Experts and Doctors on humans in San Francisco, California, United States

Summary

Locale: San Francisco, California, United States
Topic: humans

Top Publications

  1. Gum J, Byrd J, Hicks J, Toribara N, Lamport D, Kim Y. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem. 1989;264:6480-7 pubmed
    ..These findings may be important in assessing the abnormal mucins found associated with several human diseases. ..
  2. Wang D, Donner D, Warren R. Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF. J Biol Chem. 2000;275:15905-11 pubmed
  3. Sabbatini P, McCormick F. MDMX inhibits the p300/CBP-mediated acetylation of p53. DNA Cell Biol. 2002;21:519-25 pubmed
    ..These results may have important biologic implications with respect to the MDMX-mediated regulation of p53 activity during development. ..
  4. Tanaka Y, Sasaki M, Kaneuchi M, Shiina H, Igawa M, Dahiya R. Polymorphisms of estrogen receptor alpha in prostate cancer. Mol Carcinog. 2003;37:202-8 pubmed
    ..The present study suggests that polymorphism in codon 10 of ERalpha may be a risk factor for prostate cancer. These results are important in understanding the role of ERalpha polymorphism in the pathogenesis of prostate cancer. ..
  5. Yamamoto Tabata T, McDonagh S, Chang H, Fisher S, Pereira L. Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro. J Virol. 2004;78:2831-40 pubmed
    ..Reduced MMP activity early in placental development could impair cytotrophoblast remodeling of the uterine vasculature and eventually restrict fetal growth in affected pregnancies. ..
  6. Ewart Toland A, Balmain A. The genetics of cancer susceptibility: from mouse to man. Toxicol Pathol. 2004;32 Suppl 1:26-30 pubmed
    ..Allelic variants in both mouse and human can then be used to better understand the mechanisms behind cancer risk and as targets for intervention. ..
  7. Macrae M, Neve R, Rodriguez Viciana P, Haqq C, Yeh J, Chen C, et al. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 2005;8:111-8 pubmed
    ..Our results suggest that an escape from the negative effects of this interaction may be important in the development of cancer. ..
  8. Tanaka Y, Sasaki M, Shiina H, Tokizane T, Deguchi M, Hirata H, et al. Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:238-44 pubmed
    ..This is the first report that shows the polymorphisms of COMT to be associated with sporadic prostatic carcinogenesis. These results are important in understanding the role of COMT polymorphisms in the pathogenesis of prostate cancer. ..
  9. Mellon S, Bair S, Depoix C, Vigne J, Hecht N, Brake P. Translin coactivates steroidogenic factor-1-stimulated transcription. Mol Endocrinol. 2007;21:89-105 pubmed
    ..Thus, we have identified a new factor that works together with SF-1 to augment gene transcription in a DNA-specific fashion. ..

More Information

Publications884 found, 100 shown here

  1. Chen A, Glantz S, Tong E. Asian herbal-tobacco cigarettes: "not medicine but less harmful"?. Tob Control. 2007;16:e3 pubmed
    ..Asia faces additional challenges in tobacco control with these culturally concordant products that may discourage smokers from quitting. ..
  2. Lin G, Garcia M, Ning H, Banie L, Guo Y, Lue T, et al. Defining stem and progenitor cells within adipose tissue. Stem Cells Dev. 2008;17:1053-63 pubmed publisher
    ..Isolated, ADSC can be induced to differentiate into additional cell types such as osteoblasts and chondrocytes. ..
  3. Tso H, Lee J, Huang J, Maki K, Hatcher D, Miller A. Evaluation of the human airway using cone-beam computerized tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:768-76 pubmed publisher
    ..The maximum constriction of the airway in 10 subjects quietly breathing for 10 seconds indicated variation in the level of the pharynx and the extent of the rostrocaudal zone of restriction. ..
  4. Johnstone E, Rosen M, Neril R, Trevithick D, Sternfeld B, Murphy R, et al. The polycystic ovary post-rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance. J Clin Endocrinol Metab. 2010;95:4965-72 pubmed publisher
    ..PCO is a common, age-dependent finding among ovulatory women. These women lack the metabolic abnormalities seen in PCO syndrome. Isolated PCO in an ovulatory woman is not an indication for metabolic evaluation. ..
