Genomes and Genes
Experts and Doctors on cell nucleus in Davis, California, United States
Locale: Davis, California, United States
Topic: cell nucleus
- Clegg J, Jackson S, Popov V. Long-term anoxia in encysted embryos of the crustacean, Artemia franciscana: viability, ultrastructure, and stress proteins. Cell Tissue Res. 2000;301:433-46 pubmed
- Tassone F, Iwahashi C, Hagerman P. FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS). RNA Biol. 2004;1:103-5 pubmed..Consistent with this model, we have now identified FMR1 mRNA within the intranuclear inclusions isolated from post-mortem (FXTAS) brain tissue...
- Banerjee T, Valacchi G, Ziboh V, van Der Vliet A. Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells. Mol Cell Biochem. 2002;238:105-10 pubmed..Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role. ..
- LaSalle J, Hogart A, Thatcher K. Rett syndrome: a Rosetta stone for understanding the molecular pathogenesis of autism. Int Rev Neurobiol. 2005;71:131-65 pubmed
- Rojas M, Jiang H, Salati R, Xoconostle Cazares B, Sudarshana M, Lucas W, et al. Functional analysis of proteins involved in movement of the monopartite begomovirus, Tomato yellow leaf curl virus. Virology. 2001;291:110-25 pubmed..Thus, the V1 and/or C4 may be analogs of the bipartite begomovirus BC1 that have evolved to mediate TYLCV movement within phloem tissue...
- Chen J, Thirkill T, Overstreet J, Lasley B, Douglas G. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotropin secretion by human trophoblasts. Reprod Toxicol. 2003;17:87-93 pubmed..These in vitro results support earlier in vivo studies in macaques suggesting that trophoblast is a target for TCCD and that TCDD-induced early pregnancy loss is accompanied by a decrease in the CG B/I ratio. ..
- Fridolfsson H, Ly N, Meyerzon M, Starr D. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Dev Biol. 2010;338:237-50 pubmed publisher..Kinesin-1 functions as the major force generator during nuclear migration, while dynein is involved in regulation of bidirectional transport of the nucleus. ..
- Gonzales M, Adams S, Dunaway K, LaSalle J. Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation. Mol Cell Biol. 2012;32:2894-903 pubmed publisher..These results demonstrate that phosphorylation is one of several factors that are important for interpreting the complexities of MeCP2 transcriptional modulation. ..
- Morishita M, Engebrecht J. End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae. Genetics. 2005;170:1561-74 pubmed..Thus, END3-mediated endocytosis is important for spore wall formation. Additionally, cytological analyses suggest that trafficking between the plasma membrane and PSMs is important earlier during sporulation. ..
- Provencher L, Miao L, Sinha N, Lucas W. Sucrose export defective1 encodes a novel protein implicated in chloroplast-to-nucleus signaling. Plant Cell. 2001;13:1127-41 pubmed
- Siino J, Nazarov I, Svetlova M, Solovjeva L, Adamson R, Zalenskaya I, et al. Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus. Biochem Biophys Res Commun. 2002;297:1318-23 pubmed..This suggests that gamma-H2AX formation in chromatin is unlikely to occur by diffusion of free histone and gamma-H2AX dephosphorylation may involve the mammalian protein phosphatase 1alpha. ..
- Starr D, Fridolfsson H. Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annu Rev Cell Dev Biol. 2010;26:421-44 pubmed publisher..Knockouts of SUN or KASH proteins disrupt neurological and muscular development in mice. Defects in SUN and KASH proteins have been linked to human diseases including muscular dystrophy, ataxia, progeria, lissencephaly, and cancer. ..
- Starr D, Rose L. TorsinA regulates the LINC to moving nuclei. J Cell Biol. 2017;216:543-545 pubmed publisher..2017. J. Cell Biol. https://doi.org/10.1083/jcb.201507113) show that the AAA+ ATPase torsinA and its partner LAP1 are required for nuclear migration during fibroblast polarization by mediating the dynamics of LINC complexes. ..
- Martin Tryon E, Harmer S. XAP5 CIRCADIAN TIMEKEEPER coordinates light signals for proper timing of photomorphogenesis and the circadian clock in Arabidopsis. Plant Cell. 2008;20:1244-59 pubmed publisher..Downregulation of the XCT ortholog in Caenorhabditis elegans is lethal, suggesting that studies in Arabidopsis may be instrumental to understanding the biochemical activity of XCT...
