Genomes and Genes
Experts and Doctors on drosophila melanogaster in Davis, California, United States
Locale: Davis, California, United States
Topic: drosophila melanogaster
- Saltz J, Alicuben E, Grubman J, Harkenrider M, Megowan N, Nuzhdin S. Nonadditive indirect effects of group genetic diversity on larval viability in Drosophila melanogaster imply key role of maternal decision-making. Mol Ecol. 2012;21:2270-81 pubmed publisher..melanogaster and that predicting the consequences of genetic diversity at the population level may not be straightforward. ..
- Langley C, Stevens K, Cardeno C, Lee Y, Schrider D, Pool J, et al. Genomic variation in natural populations of Drosophila melanogaster. Genetics. 2012;192:533-98 pubmed publisher..Comparison of the variation among these genomes to variation among genomes from D. simulans suggests that many targets of directional selection are shared between these species. ..
- Sekelsky J, McKim K, Messina L, French R, Hurley W, Arbel T, et al. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999;152:529-42 pubmed..Although most of these are alleles of previously undescribed genes, five were in the known genes alphaTubulin67C, CycE, push, and Trl. The five mutations in known genes produce novel phenotypes for those genes...
- Civelekoglu Scholey G, Sharp D, Mogilner A, Scholey J. Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosis. Biophys J. 2006;90:3966-82 pubmed
- Burtis K, Coschigano K, Baker B, Wensink P. The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer. EMBO J. 1991;10:2577-82 pubmed..This result suggests strongly that dsx is a final regulatory gene in the hierarchy of regulatory genes controlling somatic sexual differentiation. ..
- Barbash D, Awadalla P, Tarone A. Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. PLoS Biol. 2004;2:e142 pubmed..Our findings suggest that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incompatibility alleles. ..
- Hawley R, Irick H, Zitron A, Haddox D, Lohe A, New C, et al. There are two mechanisms of achiasmate segregation in Drosophila females, one of which requires heterochromatic homology. Dev Genet. 1992;13:440-67 pubmed..elegans males. We also suggest that the physical basis of this process may reflect known properties of the Drosophila meiotic spindle...
- Syed Z, Ishida Y, Taylor K, Kimbrell D, Leal W. Pheromone reception in fruit flies expressing a moth's odorant receptor. Proc Natl Acad Sci U S A. 2006;103:16538-43 pubmed..We also found an endogenous receptor in one of the sensillum types on Drosophila antenna that responds to bombykol and bombykal with sensitivity comparable to the pheromone-detecting sensilla on B. mori male antennae...
- Sekelsky J, Burtis K, Hawley R. Damage control: the pleiotropy of DNA repair genes in Drosophila melanogaster. Genetics. 1998;148:1587-98 pubmed
- Long A, Lyman R, Morgan A, Langley C, Mackay T. Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster. Genetics. 2000;154:1255-69 pubmed
- Lawniczak M, Begun D. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Mol Biol Evol. 2007;24:1944-51 pubmed publisher..These genes are evolving rapidly, in some cases under directional selection, consistent with models of conflict...
- Lai C, Langley C. A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster. Gene. 1997;203:59-63 pubmed..The most conserved amino acid residues across these species are located at those sites required for in vitro association with the 7S RNA component of the SRP. ..
- Page S, Hawley R. c(3)G encodes a Drosophila synaptonemal complex protein. Genes Dev. 2001;15:3130-43 pubmed..Moreover, the observation of interference among the residual exchanges in these mutant oocytes implies that complete SC formation is not required for crossover interference in Drosophila. ..
- Syed Z, Kopp A, Kimbrell D, Leal W. Bombykol receptors in the silkworm moth and the fruit fly. Proc Natl Acad Sci U S A. 2010;107:9436-9 pubmed publisher..As opposed to the empty neuron system in the basiconic sensilla, the structural, biochemical, and/or biophysical features of the sensilla make the T1 trichoid system of the fly a better surrogate for the moth receptor. ..
- Oliveri D, Harris P, Boyd J. X-ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster. Mutat Res. 1990;235:25-31 pubmed..Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection. ..
- McKim K, Dahmus J, Hawley R. Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E. Genetics. 1996;144:215-28 pubmed..The mei-218 gene is predicted to produce an 1186-amino acid protein that has no significant similarities to any known proteins. ..