  5. Fomin M, Tai L, Barcena A, Muench M. Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver. Stem Cells Dev. 2011;20:1247-57 pubmed publisher
  6. Montagu D, Yamey G, Visconti A, Harding A, Yoong J. Where do poor women in developing countries give birth? A multi-country analysis of demographic and health survey data. PLoS ONE. 2011;6:e17155 pubmed publisher
    ..In developing countries, most poor women deliver at home. This suggests that, at least in the near term, efforts to reduce maternal deaths should prioritize community-based interventions aimed at making home births safer. ..
  7. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS ONE. 2013;8:e55776 pubmed publisher
    ..HIV-suppressed coinfected subjects with controlled HIV viral load experiencing immune activation could benefit significantly from successful anti-HCV therapy and may be considered as preferential candidates. ..
  8. Lemieux G, Keiser M, Sassano M, Laggner C, Mayer F, Bainton R, et al. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013;11:e1001712 pubmed publisher
  9. Walsh K, Codd V, Smirnov I, Rice T, Decker P, Hansen H, et al. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014;46:731-5 pubmed publisher
    ..No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis. ..
  10. Lempert L, Grana R, Glantz S. The importance of product definitions in US e-cigarette laws and regulations. Tob Control. 2016;25:e44-51 pubmed publisher
  11. Jenkins J, Sakamuri S, Katz J, Forshew D, Guion L, Moore D, et al. Phrenic nerve conduction studies as a biomarker of respiratory insufficiency in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2016;17:213-20 pubmed publisher
    ..3 mV (p <0.001). In conclusion, the phrenic Pamp correlated closely with multiple symptoms, signs, and laboratory measures of respiratory insufficiency and may prove to be a useful biomarker of respiratory dysfunction in ALS. ..
  12. McGinley K, Sun X, Howard L, Aronson W, Terris M, Kane C, et al. Utilization and impact of surgical technique on the performance of pelvic lymph node dissection at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database. Int J Urol. 2016;23:241-6 pubmed publisher
    ..Further attention to the discrepancy between provided and guideline recommended pelvic lymph node dissection performance is required to improve prostate cancer care. ..
  13. Sprowl J, Ong S, Gibson A, Hu S, Du G, Lin W, et al. A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016;7:10880 pubmed publisher
  14. Grant W, Boucher B. Randomized controlled trials of vitamin D and cancer incidence: A modeling study. PLoS ONE. 2017;12:e0176448 pubmed publisher
  15. Chen S, Singh K, Lin S. Use of phosphodiesterase inhibitors and prevalence of self-reported glaucoma in the United States. PLoS ONE. 2017;12:e0183388 pubmed publisher
    ..Use of sildenafil and theophylline for one or more years was associated with greater prevalence of self-reported glaucoma, a finding which requires further prospective study to assess causality and possible mechanisms of action. ..
  16. Qualmann B, Roos J, DiGregorio P, Kelly R. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. Mol Biol Cell. 1999;10:501-13 pubmed
    ..These characteristics of syndapin I suggest a molecular link between cytoskeletal dynamics and synaptic vesicle recycling in the nerve terminal. ..
  17. Ahlfors C. Unbound bilirubin associated with kernicterus: a historical approach. J Pediatr. 2000;137:540-4 pubmed
    ..To determine the unbound bilirubin concentration (UBC) associated with kernicterus with the use of clinical data from clusters of kernicterus after sulfisoxazole and benzyl alcohol administration...
  18. Deeks S. International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance. J Acquir Immune Defic Syndr. 2001;26 Suppl 1:S25-33 pubmed
    ..This article describes the scientific literature establishing the efficacy and limitations of NNRTI therapy and attempts to define a role for this class of drug in the long-term treatment of HIV-1 disease. ..
  19. Komuves L, Ma X, Stelnicki E, Rozenfeld S, Oda Y, Largman C. HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. Dev Dyn. 2003;227:192-202 pubmed
    ..Expression in hyperproliferative skin conditions remained cytoplasmic with the exception of epidermis associated with Kaposi's sarcoma, which showed strong HOXB13 expression that was partially localized to the nucleus. ..
  20. Bohuslav J, Chen L, Kwon H, Mu Y, Greene W. p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem. 2004;279:26115-25 pubmed
    ..These findings highlight a rather unusual pathway of NF-kappaB activation, which is utilized by the p53 tumor suppressor. ..
  21. Schmuth M, Haqq C, Cairns W, Holder J, Dorsam S, Chang S, et al. Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol. 2004;122:971-83 pubmed
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes. ..
