Genomes and Genes
Experts and Doctors on mice in Novato, California, United States
Locale: Novato, California, United States
- Sun Y, Jin K, Childs J, Xie L, Mao X, Greenberg D. Neuronal nitric oxide synthase and ischemia-induced neurogenesis. J Cereb Blood Flow Metab. 2005;25:485-92 pubmed..Selective inhibition of neuronal NO synthase may have the potential to both reduce infarct size and enhance neurogenesis in stroke. ..
- Sousa Victor P, Gutarra S, García Prat L, Rodriguez Ubreva J, Ortet L, Ruiz Bonilla V, et al. Geriatric muscle stem cells switch reversible quiescence into senescence. Nature. 2014;506:316-21 pubmed publisher..As p16(INK4a) is dysregulated in human geriatric satellite cells, these findings provide the basis for stem-cell rejuvenation in sarcopenic muscles. ..
- Lee D, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal M, et al. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J Biol Chem. 2009;284:29065-76 pubmed publisher
- Zhang J, Gorostiza O, Tang H, Bredesen D, Galvan V. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res. 2010;206:202-7 pubmed publisher..Our results suggest that early experience reduces the contribution of non-cognitive components of behaviour to performance, and may contribute to the restoration of learning at later ages in PDAPP(D664A) mice. ..
- Kaur D, Rajagopalan S, Chinta S, Kumar J, Di Monte D, Cherny R, et al. Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Brain Res. 2007;1140:188-94 pubmed..This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases. ..
- Lucanic M, Lithgow G, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013;12:445-58 pubmed publisher..Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies. ..
- Khan A, Wang Y, Sun Y, Mao X, Xie L, Miles E, et al. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A. 2006;103:17944-8 pubmed..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms. ..
- Neves J, Zhu J, Sousa Victor P, Konjikusic M, Riley R, Chew S, et al. Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science. 2016;353:aaf3646 pubmed publisher..Thus, immune modulation is required during tissue repair and regeneration. This approach may improve the efficacy of stem-cell-based regenerative therapies. ..
- Stoka V, Turk V, Bredesen D. Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett. 2006;580:3739-45 pubmed..These results suggest that a decrease in apoptosis activation during ageing is not tissue-specific, but rather displays a complex dependence on species and strains of animals. ..
- Calder R, Beems R, van Steeg H, Mian I, Lohman P, Vijg J. MPHASYS: a mouse phenotype analysis system. BMC Bioinformatics. 2007;8:183 pubmed..It provides a framework for developing data analysis applications, and tools for collecting and distributing high-quality data. The software is platform independent and freely available under an open-source license 1. ..
- Kurakin A, Wu S, Bredesen D. Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening. J Biol Chem. 2003;278:34102-9 pubmed..A direct interaction of synaptojanin 1 and PAK2 with CIN85 SH3 domains was confirmed by Far Western blotting. ..
- Stoka V, Turk V, Bredesen D. Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med. 2007;9:255-63 pubmed..These results indicate that the activation pattern of the intrinsic pathway of apoptosis undergoes a marked shift during postnatal maturation. ..
- Khan A, Mao X, Banwait S, Jin K, Greenberg D. Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc Natl Acad Sci U S A. 2007;104:19114-9 pubmed
- Miller J, Holcomb J, Al Ramahi I, de Haro M, Gafni J, Zhang N, et al. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 2010;67:199-212 pubmed publisher..Correspondingly, MMPs are activated in HD mouse models, and loss of function of Drosophila homologs of MMPs suppresses Htt-induced neuronal dysfunction in vivo. ..
- Parmentier Batteur S, Jin K, Mao X, Xie L, Greenberg D. Increased severity of stroke in CB1 cannabinoid receptor knock-out mice. J Neurosci. 2002;22:9771-5 pubmed
- Gafni J, Papanikolaou T, DeGiacomo F, Holcomb J, Chen S, Menalled L, et al. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. J Neurosci. 2012;32:7454-65 pubmed publisher..However, our studies do suggest a role for caspase-6 activity in clearance pathways for mHtt protein. ..
