Experts and Doctors on carrier proteins in San Diego, California, United States

Summary

Locale: San Diego, California, United States
Topic: carrier proteins

Top Publications

  1. Burton D, Geller J, Yang M, Jiang P, Barken I, Hastings R, et al. Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP. Prostate. 2005;62:275-81 pubmed
    ..PTHrP and OPG may be useful as tumor biomarkers for PCa that has metastasized to bone. This novel human PCa model can be used to study the clinical potential of diagnostic and therapeutic modalities in the skeletal progression of PCas. ..
  2. Mercurio F, Murray B, Shevchenko A, Bennett B, Young D, Li J, et al. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19:1526-38 pubmed
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation. ..
  3. Kelner G, Lee M, Clark M, Maciejewski D, McGrath D, Rabizadeh S, et al. The copper transport protein Atox1 promotes neuronal survival. J Biol Chem. 2000;275:580-4 pubmed
    ..Therefore, Atox1 is a component of the cellular pathways used for protection against oxidative stress. ..
  4. Triana Baltzer G, Blank M. Cytoplasmic domain of protocadherin-alpha enhances homophilic interactions and recognizes cytoskeletal elements. J Neurobiol. 2006;66:393-407 pubmed
    ..These findings suggest cytoskeletal links for pcdh-alphas and identify candidate targets. They also demonstrate homophilic interactions for pcdh-alphas as described for classical cadherins. ..
  5. Shah M, Sakurai H, Gallegos T, Sweeney D, Bush K, Esko J, et al. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011;356:19-27 pubmed publisher
    ..2004). ..
  6. Clarke K, Mercer A, La Clair J, Burkart M. In vivo reporter labeling of proteins via metabolic delivery of coenzyme A analogues. J Am Chem Soc. 2005;127:11234-5 pubmed
    ..These methods may be applied to natural product pathway manipulation as well as applications in conventional molecular and cellular biology. ..
  7. Lorrain D, Bain G, Correa L, Chapman C, Broadhead A, Santini A, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010;640:211-8 pubmed publisher
    ..In summary, AM803 is a novel, potent and selective FLAP inhibitor that has excellent pharmacodynamic properties in vivo and is effective in animal models of acute inflammation and in a model of lethal shock. ..
  8. Philpott C, Ryu M, Frey A, Patel S. Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells. J Biol Chem. 2017;292:12764-12771 pubmed publisher
    ..The monothiol glutaredoxin Glrx3 and BolA2 function as a [2Fe-2S] chaperone complex. These proteins form a core system of cytosolic iron cofactor chaperones in mammalian cells. ..
  9. Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, et al. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003;112:30-41 pubmed
    ..These findings provide evidence for an angiogenic switch that can be initiated in the absence of exogenous growth factors and indicate that the angiogenic matrix protein Del-1 may be a useful tool for the therapy of ischemic disease. ..

More Information

Publications88

  1. Pratt V, Everts R, Aggarwal P, Beyer B, Broeckel U, EPSTEIN BAAK R, et al. Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project. J Mol Diagn. 2016;18:109-23 pubmed publisher
    ..These publicly available samples will help ensure the accuracy of pharmacogenetic testing. ..
  2. Stone G, Zhang Q, Castillo R, Doppalapudi V, Bueno A, Lee J, et al. Mechanism of action of NB2001 and NB2030, novel antibacterial agents activated by beta-lactamases. Antimicrob Agents Chemother. 2004;48:477-83 pubmed
    ..aureus and E. coli. Taken together, the results suggest that NB2001 and NB2030 act primarily as triclosan prodrugs in S. aureus and E. coli. ..
  3. Ralph E, Thomson J, Almaden J, Sun S. Glucose modulation of glucokinase activation by small molecules. Biochemistry. 2008;47:5028-36 pubmed publisher
    ..The regulation of GK activation by glucose may have an important implication for the discovery and design of GK activators as potential antidiabetic agents. ..
