Genomes and Genes
Experts and Doctors on drosophila proteins in Davis, California, United States
Locale: Davis, California, United States
Topic: drosophila proteins
- Kimbrell D, Hice C, Bolduc C, Kleinhesselink K, Beckingham K. The Dorothy enhancer has Tinman binding sites and drives hopscotch-induced tumor formation. Genesis. 2002;34:23-8 pubmed
- Tatebe H, Shiozaki K. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Mol Cell Biol. 2003;23:5132-42 pubmed..These results suggest that Spc1 SAPK is a novel client protein for the Cdc37 chaperone, and the Cdc37 function is important to maintain the stability of the Spc1 protein and to facilitate stress signaling from Wis1 MAPKK to Spc1 SAPK. ..
- Kwon M, Morales Mulia S, Brust Mascher I, Rogers G, Sharp D, Scholey J. The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility. Mol Biol Cell. 2004;15:219-33 pubmed..We propose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT bundles, to drive spindle pole separation and to facilitate chromatid motility. ..
- Begun D, Lindfors H. Rapid evolution of genomic Acp complement in the melanogaster subgroup of Drosophila. Mol Biol Evol. 2005;22:2010-21 pubmed publisher..yakuba and its close relative, Drosophila teissieri. These data suggest that turnover of Acps occurs rapidly in Drosophila, consistent with rapid evolution of seminal fluid function...
- Langley C, Lazzaro B, Phillips W, Heikkinen E, Braverman J. Linkage disequilibria and the site frequency spectra in the su(s) and su(w(a)) regions of the Drosophila melanogaster X chromosome. Genetics. 2000;156:1837-52 pubmed..We conclude that gene conversion must be high in these regions of low crossing over. ..
- Lawniczak M, Begun D. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Mol Biol Evol. 2007;24:1944-51 pubmed publisher..These genes are evolving rapidly, in some cases under directional selection, consistent with models of conflict...
- Ng C, Kopp A. Sex combs are important for male mating success in Drosophila melanogaster. Behav Genet. 2008;38:195-201 pubmed publisher..Rapid evolution of sex comb morphology may be driven either by changes in female preferences, or by co-evolution between sex combs and female external genitalia. ..
- Sekelsky J, Burtis K, Hawley R. Damage control: the pleiotropy of DNA repair genes in Drosophila melanogaster. Genetics. 1998;148:1587-98 pubmed
- Scholey J. Kinesin-5 in Drosophila embryo mitosis: sliding filament or spindle matrix mechanism?. Cell Motil Cytoskeleton. 2009;66:500-8 pubmed publisher..Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc. ..
- Rasooly R, Zhang P, Tibolla A, Hawley R. A structure-function analysis of NOD, a kinesin-like protein from Drosophila melanogaster. Mol Gen Genet. 1994;242:145-51 pubmed..These findings are consistent with the biochemical basis of the mode of action of each mutagen. ..
- Tucker R, Chiquet Ehrismann R. Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development. Dev Biol. 2006;290:237-45 pubmed..Teneurin function appears to be required for a fundamentally important signaling mechanism conserved between invertebrates and vertebrates having an impact on many processes relying on cell-cell contact throughout development. ..
- Begun D, Lindfors H, Thompson M, Holloway A. Recently evolved genes identified from Drosophila yakuba and D. erecta accessory gland expressed sequence tags. Genetics. 2006;172:1675-81 pubmed publisher..We found no evidence that these novel genes are attributable primarily to duplication and divergence, which suggests the possibility that Acp's or other genes coding for small proteins may originate from ancestrally noncoding DNA...
- Kopp A, Barmina O, Hamilton A, Higgins L, McIntyre L, Jones C. Evolution of gene expression in the Drosophila olfactory system. Mol Biol Evol. 2008;25:1081-92 pubmed publisher..citrifolia, and several genes that are yet to be characterized in detail. Increased expression of these genes in D. sechellia may have contributed to the evolution of its unique chemotactic behavior. ..
- Bossuyt W, Chen C, Chen Q, Sudol M, McNeill H, Pan D, et al. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene. 2014;33:1218-28 pubmed publisher..We conclude that fundamental differences exist in the upstream regulatory mechanisms of Hippo signaling between Drosophila and vertebrates. ..