- Peng J, Andersen J. Mutant ?-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Aging Cell. 2011;10:255-62 pubmed publisher..This could provide a novel therapeutic target for chronic brain repair in this condition...
- Golden T, Hubbard A, Morten K, Hinerfeld D, Melov S. Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. Free Radic Biol Med. 2005;39:152-63 pubmed..The normalization of expression of some of these pathways by antioxidant treatment suggests approaches to treating disease in which endogenous oxidative stress plays a role. ..
- Siddiqui A, Mallajosyula J, Rane A, Andersen J. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiol Dis. 2010;40:444-8 pubmed publisher..This has implications for early intervention therapies. ..
- Kaminker P, Kim S, Desprez P, Campisi J. A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle. 2009;8:931-9 pubmed..Our results suggest a dual role for TIN2 in mediating the function of the shelterin complex and tethering telomeres to the nuclear matrix. ..
- Siddiqui A, Chinta S, Mallajosyula J, Rajagopolan S, Hanson I, Rane A, et al. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. 2012;53:993-1003 pubmed publisher..This represents a novel role for alpha-synuclein as it relates to mitochondrial dysfunction in PD. ..
- Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld M, Hook V. Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. J Neurochem. 2003;86:556-63 pubmed..Overall, these studies demonstrated that the PC2 processing enzyme is critical for the in vivo production of alpha-MSH in pituitary and brain. ..
- Sarantos M, Papanikolaou T, Ellerby L, Hughes R. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. J Huntingtons Dis. 2012;1:195-210 pubmed publisher..Huntington's disease (HD) is a dominantly inherited neurodegenerative condition characterized by dysfunction in striatal and cortical neurons. There are currently no approved drugs known to slow the progression of HD...
- Rao R, Peel A, Logvinova A, Del Rio G, Hermel E, Yokota T, et al. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002;514:122-8 pubmed..These results define a novel protective role for GRP78 in preventing ER stress-induced cell death. ..
- Duncan C, An M, Papanikolaou T, Rugani C, Vitelli C, Ellerby L. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Mol Neurodegener. 2013;8:42 pubmed publisher..This study implicates HDAC3 and ataxin-7 interaction as a target for therapeutic intervention in SCA7, adding to a growing list of neurodegenerative diseases that may be treated by HDAC inhibitors. ..
- Danielson S, Held J, Oo M, Riley R, Gibson B, Andersen J. Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model. J Biol Chem. 2011;286:7601-8 pubmed publisher..Three of these residues were found to reside within iron-sulfur clusters of Complex I, suggesting that their redox state may affect electron transport function. ..
- Velarde M, Flynn J, Day N, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4:3-12 pubmed..Our results support the idea that mitochondrial oxidative stress and cellular senescence contribute to aging skin phenotypes in vivo. ..
- Haines B, Demaria M, Mao X, Xie L, Campisi J, Jin K, et al. Hypoxia-inducible factor-1 and neuroglobin expression. Neurosci Lett. 2012;514:137-40 pubmed publisher..These findings may have implications for understanding the hypoxia-response repertoire of neural cells and devising therapeutic strategies for neurologic disorders. ..
- Agrawal P, Chen Y, Schilling B, Gibson B, Hughes R. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem. 2012;287:21164-75 pubmed publisher..Taken together, our data describe the identification of the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR activity and skeletal muscle differentiation. ..
- Miller J, Yates B, Al Ramahi I, Berman A, Sanhueza M, Kim E, et al. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. PLoS Genet. 2012;8:e1003042 pubmed publisher..These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease. ..
- Swistowska A, da Cruz A, Han Y, Swistowski A, Liu Y, Shin S, et al. Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells. Stem Cells Dev. 2010;19:71-82 pubmed publisher..We conclude that PA6-CM can induce dopaminergic differentiation in hESCs in a stage-specific manner. Shh is likely an important soluble dopaminergic inducing factor secreted by stromal cells and acts after the neural fate determination. ..
