Genomes and Genes
Experts and Doctors on humans in Novato, California, United States
Locale: Novato, California, United States
Publications146 found, 100 shown here
- Ruane T, Haskins M, Cheng A, Wang P, AGUIRRE G, Knox V, et al. Pharmacodynamics, pharmacokinetics and biodistribution of recombinant human N-acetylgalactosamine 4-sulfatase after 6months of therapy in cats using different IV infusion durations. Mol Genet Metab. 2016;117:157-63 pubmed publisher..Additional studies may determine if shorter infusion times are appropriate for MPS VI patients without significant infusion-associated reactions. ..
- Nicholls D. Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Curr Mol Med. 2004;4:149-77 pubmed
- Vijg J, Campisi J. Puzzles, promises and a cure for ageing. Nature. 2008;454:1065-71 pubmed publisher..A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect. ..
- Miller J, Yates B, Al Ramahi I, Berman A, Sanhueza M, Kim E, et al. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. PLoS Genet. 2012;8:e1003042 pubmed publisher..These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease. ..
- Cardnell R, Feng Y, Mukherjee S, Diao L, Tong P, Stewart C, et al. Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer. PLoS ONE. 2016;11:e0152584 pubmed publisher..008). The data presented here suggest that combining PARP and PI3K inhibitors enhances the effect of either agent alone in preclinical models of SCLC, warranting further investigation of such combinations in SCLC patients. ..
- Cottrell B, Galvan V, Banwait S, Gorostiza O, Lombardo C, Williams T, et al. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005;58:277-89 pubmed..In agreement with previous studies, our results are compatible with an involvement of APP in axonal transport and vesicular trafficking, and with a potential association of APP with cellular protein folding/protein degradation systems. ..
- Wenker S, Leal M, FarÃas M, Zeng X, Pitossi F. Cell therapy for Parkinson's disease: Functional role of the host immune response on survival and differentiation of dopaminergic neuroblasts. Brain Res. 2016;1638:15-29 pubmed publisher..This article is part of a Special Issue entitled SI: PSC and the brain. ..
- Robertson A, Shih J, Yau C, Gibb E, Oba J, Mungall K, et al. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. Cancer Cell. 2017;32:204-220.e15 pubmed publisher..Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes. ..
- Jin K, Mao X, Xie L, Greenberg D. Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage. Acta Neurochir Suppl. 2011;111:315-9 pubmed publisher..In these disorders, as in other clinical settings, such as ischemic stroke, AVM- and ICH-induced overexpression of Ngb may be stimulated by ischemic hypoxia and may help to constrain brain injury. ..
- Vuillemenot B, Katz M, Coates J, Kennedy D, Tiger P, Kanazono S, et al. Intrathecal tripeptidyl-peptidase 1 reduces lysosomal storage in a canine model of late infantile neuronal ceroid lipofuscinosis. Mol Genet Metab. 2011;104:325-37 pubmed publisher..Further studies with this model will be necessary to optimize the dosing route and regimen to attenuate functional decline. ..
- Miyamoto B, Kakkis E. The potential investment impact of improved access to accelerated approval on the development of treatments for low prevalence rare diseases. Orphanet J Rare Dis. 2011;6:49 pubmed publisher..Our research brings attention to the need for well-defined and practical qualification criteria for the use of surrogate endpoints to allow more access to the AA approval pathway in clinical trials for rare diseases. ..
- Martell L, Lau K, Mei M, Burnett V, Decker C, Foehr E. Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers. Orphanet J Rare Dis. 2011;6:84 pubmed publisher..Candidate biomarkers alpha-1-antitrypsin, lipoprotein(a), and serum amyloid P may be suitable markers, in addition to urinary KS, to follow the response to ERT in MPSIVA patients. ..
- Greenberg D, Jin K. Vascular endothelial growth factors (VEGFs) and stroke. Cell Mol Life Sci. 2013;70:1753-61 pubmed publisher..VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke. ..
- Spilman P, Corset V, Gorostiza O, Poksay K, Galvan V, Zhang J, et al. Netrin-1 Interrupts Amyloid-? Amplification, Increases sA?PP? in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;52:223-42 pubmed publisher..Taken together, these data provide mechanistic insights into A? self-amplification and the ability of netrin-1 to disrupt it. ..