- Cytrynbaum E, Scholey J, Mogilner A. A force balance model of early spindle pole separation in Drosophila embryos. Biophys J. 2003;84:757-69 pubmed
- Wang H, Brust Mascher I, Civelekoglu Scholey G, Scholey J. Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation. J Cell Biol. 2013;203:35-46 pubmed publisher..Although intact cortices, kinetochore MTs, and midzone augmentation are dispensable, this patronin-based change in ipMT minus-end dynamics is sufficient to induce the elongation of spindles capable of separating chromosomes...
- Sekelsky J, Hawley R. The bond between sisters. Cell. 1995;83:157-60 pubmed
- Zwick M, Salstrom J, Langley C. Genetic variation in rates of nondisjunction: association of two naturally occurring polymorphisms in the chromokinesin nod with increased rates of nondisjunction in Drosophila melanogaster. Genetics. 1999;152:1605-14 pubmed..The oötid competition model can account for both high mean rates of female-specific nondisjunction in Drosophila and humans as well as the standing genetic variation in this critical fitness character in natural populations. ..
- Matthies H, Baskin R, Hawley R. Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity. Mol Biol Cell. 2001;12:4000-12 pubmed..We suggest that the microtubule-activated ATPase activity of NOD provides transient attachments of chromosomes to microtubules rather than producing vectorial transport. ..
- Afshar K, Barton N, Hawley R, Goldstein L. DNA binding and meiotic chromosomal localization of the Drosophila nod kinesin-like protein. Cell. 1995;81:129-38 pubmed..Thus, motor-based chromosome-microtubule interactions are not limited to the centromere, but extend along the chromosome arms, providing a molecular explanation for the polar ejection force. ..
- Sekelsky J, McKim K, Chin G, Hawley R. The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1. Genetics. 1995;141:619-27 pubmed..cerevisiae, in that it requires an NER protein. The biochemical properties of the Rad1 protein allow us to explain the observation that mei-9 mutants suppress reciprocal exchange without suppressing the frequency of gene conversion. ..
- Barmina O, Kopp A. Sex-specific expression of a HOX gene associated with rapid morphological evolution. Dev Biol. 2007;311:277-86 pubmed..This is the first example of a sex-specific regulation of a HOX gene contributing to the development and evolution of a secondary sexual trait. ..
- McKim K, Dahmus J, Hawley R. Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E. Genetics. 1996;144:215-28 pubmed..The mei-218 gene is predicted to produce an 1186-amino acid protein that has no significant similarities to any known proteins. ..
- Matthies H, Messina L, Namba R, Greer K, Walker M, Hawley R. Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster. J Cell Biol. 1999;147:1137-44 pubmed..These results suggest that the accurate segregation of achiasmate chromosomes requires the proper balancing of forces acting on the chromosomes during prometaphase. ..
- Long A, Lyman R, Morgan A, Langley C, Mackay T. Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster. Genetics. 2000;154:1255-69 pubmed
- Barbash D, Awadalla P, Tarone A. Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. PLoS Biol. 2004;2:e142 pubmed..Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles. ..
- Scholey J, Rogers G, Sharp D. Mitosis, microtubules, and the matrix. J Cell Biol. 2001;154:261-6 pubmed..The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question. ..
- Burtis K, Coschigano K, Baker B, Wensink P. The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer. EMBO J. 1991;10:2577-82 pubmed..This result suggests strongly that dsx is a final regulatory gene in the hierarchy of regulatory genes controlling somatic sexual differentiation. ..
- Laurencon A, Purdy A, Sekelsky J, Hawley R, Su T. Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics. 2003;164:589-601 pubmed
- Harris P, Mazina O, Leonhardt E, Case R, Boyd J, Burtis K. Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes. Mol Cell Biol. 1996;16:5764-71 pubmed..Identification of a closely related gene in the genome of Caenorhabditis elegans suggests that this novel polypeptide may play an evolutionarily conserved role in the repair of DNA damage in eukaryotic organisms. ..
- Begun D, Holloway A, Stevens K, Hillier L, Poh Y, Hahn M, et al. Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. PLoS Biol. 2007;5:e310 pubmed..simulans. ..
- Atallah J, Vurens G, Mavong S, Mutti A, Hoang D, Kopp A. Sex-specific repression of dachshund is required for Drosophila sex comb development. Dev Biol. 2014;386:440-7 pubmed publisher..This mode of gene co-option may be an important driver of evolutionary innovations. ..
