Genomes and Genes
Experts and Doctors on drosophila proteins in San Diego, California, United States
Locale: San Diego, California, United States
Topic: drosophila proteins
- van Swinderen B, Greenspan R. Salience modulates 20-30 Hz brain activity in Drosophila. Nat Neurosci. 2003;6:579-86 pubmed..We demonstrated the association of these responses with behavioral tracking and initiated a genetic approach to investigating neural correlates of perception. ..
- Griffitts J, Huffman D, Whitacre J, Barrows B, Marroquin L, Müller R, et al. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. J Biol Chem. 2003;278:45594-602 pubmed..elegans. Resistance to Cry toxins has uncovered a four component glycosylation pathway that is functionally conserved between nematodes and insects and that provides the basis of the dominant mechanism of resistance in C. elegans. ..
- Li C, Harding G, Parise J, McNamara Schroeder K, Stumph W. Architectural arrangement of cloned proximal sequence element-binding protein subunits on Drosophila U1 and U6 snRNA gene promoters. Mol Cell Biol. 2004;24:1897-906 pubmed..These substantial differences in the cross-linking pattern are consistent with those of a model in which conformational differences in DmPBP-DNA complexes lead to selective RNA polymerase recruitment to U1 and U6 promoters. ..
- Lunde K, Biehs B, Nauber U, Bier E. The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development. 1998;125:4145-54 pubmed..We propose a model in which the combined activities of kni and knrl organize development of the L2 vein in the appropriate position. ..
- Guichard A, McGillivray S, Cruz Moreno B, van Sorge N, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010;467:854-8 pubmed publisher..This coordinated disruption of the Rab11/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection. ..
- Yoshikawa S, Bonkowsky J, Kokel M, Shyn S, Thomas J. The derailed guidance receptor does not require kinase activity in vivo. J Neurosci. 2001;21:RC119 pubmed..Our results indicate that DRL does not require kinase activity in vivo and suggest that members of the RYK subfamily of RTKs transduce signals unconventionally. ..
- Mizutani C, Nie Q, Wan F, Zhang Y, Vilmos P, Sousa Neves R, et al. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005;8:915-24 pubmed
- Madigan S, Edeen P, Esnayra J, McKeown M. att, a target for regulation by tra2 in the testes of Drosophila melanogaster, encodes alternative RNAs and alternative proteins. Mol Cell Biol. 1996;16:4222-30 pubmed..This produces a novel truncated version of the Graves' disease carrier protein-like protein that lacks all sequences N terminal to the first transmembrane domain. ..
- Hung K, Titus M, Chiang S, Stumph W. A map of Drosophila melanogaster small nuclear RNA-activating protein complex (DmSNAPc) domains involved in subunit assembly and DNA binding. J Biol Chem. 2009;284:22568-79 pubmed publisher..Comparison with functional domains identified in human SNAPc indicates many parallels but also reveals significant differences in this ancient yet rapidly evolving system. ..
- Yucel J, Marszalek J, McIntosh J, Goldstein L, Cleveland D, Philp A. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J Cell Biol. 2000;150:1-11 pubmed
- Callahan C, Muralidhar M, Lundgren S, Scully A, Thomas J. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member. Nature. 1995;376:171-4 pubmed..In drl mutant embryos these neurons fail to make the correct pathway choices. Our results provide evidence for receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition. ..
- Alexiadis V, Kadonaga J. Strand pairing by Rad54 and Rad51 is enhanced by chromatin. Genes Dev. 2002;16:2767-71 pubmed..These findings indicate that Rad54 and Rad51 have evolved to function with chromatin, the natural substrate, rather than with naked DNA. ..
- Towb P, Bergmann A, Wasserman S. The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway. Development. 2001;128:4729-36 pubmed..Our results point to a mechanism operating to modulate the domain or duration of signaling downstream from Tube and Pelle. ..
- Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka K, Kimelman D, et al. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development. 2000;127:2143-54 pubmed
- Chitnis A, Henrique D, Lewis J, Ish Horowicz D, Kintner C. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature. 1995;375:761-6 pubmed
- Ito T, Tyler J, Bulger M, Kobayashi R, Kadonaga J. ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem. 1996;271:25041-8 pubmed..These and other data collectively suggest that dNLP may participate in parallel with other histone-binding proteins such as dNAP-1 in the assembly of chromatin. ..
- Lusser A, Urwin D, Kadonaga J. Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly. Nat Struct Mol Biol. 2005;12:160-6 pubmed..These results suggest a role for CHD1 in the assembly of active chromatin and a function of ACF in the assembly of repressive chromatin. ..
- Barakat N, Stumph W. TBP recruitment to the U1 snRNA gene promoter is disrupted by substituting a U6 proximal sequence element A (PSEA) for the U1 PSEA. FEBS Lett. 2008;582:2413-6 pubmed publisher..These findings support a model wherein sequence differences between the U1 and U6 PSEAs induce distinct DmSNAPc conformational states involved in RNA polymerase selectivity. ..
- Lai H, Kang Y, Stumph W. Subunit stoichiometry of the Drosophila melanogaster small nuclear RNA activating protein complex (SNAPc). FEBS Lett. 2008;582:3734-8 pubmed publisher..The results reveal that DmSNAPc contains only a single copy of each of the three subunits. ..
- Doherty M, Kang Y, Lee C, Stumph W. Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA. J Biol Chem. 2012;287:39369-79 pubmed publisher..The results reveal the topological arrangement of the 4.5 SNAP190 Myb repeats relative to the DNA and to each other when SNAP190 is bound to a U1 promoter as a subunit of SNAPc. ..
- Chappell P, White R, Mellon P. Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci. 2003;23:11202-13 pubmed..This effect persists in normal light/dark (LD) cycles, suggesting that a suprachiasmatic nucleus-independent endogenous clock in GnRH neurons is required for eliciting normal pulsatile patterns of GnRH secretion. ..
- Ronen R, Udpa N, Halperin E, Bafna V. Learning natural selection from the site frequency spectrum. Genetics. 2013;195:181-93 pubmed publisher..We further apply our test to human data and identify regions that are in agreement with earlier studies, as well as many novel regions. ..
- Ray K, Perez S, Yang Z, Xu J, Ritchings B, Steller H, et al. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. J Cell Biol. 1999;147:507-18 pubmed..Furthermore, the data lead to the conclusion that the cargo transport requirements of different classes of neurons may lead to upregulation of specific pathways of axonal transport. ..
- Van Antwerp D, Verma I. Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required. Mol Cell Biol. 1996;16:6037-45 pubmed..Additionally, the PEST sequence may be required for constitutive turnover of free I(kappa)B(alpha). ..
- Yaffe M. Mitochondrial morphogenesis: fusion factor for fly fertility. Curr Biol. 1997;7:R782-3 pubmed..The Drosophila Fzo protein is required for mitochondrial fusion during a key step in sperm formation. This novel, membrane-bound GTPase defines a family of proteins that may mediate mitochondrial fusion in a variety of eukaryotic cells. ..
- O Keefe D, Thor S, Thomas J. Function and specificity of LIM domains in Drosophila nervous system and wing development. Development. 1998;125:3915-23 pubmed..This suggests that the Ap LIM domains mediate different protein interactions in different developmental processes, and that LIM domains can participate in conferring specificity of target gene selection. ..
- Jen W, Gawantka V, Pollet N, Niehrs C, Kintner C. Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. Genes Dev. 1999;13:1486-99 pubmed..We propose a model in which Notch signaling plays a key role in both establishing and maintaining segmental identity during somitomere formation in Xenopus embryos. ..
- Ito T, Levenstein M, Fyodorov D, Kutach A, Kobayashi R, Kadonaga J. ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Genes Dev. 1999;13:1529-39 pubmed..These results indicate that both Acf1 and ISWI participate in the chromatin assembly process and suggest further that the Acf1 subunit confers additional functionality to the general 'motor' activity of ISWI. ..
