Ament J, Kim T, Gold Markel J, Germano I, Dempsey R, Weaver J, et al
. Planning and Executing the Neurosurgery Boot Camp: The Bolivia Experience. World Neurosurg. 2017;104:407-410 pubmed publisher
..This humanitarian model provides a sustainable solution to education needs and should be expanded to other regions as a means for standardizing the core competencies in neurosurgery. ..
Dasu M, Devaraj S, Park S, Jialal I. Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care. 2010;33:861-8 pubmed publisher
Benedict S, El Naqa I, Klein E. Introduction to Big Data in Radiation Oncology: Exploring Opportunities for Research, Quality Assessment, and Clinical Care. Int J Radiat Oncol Biol Phys. 2016;95:871-872 pubmed publisher
Handa V, Danielsen B, Gilbert W. Obstetric anal sphincter lacerations. Obstet Gynecol. 2001;98:225-30 pubmed
..To estimate the frequency of obstetric anal sphincter laceration and to identify characteristics associated with this complication, including modifiable risk factors...
Zhu Y, Liu C, Tummala R, Nadiminty N, Lou W, Gao A. RhoGDIα downregulates androgen receptor signaling in prostate cancer cells. Prostate. 2013;73:1614-22 pubmed publisher
..GDIα regulatory pathway may play a critical role in regulating AR signaling and prostate cancer growth and progression. ..
Workman H, Sweeney C, Carraway K. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 2009;69:2845-52 pubmed publisher
Hahn Y, Diaz R, Hartman J, Bobinski M, Brodie H. Assessing stapes piston position using computed tomography: a cadaveric study. Otol Neurotol. 2009;30:223-30 pubmed publisher
..Temporal bone computed tomographic (CT) scanning in the postoperative stapedotomy patient is inaccurate in assessing stapes piston position within the vestibule...
Bair A, Smith D, Lichty L. Intubation confirmation techniques associated with unrecognized non-tracheal intubations by pre-hospital providers. J Emerg Med. 2005;28:403-7 pubmed
..In this EMS system, more frequent use of multiple confirmatory techniques (including end tidal CO2 detection) may help to reduce the incidence of this potentially life-threatening scenario. ..
Lee C. Delusions of parasitosis. Dermatol Ther. 2008;21:2-7 pubmed publisher
..However, the most challenging aspect of managing these patients may be the challenge of establishing rapport in the face of unshakable delusional ideation. ..
Horiuchi M, Itoh A, Pleasure D, Ozato K, Itoh T. Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells. J Neuroinflammation. 2011;8:8 pubmed publisher
..Therapies targeting at these transcription factors and their target genes could reduce IFNγ-induced OPC loss and thereby enhance remyelination in MS patients. ..
Adams P, Adams J, Nguyen D, Hessl D, Brunberg J, Tassone F, et al
. Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:775-85 pubmed publisher
..Though the presentation of FXTAS symptoms is less common in females, anxiety-related problems are common both prior to and after the onset of FXTAS, and may be related to hippocampal changes. ..
Cohen S, Gerding D, Johnson S, Kelly C, Loo V, McDonald L, et al
. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-55 pubmed publisher
..Despite the increasing quantity of data available, areas of controversy still exist. This guideline updates recommendations regarding epidemiology, diagnosis, treatment, and infection control and environmental management. ..
Nantajit D, Fan M, Duru N, Wen Y, Reed J, Li J. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PLoS ONE. 2010;5:e12341 pubmed publisher
Duan Z, Zou J, Yang P, Wang Y, Borowsky A, Gao A, et al
. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013;73:455-66 pubmed publisher
..Regulation of EZH2 by ANCCA emphasizes bromodomain protein ANCCA as a potential therapeutic target against prostate cancer. ..
Majumdar M, Tarui T, Shi B, Akakura N, Ruf W, Takada Y. Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1). J Biol Chem. 2004;279:37528-34 pubmed
..These results suggest that plasmin induces migration by kringle-mediated binding to alpha(9)beta(1) and simultaneous proteolytic activation of PAR-1. ..
Richards J, Schneir A. Droperidol in the emergency department: is it safe?. J Emerg Med. 2003;24:441-7 pubmed
..In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department. ..
Nguyen V, Ndoye A, Grando S. Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. Am J Pathol. 2000;157:1377-91 pubmed
..We conclude that alpha9 is coupled to physiological regulation of keratinocyte adhesion, and its interaction with PV IgG may lead to blister development. ..
Tseng W, Martinez S, Tamurian R, Chen S, Bold R, Canter R. Contiguous organ resection is safe in patients with retroperitoneal sarcoma: An ACS-NSQIP analysis. J Surg Oncol. 2011;103:390-4 pubmed publisher
..We examined rates of 30-day morbidity and mortality following resection of RPS utilizing data from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database...
