Genomes and Genes
Experts and Doctors on brain in Davis, California, United States
Locale: Davis, California, United States
Publications112 found, 100 shown here
- Di Giorgio A, Hou Y, Zhao X, Zhang B, Lyeth B, Russell M. Dimethyl sulfoxide provides neuroprotection in a traumatic brain injury model. Restor Neurol Neurosci. 2008;26:501-7 pubmed..The results suggest that DMSO may be acting as an overriding neuroprotectant in this experiment. We conclude that DMSO is a viable neuroprotective agent against secondary cell death in TBI. ..
- Li C, Pan W, Braunewell K, Ames J. Structural analysis of Mg2+ and Ca2+ binding, myristoylation, and dimerization of the neuronal calcium sensor and visinin-like protein 1 (VILIP-1). J Biol Chem. 2011;286:6354-66 pubmed publisher..We present the structure of the VILIP-1 dimer and a Ca(2+)-myristoyl switch to provide structural insights into Ca(2+)-induced trafficking of nicotinic acetylcholine receptors. ..
- Fox E, Amaral D, Van de Water J. Maternal and fetal antibrain antibodies in development and disease. Dev Neurobiol. 2012;72:1327-34 pubmed publisher..2009]: Nat Med 15:91-96). In this review, we will discuss the current state of research in the area of maternal autoantibodies and the development of autism. ..
- Pemberton T, Choi S, Mayer J, Li F, Gokey N, Svaren J, et al. A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination. Glia. 2014;62:39-51 pubmed publisher..While the functional role of FNIP2 is not known, our data would suggest that production of truncated protein results in a delay or failure of maturation of a subpopulation of oligodendrocytes. ..
- Yokoyama J, Lee A, Takada L, Busovaca E, Bonham L, Chao S, et al. Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults. PLoS ONE. 2015;10:e0118338 pubmed publisher..This represents a novel finding that, if verified in larger studies, has implications for how biological, environmental and/or lifestyle factors may modify APOE ε4 effects on the brain in diverse populations. ..
- Bailus B, Pyles B, McAlister M, O Geen H, Lockwood S, Adams A, et al. Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Mol Ther. 2016;24:548-55 pubmed publisher..These observations have important implications for the study and treatment of AS and other neurological disorders. ..
- Liu S, Molenaar P. Testing for Granger Causality in the Frequency Domain: A Phase Resampling Method. Multivariate Behav Res. 2016;51:53-66 pubmed publisher..We illustrate the utility of phase resampling with two empirical examples involving multivariate electroencephalography (EEG) and skin conductance data. ..
- Wedaman K, Knight A, Kendrick Jones J, Scholey J. Sequences of sea urchin kinesin light chain isoforms. J Mol Biol. 1993;231:155-8 pubmed publisher..C-terminal sequence differences between light chains may provide inter- and intraspecies differences in the functional properties of the presumptive cargo attachment elements of kinesin...
- LaSalle J, Goldstine J, Balmer D, Greco C. Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. Hum Mol Genet. 2001;10:1729-40 pubmed..In addition, our results demonstrate the power of laser scanning cytometry in examining complex cellular phenotypes in disease pathogenesis. ..
- Balmer D, Arredondo J, Samaco R, LaSalle J. MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. Hum Genet. 2002;110:545-52 pubmed..In conclusion, our results do not support an essential role for either MeCP2 or HDAC in the silencing of several imprinted genes. ..
- Sharp J, Magrum L, Gietzen D. Role of MAP kinase in signaling indispensable amino acid deficiency in the brain. Brain Res Mol Brain Res. 2002;105:11-8 pubmed
- Balmer D, Goldstine J, Rao Y, LaSalle J. Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation. J Mol Med (Berl). 2003;81:61-8 pubmed..Acquired elevated MeCP2 expression in neurons beginning in infancy and progressing through childhood may explain the delayed onset and developmental arrest of Rett syndrome ..
- Menegola M, Trimmer J. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. J Neurosci. 2006;26:12137-42 pubmed..2-dependent effects on KChIPs. The impact of Kv4.2 deletion on KChIP expression also supports the major role of KChIPs as auxiliary subunits of Kv4 channels. ..
