpl receptor on circulating platelets. ..
  21. Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, et al. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. J Cell Biol. 1997;138:845-60 pubmed
    ..pombe results in a dominant-negative inhibition of cytokinesis. PSTPIP is therefore a novel actin-associated protein, potentially involved with cytokinesis, whose tyrosine phosphorylation is regulated by PTP HSCF. ..
  22. Wu Y, Dowbenko D, Pisabarro M, Dillard Telm L, Koeppen H, Lasky L. PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase. J Biol Chem. 2001;276:21745-53 pubmed
    ..Together, these data suggest that PTEN 2 is a Golgi-localized, testis-specific phospholipid phosphatase, which may contribute to the terminal stages of spermatocyte differentiation. ..
  23. Ye W, Bouchard M, Stone D, Liu X, Vella F, Lee J, et al. Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nat Neurosci. 2001;4:1175-81 pubmed
    ..Our results indicate that the expression of local organizing factors is controlled by combinatorial interaction between inductive and modulatory factors. ..
  24. Tang T, Dowbenko D, Jackson A, Toney L, Lewin D, Dent A, et al. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J Biol Chem. 2002;277:14255-65 pubmed
    ..Finally, macrophages isolated from BCL-6-/- mice show enhanced survival in vitro. These results suggest that AFX regulates apoptosis in part by suppressing the levels of anti-apoptotic BCL-XL through the transcriptional repressor BCL-6. ..
  25. Marik J, Ogasawara A, Martin McNulty B, Ross J, Flores J, Gill H, et al. PET of glial metabolism using 2-18F-fluoroacetate. J Nucl Med. 2009;50:982-90 pubmed publisher
    ..Our data support the further evaluation of (18)F-FAC PET for the assessment of glial cell metabolism associated with neuroinflammation. ..
  26. Chiang E, Kolumam G, Yu X, Francesco M, Ivelja S, Peng I, et al. Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease. Nat Med. 2009;15:766-73 pubmed publisher
    ..These data indicate that depleting LT-alpha-expressing lymphocytes with LT-alpha-specific mAb may be beneficial in the treatment of autoimmune disease. ..
  27. Jumbe N, Xin Y, Leipold D, Crocker L, Dugger D, Mai E, et al. Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice. J Pharmacokinet Pharmacodyn. 2010;37:221-42 pubmed publisher
  28. Junttila T, Parsons K, Olsson C, Lu Y, Xin Y, Theriault J, et al. Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res. 2010;70:4481-9 pubmed publisher
    ..Our results show that afucosylated trastuzumab has superior efficacy in treating in vivo models of HER2-amplified breast cancer and support the development of effector function-enhanced antibodies for solid tumor therapy. ..
  29. DeVay R, Shelton D, Liang H. Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2). J Biol Chem. 2013;288:10805-18 pubmed publisher
  30. Erickson S, de Sauvage F, Kikly K, Carver Moore K, Pitts Meek S, Gillett N, et al. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature. 1994;372:560-3 pubmed
    ..Additionally, such mice injected subcutaneously with TNF show a dramatic decrease in tissue necrosis, indicating that this receptor plays a role in the necrotic effects of TNF. ..
  31. Gerlai R, McNamara A, Choi Lundberg D, Armanini M, Ross J, Powell Braxton L, et al. Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation. Eur J Neurosci. 2001;14:1153-63 pubmed
    ..These results suggest that endogenous GDNF may not be critical for the development and functioning of the nigrostriatal dopaminergic system but it plays an important role in cognitive abilities. ..
  32. Gross M, Clements J, Beckett R, Thomas W, Taylor S, Lofland D, et al. Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor. J Antimicrob Chemother. 2004;53:487-93 pubmed
    ..pneumoniae in vitro, was the first compound of this class to be profiled for oral pharmacokinetics and tissue disposition and to demonstrate oral anti-pneumococcal efficacy in mice. ..