- L HEUREUX N, Dusserre N, Marini A, Garrido S, de la Fuente L, McAllister T. Technology insight: the evolution of tissue-engineered vascular grafts--from research to clinical practice. Nat Clin Pract Cardiovasc Med. 2007;4:389-95 pubmed..The unique regulatory, reimbursement and production challenges facing personalized medicine are also discussed. ..
- McPherson L, Shen Y, Ford J. Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells. Cancer Lett. 2014;343:217-23 pubmed publisher..Synergism was evident between LT-626 and cisplatin, oxaliplatin and SN-38 suggesting that PARP inhibitors in combination with DNA damaging agents may be a successful strategy for treatment of CRC. ..
- Jin K, Lafevre Bernt M, Sun Y, Chen S, Gafni J, Crippen D, et al. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A. 2005;102:18189-94 pubmed..We conclude that FGF-2 improves neurological deficits and longevity in a transgenic mouse model of HD, and that its neuroprotective and neuroproliferative effects may contribute to this improvement. ..
- Nicholls D. Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease. Int J Biochem Cell Biol. 2002;34:1372-81 pubmed..These interactions are incompletely understood and in this review I present an overview of some of the current research in this area, and its possible relevance to aging and aging-related disease. ..
- Tourette C, Li B, Bell R, O Hare S, Kaltenbach L, Mooney S, et al. A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. J Biol Chem. 2014;289:6709-26 pubmed publisher..These data indicate that HTT is involved directly in membrane dynamics, cell attachment, and motility. Furthermore, they implicate dysregulation in these pathways as pathological mechanisms in HD. ..
- Laberge R, Zhou L, Sarantos M, Rodier F, Freund A, de Keizer P, et al. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell. 2012;11:569-78 pubmed publisher..They further show that glucocorticoids inhibit selected components of the SASP and suggest that corticosterone and cortisol, two FDA-approved drugs, might exert their effects in part by suppressing senescence-associated inflammation. ..
- Bredesen D. mCiRNA-synaptic crystal ball?. Aging (Albany NY). 2012;4:732-3 pubmed..Comment on: Sheinerman KS, Tsivinsky VG, Crawford F, Mullan MJ, Abdullah L, Umansky SR. Plasma microRNA biomarkers for detection of mild cognitive impairment. Aging (Albany NY). 2012; 4:590-605. ..
- Chinta S, Andersen J. Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. Free Radic Biol Med. 2006;41:1442-8 pubmed
- Kurakin A, Bredesen D. Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins. J Biomol Struct Dyn. 2002;19:1015-29 pubmed..The novel screening format, dubbed TAIS (target-assisted iterative screening), is discussed as an alternative platform to existing technologies for a pair-wise characterization of protein-protein interactions. ..
- Nguyen T, Galvan V, Huang W, Banwait S, Tang H, Zhang J, et al. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008;104:1065-80 pubmed
- Held J, Danielson S, Behring J, Atsriku C, Britton D, Puckett R, et al. Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Mol Cell Proteomics. 2010;9:1400-10 pubmed publisher..OxMRM also complements unbiased redox proteomics discovery studies as a verification tool through its high sensitivity, accuracy, precision, and throughput. ..
- Bhaumik D, Scott G, Schokrpur S, Patil C, Campisi J, Benz C. Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene. 2008;27:5643-7 pubmed publisher..These findings implicate miR-146a/b as a negative regulator of constitutive NF-kappaB activity in a breast cancer setting and suggest that modulating miR-146a/b levels has therapeutic potential to suppress breast cancer metastases. ..
- Duncan C, An M, Papanikolaou T, Rugani C, Vitelli C, Ellerby L. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Mol Neurodegener. 2013;8:42 pubmed publisher..This study implicates HDAC3 and ataxin-7 interaction as a target for therapeutic intervention in SCA7, adding to a growing list of neurodegenerative diseases that may be treated by HDAC inhibitors. ..
- Lucanic M, Lithgow G, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013;12:445-58 pubmed publisher..Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies. ..
- Sperandio S, Poksay K, Schilling B, Crippen D, Gibson B, Bredesen D. Identification of new modulators and protein alterations in non-apoptotic programmed cell death. J Cell Biochem. 2010;111:1401-12 pubmed publisher..Identification of specific paraptotic changes will ultimately lead to tools to detect this type of programmed cell death in in vivo systems and allow for its further characterization. ..