- Beaman B, Tam S. An unusual murine behavior following infection with log-phase Nocardia asteroides type 6 strain GUH-2 (Nocardia cyriacigeorgica GUH-2). Microbes Infect. 2008;10:840-3 pubmed publisher..The attached video presents a typical mouse following infection with this organism, as compared to an age- and gender-matched uninfected control mouse. ..
- Schwarz C, Fletcher E, DeCarli C, Carmichael O. Fully-automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR. Inf Process Med Imaging. 2009;21:239-51 pubmed..The method is also shown to perform well when training and test data are drawn from distinct scanners and subject pools. ..
- McAllister A, Van de Water J. Breaking boundaries in neural-immune interactions. Neuron. 2009;64:9-12 pubmed publisher..For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ..
- McAssey M, Hsieh F, Smith A. Coupling among electroencephalogram gamma signals on a short time scale. Comput Intell Neurosci. 2010;: pubmed publisher..We then focus on gamma signals recorded in two regions of the rat hippocampus. Our results indicate that this may be a useful method for mapping coupling patterns among signals in EEG datasets. ..
- Seelke A, Dooley J, Krubitzer L. Differential changes in the cellular composition of the developing marsupial brain. J Comp Neurol. 2013;521:2602-20 pubmed publisher..The relatively low number of neurons and correspondingly high number of nonneurons suggests that in the marsupial brain nonneurons may play a significant role in signal processing. ..
- Watrous A, Tandon N, Conner C, Pieters T, Ekstrom A. Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval. Nat Neurosci. 2013;16:349-56 pubmed publisher..These results emphasize dynamic network interactions as being central to episodic memory retrieval, providing insight into how multiple contexts underlying a single event can be recreated in the same network. ..
- Omata Y, Salvador G, Supasai S, Keenan A, Oteiza P. Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicol Sci. 2013;133:90-100 pubmed publisher..This can in part underlie the GSH depletion associated with ZD and the high sensitivity of Zn-deficient neurons to pro-oxidative stressors. ..
- Erickson J, Pereira L, Wang L, Han G, Ferguson A, Dao K, et al. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 2013;502:372-6 pubmed publisher..Thus, O-GlcNAc modification of CaMKII is a novel signalling event in pathways that may contribute critically to cardiac and neuronal pathophysiology in diabetes and other diseases. ..
- Masten C, Telzer E, Fuligni A, Lieberman M, Eisenberger N. Time spent with friends in adolescence relates to less neural sensitivity to later peer rejection. Soc Cogn Affect Neurosci. 2012;7:106-14 pubmed publisher..These findings are consistent with the notion that positive relationships during adolescence may relate to individuals being less sensitive to negative social experiences later on. ..
- Karakis I, Pase M, Beiser A, Booth S, Jacques P, Rogers G, et al. Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study. J Alzheimers Dis. 2016;51:451-61 pubmed publisher..In this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function. ..
- Conley A, Hinshelwood M. Mammalian aromatases. Reproduction. 2001;121:685-95 pubmed
- Werner J, Pinna B, Spillmann L. Illusory color & the brain. Novel illusions suggest that the brain does not separate perception of color from perception of form and depth. Sci Am. 2007;296:90-5 pubmed
- Tucker R, Hagios C, Chiquet Ehrismann R, Lawler J. In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo. Dev Dyn. 1997;208:326-37 pubmed..The pattern of TSP-1 expression in avascular tissues and in the floor plate is consistent with possible roles for this glycoprotein in regulating angiogenesis and establishing morphogenetic gradients. ..
- Thatcher K, Peddada S, Yasui D, LaSalle J. Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet. 2005;14:785-97 pubmed..These combined results suggest a role for MeCP2 in chromosome organization in the developing brain and provide a potential mechanistic association between several related neurodevelopmental disorders. ..
- Gohil K, Schock B, Chakraborty A, Terasawa Y, Raber J, Farese R, et al. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Free Radic Biol Med. 2003;35:1343-54 pubmed..The repression of specific genes that determine synaptic plasticity and neuronal development may account for suppressed electrophysiological activities of cortex and impaired behavior in Ttpa(-/-) mice. ..