Shih Y, Takada Y, Lo S. Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells. Mol Cancer Res. 2012;10:34-9 pubmed publisher
Tian Y, Stamova B, Jickling G, Xu H, Liu D, Ander B, et al
. Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls. Gend Med. 2012;9:68-75.e3 pubmed publisher
..Specific genes on the Y chromosome are differentially expressed in blood after ischemic stroke. These genes provide insight into potential molecular contributors to sex differences in ischemic stroke. ..
Kalashnikova E, Revenko A, Gemo A, Andrews N, Tepper C, Zou J, et al
. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res. 2010;70:9402-12 pubmed publisher
..Our results suggest that ANCCA may integrate multiple oncogenic programs in breast cancer, serving in particular as a prognostic marker and a therapeutic target for triple-negative cancers. ..
Walker J, Chen R, McGee J, Nacey C, Pollard R, Abedi M, et al
. Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. J Virol. 2012;86:5719-29 pubmed publisher
..The data provided from our study confirm the safety and efficacy of this combination anti-HIV lentiviral vector in a hematopoietic stem cell gene therapy setting for HIV and validates its potential application in future clinical trials. ..
Loomba Albrecht L, Jame M, Bremer A. A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2. Diabetes Res Clin Pract. 2010;87:e23-5 pubmed publisher
..We report a case of MODY2 caused by a novel GCK mutation and demonstrate differential glycemic/C-peptide responses to treatment with insulin, no medication, and an oral sulfonylurea. ..
Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. Cell Immunol. 1999;196:80-6 pubmed
..The identification of TSSP further supports the theory that MHC class II antigen processing and presentation in the thymic cortex involves a proteolytic milieu that differs from that of other antigen-presenting cells. ..
Nadiminty N, Dutt S, Tepper C, Gao A. Microarray analysis reveals potential target genes of NF-kappaB2/p52 in LNCaP prostate cancer cells. Prostate. 2010;70:276-87 pubmed publisher
..This study provides a comprehensive analysis of genes potentially regulated by NF-kappaB2/p52 in the LNCaP prostate cancer cell line and provides a rationale for the induction of castration-resistant growth by p52 in LNCaP cells. ..
Parise C, Bauer K, Brown M, Caggiano V. Breast cancer subtypes as defined by the estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) among women with invasive breast cancer in California, 1999-2004. Breast J. 2009;15:593-602 pubmed publisher
..We recommend reporting breast cancer as an ER/PR/HER2 subtype and precisely documenting demographic and tumor characteristics. ..
Dasu M, Devaraj S, Zhao L, Hwang D, Jialal I. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes. 2008;57:3090-8 pubmed publisher
..Collectively, these data suggest that high glucose induces TLR2 and -4 expression via PKC-alpha and PKC-delta, respectively, by stimulating NADPH oxidase in human monocytes. ..
Sun H, Breslin J, Zhu J, Yuan S, Wu M. Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability. Microcirculation. 2006;13:237-47 pubmed
..Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation. ..
McCausland A, McCausland V. Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention. J Minim Invasive Gynecol. 2007;14:399-406 pubmed
..This review will thoroughly discuss how to diagnose and treat these problems. Possible ways of preventing these long-term complications will also be discussed. ..
Umutyan A, Chiechi C, Beckett L, Paterniti D, Turrell C, Gandara D, et al
. Overcoming barriers to cancer clinical trial accrual: impact of a mass media campaign. Cancer. 2008;112:212-9 pubmed
..Enhancing patient willingness and accrual will require targeting other variables, such as physician or resource barriers, rather than just CCT and reimbursement awareness. ..
Sykes J, Kim J, Shaye D, Boccieri A. The importance of the nasal septum in the deviated nose. Facial Plast Surg. 2011;27:413-21 pubmed publisher
..The "four R's" of nasal septal repair--resection, reposition, reconstruction, and replacement--can be used to straighten the septum and maximize nasal appearance and function...
Shah D, Martinez S, Canter R, Yang A, Bold R, Khatri V. Comparative morbidity and mortality from cervical or thoracic esophageal anastomoses. J Surg Oncol. 2013;108:472-6 pubmed publisher
..13: 95%CI 0.83-1.54). After esophagectomy, the site of anastomosis does not predict an increased risk of perioperative morbidity or mortality. ..
Atkinson R. Ancrod in the treatment of acute ischaemic stroke. Drugs. 1997;54 Suppl 3:100-8 pubmed
Fujita M, Ieguchi K, Cedano Prieto D, Fong A, Wilkerson C, Chen J, et al
. An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R. J Biol Chem. 2013;288:19593-603 pubmed publisher
..Our results are consistent with a model in which ternary complex formation is critical for IGF signaling. ..