- Liu Q, Pedersen O, Peng J, Couture L, Rao M, Zeng X. Optimizing dopaminergic differentiation of pluripotent stem cells for the manufacture of dopaminergic neurons for transplantation. Cytotherapy. 2013;15:999-1010 pubmed publisher..Our results suggest that this optimized protocol can be used to generate dopaminergic neurons for Investigational New Drug enabling studies. ..
- Sun F, Mao X, Xie L, Greenberg D, Jin K. Neuroglobin protein is upregulated in Alzheimer's disease. J Alzheimers Dis. 2013;36:659-63 pubmed publisher..We conclude that, as in transgenic mouse models, neuroglobin may influence the course of clinical Alzheimer's disease. ..
- Gafni J, Cong X, Chen S, Gibson B, Ellerby L. Calpain-1 cleaves and activates caspase-7. J Biol Chem. 2009;284:25441-9 pubmed publisher..Our studies suggest the calpain-activated form of caspase-7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form. ..
- Laberge R, Adler D, DeMaria M, Mechtouf N, Teachenor R, Cardin G, et al. Mitochondrial DNA damage induces apoptosis in senescent cells. Cell Death Dis. 2013;4:e727 pubmed publisher..Thus, cellular senescence and mtDNA damage are outcomes of synthetic nucleoside analog treatment, indicating that the GCV-HSVtk combination can be used effectively to promote the targeted formation or eradication of senescent cells. ..
- Jin K, Mao X, Xie L, Galvan V, Lai B, Wang Y, et al. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab. 2010;30:534-44 pubmed publisher..These results indicate that transplantation of human neural cells together with biomaterial scaffolding has the potential to improve the outcome from stroke, even when treatment is delayed for several weeks after the ischemic event. ..
- Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo J, Boonplueang R, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 2003;37:899-909 pubmed
- Chinta S, Andersen J. Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease. Free Radic Res. 2011;45:53-8 pubmed publisher..Strategies to modulate mitochondrial NO levels will therefore likely be a promising approach to enhance mitochondrial function and protect dopaminergic neurons against oxidative or nitrosative insult. ..
- Liu Q, Spusta S, Mi R, Lassiter R, Stark M, Hoke A, et al. Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells. Stem Cells Transl Med. 2012;1:266-78 pubmed publisher..Schwann cells generated by our protocol myelinated rat dorsal root ganglia neurons in vitro. To our knowledge, this is the first report on myelination by hESC- or iPSC-derived Schwann cells. ..
- Schreier H, Erdos G, Reimer K, Konig B, Konig W, Fleischer W. Molecular effects of povidone-iodine on relevant microorganisms: an electron-microscopic and biochemical study. Dermatology. 1997;195 Suppl 2:111-6 pubmed
- Scott G, Atsriku C, Kaminker P, Held J, Gibson B, Baldwin M, et al. Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation. Mol Pharmacol. 2005;68:606-15 pubmed..These findings delineate new pathways associated with K3-induced stress and suggest a potentially novel role for H3 Cys110 as a nuclear stress sensor. ..
- Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev. 2011;21:107-12 pubmed publisher..These discoveries provide potential mechanisms by which cellular senescence might contribute to the diverse, and seemingly incongruent, processes of tumor suppression, tumor promotion, tissue repair, and aging. ..
- Swistowski A, Zeng X. Scalable production of transplantable dopaminergic neurons from hESCs and iPSCs in xeno-free defined conditions. Curr Protoc Stem Cell Biol. 2012;Chapter 2:Unit2D.12 pubmed publisher..Here, the derivation and differentiation of functional dopaminergic neurons from hESCs and iPSCs under xeno-free defined conditions are described. These protocols have been validated in multiple hESC and iPSC lines. ..
- Galvan V, Logvinova A, Sperandio S, Ichijo H, Bredesen D. Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem. 2003;278:13325-32 pubmed
- Choi S, Gerencser A, Ng R, Flynn J, Melov S, Danielson S, et al. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012;32:16775-84 pubmed publisher..Our results support the conclusion that the intrinsic bioenergetic capacities of presynaptic nerve terminals are maintained in these symptomatic AD mouse models. ..