- Cheerambathur D, Brust Mascher I, Civelekoglu Scholey G, Scholey J. Dynamic partitioning of mitotic kinesin-5 cross-linkers between microtubule-bound and freely diffusing states. J Cell Biol. 2008;182:429-36 pubmed publisher..KLP61F appears to transiently bind MTs, moving short distances along them before detaching. Thus, kinesin-5 motors can function by cross-linking and sliding adjacent spindle MTs without the need for a static spindle matrix. ..
- Leonhardt E, Henderson D, Rinehart J, Boyd J. Characterization of the mus308 gene in Drosophila melanogaster. Genetics. 1993;133:87-96 pubmed..In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei. ..
- Langley C, MacDonald J, Miyashita N, Aguade M. Lack of correlation between interspecific divergence and intraspecific polymorphism at the suppressor of forked region in Drosophila melanogaster and Drosophila simulans. Proc Natl Acad Sci U S A. 1993;90:1800-3 pubmed
- Green M. The foundations of genetic fine structure: a retrospective from memory. Genetics. 1990;124:793-6 pubmed
- Sharp D, Yu K, Sisson J, Sullivan W, Scholey J. Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos. Nat Cell Biol. 1999;1:51-4 pubmed..Our data indicate that KLP61F and Ncd may function by crosslinking and sliding antiparallel spindle microtubules in relation to one another, allowing KLP61F to push centrosomes apart and Ncd to pull them together. ..
- Kimbrell D, Hice C, Bolduc C, Kleinhesselink K, Beckingham K. The Dorothy enhancer has Tinman binding sites and drives hopscotch-induced tumor formation. Genesis. 2002;34:23-8 pubmed
- Levine M, Begun D. Evidence of spatially varying selection acting on four chromatin-remodeling loci in Drosophila melanogaster. Genetics. 2008;179:475-85 pubmed publisher..Specifically, both stress-induced transcription and developmental homeostasis emerge as potential functional targets of environment-dependent selection. ..
- di Luccio E, Elling R, Wilson D. Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies. Biochem J. 2006;400:105-14 pubmed..This should allow improved prediction of co-substrate specificity and provide a basis for engineering enzymes with altered co-substrate utilization for this class of enzymes. ..
- Morales Mulia S, Scholey J. Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A. Mol Biol Cell. 2005;16:3176-86 pubmed..These results extend recent findings from Xenopus extracts to Drosophila cultured cells and suggest that common pathways contribute to spindle pole organization and length determination. ..
- Zhao L, Saelao P, Jones C, Begun D. Origin and spread of de novo genes in Drosophila melanogaster populations. Science. 2014;343:769-72 pubmed publisher..These results reveal a heretofore unappreciated dynamism of gene content. ..
- Banga S, Boyd J. Oligonucleotide-directed site-specific mutagenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1992;89:1735-9 pubmed
- Hawley R. Meiosis as an "M" thing: twenty-five years of meiotic mutants in Drosophila. Genetics. 1993;135:613-8 pubmed
- Erdman S, Burtis K. The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain. EMBO J. 1993;12:527-35 pubmed
- Green M, Piergentili R. On the origin of metacentric, attached-X (A-X) chromosomes in Drosophila melanogaster males. Proc Natl Acad Sci U S A. 2000;97:14484-7 pubmed..The inseparabile mutation also affects disjunction of the chromosome 4 in males. We suspect that the mutation was responsible for the original A-X female found by L. V. Morgan in 1921. ..
- Bossuyt W, Chen C, Chen Q, Sudol M, McNeill H, Pan D, et al. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene. 2014;33:1218-28 pubmed publisher..We conclude that fundamental differences exist in the upstream regulatory mechanisms of Hippo signaling between Drosophila and vertebrates. ..
- Banga S, Boyd J, Valerie K, Harris P, Kurz E, de Riel J. denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1989;86:3227-31 pubmed..It also provides a model system for future investigations of other well-characterized microbial repair genes on DNA damage in the germ line of this metazoan organism. ..
- Settle S, Green M, Burtis K. The silver gene of Drosophila melanogaster encodes multiple carboxypeptidases similar to mammalian prohormone-processing enzymes. Proc Natl Acad Sci U S A. 1995;92:9470-4 pubmed..One class of svr mRNAs is alternatively spliced to encode at least two polyproteins, each of which is composed of two carboxypeptidase domains. ..
- Kashina A, Baskin R, Cole D, Wedaman K, Saxton W, Scholey J. A bipolar kinesin. Nature. 1996;379:270-2 pubmed..Such a bipolar 'minifilament' could crosslink spindle MTs and slide them relative to one another. We do not know of any other MT motors that have a bipolar structure. ..