- Libon D, Preis S, Beiser A, Devine S, Seshadri S, Wolf P, et al. Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study. Am J Alzheimers Dis Other Demen. 2015;30:622-8 pubmed publisher..Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia. ..
- Tassone F, De Rubeis S, Carosi C, La Fata G, Serpa G, Raske C, et al. Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles. Nucleic Acids Res. 2011;39:6172-85 pubmed publisher..Importantly, in both human and mouse, a specific regulation of the UTRs is observed in brain of FMR1 premutation alleles, suggesting that the transcript variants may play a role in premutation-related pathologies. ..
- MacKenzie G, Salvador G, Romero C, Keen C, Oteiza P. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med. 2011;51:480-9 pubmed publisher..g., NF-?B) involved in critical developmental events. ..
- Bongiovanni K, DePeters E, Van Eenennaam A. Neonatal growth rate and development of mice raised on milk transgenically enriched with omega-3 fatty acids. Pediatr Res. 2007;62:412-6 pubmed..This transgenic model enables the provision of a high n-3 PUFA lactational environment independent of maternal diet or gestational FA status. ..
- Vu K, Eigenheer R, Phinney B, Gelli A. Cryptococcus neoformans promotes its transmigration into the central nervous system by inducing molecular and cellular changes in brain endothelial cells. Infect Immun. 2013;81:3139-47 pubmed publisher..neoformans elicits changes in brain endothelial cells that facilitate the migration of cryptococci across the BBB and ultimately induce endothelial cell necrosis. ..
- Kaiser A, Nishi K, Gorin F, Walsh D, Bradbury E, Schnier J. The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. Arch Biochem Biophys. 2001;386:179-87 pubmed..These results suggest that the cyclin-dependent kinase inhibitor flavopiridol interferes with glycogen degradation, which may be responsible for flavopiridol's cytotoxicity and explain its resistance in some cell lines. ..
- Glaser N, Yuen N, Anderson S, Tancredi D, O Donnell M. Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. Diabetes. 2010;59:702-9 pubmed publisher..Treatment with bumetanide may help diminish the adverse effects of initial treatment with insulin/saline. ..
- Moran F, Hendrickx A, Shideler S, Overstreet J, Watkins S, Lasley B. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on fatty acid availability and neural tube formation in cynomolgus macaque, Macaca fascicularis. Birth Defects Res B Dev Reprod Toxicol. 2004;71:37-46 pubmed..Since neural tube development is dependent, in part, on n-3 and n-6 fatty acids, it is possible that the limitation of these essential fatty acids in plasma resulted in the observed detrimental effects on early brain development. ..
- Iwahashi C, Yasui D, An H, Greco C, Tassone F, Nannen K, et al. Protein composition of the intranuclear inclusions of FXTAS. Brain. 2006;129:256-71 pubmed..The list of proteins includes at least two RNA binding proteins, heterogeneous nuclear ribonucleoprotein A2 and muscle blind-like protein 1, which are possible mediators of the RNA gain-of-function in FXTAS. ..
- Misonou H, Mohapatra D, Menegola M, Trimmer J. Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci. 2005;25:11184-93 pubmed..1 in response to hypoxia/ischemia suppresses neuronal excitability and could confer neuroprotection in response to brief ischemic insults. ..
- Park K, Mohapatra D, Misonou H, Trimmer J. Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science. 2006;313:976-9 pubmed..Mutations at multiple sites were additive, showing that variable phosphorylation of Kv2.1 at a large number of sites allows graded activity-dependent regulation of channel gating and neuronal firing properties. ..
- Hogart A, Leung K, Wang N, Wu D, Driscoll J, Vallero R, et al. Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number. J Med Genet. 2009;46:86-93 pubmed publisher..Our findings suggest that genetic copy number changes combined with additional genetic or environmental influences on epigenetic mechanisms impact outcome and clinical heterogeneity of 15q11-13 duplication syndromes. ..