- Schnier J, Nishi K, Harley W, Gorin F. An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008;89:19-26 pubmed publisher..0. Upon prolonged (24 h) incubation at pH(ext) 6.0, nuclear cyclin D1 was nearly absent in T98G in contrast to U87 cells. Thus, an acidic environment triggers cytoplasmic localization and proteasomal degradation of cyclin D1. ..
- Easlon E, Tsang F, Skinner C, Wang C, Lin S. The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev. 2008;22:931-44 pubmed publisher..Together, these data suggest that CR may extend life span and ameliorate age-associated metabolic diseases by activating components of the NADH shuttles. ..
- Page S, Hawley R. c(3)G encodes a Drosophila synaptonemal complex protein. Genes Dev. 2001;15:3130-43 pubmed..Moreover, the observation of interference among the residual exchanges in these mutant oocytes implies that complete SC formation is not required for crossover interference in Drosophila. ..
- MacKenzie G, Oteiza P. Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. J Cell Physiol. 2007;210:246-56 pubmed
- García Varela M, Nadler S. Phylogenetic relationships among Syndermata inferred from nuclear and mitochondrial gene sequences. Mol Phylogenet Evol. 2006;40:61-72 pubmed
- Nazarov I, Smirnova A, Krutilina R, Svetlova M, Solovjeva L, Nikiforov A, et al. Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A. Radiat Res. 2003;160:309-17 pubmed..Our results confirm the tight association between DSBs and gamma-H2AX and the coupling of its in situ dephosphorylation to DSB repair. ..
- Kumar P, Kumar P, Lindberg L, Thirkill T, Ji J, Martsching L, et al. The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. PLoS ONE. 2012;7:e42712 pubmed publisher..These results suggest that MUC1-N translocates to the nucleus where it is expressed in nuclear speckles and that MUC1-N and MUC1-C have dissimilar intranuclear distribution patterns...
- Fridolfsson H, Starr D. Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei. J Cell Biol. 2010;191:115-28 pubmed publisher..This organization of microtubules fits with our model that kinesin-1 moves nuclei forward and dynein functions to move nuclei backward for short stretches to bypass cellular roadblocks. ..
- Cytrynbaum E, Scholey J, Mogilner A. A force balance model of early spindle pole separation in Drosophila embryos. Biophys J. 2003;84:757-69 pubmed
- Tapley E, Ly N, Starr D. Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane. Mol Biol Cell. 2011;22:1739-52 pubmed publisher..Multiple mechanisms might also be used to target other proteins to the INM, thereby ensuring their proper and timely localization for essential cellular and developmental functions. ..
- Cytrynbaum E, Sommi P, Brust Mascher I, Scholey J, Mogilner A. Early spindle assembly in Drosophila embryos: role of a force balance involving cytoskeletal dynamics and nuclear mechanics. Mol Biol Cell. 2005;16:4967-81 pubmed..Thus, the force-balance driving early spindle morphogenesis depends upon MT-based motors acting in concert with the cortex and nucleus. ..
- Leaché A. Species trees for spiny lizards (genus Sceloporus): identifying points of concordance and conflict between nuclear and mitochondrial data. Mol Phylogenet Evol. 2010;54:162-71 pubmed publisher..The points of concordance and conflict between the nuclear and mtDNA data are discussed, and arguments for preferring the species trees estimated from the multilocus nuclear data are presented. ..
- Boucher P, Koning A, Privalsky M. The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations. J Virol. 1988;62:534-44 pubmed
- Dowling T, Markle D, Tranah G, Carson E, Wagman D, May B. Introgressive Hybridization and the Evolution of Lake-Adapted Catostomid Fishes. PLoS ONE. 2016;11:e0149884 pubmed publisher..We examine parallel evolution and syngameon hypotheses and conclude that observed patterns are most easily explained by introgressive hybridization among Klamath Basin catostomids. ..
- Tapley E, Starr D. Connecting the nucleus to the cytoskeleton by SUN-KASH bridges across the nuclear envelope. Curr Opin Cell Biol. 2013;25:57-62 pubmed publisher..KASH proteins at the outer nuclear membrane link the nuclear envelope to the cytoskeleton where forces are generated to move nuclei. Significantly, SUN proteins were recently shown to contribute to the progression of laminopathies...