  22. Perez Losada J, Mao J, Balmain A. Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res. 2005;65:6488-92 pubmed
  23. Chang J, Benet L. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Mol Pharm. 2005;2:428-34 pubmed
    ..Since these cells have been previously used to study drug transport, they may be a useful tool in future studies to explore the effect of drug transporters on glucuronidation. ..
  24. Chertow G, Soroko S, Paganini E, Cho K, Himmelfarb J, Ikizler T, et al. Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int. 2006;70:1120-6 pubmed
    ..By incorporating exposures over time, the discriminatory power of predictive models in ARF can be significantly improved. ..
  25. Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer. 2007;7:295-308 pubmed
    ..Here we will discuss the implications of germline mutations in the Ras-Raf-MEK-ERK pathway for understanding normal developmental processes and cancer pathogenesis. ..
  26. Tzingounis A, Wadiche J. Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci. 2007;8:935-47 pubmed
    ..We highlight how the diversity of glutamate-transporter function relates to transporter location, density and affinity. ..
  27. Price V, Hordinsky M, Olsen E, Roberts J, Siegfried E, Rafal E, et al. Subcutaneous efalizumab is not effective in the treatment of alopecia areata. J Am Acad Dermatol. 2008;58:395-402 pubmed publisher
    ..Efalizumab was well tolerated. Numbers were too small for certain analyses. A 3- to 6-month trial of efalizumab was not effective in promoting hair regrowth in this small cohort of patients with moderate-to-severe AA. ..
  28. Stoller M, Chi T, Eisner B, Shami G, Gentle D. Changes in urinary stone risk factors in hypocitraturic calcium oxalate stone formers treated with dietary sodium supplementation. J Urol. 2009;181:1140-4 pubmed publisher
    ..We investigated the effects of supplemental dietary sodium on risk factors for urinary stone disease in stone forming patients with hypocitraturia...
  29. Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, et al. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. Clin Cancer Res. 2009;15:2488-96 pubmed publisher
    ..The aim was to study the biological and molecular effects of the histone deacetylase (HDAC) inhibitor, valproic acid, in patients with solid tumor malignancies...
  30. Silkiss R, Reier A, Coleman M, Lauer S. Rituximab for thyroid eye disease. Ophthalmic Plast Reconstr Surg. 2010;26:310-4 pubmed publisher
    ..The variable natural history of TED makes it difficult to definitively assign efficacy. The results support the continued investigation of rituximab for TED in a larger placebo-controlled trial. ..
  31. Wallace A, Au S, Cason B. Association of the pattern of use of perioperative ?-blockade and postoperative mortality. Anesthesiology. 2010;113:794-805 pubmed publisher
    ..Perioperative withdrawal of ?-blockers is associated with increased mortality. ..
  32. Mishra J, Zinni M, Bavelier D, Hillyard S. Neural basis of superior performance of action videogame players in an attention-demanding task. J Neurosci. 2011;31:992-8 pubmed publisher
  33. Zhou Y, Goenaga A, Harms B, Zou H, Lou J, Conrad F, et al. Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies. Mol Cancer Ther. 2012;11:1467-76 pubmed publisher
    ..Overall, our work indicates that higher intrinsic affinity combined with bivalent binding can achieve avidity that leads to greater in vitro potency of antibodies, which may translate into greater therapeutic efficacy. ..
  34. Webel A, Wantland D, Rose C, Kemppainen J, Holzemer W, Chen W, et al. A Cross-Sectional Relationship Between Social Capital, Self-Compassion, and Perceived HIV Symptoms. J Pain Symptom Manage. 2015;50:59-68 pubmed publisher
    ..This may be increasingly important as PLWH age. The relationship between employment status and HIV symptom experience was significant and should be explored further. ..
  35. Forero Torres A, Varley K, Abramson V, Li Y, Vaklavas C, Lin N, et al. TBCRC 019: A Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel with or without the Anti-Death Receptor 5 Monoclonal Antibody Tigatuzumab in Patients with Triple-Negative Breast Cancer. Clin Cancer Res. 2015;21:2722-9 pubmed publisher
    ..Preclinical activity of TIG in basal-like breast cancer and prolonged PFS in few patients in the combination arm support further investigation of anti-DR5 agents. ROCK pathway activation merits further evaluation. ..
  36. Chao L, Reeb R, Esparza I, Abadjian L. Associations between the self-reported frequency of hearing chemical alarms in theater and regional brain volume in Gulf War Veterans. Neurotoxicology. 2016;53:246-256 pubmed publisher
    ..Many veterans reported hearing chemical alarms sound during the Gulf War. The current findings suggest that exposure to substances that triggered those chemical alarms during the Gulf War likely had adverse neuroanatomical effects. ..