  4. Zhang X, Brunner T, Carter L, Dutton R, Rogers P, Bradley L, et al. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med. 1997;185:1837-49 pubmed
    ..The rapid death of Th1 effectors leading to selective Th2 survival provides a novel mechanism for differential regulation of the two subsets. ..
  5. Behan D, Potter E, Lewis K, Jenkins N, Copeland N, Lowry P, et al. Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP). Genomics. 1993;16:63-8 pubmed
    ..The promoter sequence contained a number of putative promoter elements including an AP-1 site, three ER-half sites, the immunoglobulin enhancer elements NF-kappa B and INF-1, and the liver-specific enhancers LFA1 and LFB1. ..
  6. Suckow A, Comoletti D, Waldrop M, Mosedale M, Egodage S, Taylor P, et al. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 2008;149:6006-17 pubmed publisher
    ..Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus...
  7. Kasimsetty S, McKay D. Ischemia as a factor affecting innate immune responses in kidney transplantation. Curr Opin Nephrol Hypertens. 2016;25:3-11 pubmed publisher
    ..As we learn more about how these important receptors are regulated by ischemia, strategies will likely evolve to allow their modulation in ischemic renal injury. ..
  8. Shi J, Koeppe J, Komives E, Taylor P. Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 2006;281:12170-7 pubmed
    ..These results reveal dynamic states and fluctuating movements in the vicinity of the binding site for unligated AChBP that can be influenced selectively by ligands. ..
  9. Bazirgan O, Hampton R. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem. 2008;283:12797-810 pubmed publisher
    ..Moreover, it suggests a previously unappreciated mode for regulation of E2s by Cue1p-like interacting partners. ..
  10. Yamauchi J, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing J, et al. Synthesis of selective agonists for the ?7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates. Mol Pharmacol. 2012;82:687-99 pubmed
  11. Huang L, Durick K, Weiner J, Chun J, Taylor S. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem. 1997;272:8057-64 pubmed
    ..These results raise a novel possibility that the type I regulatory subunit may be anchored via anchoring proteins. ..
  12. Stan R, Ghitescu L, Jacobson B, Palade G. Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein. J Cell Biol. 1999;145:1189-98 pubmed
  13. Magistri P, Leonard S, Tang C, Chan J, Lee T, Sicklick J. The glypican 3 hepatocellular carcinoma marker regulates human hepatic stellate cells via Hedgehog signaling. J Surg Res. 2014;187:377-85 pubmed publisher
    ..This expands on existing data suggesting a role for tumor-stroma interactions in the liver and suggests that GPC3 plays a role in this process. ..
  14. Xu S, Abbasian M, Patel P, Jensen Pergakes K, Lombardo C, Cathers B, et al. Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase. J Biol Chem. 2007;282:15462-70 pubmed
    ..In the absence of p27, Cdk2/E and Cks1 increase Skp2 phosphorylation. This phosphorylation enhances Skp2 auto-ubiquitination, whereas p27 inhibits both phosphorylation and auto-ubiquitination of Skp2. ..
  15. Kerk D, Bulgrien J, Smith D, Gribskov M. Arabidopsis proteins containing similarity to the universal stress protein domain of bacteria. Plant Physiol. 2003;131:1209-19 pubmed
    ..It is clear that all the plant sequences have arisen from a 1MJH-like ancestor. ..
  16. Wang X, Wang D, Zhu W, Delrahim K, Dolnak D, Rapaport M. Studies characterizing 60 kda autoantibodies in subjects with schizophrenia. Biol Psychiatry. 2003;53:361-75 pubmed
    ..There is an increased prevalence of autoantibodies that bind to proteins migrating at 60 kDa in subjects with schizophrenia. Potential target antigens include HSP60 and PAM. ..
  17. Morello C, Ye M, Spector D. Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replication. J Virol. 2002;76:4822-35 pubmed
    ..Taken together, these results show that immunization with pDNA and inactivated virus provides strong antibody and cell-mediated immunity against CMV infection. ..