- Privalsky M. A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90. J Biol Chem. 1991;266:1456-62 pubmed
- Yang H, McNally K, McNally F. MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans. Dev Biol. 2003;260:245-59 pubmed..These results indicate a direct role of microtubule severing in translocation of the meiotic spindle to the cortex. ..
- Lucas W. Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomes. Virology. 2006;344:169-84 pubmed
- Sinitsyna N, Reznikova T, Qin Q, Song H, Phillips M, Rice R. Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes. Toxicol Appl Pharmacol. 2010;243:275-82 pubmed publisher..These findings help trace a mechanism by which transcriptional effects of arsenite become manifest and help rationalize the unique action of arsenite, compared to the other agents, to preserve proliferative ability. ..
- Huang F, Kao C, Wachi S, Thai P, Ryu J, Wu R. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. J Immunol. 2007;179:6504-13 pubmed
- Hawkes W, Alkan Z. Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway. J Biol Chem. 2012;287:27371-9 pubmed publisher..These results imply that SEPW1 silencing increases MKK4, which activates p38?, p38?, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest. ..
- Chang Y, Dranow D, Kuhn J, Meyerzon M, Ngo M, Ratner D, et al. toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans. Genetics. 2013;193:187-200 pubmed publisher..The other emu mutations potentially represent other components of this novel pathway. ..
- Sekelsky J, Brodsky M, Rubin G, Hawley R. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing. Nucleic Acids Res. 1999;27:3762-9 pubmed..A combination of RACE and cDNA analysis of human RECQ5 demonstrates extensive alternative splicing for this gene also, including some forms lacking helicase motifs and other conserved regions. ..
- Tsou M, Hayashi A, DeBella L, McGrath G, Rose L. LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development. 2002;129:4469-81 pubmed..Together, the data indicate that LET-99 acts downstream of PAR-3 and PAR-2 to determine spindle positioning, potentially through the asymmetric regulation of forces on the spindle. ..
- Kwon M, Morales Mulia S, Brust Mascher I, Rogers G, Sharp D, Scholey J. The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility. Mol Biol Cell. 2004;15:219-33 pubmed..We propose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT bundles, to drive spindle pole separation and to facilitate chromatid motility. ..
- Hong S, Yang Z, Privalsky M. Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia. Mol Cell Biol. 2001;21:7172-82 pubmed..Conversely, inhibition of this MAP kinase cascade attenuates the effects of arsenite on APL cells. Our results implicate SMRT as an important biological target for the actions of arsenite in both normal and neoplastic cells. ..
- Caldwell C, Green R, Kaplan K. APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol. 2007;178:1109-20 pubmed..We provide direct evidence that the dominant activity of APC mutants induces aneuploidy in vivo. Our data support a model whereby tetraploid cells represent a first step in the onset of genomic instability and colorectal cancer. ..
- Wu J, Rose L. PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos. Mol Biol Cell. 2007;18:4470-82 pubmed..Finally, examination of par-1 embryos suggests that the banded pattern of LET-99 is critical for normal posterior spindle displacement and to prevent spindle misorientation caused by cell shape constraints. ..
- Near T, Bolnick D, Wainwright P. Investigating phylogenetic relationships of sunfishes and black basses (Actinopterygii: Centrarchidae) using DNA sequences from mitochondrial and nuclear genes. Mol Phylogenet Evol. 2004;32:344-57 pubmed publisher..Slightly more than half of the 27 previously proposed hypotheses of centrarchid relationships were rejected based on the Shomodaira-Hasegawa test...
- Philp A, Chen A, Lan D, Meyer G, Murphy A, Knapp A, et al. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011;286:30561-70 pubmed publisher
- Liu J, Coaker G. Nuclear trafficking during plant innate immunity. Mol Plant. 2008;1:411-22 pubmed publisher..Taken together, these data illustrate the importance of nuclear trafficking in the manifestation of disease resistance mediated by R genes. ..
- McIntyre P. Cytogeography and genome size variation in the Claytonia perfoliata (Portulacaceae) polyploid complex. Ann Bot. 2012;110:1195-203 pubmed publisher..The C. perfoliata complex is characterized by polyploids ranging from tetraploid to decaploid, with large magnitude variation in genome size at higher ploidy levels, associated in part with environmental variation in temperature. ..