- Levine M, Holloway A, Arshad U, Begun D. Pervasive and largely lineage-specific adaptive protein evolution in the dosage compensation complex of Drosophila melanogaster. Genetics. 2007;177:1959-62 pubmed..melanogaster. Within these four proteins, several domains that range in function from X chromosome localization to protein-protein interactions have elevated, D. melanogaster-specific, amino acid divergence. ..
- Sharp D, McDonald K, Brown H, Matthies H, Walczak C, Vale R, et al. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999;144:125-38 pubmed..Thus we propose that bipolar kinesin motors and MTs interact by a "sliding filament mechanism" during the formation and function of the mitotic spindle. ..
- Begun D, Lindfors H. Rapid evolution of genomic Acp complement in the melanogaster subgroup of Drosophila. Mol Biol Evol. 2005;22:2010-21 pubmed publisher..yakuba and its close relative, Drosophila teissieri. These data suggest that turnover of Acps occurs rapidly in Drosophila, consistent with rapid evolution of seminal fluid function...
- Kiger J, Natzle J, Green M. Hemocytes are essential for wing maturation in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2001;98:10190-5 pubmed..We propose that batone is required for the release of a hormone necessary for wing expansion and tissue remodeling by hemocytes in the wing. ..
- Henderson D, Banga S, Grigliatti T, Boyd J. Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA. EMBO J. 1994;13:1450-9 pubmed..All three ts mutants strongly suppress PEV, which suggests a role for PCNA in chromatin assembly or modification. ..
- Hari K, Santerre A, Sekelsky J, McKim K, Boyd J, Hawley R. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell. 1995;82:815-21 pubmed..Thus, the mei-41 gene of Drosophila may be considered to be a functional homolog of the human ATM gene. ..
- Levine M, Eckert M, Begun D. Whole-genome expression plasticity across tropical and temperate Drosophila melanogaster populations from Eastern Australia. Mol Biol Evol. 2011;28:249-56 pubmed publisher..melanogaster populations. ..
- Long A, Mullaney S, Mackay T, Langley C. Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. Genetics. 1996;144:1497-510 pubmed
- Nuzhdin S, Tufts D, Hahn M. Abundant genetic variation in transcript level during early Drosophila development. Evol Dev. 2008;10:683-9 pubmed publisher..Finally, we estimate the dimensionality of gene expression in these two networks and find that-despite large numbers of varying genes-there appear to be only two factors controlling this variation...
- Orr H. Mapping and characterization of a 'speciation gene' in Drosophila. Genet Res. 1992;59:73-80 pubmed..Hms is zygotically acting, and the D. simulans allele of hms is completely recessive. Furthermore, complementation tests suggest that hms is not an allele of any known locus in D. melanogaster. ..
- Taylor K, Kimbrell D. Host immune response and differential survival of the sexes in Drosophila. Fly (Austin). 2007;1:197-204 pubmed..These studies highlight the need to include both sexes in studies of immune function as well as the associated opportunities for advancing our understanding of immunity. ..
- Langley C, Crepeau M, Cardeno C, Corbett Detig R, Stevens K. Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo. Genetics. 2011;188:239-46 pubmed publisher..This method provides a solid path forward for population genomic sequencing and offers applications to many other systems in which small amounts of genomic DNA have unique experimental relevance. ..
- Miyazaki M, Matsumura F, Beeman R. DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tribolium castaneum. Comp Biochem Physiol B Biochem Mol Biol. 1995;111:399-406 pubmed
- Cole D, Saxton W, Sheehan K, Scholey J. A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos. J Biol Chem. 1994;269:22913-6 pubmed..Therefore, KRP130 appears to be the first Drosophila KRP, and the first member of the BimC subfamily in any organism, to be purified from native tissue as a multimeric motor complex. ..
- Abo Elghar G, Fujiyoshi P, Matsumura F. Significance of the sulfonylurea receptor (SUR) as the target of diflubenzuron in chitin synthesis inhibition in Drosophila melanogaster and Blattella germanica. Insect Biochem Mol Biol. 2004;34:743-52 pubmed..germanica in a manner very similar to diflubenzuron. These results support our conclusion that the sulfonylurea receptor (SUR) is the target of diflubenzuron in inhibition of chitin synthesis in these two insect species...
- Sekelsky J, Hollis K, Eimerl A, Burtis K, Hawley R. Nucleotide excision repair endonuclease genes in Drosophila melanogaster. Mutat Res. 2000;459:219-28 pubmed..The Drosophila Ercc1 gene maps to polytene region 51D1-2. The nucleotide excision repair gene mus210 maps nearby (51E-F) but is distinct from Ercc1. ..