Enepekides D. Recent advances in the treatment of juvenile angiofibroma. Curr Opin Otolaryngol Head Neck Surg. 2004;12:495-9 pubmed
..This article reviews recent contributions to the study and treatment of this disease. In particular, advances in minimally invasive endoscopic resection of juvenile nasopharyngeal angiofibroma are evaluated...
Zhu Y, Tummala R, Liu C, Nadiminty N, Lou W, Evans C, et al
. RhoGDIα suppresses growth and survival of prostate cancer cells. Prostate. 2012;72:392-8 pubmed publisher
..In addition, GDIα suppressed the tumorigenic ability of prostate tumor xenografts in vivo. These results demonstrate that loss of GDIα expression promotes the development and progression of prostate cancer. ..
Sandhu R, Pan C, Wun T, Harvey D, Zhou H, White R, et al
. The incidence of venous thromboembolism and its effect on survival among patients with primary bladder cancer. Cancer. 2010;116:2596-603 pubmed publisher
..It was noteworthy that cancer-associated surgery was associated with a higher risk of VTE, which differed from the results reported from other studies in solid tumors. VTE was a significant predictor of death in the first 2 years. ..
Li Y, Budamagunta M, Luo J, Xiao W, Voss J, Lam K. Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins. ACS Nano. 2012;6:9485-95 pubmed publisher
..These findings identify factors that are crucial to the performance of nanomedicines and provide design modes to control their interplay with blood factors. ..
Mori S, Hatori N, Kawaguchi N, Hamada Y, Shih T, Wu C, et al
. The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. Biosci Rep. 2017;37: pubmed publisher
..The newly developed FGF2 mutants have potential as anti-angiogenic agents and useful tools for studying the role of integrins in FGF2 signalling. ..
Maezawa I, Swanberg S, Harvey D, LaSalle J, Jin L. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci. 2009;29:5051-61 pubmed publisher
..Our results suggest that astrocytes are viable therapeutic targets for RTT and perhaps regressive forms of autism. ..
McLaughlin R, Gomez S, Deapen D, Induni M. Human Subjects Protection and Cancer Surveillance Research: Revised Regulations, Expanded Opportunities. Cancer Res. 2017;77:3140-3143 pubmed publisher
..i>Cancer Res; 77(12); 3140-3. ©2017 AACR. ..
Yang P, Guo L, Duan Z, Tepper C, Xue L, Chen X, et al
. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol Cell Biol. 2012;32:3121-31 pubmed publisher
Rosová I, Dao M, Capoccia B, Link D, Nolta J. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells. 2008;26:2173-82 pubmed publisher
..Collectively, these data suggest that preculturing MSC under hypoxic conditions prior to transplantation improves their tissue regenerative potential. Disclosure of potential conflicts of interest is found at the end of this article. ..
Rossaro L, Tran T, Ransibrahmanakul K, Rainwater J, Csik G, Cole S, et al
. Hepatitis C videoconferencing: the impact on continuing medical education for rural healthcare providers. Telemed J E Health. 2007;13:269-77 pubmed
..In addition, VC has the potential to eliminate the financial and geographic barriers to professional education for rural practitioners. ..
Lebus D, Casazza G, Hoffman M, Van Loan M. Can changes in body mass and total body water accurately predict hyponatremia after a 161-km running race?. Clin J Sport Med. 2010;20:193-9 pubmed publisher
..To relate changes in body mass, total body water (TBW), extracellular fluid (ECF), and serum sodium concentration ([Na]) from a 161-km ultramarathon to finish time and incidence of hyponatremia...
Agnihotri P, Telfer M, Butt Z, Jella A, Cella D, Kozma C, et al
. Chronic anemia and fatigue in elderly patients: results of a randomized, double-blind, placebo-controlled, crossover exploratory study with epoetin alfa. J Am Geriatr Soc. 2007;55:1557-65 pubmed
..Epoetin alfa was well tolerated. In this trial involving predominantly older African-American women with anemia, a direct relationship existed between increases in Hb during epoetin alfa therapy and improvements in fatigue and QOL. ..
Chenoweth J, Colby D, Sutter M, Radke J, Ford J, Nilas Young J, et al
. Massive diltiazem and metoprolol overdose rescued with extracorporeal life support. Am J Emerg Med. 2017;35:1581.e3-1581.e5 pubmed publisher
..This case highlights the potential utility of extracorporeal life support in cases of severe toxicity due to multiple cardioactive medications. ..
Hessl D, Wang J, Schneider A, Koldewyn K, Le L, Iwahashi C, et al
. Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation. Biol Psychiatry. 2011;70:859-65 pubmed publisher
..Although prior studies have emphasized a toxic gain-of-function effect of elevated messenger RNA associated with the premutation, the current results point to the role of reduced FMRP in alterations of brain activity and behavior. ..