- Rao R, Hermel E, Castro Obregon S, del Rio G, Ellerby L, Ellerby H, et al. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem. 2001;276:33869-74 pubmed..The data underscore the involvement of ER and caspases associated with it in the ER stress-induced apoptotic process. ..
- Peel A, Bredesen D. Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol Dis. 2003;14:52-62 pubmed..These findings support a role for PKR activation in the pathogenesis of AD. ..
- Melov S, Adlard P, Morten K, Johnson F, Golden T, Hinerfeld D, et al. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS ONE. 2007;2:e536 pubmed..These findings mechanistically link mitochondrial oxidative stress with the pathological features of AD. ..
- Peel A, Rao R, Cottrell B, Hayden M, Ellerby L, Bredesen D. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Hum Mol Genet. 2001;10:1531-8 pubmed..The increased immunolocalization of the activated kinase is more pronounced in areas most affected by the disease and, coupled with the RNA binding results, suggests a role for PKR activation in the disease process. ..
- Won S, Kim S, Xie L, Wang Y, Mao X, Jin K, et al. Reelin-deficient mice show impaired neurogenesis and increased stroke size. Exp Neurol. 2006;198:250-9 pubmed..These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain. ..
- Sun Y, Jin K, Childs J, Xie L, Mao X, Greenberg D. Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. J Cereb Blood Flow Metab. 2004;24:1146-52 pubmed..VegfB also protected cultured cerebral cortical neurons from hypoxic injury, suggesting that its protective action is mediated at least in part through a direct effect on neurons. ..
- Jin K, Lafevre Bernt M, Sun Y, Chen S, Gafni J, Crippen D, et al. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A. 2005;102:18189-94 pubmed..We conclude that FGF-2 improves neurological deficits and longevity in a transgenic mouse model of HD, and that its neuroprotective and neuroproliferative effects may contribute to this improvement. ..
- Schilling B, Murray J, Yoo C, Row R, Cusack M, Capaldi R, et al. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Biochim Biophys Acta. 2006;1762:213-22 pubmed..The identification of several posttranslational modifications, including the covalent FAD modification of flavoprotein subunit 1 from Complex II, was possible due to high mass spectrometric sequence coverage. ..
- Greenberg D. The jaundice of the cell. Proc Natl Acad Sci U S A. 2002;99:15837-9 pubmed
- Parmentier Batteur S, Jin K, Xie L, Mao X, Greenberg D. DNA microarray analysis of cannabinoid signaling in mouse brain in vivo. Mol Pharmacol. 2002;62:828-35 pubmed..These findings suggest that MRG1 and GK are cannabinoid-regulated genes and that they may be involved in the vascular and hypothalamic effects of cannabinoids, respectively. ..
- Flynn J, Czerwieniec G, Choi S, Day N, Gibson B, Hubbard A, et al. Proteogenomics of synaptosomal mitochondrial oxidative stress. Free Radic Biol Med. 2012;53:1048-60 pubmed publisher..As a result of using these approaches, we report for the first time an activation of the mTOR pathway in synaptosomes isolated from Sod2 null mice, confirmed by an upregulation of the phosphorylation of 4E-BP1. ..
- Hermel E, Gafni J, Propp S, Leavitt B, Wellington C, Young J, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 2004;11:424-38 pubmed..These data support the involvement of caspase-2 in the selective neuronal cell death associated with HD in the striatum and cortex. ..
- Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, et al. The small co-chaperone p23 overexpressing transgenic mouse. J Neurosci Methods. 2013;212:190-4 pubmed publisher..These mice should prove useful for studying the role of p23 and/or uncleavable p23 in cellular stress-induced cell death. ..