  18. Moyer B, Allan B, Balch W. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering. Traffic. 2001;2:268-76 pubmed
  19. Stan R, Arden K, Palade G. cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes. Genomics. 2001;72:304-13 pubmed
    ..Radiation hybrid panel mapping has localized the human and mouse PLVAP genes to chromosomes 19p13.2 and 8B3-C1, respectively. ..
  20. Huang L, Wang L, Ma Y, Durick K, Perkins G, Deerinck T, et al. NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol. 1999;145:951-9 pubmed
    ..This represents the first example of a differentially targeted AKAP and adds an additional level of complexity to the PKA signaling network. ..
  21. Hoffman H, Mueller J, Broide D, Wanderer A, Kolodner R. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 2001;29:301-5 pubmed
  22. Gardner R, Shearer A, Hampton R. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol. 2001;21:4276-91 pubmed
    ..Thus, it appears that the physiologically regulated, HRD-dependent degradation of HMGR is effected by a programmed structural transition from a stable protein to a quality control substrate. ..
  23. Ferrigno A, Di Pasqua L, Berardo C, Siciliano V, Rizzo V, Adorini L, et al. The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury. PLoS ONE. 2018;13:e0191430 pubmed publisher
    ..Conversely, the mechanism involved in further increasing biliary ADMA levels in sham and I/R groups treated with OCA appears to be MATE-1-dependent. ..
  24. Kang S, Spann N, Hui T, Davis R. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. J Biol Chem. 2003;278:30478-86 pubmed
    ..This dual function of ARP-1/COUP-TFII may play an important role in determining the metabolic phenotype of individual liver cells. ..
  25. Rudge S, Sciorra V, Iwamoto M, Zhou C, Strahl T, Morris A, et al. Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation. Mol Biol Cell. 2004;15:207-18 pubmed
  26. Heredia V, Carlson T, Garcia E, Sun S. Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations. J Biol Chem. 2006;281:40201-7 pubmed
    ..This suggests that the alteration in GK enzyme activity may have a more profound biological impact than the alleviation of GKRP inhibition. ..
  27. Garcia Marcos M, Ghosh P, Ear J, Farquhar M. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010;285:12765-77 pubmed publisher
  28. Giguere V, Ong E, Segui P, Evans R. Identification of a receptor for the morphogen retinoic acid. Nature. 1987;330:624-9 pubmed
    ..Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid. ..
  29. Behan D, De Souza E, Lowry P, Potter E, Sawchenko P, Vale W. Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides. Front Neuroendocrinol. 1995;16:362-82 pubmed
    ..Thus, by controlling the amount of free CRF which activates CRF receptors, it is likely that the CRF-BP is an important modulator of CRF both in the CNS and in the periphery. ..
  30. Baughman G, Wiederrecht G, Chang F, Martin M, Bourgeois S. Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition. Biochem Biophys Res Commun. 1997;232:437-43 pubmed
    ..Unlike its murine counterpart, the human FKBP51 is abundantly expressed in numerous tissues and in many cases, is in molar excess over FKBP12. ..
  31. Chen T, Wang J. Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function. Mol Cell Biol. 2000;20:5571-80 pubmed
    ..Moreover, the LXCXE-binding pocket is dispensable for the intrinsic growth suppression function of RB. However, the LXCXE-binding function is essential for RB to establish the serum-refractory state in differentiated myocytes...
  32. Rehling P, Skaletz Rorowski A, Girzalsky W, Voorn Brouwer T, Franse M, Distel B, et al. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p. J Biol Chem. 2000;275:3593-602 pubmed
    ..In pex8Delta cells, the PTS1 and PTS2 receptor still associate with membrane bound components of the protein import machinery, supporting the assumption that the Pex8p function in protein translocation follows the docking event. ..