- Galvan V, Kurakin A, Bredesen D. Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. FEBS Lett. 2004;558:57-62 pubmed..An interaction of Chk1 and XIAP may imply a mechanism of coupling between the regulatory networks that control cell cycle progression and apoptosis during mitosis. ..
- L HEUREUX N, Dusserre N, Konig G, Victor B, Keire P, Wight T, et al. Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med. 2006;12:361-5 pubmed..These results indicate that a completely biological and clinically relevant TEBV can be assembled exclusively from an individual's own cells. ..
- Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen D. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol. 2009;65:294-303 pubmed publisher..In addition, the results argue that the interaction between APP and p75(NTR) may represent a therapeutic target in Alzheimer's disease. ..
- Siddiqui A, Chinta S, Mallajosyula J, Rajagopolan S, Hanson I, Rane A, et al. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. 2012;53:993-1003 pubmed publisher..This represents a novel role for alpha-synuclein as it relates to mitochondrial dysfunction in PD. ..
- Schilling B, Gafni J, Torcassi C, Cong X, Row R, LaFevre Bernt M, et al. Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity. J Biol Chem. 2006;281:23686-97 pubmed..Dissection of phosphorylation modifications in Htt may provide clues to Huntington disease pathogenesis and targets for therapeutic development. ..
- Kaminker P, Kim S, Desprez P, Campisi J. A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle. 2009;8:931-9 pubmed..Our results suggest a dual role for TIN2 in mediating the function of the shelterin complex and tethering telomeres to the nuclear matrix. ..
- Martell L, Cunico R, Ohh J, Fulkerson W, FURNEAUX R, Foehr E. Validation of an LC-MS/MS assay for detecting relevant disaccharides from keratan sulfate as a biomarker for Morquio A syndrome. Bioanalysis. 2011;3:1855-66 pubmed publisher..104 µg/ml (urine), with a quantitation range of 0.026-5 µg/ml (plasma) and 0.104-20 µg/ml (urine). Clinical sample analysis in 168 MPS IVA patients and 225 healthy controls demonstrates the clinical utility of this method. ..
- Zhang Y, Bharathi S, Rardin M, Lu J, Maringer K, Sims Lucas S, et al. Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem. 2017;292:10239-10249 pubmed publisher..Our findings suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function. ..
- Rao R, Peel A, Logvinova A, Del Rio G, Hermel E, Yokota T, et al. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002;514:122-8 pubmed..These results define a novel protective role for GRP78 in preventing ER stress-induced cell death. ..
- Kaminker P, Plachot C, Kim S, Chung P, Crippen D, Petersen O, et al. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci. 2005;118:1321-30 pubmed..Here we show that a novel extra-telomeric organization of TIN2 is associated with the control of cell proliferation and identify TIN2 as an important regulator of mammary epithelial differentiation. ..
- Lee D, Andersen J. Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr Mol Med. 2006;6:883-93 pubmed
- Benz C, Yau C. Ageing, oxidative stress and cancer: paradigms in parallax. Nat Rev Cancer. 2008;8:875-9 pubmed publisher..gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer development? ..
- Orjalo A, Bhaumik D, Gengler B, Scott G, Campisi J. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A. 2009;106:17031-6 pubmed publisher..Thus, cell surface IL-1alpha is an essential cell-autonomous regulator of the senescence-associated IL-6/IL-8 cytokine network. ..
- Tollervey J, Lunyak V. Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics. 2012;7:823-40 pubmed publisher..Further investigation into stem cell epigenetics promises to provide novel advances in the diagnosis and treatment of a wide array of human diseases. ..
- Hermel E, Gafni J, Propp S, Leavitt B, Wellington C, Young J, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 2004;11:424-38 pubmed..These data support the involvement of caspase-2 in the selective neuronal cell death associated with HD in the striatum and cortex. ..
- Kumar M, Andersen J. Perspectives on MAO-B in aging and neurological disease: where do we go from here?. Mol Neurobiol. 2004;30:77-89 pubmed..In this review, we address several factors contributing to a possible role for MAO-B in normal brain aging and neurological disease and also discuss the use of MAO-B inhibitors as drug therapy for these conditions. ..
- Jin K, Wang X, Xie L, Mao X, Zhu W, Wang Y, et al. Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci U S A. 2006;103:13198-202 pubmed..These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy. ..