- Dowd W, Renshaw G, Cech J, Kültz D. Compensatory proteome adjustments imply tissue-specific structural and metabolic reorganization following episodic hypoxia or anoxia in the epaulette shark (Hemiscyllium ocellatum). Physiol Genomics. 2010;42:93-114 pubmed publisher..Overall, our data show that episodic hypoxic or anoxic exposure and recovery in the epaulette shark amplifies a constitutive suite of compensatory mechanisms that further prepares them for subsequent insults...
- Sarahan K, Fisler J, Warden C. Four out of eight genes in a mouse chromosome 7 congenic donor region are candidate obesity genes. Physiol Genomics. 2011;43:1049-55 pubmed publisher..Our findings highlight the difficulty of using expression and sequence to identify quantitative trait genes underlying obesity even in small genomic regions. ..
- Gu Y, Scarmeas N, Short E, Luchsinger J, DeCarli C, Stern Y, et al. Alcohol intake and brain structure in a multiethnic elderly cohort. Clin Nutr. 2014;33:662-7 pubmed publisher..These findings suggest that light to moderate alcohol consumption is potentially beneficial for brain aging, but replication is needed. ..
- Foley J, Rand C, Leutenegger C. Inflammation and changes in cytokine levels in neurological feline infectious peritonitis. J Feline Med Surg. 2003;5:313-22 pubmed..A large component of the variance (91.7%) was accounted for by levels of IL-6, MIP-1 alpha, and RANTES. These findings provide new insight into the immunopathogenesis of FIP and suggest targets for immune therapy of this disease...
- Lansdon E, Fisher A, Segel I. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004;43:4356-65 pubmed..Chlorate and perchlorate form dead-end E.MgATP.oxyanion complexes. Phenylalanine, reported to be an inhibitor of brain ATP sulfurylase, was without effect on PAPS synthetase isoform 1. ..
- Vacher H, Mohapatra D, Trimmer J. Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev. 2008;88:1407-47 pubmed publisher..Finally, we discuss the emerging mechanisms for determining the discrete subcellular distributions observed for many neuronal ion channels. ..
- Jiang C, Aston J, Wang J. Smoothing dynamic positron emission tomography time courses using functional principal components. Neuroimage. 2009;47:184-93 pubmed publisher..This preprocessing step to smooth the data then allows subsequent analysis by methods such as Spectral Analysis to be substantially improved in terms of their mean squared error. ..
- Carmichael O, Mungas D, Beckett L, Harvey D, Tomaszewski Farias S, Reed B, et al. MRI predictors of cognitive change in a diverse and carefully characterized elderly population. Neurobiol Aging. 2012;33:83-95 pubmed publisher..Conventional MRI measures may have use for predicting cognitive outcomes in highly heterogeneous elderly populations. ..
- Tassone F, Greco C, Hunsaker M, Seritan A, Berman R, Gane L, et al. Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS. Genes Brain Behav. 2012;11:577-85 pubmed publisher..Although further studies are required, our observation suggests that in a portion of FXTAS cases there is Alzheimer pathology and perhaps a synergistic effect on the progression of the disease may occur. ..
- Gorin F, Mullinax R, Ignacio P, Neve R, Kurnit D. McArdle's & Hers' diseases: glycogen phosphorylase transcriptional expression in human tissues. J Neurogenet. 1987;4:293-308 pubmed..Furthermore, using degenerate oligonucleotide probes to two different coding regions of M-phosphorylase, a novel 4.1-kb transcript was demonstrated to be present in human fetal and adult brain. ..
- Fuller C, Hoban Higgins T, Klimovitsky V, Griffin D, Alpatov A. Primate circadian rhythms during spaceflight: results from Cosmos 2044 and 2229. J Appl Physiol (1985). 1996;81:188-93 pubmed..Furthermore, the data also support the concept of a multioscillator organization of the primate CTS due to the differential responses of the rhythms measured...
- Braunschweig D, Simcox T, Samaco R, LaSalle J. X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brain. Hum Mol Genet. 2004;13:1275-86 pubmed..These results help in explaining the role of XCI in the pathogenesis of RTT and have important implications in designing therapies for female RTT patients. ..