  33. Baughman G, Wiederrecht G, Campbell N, Martin M, Bourgeois S. FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. Mol Cell Biol. 1995;15:4395-402 pubmed
  34. Bossy Wetzel E, Green D. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J Biol Chem. 1999;274:17484-90 pubmed
    ..Our data suggest that cytochrome c release, initiated by the action of caspases on a cytosolic substrates, may act to amplify a caspase cascade during apoptosis. ..
  35. Westberg C, Yang J, Tang H, Reddy T, Wong Staal F. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. J Biol Chem. 2000;275:21396-401 pubmed
    ..Overexpression of HAP95 significantly increases CTE-dependent gene expression but has no effect on general gene expression or that mediated by the Rev/Rev response element of human immunodeficiency virus type 1. ..
  36. Behan D, Heinrichs S, Troncoso J, Liu X, Kawas C, Ling N, et al. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature. 1995;378:284-7 pubmed
  37. Darsow T, Rieder S, Emr S. A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol. 1997;138:517-29 pubmed
    ..This result indicated that SNAREs alone do not define the specificity of vesicle docking reactions. ..
  38. Hutchinson J, Li Y, Arruda J, Baccei C, Bain G, Chapman C, et al. 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). J Med Chem. 2009;52:5803-15 pubmed publisher
    ..Compound 11j was selected for clinical development and has successfully completed phase 1 trials in healthy volunteers. ..
  39. Djakovic S, Marquez Lona E, Jakawich S, Wright R, Chu C, Sutton M, et al. Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons. J Neurosci. 2012;32:5126-31 pubmed publisher
    ..Together, these data suggest that CaMKII-dependent phosphorylation of Rpt6 at S120 may be an important regulatory mechanism for proteasome-dependent control of synaptic remodeling in slow homeostatic plasticity. ..
  40. Rehling P, Darsow T, Katzmann D, Emr S. Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol. 1999;1:346-53 pubmed
    ..Vps41 binds to the AP-3 delta-adaptin subunit, suggesting that they function together in the formation of ALP pathway transport intermediates at the late Golgi. ..
  41. Witte S, Villalba M, Bi K, Liu Y, Isakov N, Altman A. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem. 2000;275:1902-9 pubmed
    ..These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system. ..
  42. Zhang T, Zhuang S, Casteel D, Looney D, Boss G, Pilz R. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007;282:33367-80 pubmed
    ..Thus, CRP4 mediates cGMP/PKG stimulation of SM-specific gene expression, and PKG plays an important role in regulating the phenotype of VSMCs. ..
  43. Stan R, Tkachenko E, Niesman I. PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms. Mol Biol Cell. 2004;15:3615-30 pubmed
    ..Taken together, these data show that PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms. ..
  44. Huang S, Lavine J, Boland P, Newbury R, Kolodner R, Pham T, et al. Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancer. J Pediatr. 2001;138:629-35 pubmed
    ..Genetic screening of other suspected HNPCC families with unusually young members with cancer might reveal certain genotypes with particularly virulent forms of this disease. ..
  45. Yang J, Tang H, Reddy T, Wong Staal F. Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. J Biol Chem. 2001;276:30694-700 pubmed
    ..Taken together, these data support the proposal that HAP95 specifically facilitates CTE-mediated gene expression by directly binding to RHA. ..
  46. Sweet D, Bush K, Nigam S. The organic anion transporter family: from physiology to ontogeny and the clinic. Am J Physiol Renal Physiol. 2001;281:F197-205 pubmed
    ..Additionally, increased understanding of single nucleotide polymorphisms in OATs and other transporters may eventually allow the use of a patient's expression profile and polymorphisms to individualize drug therapy...
  47. Broderick L, Hoffman H. cASCading specks. Nat Immunol. 2014;15:698-700 pubmed publisher
  48. Dervieux T, Furst D, Lein D, Capps R, Smith K, Walsh M, et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum. 2004;50:2766-74 pubmed
    ..01). These data suggest that measuring RBC MTXPG levels and/or the common polymorphisms in the folate-purine-pyrimidine pathway may help in monitoring MTX therapy. ..