- Jin K, Zhu Y, Sun Y, Mao X, Xie L, Greenberg D. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A. 2002;99:11946-50 pubmed..Cells labeled with BrdUrd after VEGF treatment in vivo include immature and mature neurons, astroglia, and endothelial cells. These findings implicate the angiogenesis factor VEGF in neurogenesis as well. ..
- Melov S, Doctrow S, Schneider J, Haberson J, Patel M, Coskun P, et al. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci. 2001;21:8348-53 pubmed
- Zhang Y, Bharathi S, Rardin M, Uppala R, Verdin E, Gibson B, et al. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase. PLoS ONE. 2015;10:e0122297 pubmed publisher..Regulation of cardiolipin binding by reversible lysine acylation is a novel mechanism that is predicted to extrapolate to other metabolic proteins that localize to the inner mitochondrial membrane. ..
- Wiley C, Velarde M, Lecot P, Liu S, Sarnoski E, Freund A, et al. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab. 2016;23:303-14 pubmed publisher..Our data identify a distinct senescence response and provide a mechanism by which mitochondrial dysfunction can drive aging phenotypes. ..
- Jin K, Graham S, Mao X, He X, Nagayama T, Simon R, et al. Bax kappa, a novel Bax splice variant from ischemic rat brain lacking an ART domain, promotes neuronal cell death. J Neurochem. 2001;77:1508-19 pubmed..Moreover, co-overexpression of Bax kappa and Bax alpha increased HN33 cell death. The results suggest that the Bax kappa may have a role in ischemic neuronal death. ..
- Miller R, Toneff T, Vishnuvardhan D, Beinfeld M, Hook V. Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice. Neuropeptides. 2003;37:140-8 pubmed..These results demonstrate the selective role of PC2 in neuropeptide production that provides active peptide neurotransmitter or hormones for biological functions in brain and neuroendocrine systems. ..
- Yasothornsrikul S, Greenbaum D, Medzihradszky K, Toneff T, Bundey R, Miller R, et al. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003;100:9590-5 pubmed..These findings indicate a previously uncharacterized biological role for secretory vesicle cathepsin L in the production of [Met]enkephalin, an endogenous peptide neurotransmitter. ..
- Chinta S, Rane A, Yadava N, Andersen J, Nicholls D, Polster B. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med. 2009;46:939-47 pubmed..These findings raise the important possibility that complex I contributes less to physiological ROS production by brain mitochondria than previously suggested. ..
- Boonplueang R, Akopian G, Stevenson F, Kuhlenkamp J, Lu S, Walsh J, et al. Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death. Exp Neurol. 2005;192:203-14 pubmed..This could be due to alterations in the redox state of the glutathione system resulting in elevated glutathione disulfide (GSSG) levels which, in turn, may directly activate NMDA receptors or enhanced response of the NMDA receptor. ..
- Jin K, Mao X, Del Rio Guerra G, Jin L, Greenberg D. Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase. J Neurosci Res. 2005;81:497-505 pubmed..These findings help to clarify the molecular mechanisms through which HB-EGF operates. ..
- Jin K, Mao X, Greenberg D. Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling. J Neurobiol. 2006;66:236-42 pubmed..We conclude that VEGF promotes neurite outgrowth from cerebral cortical neurons by interacting with VEGFR2 and activating Rho/ROK signaling pathways. ..
- Khan A, Mao X, Banwait S, DerMardirossian C, Bokoch G, Jin K, et al. Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J. 2008;22:1737-47 pubmed publisher..We link the protective actions of Ngb to inhibition of Pak1 kinase activity and Rac1-GDP-dissociation inhibitor disassociation, and inhibition of actin assembly and death-signaling module polarization. ..
- Busuttil R, Muñoz D, Garcia A, Rodier F, Kim W, Suh Y, et al. Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. PLoS ONE. 2008;3:e3458 pubmed publisher..e., in young adult animals. The observed premature aging likely results from a combination of increased cellular senescence and an increased load of stable, genome rearrangements. ..