- Privalsky M. Activation incarnate. Dev Cell. 2003;5:1-2 pubmed..Three new publications reveal that the nuclear receptors LRH-1, DHR38, and Nurr1 can assume active conformations in the absence of a ligand agonist. These reports help elucidate how transcriptional regulators are themselves regulated. ..
- Graze R, Barmina O, Tufts D, Naderi E, Harmon K, Persianinova M, et al. New candidate genes for sex-comb divergence between Drosophila mauritiana and Drosophila simulans. Genetics. 2007;176:2561-76 pubmed..Further supporting the potential involvement of these genes in sex-comb divergence, we found a significant difference in sex-comb tooth number between co-isogenic D. melanogaster lines with and without P-element insertions at CG2791. ..
- Huang Q, Deveraux Q, Maeda S, Stennicke H, Hammock B, Reed J. Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori. Biochim Biophys Acta. 2001;1499:191-8 pubmed..These results suggest that suppression of apoptosis by lepidopteran IAPs in insect cells may involve inhibition of an upstream initiator caspase in the conserved mitochondria/cytochrome-c pathway for apoptosis. ..
- Page S, McKim K, Deneen B, Van Hook T, Hawley R. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Genetics. 2000;155:1757-72 pubmed..These data suggest that the pathways controlling germline differentiation and meiotic exchange are related and that factors involved in the mitotic divisions of the germline may regulate meiotic recombination. ..
- Burtis K. Development. Doublesex in the middle. Science. 2002;297:1135-6 pubmed
- Brust Mascher I, Civelekoglu Scholey G, Kwon M, Mogilner A, Scholey J. Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongation. Proc Natl Acad Sci U S A. 2004;101:15938-43 pubmed
- Erdman S, Burtis K. The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain. EMBO J. 1993;12:527-35 pubmed
- Morales Mulia S, Scholey J. Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A. Mol Biol Cell. 2005;16:3176-86 pubmed..These results extend recent findings from Xenopus extracts to Drosophila cultured cells and suggest that common pathways contribute to spindle pole organization and length determination. ..
- Green M. 2010: A century of Drosophila genetics through the prism of the white gene. Genetics. 2010;184:3-7 pubmed publisher..Here, I review some of the highlights of a century's productive use of white in Drosophila genetics...
- Tao L, Mogilner A, Civelekoglu Scholey G, Wollman R, Evans J, Stahlberg H, et al. A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays. Curr Biol. 2006;16:2293-302 pubmed
- Brust Mascher I, Sommi P, Cheerambathur D, Scholey J. Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis. Mol Biol Cell. 2009;20:1749-62 pubmed publisher..Finally, KLP61F activity contributes to normal chromosome congression, kinetochore spacing, and anaphase A rates. Thus, a KLP61F-driven sliding filament mechanism contributes to multiple aspects of mitosis in this system. ..
- Levine M, Begun D. Comparative population genetics of the immunity gene, Relish: is adaptive evolution idiosyncratic?. PLoS ONE. 2007;2:e442 pubmed
- Meyer D, Rines D, Kashina A, Cole D, Scholey J. Purification of novel kinesins from embryonic systems. Methods Enzymol. 1998;298:133-54 pubmed..Protein purification methods therefore represent an important complementary approach to molecular genetic approaches that are being pursued in many other laboratories. ..
- Sharp D, McDonald K, Brown H, Matthies H, Walczak C, Vale R, et al. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999;144:125-38 pubmed..Thus we propose that bipolar kinesin motors and MTs interact by a "sliding filament mechanism" during the formation and function of the mitotic spindle. ..
- Levine M, Holloway A, Arshad U, Begun D. Pervasive and largely lineage-specific adaptive protein evolution in the dosage compensation complex of Drosophila melanogaster. Genetics. 2007;177:1959-62 pubmed..melanogaster. Within these four proteins, several domains that range in function from X chromosome localization to protein-protein interactions have elevated, D. melanogaster-specific, amino acid divergence. ..
- Hawley R, Theurkauf W. Requiem for distributive segregation: achiasmate segregation in Drosophila females. Trends Genet. 1993;9:310-7 pubmed..The other system facilitates the segregation of heterologous chromosomes, by an as yet undiscovered mechanism...
- Sharp D, Yu K, Sisson J, Sullivan W, Scholey J. Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos. Nat Cell Biol. 1999;1:51-4 pubmed..Our data indicate that KLP61F and Ncd may function by crosslinking and sliding antiparallel spindle microtubules in relation to one another, allowing KLP61F to push centrosomes apart and Ncd to pull them together. ..