  49. Zhang W, Shao Y, Fang D, Huang J, Jeon M, Liu Y. Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. J Biol Chem. 2003;278:23978-83 pubmed
    ..Thus, Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells. ..
  50. Tkachenko E, Tse D, Sideleva O, Deharvengt S, Luciano M, Xu Y, et al. Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells. PLoS ONE. 2012;7:e32655 pubmed publisher
  51. Lee J, Kim H, Quinley C, Kim J, Gonzalez Navajas J, Xavier R, et al. Autophagy suppresses interleukin-1? (IL-1?) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem. 2012;287:4033-40 pubmed publisher
    ..Taken together our data indicate that loss-of-function of ATG16L1 results in a hyper-responsiveness to the IL-1? signaling because of the increased p62 level. ..
  52. Talley T, Yalda S, Ho K, Tor Y, Soti F, Kem W, et al. Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry. 2006;45:8894-902 pubmed
  53. Mohanty S, Lee S, Yadava N, Dealy M, Johnson R, Firtel R. Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes Dev. 2001;15:1435-48 pubmed
    ..We propose that CulA and FbxA regulate multicellular development by targeting RegA for degradation via a pathway that requires ERK2 function, leading to an increase in cAMP and PKA activity. ..
  54. Madigan S, Edeen P, Esnayra J, McKeown M. att, a target for regulation by tra2 in the testes of Drosophila melanogaster, encodes alternative RNAs and alternative proteins. Mol Cell Biol. 1996;16:4222-30 pubmed
    ..This produces a novel truncated version of the Graves' disease carrier protein-like protein that lacks all sequences N terminal to the first transmembrane domain. ..
  55. Miyake J, Doung X, Strauss W, Moore G, Castellani L, Curtiss L, et al. Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase. J Biol Chem. 2001;276:23304-11 pubmed
    ..These findings emphasize the important homeostatic role that CYP7A1 plays in balancing the anabolic lipoprotein assembly/secretion pathway with the cholesterol catabolic bile acid synthetic pathway. ..
  56. Murao K, Terpstra V, Green S, Kondratenko N, Steinberg D, Quehenberger O. Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes. J Biol Chem. 1997;272:17551-7 pubmed
    ..An additional role in recognition of damaged cells is suggested by these studies. ..
  57. Larkin S, Mull E, Miao W, Pittner R, Albrandt K, Moore C, et al. Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone. Biochem Biophys Res Commun. 1997;240:222-7 pubmed
    ..In skeletal muscle, UCP3 mRNA was also upregulated by T3 but, surprisingly, not by cold exposure. A hypothesis is proposed to account for this differential regulation. ..
  58. Bourgeois S, Gruol D, Newby R, Rajah F. Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol Endocrinol. 1993;7:840-51 pubmed
    ..The results indicate that we have identified a new form of glucocorticoid resistance, one associated with expression of the mouse mdr1 P-glycoprotein. ..
  59. Peterson M, Emr S. The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic. 2001;2:476-86 pubmed
    ..Collectively, these results indicate that the Class C Vps complex plays essential roles in the processes of membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of transport. ..
  60. Lorrain D, Bain G, Correa L, Chapman C, Broadhead A, Santini A, et al. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces a. J Pharmacol Exp Ther. 2009;331:1042-50 pubmed publisher
    ..In summary, AM103 is a novel, potent and selective FLAP inhibitor that has excellent pharmacodynamic properties in vivo and is effective in animal models of acute and chronic inflammation and in a model of lethal shock. ..
  61. Tang Y, Wallace M, Sanchez Gurmaches J, Hsiao W, Li H, Lee P, et al. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016;7:11365 pubmed publisher
    ..These data suggest mTORC2 functions in WAT as part of an extra-hepatic nutrient-sensing mechanism to control glucose homeostasis. ..