- Park C, Ronald P. Cleavage and nuclear localization of the rice XA21 immune receptor. Nat Commun. 2012;3:920 pubmed publisher..These results suggest a new model for immune receptor function: on receptor recognition of conserved microbial signatures, the associated kinase translocates to the nucleus where it directly interacts with transcriptional regulators. ..
- Zhou Y, Rojas M, Park M, Seo Y, Lucas W, Gilbertson R. Histone H3 interacts and colocalizes with the nuclear shuttle protein and the movement protein of a geminivirus. J Virol. 2011;85:11821-32 pubmed publisher..Taken together, these findings implicate the host factor histone H3 in the process by which an infectious geminiviral DNA complex forms within the nucleus for export to the cell periphery and cell-to-cell movement through plasmodesmata...
- Barley A, Spinks P, Thomson R, Shaffer H. Fourteen nuclear genes provide phylogenetic resolution for difficult nodes in the turtle tree of life. Mol Phylogenet Evol. 2010;55:1189-94 pubmed publisher..Within this clade, snapping turtles (Chelydridae) and mud/musk turtles (Kinosternidae) are sister taxa, again with strong support. Our results emphasize the utility of multi-locus datasets in phylogenetic analyses of difficult problems. ..
- Tsou M, Hayashi A, Rose L. LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development. 2003;130:5717-30 pubmed..These results provide insight into how polarity cues are transmitted into specific spindle positions in both extrinsic and intrinsic pathways of asymmetric cell division. ..
- Suzuki Y, Wong H, Ashida K, Schryvers A, Lonnerdal B. The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus. Biochemistry. 2008;47:10915-20 pubmed publisher..These results indicate that the N1.1 subdomain of hLf is sufficient for binding, internalization, and targeting to the nucleus of Caco-2 cells. ..
- Nagy S, Denison M. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochem Biophys Res Commun. 2002;296:799-805 pubmed..These results suggest that repression of CYP1A1 gene expression in high passage keratinocytes may involve the interplay between at least two specific NeRD binding factors. ..
- Mak S, Kültz D. Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. J Biol Chem. 2004;279:39075-84 pubmed
- Arocena D, Iwahashi C, Won N, Beilina A, Ludwig A, Tassone F, et al. Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. Hum Mol Genet. 2005;14:3661-71 pubmed
- DeBella L, Hayashi A, Rose L. LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos. Mol Biol Cell. 2006;17:4911-24 pubmed..We therefore propose that LET-711 inhibits the expression of ZYG-9 and potentially other centrosome-associated proteins, in order to maintain normal centrosome size and microtubule dynamics during early embryonic divisions. ..
- Pagnussat G, Yu H, Sundaresan V. Cell-fate switch of synergid to egg cell in Arabidopsis eostre mutant embryo sacs arises from misexpression of the BEL1-like homeodomain gene BLH1. Plant Cell. 2007;19:3578-92 pubmed..As eostre-1 embryo sacs also show nuclear migration abnormalities, this study suggests that a positional mechanism might be directing establishment of cell fates in early megagametophyte development. ..
- Kao C, Kim C, Huang F, Wu R. Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. J Biol Chem. 2008;283:15309-18 pubmed publisher..This is the first demonstration of the involvement of two proximal NF-kappaB sites and IkappaB-zeta in the regulation of hBD-2 by IL-17A, two important genes responsible for host defense. ..
- Zalensky A, Siino J, Gineitis A, Zalenskaya I, Tomilin N, Yau P, et al. Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. J Biol Chem. 2002;277:43474-80 pubmed..This fact may be of particular importance, because the hTSH2B "positive" and "negative" sperm cells may undergo significantly different decondensation processes following fertilization. ..
- Chu W, Wang Z, Roeder R, Schmid C. RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. J Biol Chem. 1997;272:14755-61 pubmed..While Rb interacts with both factors, the A subdomain is more important than the B subdomain in directing Rb-mediated repression, and TFIIIB is the principal target of that activity. ..
- Kim J, Yu C, Bailey A, Hardison R, Shen C. Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. Nucleic Acids Res. 1989;17:5687-700 pubmed
- Heyer W, Ehmsen K, Solinger J. Holliday junctions in the eukaryotic nucleus: resolution in sight?. Trends Biochem Sci. 2003;28:548-57 pubmed..Holliday junction resolution to non-crossover products can also be achieved topologically, for example, by the action of RecQ-like DNA helicases combined with topoisomerase III. ..