- Daft B, Visvesvara G, Read D, Kinde H, Uzal F, Manzer M. Seasonal meningoencephalitis in Holstein cattle caused by Naegleria fowleri. J Vet Diagn Invest. 2005;17:605-9 pubmed..Naegleria meningoencephalitis should be included among differential diagnoses of central nervous system disease in cattle during the summer season in areas with high ambient temperatures...
- Whited K, Tso P, Raybould H. Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedback. Endocrinology. 2007;148:4695-703 pubmed..The data suggest a role for apo A-IV and the CCK(1)R in PYY(3-36)-induced activation of the vagal afferent pathway and inhibition of gastric emptying, but this is likely not the pathway mediating the effects of PYY(3-36) on food intake. ..
- Wainwright K, Miller M, Barr B, Gardner I, Melli A, Essert T, et al. Chemical inactivation of Toxoplasma gondii oocysts in water. J Parasitol. 2007;93:925-31 pubmed..Results of the chemical exposure experiments indicate that neither sodium hypochlorite nor ozone effectively inactivate T. gondii oocysts, even when used at high concentrations. ..
- Yang J, Vacher H, Park K, Clark E, Trimmer J. Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression. Proc Natl Acad Sci U S A. 2007;104:20055-60 pubmed..These data support Kv1.2 phosphorylation at these clustered C-terminal sites as playing an important role in regulating trafficking of Kv1.2-containing Kv channels. ..
- Gonzales M, LaSalle J. The role of MeCP2 in brain development and neurodevelopmental disorders. Curr Psychiatry Rep. 2010;12:127-34 pubmed publisher..As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies. ..
- Aly M, Knight R, Yonelinas A. Faces are special but not too special: spared face recognition in amnesia is based on familiarity. Neuropsychologia. 2010;48:3941-8 pubmed publisher..In addition, the findings challenge material-general theories of memory, and suggest that both material and process are important determinants of memory performance in amnesia...
- Maillard P, Fletcher E, Harvey D, Carmichael O, Reed B, Mungas D, et al. White matter hyperintensity penumbra. Stroke. 2011;42:1917-22 pubmed publisher..001). WMH may represent foci of more widespread and subtle white matter changes rather than distinct, sharply delineated anatomic abnormalities. We use the term white matter hyperintensities penumbra to explain this phenomenon. ..
- Yasui D, Scoles H, Horike S, Meguro Horike M, Dunaway K, Schroeder D, et al. 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet. 2011;20:4311-23 pubmed publisher..Thus, loss of long-range chromatin interactions within 15q11.2-13.3 may contribute to multiple human neurodevelopmental disorders. ..
- Wallace B, Jelks K, O Donnell M. Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases. Am J Physiol Cell Physiol. 2012;302:C505-17 pubmed publisher..These findings support the hypothesis that ischemic factor stimulation of the BBB NKCC involves activation of p38 and JNK MAPKs...
- Matelski L, Van de Water J. Risk factors in autism: Thinking outside the brain. J Autoimmun. 2016;67:1-7 pubmed publisher..The ongoing search for biomarkers and better treatments will result in earlier identification of ASD and provide much needed help and relief for afflicted families. ..
- Payne J. Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. Am J Physiol. 1997;273:C1516-25 pubmed
- Golub M, Germann S, Mercer M, Gordon M, Morgan D, Mayer L, et al. Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse. Neurobiol Aging. 2008;29:1512-23 pubmed
- Brillault J, Lam T, Rutkowsky J, Foroutan S, O Donnell M. Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells. Am J Physiol Cell Physiol. 2008;294:C88-96 pubmed
- Krubitzer L. In search of a unifying theory of complex brain evolution. Ann N Y Acad Sci. 2009;1156:44-67 pubmed publisher..While this cortical plasticity is a defining feature of mammalian neocortex, it appears to be exaggerated in humans and could be considered a unique derivation of our species. ..
- Lam T, Wise P, O Donnell M. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. Am J Physiol Cell Physiol. 2009;297:C278-89 pubmed publisher..Our findings support the hypothesis that a BBB Na/H exchanger, possibly NHE1 and/or NHE2, is stimulated during ischemia to participate in cerebral edema formation. ..
