Experts and Doctors on likelihood functions in Los Angeles, California, United States


Locale: Los Angeles, California, United States
Topic: likelihood functions

Top Publications

  1. Childs E, Palmer C, Lange K, Sinsheimer J. Modeling maternal-offspring gene-gene interactions: the extended-MFG test. Genet Epidemiol. 2010;34:512-21 pubmed publisher
  2. Faircloth B, Sorenson L, Santini F, Alfaro M. A Phylogenomic Perspective on the Radiation of Ray-Finned Fishes Based upon Targeted Sequencing of Ultraconserved Elements (UCEs). PLoS ONE. 2013;8:e65923 pubmed publisher
    ..Our approach additionally reveals that sequence capture of UCE regions and their flanking sequence offers enormous potential for resolving phylogenetic relationships within ray-finned fishes. ..
  3. Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay G, et al. Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. PLoS ONE. 2015;10:e0120020 pubmed publisher
    ..Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers. ..
  4. Carreras Torres R, Johansson M, Haycock P, Wade K, Relton C, Martin R, et al. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study. PLoS ONE. 2017;12:e0177875 pubmed publisher
    ..Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer...
  5. Koepfli K, Wayne R. Type I STS markers are more informative than cytochrome B in phylogenetic reconstruction of the Mustelidae (Mammalia: Carnivora). Syst Biol. 2003;52:571-93 pubmed
  6. Alexander D, Novembre J, Lange K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009;19:1655-64 pubmed publisher
  7. Fuller T, Gilbert M, Martin V, Cappelle J, Hosseini P, Njabo K, et al. Predicting hotspots for influenza virus reassortment. Emerg Infect Dis. 2013;19:581-8 pubmed publisher
    ..Potential geographic foci of reassortment include the northern plains of India, coastal and central provinces of China, the western Korean Peninsula and southwestern Japan in Asia, and the Nile Delta in Egypt. ..
  8. Wright F, Sullivan P, Brooks A, Zou F, Sun W, Xia K, et al. Heritability and genomics of gene expression in peripheral blood. Nat Genet. 2014;46:430-7 pubmed publisher
    ..Our results provide a new resource toward understanding the genetic control of transcription. ..
  9. Zhang M, Yang L, Ren J, Ahlgren N, Fuhrman J, Sun F. Prediction of virus-host infectious association by supervised learning methods. BMC Bioinformatics. 2017;18:60 pubmed publisher
    ..The maximum likelihood approach can be used to estimate the fraction of true infectious associated viruses in viral tagging experiments. ..

More Information


  1. Padhukasahasram B, Wall J, Marjoram P, Nordborg M. Estimating recombination rates from single-nucleotide polymorphisms using summary statistics. Genetics. 2006;174:1517-28 pubmed
    ..We used our method to analyze a human data set recently genotyped by Perlegen Sciences. ..
  2. Langholz B, Skolnik J, Barrett J, Renbarger J, Seibel N, Zajicek A, et al. Dactinomycin and vincristine toxicity in the treatment of childhood cancer: a retrospective study from the Children's Oncology Group. Pediatr Blood Cancer. 2011;57:252-7 pubmed publisher
    ..Current dosing practices result in a fairly uniform toxicity profile within age group. However, PK/PD studies should be done to provide further provide further information on best dosing guidelines. ..
  3. Alexander D, Lange K. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics. 2011;12:246 pubmed publisher
    ..Finally, by exploiting multiple processors, large datasets can be analyzed even more rapidly. The enhancements we have described make ADMIXTURE a more accurate, efficient, and versatile tool for ancestry estimation. ..
  4. Xia L, Cram J, Chen T, Fuhrman J, Sun F. Accurate genome relative abundance estimation based on shotgun metagenomic reads. PLoS ONE. 2011;6:e27992 pubmed publisher
    ..It will be increasingly useful as an accurate and robust tool for abundance estimation with the growing size of read sets and the expanding database of reference genomes. ..