  37. Lebares C, Swanstrom L. Per-Oral Pyloromyotomy (POP): An Emerging Application of Submucosal Tunneling for the Treatment of Refractory Gastroparesis. Gastrointest Endosc Clin N Am. 2016;26:257-270 pubmed publisher
    ..Per-oral pyloromyotomy has recently been proposed as an endoscopic alternative to surgical pyloroplasty or pylormyotomy because it is less invasive by its nature and potentially more durable than current endoscopic treatments. ..
  38. Qian J, Wolters F, Beiser A, Haan M, Ikram M, Karlawish J, et al. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med. 2017;14:e1002254 pubmed publisher
  39. Keating S, Pilcher C, Jain V, Lebedeva M, Hampton D, Abdel Mohsen M, et al. HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication. J Infect Dis. 2017;216:72-81 pubmed publisher
    ..We investigated whether HIV antibody responses as measured by high-throughput quantitative and qualitative assays could be used to indirectly measure persistent HIV replication in individuals receiving antiretroviral therapy (ART)...
  40. Anwar M, Molinaro A, Morin O, Chang S, Haas Kogan D, Nelson S, et al. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017;188:303-313 pubmed publisher
    ..When combined with modern planning software, this technique may enable risk-adapted radiotherapy in any disease site with multimodal imaging. ..
  41. Chan J, Deng W, Higgins R, Tewari K, Bonebrake A, Hicks M, et al. A phase II evaluation of brivanib in the treatment of persistent or recurrent carcinoma of the cervix: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017;146:554-559 pubmed publisher
    ..Based on early results of this phase II trial, brivanib was well tolerated and demonstrated sufficient activity after first stage but trial was stopped due to lack of drug availability. ..
  42. Ng A, Dao H, Miller R, Gelinas D, Kent Braun J. Blunted pressor and intramuscular metabolic responses to voluntary isometric exercise in multiple sclerosis. J Appl Physiol (1985). 2000;88:871-80 pubmed
    ..These data suggest that the blunted pressor response to exercise in MS subjects may be largely appropriate to a blunted muscle metabolic response and differences in contracting muscle mass...
  43. Kistler A, Guthrie C. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Genes Dev. 2001;15:42-9 pubmed
    ..We propose that Sub2 functionally interacts with Mud2 both before and after PS formation. In the absence of Mud2, Sub2 function becomes dispensable. ..
  44. Zhou B, Bae S, Malone A, Levinson B, Kuo Y, Cilio M, et al. hGFRalpha-4: a new member of the GDNF receptor family and a candidate for NBIA. Pediatr Neurol. 2001;25:156-61 pubmed
    ..The implication of these findings for the relationship between this gene and Hallervorden-Spatz syndrome is discussed. ..
  45. Subak L, Waetjen L, van den Eeden S, Thom D, Vittinghoff E, Brown J. Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol. 2001;98:646-51 pubmed
    ..If all operations were reimbursed by non-Medicare sources, the annual estimated cost would increase by 52% to 1543 million dollars. The annual direct costs of operations for pelvic organ prolapse are substantial. ..
  46. Nuckton T, Goldreich D, Rogaski K, Lessani T, Higgins P, Claman D. Hypothermia from prolonged immersion: biophysical parameters of a survivor. J Emerg Med. 2002;22:371-4 pubmed
    ..0282 m(2)/L). We believe that the patient's large body habitus contributed to survival and that surface/volume ratio was likely the biophysical variable most closely associated with decreased cooling. ..
  47. Bergo M, Gavino B, Hong C, Beigneux A, McMahon M, Casey P, et al. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004;113:539-50 pubmed
    ..These studies identify Icmt as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies. ..
  48. Kido T, Lau Y. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis. 2005;42:263-75 pubmed
    ..The tissue-specific expression of the hTSPY-Cre transgene should also be useful in studies utilizing Cre-mediated gene activation/inactivation strategies in gamatogenesis and/or neurogenesis...
  49. Ganem D. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu Rev Pathol. 2006;1:273-96 pubmed
    ..The studies also highlight mechanistic differences between oncogenesis caused by KSHV and that caused by its distant relative Epstein-Barr virus...
  50. Apsel B, Blair J, Gonzalez B, Nazif T, Feldman M, Aizenstein B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008;4:691-9 pubmed publisher
    ..These molecules demonstrate the feasibility of accessing a chemical space that intersects two families of oncogenes. ..