  62. Diagana T, Thomas U, Prokopenko S, Xiao B, Worley P, Thomas J. Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. J Neurosci. 2002;22:428-36 pubmed
    ..Our results argue that in the CNS, Homer-related proteins operate in the ER and in dendrites to regulate the development and function of neural networks underlying locomotor control and behavioral plasticity. ..
  63. Mangino M, Christiansen L, STONE R, Hunt S, Horvath K, Eisenberg D, et al. DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet. 2015;52:157-62 pubmed publisher
    ..42×10(-24). We uncovered a new locus associated with LTL in the general population. We also provided preliminary findings that suggest a link of LTL through genetic mechanisms with UVR and melanoma in the general population. ..
  64. Goetzl E, Schwartz J, Mustapic M, Lobach I, Daneman R, Abner E, et al. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017;31:3689-3694 pubmed publisher
    ..Goetzl, E. J., Schwartz, J. B., Mustapic, M., Lobach, I. V., Daneman, R., Abner, E. L., Jicha, G. A. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. ..
  65. Fisk H, Yaffe M. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J Cell Biol. 1999;145:1199-208 pubmed
    ..These results indicate that protein ubiquitination mediated by Rsp5p plays an essential role in mitochondrial inheritance, and reveal a novel function for protein ubiquitination. ..
  66. Lou X, Yano H, Lee F, Chao M, Farquhar M. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol Biol Cell. 2001;12:615-27 pubmed
    ..The association of TrkA receptors with GIPC and GAIP plus the inhibition of MAP kinase by GIPC suggests that GIPC may provide a link between TrkA and G protein signaling pathways. ..
  67. Darsow T, Katzmann D, Cowles C, Emr S. Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Mol Biol Cell. 2001;12:37-51 pubmed
    ..These data indicate that a homo-oligomeric form of Vps41p is required for the formation of ALP containing vesicles at the Golgi complex via interactions with AP-3. ..
  68. Burns L, Canaves J, Pennypacker J, Blumenthal D, Taylor S. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 2003;42:5754-63 pubmed
  69. Shao G, Heyman R, Schulman I. Three amino acids specify coactivator choice by retinoid X receptors. Mol Endocrinol. 2000;14:1198-209 pubmed
    ..The ability of an optimized seven-amino acid nuclear receptor box to specifically interact with RXR and function as a selective inhibitor suggests the coactivator-binding pocket may serve as a new target for drug discovery. ..
  70. Meier J, Mercer A, Rivera H, Burkart M. Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification. J Am Chem Soc. 2006;128:12174-84 pubmed
    ..The methods demonstrated here allow carrier proteins to be visualized and isolated for the first time without the need for antibody techniques and set the stage for the future use of carrier protein fusions in chemical biology. ..
  71. Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka K, Kimelman D, et al. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development. 2000;127:2143-54 pubmed
  72. Nicholson B, Manner C, Kleeman J, MacLeod C. Sustained nitric oxide production in macrophages requires the arginine transporter CAT2. J Biol Chem. 2001;276:15881-5 pubmed
    ..In conclusion, our results show that sustained abundant NO synthesis by macrophages requires arginine transport via the CAT2 transporter. ..
  73. Fang L, Choi S, Baek J, Liu C, Almazan F, Ulrich F, et al. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013;498:118-22 pubmed publisher
    ..Our findings demonstrate that secreted AIBP positively regulates cholesterol efflux from endothelial cells and that effective cholesterol efflux is critical for proper angiogenesis...
  74. Kissinger C, Parge H, Knighton D, Lewis C, Pelletier L, Tempczyk A, et al. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1995;378:641-4 pubmed
    ..The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein. ..
  75. Whitaker L, Su H, Baskaran R, Knudsen E, Wang J. Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol Cell Biol. 1998;18:4032-42 pubmed
    ..In addition, E2F and LXCXE binding are not the only mechanisms through which RB inhibits cell growth. The C pocket also contributes to RB-mediated growth suppression. ..
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