- Bredesen D, John V, Galvan V. Importance of the caspase cleavage site in amyloid-? protein precursor. J Alzheimers Dis. 2010;22:57-63 pubmed publisher..Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in A?PP. ..
- Rardin M, He W, Nishida Y, Newman J, Carrico C, Danielson S, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013;18:920-33 pubmed publisher..Taken together, these findings establish SIRT5 as a global regulator of lysine succinylation in mitochondria and present a mechanism for inhibition of ketogenesis through HMGCS2. ..
- Zhang N, Bailus B, Ring K, Ellerby L. iPSC-based drug screening for Huntington's disease. Brain Res. 2016;1638:42-56 pubmed publisher..This article is part of a Special Issue entitled SI: PSC and the brain. ..
- Rao R, Hermel E, Castro Obregon S, del Rio G, Ellerby L, Ellerby H, et al. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem. 2001;276:33869-74 pubmed..The data underscore the involvement of ER and caspases associated with it in the ER stress-induced apoptotic process. ..
- Peel A, Rao R, Cottrell B, Hayden M, Ellerby L, Bredesen D. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Hum Mol Genet. 2001;10:1531-8 pubmed..The increased immunolocalization of the activated kinase is more pronounced in areas most affected by the disease and, coupled with the RNA binding results, suggests a role for PKR activation in the disease process. ..
- Neve R, Holbro T, Hynes N. Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene. 2002;21:4567-76 pubmed..This suggests that downstream effectors of ErbB receptors represent good therapeutic targets for breast cancer. ..
- Hwang S, Steineckert B, Toneff T, Bundey R, Logvinova A, Goldsmith P, et al. The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells. Biochemistry. 2002;41:10397-405 pubmed..These findings demonstrate that endopin 2 inhibitory functions may occur in the regulated secretory pathway. ..
- Sperandio S, Poksay K, de Belle I, Lafuente M, Liu B, Nasir J, et al. Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ. 2004;11:1066-75 pubmed..These results suggest that IGFIR-induced paraptosis is mediated by MAPKs, and inhibited by AIP-1/Alix. ..
- Swistowska A, da Cruz A, Han Y, Swistowski A, Liu Y, Shin S, et al. Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells. Stem Cells Dev. 2010;19:71-82 pubmed publisher..We conclude that PA6-CM can induce dopaminergic differentiation in hESCs in a stage-specific manner. Shh is likely an important soluble dopaminergic inducing factor secreted by stromal cells and acts after the neural fate determination. ..
- Campisi J, Andersen J, Kapahi P, Melov S. Cellular senescence: a link between cancer and age-related degenerative disease?. Semin Cancer Biol. 2011;21:354-9 pubmed publisher..We propose that both the degenerative and hyperplastic diseases of aging may be fueled by such damage signals. ..
- Velarde M, Flynn J, Day N, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4:3-12 pubmed..Our results support the idea that mitochondrial oxidative stress and cellular senescence contribute to aging skin phenotypes in vivo. ..
- Agrawal P, Chen Y, Schilling B, Gibson B, Hughes R. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem. 2012;287:21164-75 pubmed publisher..Taken together, our data describe the identification of the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR activity and skeletal muscle differentiation. ..
- McGee M, Day N, Graham J, Melov S. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY). 2012;4:256-69 pubmed
- Epel E, Lithgow G. Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S10-6 pubmed publisher..This will require interdisciplinary novel approaches that hold much promise for understanding and intervening in human chronic disease. ..
- Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-9 pubmed publisher..This article reports the main outcomes of this session. ..
- Barajas D, Aponte Ubillus J, Akeefe H, Cinek T, Peltier J, Gold D. Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae. PLoS ONE. 2017;12:e0173010 pubmed publisher..Future findings in the yeast system could be translatable to other AAV host systems and aid in more efficient production of rAAV vectors. ..
- del Rio G, Castro Obregon S, Rao R, Ellerby H, Bredesen D. APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide. FEBS Lett. 2001;494:213-9 pubmed..Among other peptides, substance P was identified as a PAP and subsequently demonstrated to be a pro-apoptotic peptide experimentally. APAP thus provides a method to detect and ultimately improve pro-apoptotic peptides for chemotherapy. ..
- Greenberg D. The jaundice of the cell. Proc Natl Acad Sci U S A. 2002;99:15837-9 pubmed