  51. Aziz N, Cheng Y, Caughey A. Factors and outcomes associated with longer latency in preterm premature rupture of membranes. J Matern Fetal Neonatal Med. 2008;21:821-5 pubmed publisher
    ..These data can be used to counsel patients with PPROM about expected duration of latency and outcomes. ..
  52. He J, Wang Y, Feng J, Zhu X, Lan X, Iyer A, et al. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. J Nucl Med. 2010;51:427-32 pubmed publisher
  53. Rodríguez Hernández A, Lawton M. Anatomical triangles defining surgical routes to posterior inferior cerebellar artery aneurysms. J Neurosurg. 2011;114:1088-94 pubmed publisher
    ..Angiography may preoperatively localize a PICA aneurysm's triangular anatomy based on the distal PICA origin or distal aneurysm location. ..
  54. Gazdzinski S, Durazzo T, Mon A, Meyerhoff D. Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study. Alcohol Clin Exp Res. 2010;34:2089-96 pubmed publisher
  55. Moltzahn F, Olshen A, Baehner L, PEEK A, Fong L, Stoppler H, et al. Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients. Cancer Res. 2011;71:550-60 pubmed publisher
    ..These serum signatures include oncogenic and tumor-suppressive miRNAs, suggesting functional roles in prostate cancer progression. ..
  56. Saini S, Majid S, Yamamura S, Tabatabai L, Suh S, Shahryari V, et al. Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. Clin Cancer Res. 2011;17:5287-98 pubmed publisher
    ..miR-203 may be an attractive target for therapeutic intervention in advanced PCa. ..
  57. Saini S, Majid S, Shahryari V, Arora S, Yamamura S, Chang I, et al. miRNA-708 control of CD44(+) prostate cancer-initiating cells. Cancer Res. 2012;72:3618-30 pubmed publisher
    ..miR-708 therefore may represent a novel therapeutic target or diagnostic and prognostic biomarker in prostate cancer. ..
  58. Paszek M, DuFort C, Rubashkin M, Davidson M, Thorn K, LIPHARDT J, et al. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012;9:825-7 pubmed publisher
    ..We use this approach to resolve nanotopographical features of the cell membrane and cytoskeleton as well as the temporal evolution, three-dimensional architecture and nanoscale dynamics of focal adhesion complexes. ..
  59. Lu C, Luo Z, Jäger S, Krogan N, Peterlin B. Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles. J Virol. 2012;86:10517-23 pubmed publisher
    ..Thus, by interfering with reverse transcription, MOV10 inhibits IAP RTP, and this inhibition is independent of P bodies. ..
  60. Gardner B, Pincus D, Gotthardt K, Gallagher C, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013;5:a013169 pubmed publisher
    ..BiP dissociation from Ire1 regulates this oligomeric equilibrium, ultimately modulating Ire1's sensitivity and duration of activation. The mechanistic principles of ER stress sensing are the focus of this review. ..
  61. Beyeler N, York De La Cruz A, Montagu D. The impact of clinical social franchising on health services in low- and middle-income countries: a systematic review. PLoS ONE. 2013;8:e60669 pubmed publisher
  62. Chiyomaru T, Yamamura S, Fukuhara S, Yoshino H, Kinoshita T, Majid S, et al. Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS ONE. 2013;8:e70372 pubmed publisher
    ..These findings enhance understanding of how genistein regulates lncRNA HOTAIR and miR-34a in PCa. ..
  63. Bettcher B, Walsh C, Watson C, Miller J, Green R, Patel N, et al. Body mass and white matter integrity: the influence of vascular and inflammatory markers. PLoS ONE. 2013;8:e77741 pubmed publisher
    ..Results partially support a vascular/inflammatory hypothesis, but also suggest a more complex relationship between BMI and white matter characterized by potentially different neuroanatomic vulnerability. ..
  64. Chiu C. 2013 update on the management of posterior capsular rupture during cataract surgery. Curr Opin Ophthalmol. 2014;25:26-34 pubmed publisher
    ..When approached carefully and systematically, patients may have good outcomes in the setting of PCR. Recent advancements in instrumentation and technique encourage further study and may lead to new standards of care. ..
  65. McGoon M, Benza R, Escribano Subias P, Jiang X, Miller D, Peacock A, et al. Pulmonary arterial hypertension: epidemiology and registries. J Am Coll Cardiol. 2013;62:D51-9 pubmed publisher
  66. Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh Hora M, Kodama T, et al. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med. 2014;20:62-8 pubmed publisher
    ..These findings establish the pathological importance of Foxp3 instability in the generation of pathogenic TH17 cells in autoimmunity. ..