- Nellesen D, Lai E, Posakony J. Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev Biol. 1999;213:33-53 pubmed
- Bonkowsky J, Yoshikawa S, O Keefe D, Scully A, Thomas J. Axon routing across the midline controlled by the Drosophila Derailed receptor. Nature. 1999;402:540-4 pubmed..Our results show that Drl is a novel component in the control of midline crossing. ..
- Zimmermann K, Ricci J, Droin N, Green D. The role of ARK in stress-induced apoptosis in Drosophila cells. J Cell Biol. 2002;156:1077-87 pubmed..These results demonstrate the central role of ARK in stress-induced apoptosis, which appears to act independently of cytochrome c. Apoptosis induced by Reaper or Grim can proceed via a distinct pathway, independent of ARK. ..
- Miller Y, Viriyakosol S, Binder C, Feramisco J, Kirkland T, Witztum J. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003;278:1561-8 pubmed
- Alexiadis V, Lusser A, Kadonaga J. A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. J Biol Chem. 2004;279:27824-9 pubmed..These findings suggest that the N-terminal region of Rad54 contains an autoinhibitory activity that is relieved by Rad51. ..
- van Swinderen B, Greenspan R. Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics. 2005;169:2151-63 pubmed..The pattern of epistatic interactions that occurs within this set of variants is dramatically altered in the two different genetic contexts. The results imply considerable flexibility in the network interactions of genes. ..
- Yoshikawa S, McKinnon R, Kokel M, Thomas J. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature. 2003;422:583-8 pubmed..Our results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events. ..
- Tan E, Yamaguchi Y, Horwitz G, Gosgnach S, Lein E, Goulding M, et al. Selective and quickly reversible inactivation of mammalian neurons in vivo using the Drosophila allatostatin receptor. Neuron. 2006;51:157-70 pubmed..Inactivation can be reversed within minutes upon washout of the ligand and is repeatable, demonstrating that the AlstR/AL system is effective for selective, quick, and reversible silencing of mammalian neurons in vivo. ..
- Dierick H, Greenspan R. Serotonin and neuropeptide F have opposite modulatory effects on fly aggression. Nat Genet. 2007;39:678-82 pubmed..Moreover, this neuropeptide F effect seems to be independent of 5-HT. The implication of these two modulatory systems in fly and mouse aggression suggest a marked degree of conservation and a deep molecular root for this behavior. ..
- Yu K, Kang K, Heine P, Pyati U, Srinivasan S, Biehs B, et al. Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein. Genetics. 2004;166:1323-36 pubmed..Cumulatively, our analysis suggests that CR domains interact physically with adjacent protein sequences to create forms of Sog with distinct BMP modulatory activities. ..
- Tyler J, Collins K, Prasad Sinha J, Amiott E, Bulger M, Harte P, et al. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Mol Cell Biol. 2001;21:6574-84 pubmed..This interaction between dCAF-1 and dASF1 may be a key component of the functional synergy observed between RCAF and dCAF-1 during the assembly of newly synthesized DNA into chromatin. ..
- Finley K, Edeen P, Foss M, Gross E, Ghbeish N, Palmer R, et al. Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior. Neuron. 1998;21:1363-74 pubmed..Expression of a female transformer cDNA under the control of a dsf enhancer in males leads to dsf-like bisexual behavior. ..
- Shaw P, Tononi G, Greenspan R, Robinson D. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 2002;417:287-91 pubmed..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat. ..
- Hung K, Stumph W. Localization of residues in a novel DNA-binding domain of DmSNAP43 required for DmSNAPc DNA-binding activity. FEBS Lett. 2012;586:841-6 pubmed publisher..The results have identified two clusters of residues within this domain required for the sequence-specific DNA-binding activity of DmSNAPc. ..
- Viswanath V, Story G, Peier A, Petrus M, Lee V, Hwang S, et al. Opposite thermosensor in fruitfly and mouse. Nature. 2003;423:822-3 pubmed