  33. Hu Y, Leo C, Yu S, Huang B, Wang H, Shen M, et al. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J Biol Chem. 2004;279:54387-97 pubmed
    ..Taken together, these results suggest that hMINK beta plays an important role in cytoskeleton reorganization, cell adhesion, and cell motility. ..
  34. Jubb A, Zhong F, Bheddah S, Grabsch H, Frantz G, Mueller W, et al. EphB2 is a prognostic factor in colorectal cancer. Clin Cancer Res. 2005;11:5181-7 pubmed
    ..18 to 0.95 (P = 0.035). In summary, EphB2 is expressed in normal crypts, colorectal adenomas, primary cancers, and metastases. High levels of EphB2 expression are associated with a longer mean duration of survival in colorectal cancer. ..
  35. Anandan S, Webb H, Chen D, Wang Y, Aavula B, Cases S, et al. 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg Med Chem Lett. 2011;21:983-8 pubmed publisher
    ..These effects were dose-dependent and well correlated with inhibition of the sEH activity in whole blood, consistent with a role of sEH in the observed pharmacology in rodents. ..
  36. Kamath A, Lu D, Gupta P, Jin D, Xiang H, Wong A, et al. Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose. Cancer Chemother Pharmacol. 2012;69:1063-9 pubmed publisher
    ..The nonspecific clearance in monkey was approximately twofold higher than typical humanized IgG1 antibodies. The projected human efficacious dose and dose regimen appear to be achievable in patients. ..
  37. Lu G, Deguzman F, Hollenbach S, Karbarz M, Abe K, Lee G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19:446-51 pubmed publisher
    ..r-Antidote has the potential to be used as a universal antidote for a broad range of fXa inhibitors. ..
  38. Austin T, Solar G, Ziegler F, Liem L, Matthews W. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood. 1997;89:3624-35 pubmed
    ..We conclude that WNTs stimulate the survival/proliferation of hematopoietic progenitors, demonstrating that WNTs comprise a novel class of hematopoietic cell regulators. ..
  39. Cacalano G, Farinas I, Wang L, Hagler K, Forgie A, Moore M, et al. GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron. 1998;21:53-62 pubmed
  40. Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, et al. BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease. Neurobiol Aging. 2008;29:861-73 pubmed
    ..These results suggest that while excess Abeta is functionally pathological, BACE1-mediated processing of APP and other substrates play a role in "normal" learning, memory and sensorimotor processes. ..
  41. van der Horst E, Frank B, Chinn L, Coxon A, Li S, Polesso F, et al. The growth factor Midkine antagonizes VEGF signaling in vitro and in vivo. Neoplasia. 2008;10:340-7 pubmed
    ..Moreover, MDK downregulates VEGF-A-induced neovascularization and vascular permeability in vivo. We propose a model in which MDK is a new modulator of the VEGF-A-VEGFR-2 axis. ..
  42. Tinianow J, Gill H, Ogasawara A, Flores J, Vanderbilt A, Luis E, et al. Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET. Nucl Med Biol. 2010;37:289-97 pubmed publisher
    ..The in vitro stability and in vivo imaging properties of site-specifically radiolabeled (89)Zr-Df-thio-trastuzumab conjugates were investigated...
  43. Wu Y, Cain Hom C, Choy L, Hagenbeek T, De Leon G, Chen Y, et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 2010;464:1052-7 pubmed publisher
  44. Wong K, Valdez P, Tan C, Yeh S, Hongo J, Ouyang W. Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages. Proc Natl Acad Sci U S A. 2010;107:8712-7 pubmed publisher
    ..Resting rPMs produce higher TNF-alpha in culture. Their response to LPS, on the contrary, is dampened. Our data support an indispensible role of Tim-4 in maintaining the homeostasis of rPMs...
  45. Wang C, Morley S, Donermeyer D, Peng I, Lee W, DeVoss J, et al. Actin-bundling protein L-plastin regulates T cell activation. J Immunol. 2010;185:7487-97 pubmed publisher
    ..Thus, LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation. ..