Workman H, Miller J, Ingalla E, Kaur R, Yamamoto D, Beckett L, et al
. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Res. 2009;11:R70 pubmed publisher
Butani L, Calogiuri G. Hypersensitivity reactions in patients receiving hemodialysis. Ann Allergy Asthma Immunol. 2017;118:680-684 pubmed publisher
..Great diligence is needed to investigate hypersensitivity reactions to avoid recurrence in this high-risk population. ..
Styne D. Childhood and adolescent obesity. Prevalence and significance. Pediatr Clin North Am. 2001;48:823-54, vii pubmed
..Screening using appropriate historical and physical data will reveal those children most in need of modification of weight gain...
Mintegi S, Dalziel S, Azkunaga B, Prego J, Arana Arri E, Acedo Y, et al
. International Variability in Gastrointestinal Decontamination With Acute Poisonings. Pediatrics. 2017;140: pubmed publisher
..001). Globally, there are substantial differences in the use and appropriateness of GID procedures in the management of pediatric poisonings. International best practices need to be better implemented. ..
Campbell K, Karski E, Olow A, Edmondson D, Kohlgruber A, Coleman M, et al
. Peripheral Blood Biomarkers Associated With Toxicity and Treatment Characteristics After 131I- Metaiodobenzylguanidine Therapy in Patients With Neuroblastoma. Int J Radiat Oncol Biol Phys. 2017;99:468-475 pubmed publisher
..The degree of modulation of a subset of these markers is associated with toxicity and receipt of concomitant radiation sensitizers. ..
Blakely C, Watkins T, Wu W, Gini B, Chabon J, McCoach C, et al
. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017;49:1693-1704 pubmed publisher
..This study calls for revisiting the prevailing single-gene driver-oncogene view and links clinical outcomes to co-occurring genetic alterations in patients with advanced-stage EGFR-mutant lung cancer. ..
Buzi A, Coblens O, MacGillivray M, Elden L. The Use of Noninvasive Positive Pressure Ventilation following Pediatric Tonsillectomy. Otolaryngol Head Neck Surg. 2017;157:297-301 pubmed publisher
..Some hesitation may exist in using this form of ventilation when open pharyngeal wounds are exposed to pressure, but this study suggests that it can be used as a suitable alternative to invasive ventilation. ..
Westin G, Armstrong E, Bang H, Yeo K, Anderson D, Dawson D, et al
. Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia. J Am Coll Cardiol. 2014;63:682-90 pubmed publisher
..Statins are associated with lower rates of mortality and MACCE and increased amputation-free survival in CLI patients. ..
Fritz C, Bronson L, Smith C, Schriefer M, Tucker J, Schwan T. Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. J Clin Microbiol. 2004;42:1123-8 pubmed
..Antibody to B. hermsii was detected in sera from 4 of 11 yellow-pine chipmunks (Tamias amoenus); no other rodent species collected were seropositive...
Jialal I, Devaraj S, Kaur H, Adams Huet B, Bremer A. Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome. J Clin Endocrinol Metab. 2013;98:E514-7 pubmed publisher
..We make the novel observation of abnormal circulating and gluteal SAT-secreted chemerin and omentin-1 levels in nascent MetS, which could confer a higher risk for diabetes and cardiovascular disease. ..
Armstrong A, Schupp C, Wu J, Bebo B. Quality of life and work productivity impairment among psoriasis patients: findings from the National Psoriasis Foundation survey data 2003-2011. PLoS ONE. 2012;7:e52935 pubmed publisher
..7, 95% CI 1.4-2.3). Patients with psoriasis and psoriatic arthritis continue to experience significant impairment of quality of life and work productivity. ..
Thai A, Prindiville T. Hepatosplenic T-cell lymphoma and inflammatory bowel disease. J Crohns Colitis. 2010;4:511-22 pubmed publisher
..In addition, we explore the history of reported cases of hepatosplenic T-cell lymphoma in relation to the possible existence of a causal relationship between infliximab use and HSTCL. The treatments for HSTCL will be briefly addressed...
Rogers J, Karimi H, Kao J, Link D, Javidan J, Yamasaki D, et al
. Internal pudendal artery stenoses and erectile dysfunction: correlation with angiographic coronary artery disease. Catheter Cardiovasc Interv. 2010;76:882-7 pubmed publisher
..Further investigation is required to determine whether the development of macrovascular disease in the IPA causes ED and whether endovascular treatment is safe and effective in this population. ..
Li S, Tancredi D. Empyema hospitalizations increased in US children despite pneumococcal conjugate vaccine. Pediatrics. 2010;125:26-33 pubmed publisher
..Pneumococcal conjugate vaccine is not decreasing the incidence of empyema. ..