  67. Moriates C, Mourad M. Striving for optimal care: Updates in quality, value, and patient experience. J Hosp Med. 2016;11:145-50 pubmed publisher
  68. Kim K, Le Q, Yom S, Ng R, Chan K, Bratman S, et al. Clinical Utility of Epstein-Barr Virus DNA Testing in the Treatment of Nasopharyngeal Carcinoma Patients. Int J Radiat Oncol Biol Phys. 2017;98:996-1001 pubmed publisher
    ..This review provides a summary of that discussion. ..
  69. Sharifi H, Karamouzian M, Baneshi M, Shokoohi M, Haghdoost A, McFarland W, et al. Population size estimation of female sex workers in Iran: Synthesis of methods and results. PLoS ONE. 2017;12:e0182755 pubmed publisher
    ..Our findings provide vital information for enhancing HIV programme planning and lay a foundation for assessing the impact of harm reduction efforts within this marginalized population. ..
  70. Frost G, Mohapatra G, Wong T, Csoka A, Gray J, Stern R. HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. Oncogene. 2000;19:870-7 pubmed
    ..Inactivation of HYAL1 in these tumor lines is a result of incomplete splicing of its pre-mRNA that appears to be epigenetic in nature. Oncogene (2000) 19, 870 - 877. ..
  71. Jo K, Rutten B, Bunn R, Bredt D. Actinin-associated LIM protein-deficient mice maintain normal development and structure of skeletal muscle. Mol Cell Biol. 2001;21:1682-7 pubmed
    ..These data suggest that ALP does not participate in muscle development or that an alternative PDZ-LIM protein can compensate for the lack of ALP. ..
  72. Li Y, Dowbenko D, Lasky L. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem. 2002;277:11352-61 pubmed
    ..Furthermore, they suggest that one mechanism of AKT/PKB regulation of tumor cell survival and/or proliferation is to stabilize p21 protein. ..
  73. Flück C, Miller W. GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1. Mol Endocrinol. 2004;18:1144-57 pubmed
    ..Thus, GATA-4 or GATA-6 and Sp1 together regulate expression of P450c17 in adrenal NCI-H295A cells and methylation of P450c17, GATA-4 and GATA-6 silence the expression of P450c17 in placental JEG-3 cells. ..
  74. Behm B, Stollman N. Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol. 2003;1:71-80 pubmed
    ..Other procedures may be helpful with low risk of adverse effects. These include early feeding and ambulation, laxatives, and possibly neostigmine. ..
  75. Hur E, Pfaff S, Payne E, Gr n H, Buehrer B, Fletterick R. Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004;2:E274 pubmed publisher
    ..Induced fit provides perfect mating of the motifs representing the known family of AR coactivators and suggests a framework for the design of AR coactivator antagonists...
  76. Esposito L, Gan L, Yu G, Essrich C, Mucke L. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J Neurochem. 2004;91:1260-74 pubmed
    ..We conclude that Abeta, especially intracellular Abeta, counteracts the antiapoptotic function of its precursor protein and predisposes cells to p53-mediated, and possibly other, proapoptotic pathways. ..
  77. Owen R, Gray J, Taylor T, Carlson E, Huang C, Kawamoto M, et al. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics. 2005;15:83-90 pubmed
    ..However, CNT2-F355S (3% allele frequency in the African-American sample) was found to alter specificity for naturally occurring nucleosides, which may have implications for nucleoside homeostasis. ..
  78. Kubo S, Nemani V, Chalkley R, Anthony M, Hattori N, Mizuno Y, et al. A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem. 2005;280:31664-72 pubmed
  79. Fan Q, Knight Z, Goldenberg D, Yu W, Mostov K, Stokoe D, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006;9:341-9 pubmed
    ..PI-103 showed significant activity in xenografted tumors with no observable toxicity. These data demonstrate an emergent efficacy due to combinatorial inhibition of mTOR and PI3 kinase alpha in malignant glioma. ..
  80. Mummaneni P, Robinson J, Haid R. Cervical arthroplasty with the PRESTIGE LP cervical disc. Neurosurgery. 2007;60:310-4; discussion 314-5 pubmed
    ..The technique used for decompression and endplate preparation is presented in detail. Optimal arthroplasty device positioning is demonstrated. The surgical pearls and pitfalls of anterior cervical arthroplasty are highlighted. ..
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