  46. Atwal J, Chen Y, Chiu C, Mortensen D, Meilandt W, Liu Y, et al. A therapeutic antibody targeting BACE1 inhibits amyloid-? production in vivo. Sci Transl Med. 2011;3:84ra43 pubmed publisher
    ..Nevertheless, therapeutic success with anti-BACE1 will depend on improving antibody uptake into the brain. ..
  47. Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon C, Dominguez S, et al. Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations. Sci Transl Med. 2012;4:164ra161 pubmed publisher
    ..These data suggest that Ser(1292) autophosphorylation may be a useful indicator of LRRK2 kinase activity in vivo and may contribute to the cellular effects of certain PD mutations. ..
  48. Foletti D, Strop P, Shaughnessy L, Hasa Moreno A, Casas M, Russell M, et al. Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus ?-hemolysin. J Mol Biol. 2013;425:1641-54 pubmed publisher
    ..The data presented here suggest that protective antibodies directed against S. aureus molecules exist in some individuals and that such antibodies have a therapeutic potential either alone or in combination with antibiotics...
  49. Zago W, Schroeter S, Guido T, Khan K, Seubert P, Yednock T, et al. Vascular alterations in PDAPP mice after anti-A? immunotherapy: Implications for amyloid-related imaging abnormalities. Alzheimers Dement. 2013;9:S105-15 pubmed publisher
    ..The data collectively suggested a vascular amyloid clearance model of ARIA, which accounts for the currently known risk factors for the incidence of ARIA in clinical studies. ..
  50. Cen B, Xiong Y, Song J, Mahajan S, DuPont R, McEachern K, et al. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. 2014;34:2517-32 pubmed publisher
    ..These results suggest that Pim inhibitors may have an important role in the treatment of patients where MET is driving tumor biology. ..
  51. Viotti M, Foley A, Hadjantonakis A. Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..Here, we review findings that have uncovered complex cell movements within the endodermal layer, before and during gastrulation, leading to the conclusion that cells from primitive endoderm contribute descendants directly to gut. ..
  52. Jubb A, Chalasani S, Frantz G, Smits R, Grabsch H, Kavi V, et al. Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia. Oncogene. 2006;25:3445-57 pubmed
    ..0008) and apcmin/+ tumours. Preliminary in vitro data suggest ascl2 may promote progression through the G2/M cell cycle checkpoint. In summary, ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia. ..
  53. Bahjat F, Pine P, Reitsma A, Cassafer G, Baluom M, Grillo S, et al. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum. 2008;58:1433-44 pubmed publisher
    ..These data suggest that Syk inhibitors may be of therapeutic benefit in human lupus and related disorders. ..
  54. Liang J, Labadie S, Zhang B, Ortwine D, Patel S, Vinogradova M, et al. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg Med Chem Lett. 2017;27:2974-2981 pubmed publisher
    ..96?M), meeting our criteria for an in vivo tool compound from a new scaffold. ..
  55. Yednock T, Cannon C, Vandevert C, Goldbach E, Shaw G, Ellis D, et al. Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand. J Biol Chem. 1995;270:28740-50 pubmed
    ..These studies provide insight into how cells maintain different constitutive levels of alpha 4 beta 1 integrin activity, and how the activity of beta 1 integrin can be modulated by activators of cell adhesion. ..
  56. Gao W, Zheng J, Karihaloo M. Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation. J Neurosci. 1995;15:2656-67 pubmed
    ..Since no additive effects were seen with the combination of NT-4/5 and BDNF, it seems likely that the two neurotrophins activate the same receptor trkB for signal transduction. ..
  57. Dalton D, Pitts Meek S, Keshav S, Figari I, Bradley A, Stewart T. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 1993;259:1739-42 pubmed
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system. ..