- Sekelsky J, Brodsky M, Rubin G, Hawley R. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing. Nucleic Acids Res. 1999;27:3762-9 pubmed..A combination of RACE and cDNA analysis of human RECQ5 demonstrates extensive alternative splicing for this gene also, including some forms lacking helicase motifs and other conserved regions. ..
- Wang H, Brust Mascher I, Civelekoglu Scholey G, Scholey J. Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation. J Cell Biol. 2013;203:35-46 pubmed publisher..Although intact cortices, kinetochore MTs, and midzone augmentation are dispensable, this patronin-based change in ipMT minus-end dynamics is sufficient to induce the elongation of spindles capable of separating chromosomes...
- Levine M, Jones C, Kern A, Lindfors H, Begun D. Novel genes derived from noncoding DNA in Drosophila melanogaster are frequently X-linked and exhibit testis-biased expression. Proc Natl Acad Sci U S A. 2006;103:9935-9 pubmed..These data support the idea that these novel genes are derived from ancestral noncoding sequence and that new, favored genes are likely to invade populations under selective pressures relating to male reproduction. ..
- Brust Mascher I, Scholey J. Microtubule flux and sliding in mitotic spindles of Drosophila embryos. Mol Biol Cell. 2002;13:3967-75 pubmed
- Kwon M, Morales Mulia S, Brust Mascher I, Rogers G, Sharp D, Scholey J. The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility. Mol Biol Cell. 2004;15:219-33 pubmed..We propose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT bundles, to drive spindle pole separation and to facilitate chromatid motility. ..
- Natzle J, Robertson J, Majumdar A, Vesenka G, Enlow B, Clark K. Sequence and expression of IMP-L1, an ecdysone-inducible gene expressed during Drosophila imaginal disc morphogenesis. Dev Genet. 1992;13:331-44 pubmed..We suggest that the delayed timing of expression of this secondary response gene is necessary for proper ordering of cellular events associated with disc morphogenesis. ..
- Hawley R, Theurkauf W. Requiem for distributive segregation: achiasmate segregation in Drosophila females. Trends Genet. 1993;9:310-7 pubmed..The other system facilitates the segregation of heterologous chromosomes, by an as yet undiscovered mechanism...
- Carey J, Papadopoulos N, Kouloussis N, Katsoyannos B, Muller H, Wang J, et al. Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata. Exp Gerontol. 2006;41:93-7 pubmed..g. supine) that emerge from the aging process be referred to as degenerative behaviors, not only to distinguish them from the conventional behavioral classifications (innate, learned), but also to reflect their emergent nature...
- Laurencon A, Orme C, Peters H, Boulton C, Vladar E, Langley S, et al. A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics. 2004;167:217-31 pubmed..At least one allele of each new gene identified in this study is available at the Bloomington Stock Center. ..
- Matthies H, Messina L, Namba R, Greer K, Walker M, Hawley R. Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster. J Cell Biol. 1999;147:1137-44 pubmed..These results suggest that the accurate segregation of achiasmate chromosomes requires the proper balancing of forces acting on the chromosomes during prometaphase. ..
- Ng C, Kopp A. Sex combs are important for male mating success in Drosophila melanogaster. Behav Genet. 2008;38:195-201 pubmed publisher..Rapid evolution of sex comb morphology may be driven either by changes in female preferences, or by co-evolution between sex combs and female external genitalia. ..
- McKim K, Green Marroquin B, Sekelsky J, Chin G, Steinberg C, Khodosh R, et al. Meiotic synapsis in the absence of recombination. Science. 1998;279:876-8 pubmed..Furthermore, the basic processes of early meiosis may have different functional or temporal relations, or both, in yeast and Drosophila. ..
- Lai C, McMahon R, Young C, Mackay T, Langley C. quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase. Genetics. 1998;149:1051-61 pubmed..An EMS-induced qm nonsense mutation at the 12th codon leads to recessive lethality at the first larval instar, indicating the essential role of qm in the isoprenoid biosynthesis of insects. ..
- Zwick M, Salstrom J, Langley C. Genetic variation in rates of nondisjunction: association of two naturally occurring polymorphisms in the chromokinesin nod with increased rates of nondisjunction in Drosophila melanogaster. Genetics. 1999;152:1605-14 pubmed..The oötid competition model can account for both high mean rates of female-specific nondisjunction in Drosophila and humans as well as the standing genetic variation in this critical fitness character in natural populations. ..