- Vincent K, Sharp J, Raybould H. Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats. Neurogastroenterol Motil. 2011;23:e282-93 pubmed publisher..The precise mechanisms involved in luminal glucose-sensing are not clear; studying gut endocrine cells is difficult due to their sparse and irregular localization within the epithelium...
- Arias A, Lame M, Santarelli L, Hen R, Greene L, Angelastro J. Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas. Oncogene. 2012;31:739-51 pubmed publisher..Moreover, d/n-ATF5 induction after tumor formation led to regression/eradication of detectable gliomas without evident damage to normal brain cells in all 24 mice assessed. ..
- Chowanadisai W, Graham D, Keen C, Rucker R, Messerli M. Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A. 2013;110:9903-8 pubmed publisher..This study identifies a Zn(2+) transporter that is specifically required for nervous system development and provides tangible links between Zn(2+), neurulation, and neuronal differentiation...
- Grimaldi A, D Alessandro G, Golia M, Grössinger E, Di Angelantonio S, Ragozzino D, et al. KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages. Cell Death Dis. 2016;7:e2174 pubmed publisher..Our data indicate that KCa3.1 channels are involved in the inhibitory effects exerted by the glioma microenvironment on infiltrating M/M?, suggesting a possible role as therapeutic targets in glioma. ..
- Gelinas R, Froman B, McElroy F, Tait R, Gorin F. Human brain glycogen phosphorylase: characterization of fetal cDNA and genomic sequences. Brain Res Mol Brain Res. 1989;6:177-85 pubmed..The predicted C-terminal sequence of the protein encoded by this cDNA and gene differ from that encoded by a phosphorylase cDNA isolated from a human astrocytoma cell line. ..
- Nihira M, Anderson K, Gorin F, Burns M. Primate rod and cone photoreceptors may differ in glucose accessibility. Invest Ophthalmol Vis Sci. 1995;36:1259-70 pubmed..However, during hypoxic insult, glycogenolysis and anaerobic glycolysis could result in increased production of intracellular lactic acid, potentially predisposing the cone to acidotic damage. ..
- Kelley G, Zagmutt Vergara F, Leutenegger C, Myklebust K, Adkison M, McDowell T, et al. Evaluation of five diagnostic methods for the detection and quantification of Myxobolus cerebralis. J Vet Diagn Invest. 2004;16:202-11 pubmed
- Silvagni P, Lowenstine L, Spraker T, Lipscomb T, Gulland F. Pathology of domoic acid toxicity in California sea lions (Zalophus californianus). Vet Pathol. 2005;42:184-91 pubmed..Chronically, there was gliosis, mild nonsuppurative inflammation, and loss of laminar organization in affected areas...
- Tucker R, Chiquet Ehrismann R. Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development. Dev Biol. 2006;290:237-45 pubmed..Teneurin function appears to be required for a fundamentally important signaling mechanism conserved between invertebrates and vertebrates having an impact on many processes relying on cell-cell contact throughout development. ..
- Alcantara D, Carmichael O, Harcourt Smith W, Sterner K, Frost S, Dutton R, et al. Exploration of shape variation using localized components analysis. IEEE Trans Pattern Anal Mach Intell. 2009;31:1510-6 pubmed publisher..This paper demonstrates that LoCA can provide intuitive presentations of shape differences associated with sex, disease state, and species in a broad range of biomedical specimens, including human brain regions and monkey crania. ..
- Lee D, Fletcher E, Martinez O, Ortega M, Zozulya N, Kim J, et al. Regional pattern of white matter microstructural changes in normal aging, MCI, and AD. Neurology. 2009;73:1722-8 pubmed publisher..Both vascular and Alzheimer disease degenerative process contribute to microstructural injury of cerebral white matter across the spectrum of cognitive ability and have different region-specific injury patterns. ..
- Woods L, Higgins R, Joseph V, Filigenzi M, Puschner B. Ronidazole toxicosis in 3 society finches (Lonchura striata). Vet Pathol. 2010;47:231-5 pubmed publisher..Ronidazole was detected in the liver tissue at 2,700 ng/g (wet weight), and 2-hydroxymethyl-1-methyl-5-nitroimidazole was detected at 140 ng/g (wet weight). ..