  58. Hoey T, Grusby M. STATs as mediators of cytokine-induced responses. Adv Immunol. 1999;71:145-62 pubmed
  59. Fuh G, Garcia K, de Vos A. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. J Biol Chem. 2000;275:26690-5 pubmed
    ..Furthermore, Flt-1 may function as a negative regulator of angiogenesis by competing for NP-1. ..
  60. van der Horst E, Degenhardt Y, Strelow A, Slavin A, Chinn L, Orf J, et al. Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc Natl Acad Sci U S A. 2005;102:15901-6 pubmed
    ..Taken together, this study supports a theory from Bernards and Weinberg [Bernards, R. & Weinberg, R. A. (2002) Nature 418, 823], which postulates that the tendency to metastasize is largely predetermined. ..
  61. Ernst J, Li H, Kim H, Nakamura G, Yansura D, Vandlen R. Isolation and characterization of the B-cell marker CD20. Biochemistry. 2005;44:15150-8 pubmed
    ..Such cross-linking may play a role in partitioning CD20 into lipid rafts and in enhancing antibody-dependent B-cell depletion activities of rituximab and other therapeutic anti-CD20 antibodies. ..
  62. Wallin J, Guan J, Prior W, Edgar K, Kassees R, Sampath D, et al. Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer. Sci Transl Med. 2010;2:48ra66 pubmed publisher
    ..These studies predict that clinical use of combination therapies with GDC-0941 in addition to DNA-damaging agents will be effective in tumors that rely on the PI3K pathway for survival. ..
  63. Wertz I, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson D, et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature. 2011;471:110-4 pubmed publisher
    ..Our findings suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics. ..
  64. Pastuskovas C, Mundo E, Williams S, Nayak T, Ho J, Ulufatu S, et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol Cancer Ther. 2012;11:752-62 pubmed publisher
    ..These findings may ultimately help inform dosing strategies to achieve improved clinical outcomes. ..
  65. Lin D, Guo Q, Luo J, Zhang J, Nguyen K, Chen M, et al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol. 2012;82:843-59 pubmed publisher
    ..These ligands with their high potencies and strong positive functional cooperativity with endogenous fatty acids, demonstrated in vitro and in vivo, have the potential to deliver therapeutic benefits. ..
  66. Kozak K, Wang J, Lye M, Chuh J, Takkar R, Kim N, et al. Micro-volume wall-less immunoassays using patterned planar plates. Lab Chip. 2013;13:1342-50 pubmed publisher
    ..PPPs therefore represent an attractive and broadly applicable approach to flexible miniaturization of plate-based immunochemical assays. ..
  67. Meunier E, Dick M, Dreier R, Schürmann N, Kenzelmann Broz D, Warming S, et al. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014;509:366-70 pubmed publisher
    ..These results indicate that host-mediated lysis of pathogen-containing vacuoles is an essential immune function and is necessary for efficient recognition of pathogens by inflammasome complexes in the cytosol. ..
  68. Shalek A, Satija R, Shuga J, Trombetta J, Gennert D, Lu D, et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature. 2014;510:363-9 pubmed publisher
    ..Our study highlights the importance of cell-to-cell communication in controlling cellular heterogeneity and reveals general strategies that multicellular populations can use to establish complex dynamic responses. ..
  69. Mark M, Scadden D, Wang Z, Gu Q, Goddard A, Godowski P. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem. 1994;269:10720-8 pubmed
    ..The gene for rse was localized to human chromosome 15. ..
  70. Zeigler F, Bennett B, Jordan C, Spencer S, Baumhueter S, Carroll K, et al. Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells. Blood. 1994;84:2422-30 pubmed
    ..These studies serve to further illustrate the importance of the flk-2/flt-3 receptor in the regulation of the hematopoietic stem cell. ..
  71. LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard Telm L, et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature. 2001;412:877-84 pubmed
    ..EG-VEGF is an example of a class of highly specific mitogens that act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner. ..
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