Genomes and Genes
Experts and Doctors on animals in San Francisco, California, United States
Locale: San Francisco, California, United States
Publications800 found, 100 shown here
- Owen R, Badagnani I, Giacomini K. Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. J Biol Chem. 2006;281:26675-82 pubmed..Our data are consistent with a model in which an increased capability for hydrogen bonding in critical amino acids that reside in the C terminus of rCNT2 contributes to its enhanced selectivity for 2CdA. ..
- Klein O, Minowada G, Peterkova R, Kangas A, Yu B, Lesot H, et al. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006;11:181-90 pubmed
- Alessandri Haber N, Dina O, Joseph E, Reichling D, Levine J. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J Neurosci. 2008;28:1046-57 pubmed publisher..We suggest that TRPV4 plays a role in mechanotransduction, as a component of a molecular complex that functions only in the setting of inflammation or nerve injury. ..
- Maatouk D, Loveland K, McManus M, Moore K, Harfe B. Dicer1 is required for differentiation of the mouse male germline. Biol Reprod. 2008;79:696-703 pubmed publisher..Rarely, sperm lacking Dicer1 could fertilize wild-type eggs to generate viable offspring. These results show that Dicer1 and miRNAs are essential for proper differentiation of the male germline. ..
- Oshima S, Turer E, Callahan J, Chai S, Advincula R, Barrera J, et al. ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009;457:906-9 pubmed publisher..These studies provide insights into how ubiquitination and ubiquitin sensing proteins regulate cellular and organismal survival. ..
- Kim S, Castro F, Paterson Y, Gravekamp C. High efficacy of a Listeria-based vaccine against metastatic breast cancer reveals a dual mode of action. Cancer Res. 2009;69:5860-6 pubmed publisher..This dual mode of action of a Listeria-based vaccine has not been described before and may provide new directions in the development of more effective vaccines against metastatic breast cancer. ..
- Fordyce P, Gerber D, Tran D, Zheng J, Li H, Derisi J, et al. De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat Biotechnol. 2010;28:970-5 pubmed publisher..We expect that these data and future use of this technique will provide information essential for understanding transcription factor specificity, improving identification of regulatory sites and reconstructing regulatory interactions. ..
- Choi Y, Patena W, Leavitt A, McManus M. Widespread RNA 3'-end oligouridylation in mammals. RNA. 2012;18:394-401 pubmed publisher..Our data revealed widespread nontemplated nucleotide addition to the 3' ends of many classes of RNA, with short stretches of uridine being the most frequently added nucleotide. ..
- Lieberman J, Feiner J, Lyon R, Rollins M. Effect of hemorrhage and hypotension on transcranial motor-evoked potentials in swine. Anesthesiology. 2013;119:1109-19 pubmed publisher..After hemorrhage, restoration of TcMEPs with epinephrine but not phenylephrine indicates that CO and DO2 affect TcMEPs more than MAP. Monitoring CO may be beneficial in major spine surgery when using TcMEP monitoring. ..
- Tang C, Seeley E, Huang X, Wolters P, Liu L. Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice. Biochem Biophys Res Commun. 2013;442:122-6 pubmed publisher..pneumoniae. Our results suggest that patients treated in clinical trials with inhibitors of GSNOR should be carefully monitored for signs of infection. ..
- Ota R, Kurihara C, Tsou T, Young W, Yeghiazarians Y, Chang M, et al. Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab. 2009;29:1547-58 pubmed publisher..These data revealed that MMPs, especially MMP-9, are critical in flow-induced outward vascular remodeling. ..
- Beaudoin G, Schofield C, Nuwal T, Zang K, Ullian E, Huang B, et al. Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci. 2012;32:99-110 pubmed publisher..The remaining synapses appeared to function normally. Thus, afadin is a key intracellular signaling molecule for cadherin recruitment and is necessary for spine and synapse formation in vivo. ..
- Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden S, et al. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012;287:33014-25 pubmed..These results strongly suggest that CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis...
- McIntire S, Reimer R, Schuske K, Edwards R, Jorgensen E. Identification and characterization of the vesicular GABA transporter. Nature. 1997;389:870-6 pubmed..Thus VGAT is the first of a new family of neurotransmitter transporters. ..
- Racine Samson L, Rockey D, Bissell D. The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J Biol Chem. 1997;272:30911-7 pubmed..Although alpha2beta1 is capable of mediating contraction, its expression by myofibroblasts occurs largely, if not exclusively, in response to culture. ..
- Defea K, Zalevsky J, Thoma M, Dery O, Mullins R, Bunnett N. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol. 2000;148:1267-81 pubmed
- Vazquez J, Schedl P. Deletion of an insulator element by the mutation facet-strawberry in Drosophila melanogaster. Genetics. 2000;155:1297-311 pubmed..Moreover, we find that insulating activity is dependent on sequences deleted in fa(swb). These results provide evidence that the element defined by the fa(swb) mutation corresponds to an insulator. ..
- Buhman K, Accad M, Novak S, Choi R, Wong J, Hamilton R, et al. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat Med. 2000;6:1341-7 pubmed..Our results indicate that ACAT2 has an important role in the response to dietary cholesterol, and suggest that ACAT2 inhibition may be a useful strategy for treating hypercholesterolemia or cholesterol gallstones. ..
- Lynch K, Weiss A. A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer. J Biol Chem. 2001;276:24341-7 pubmed..Thus, proper functioning of the immune system is dependent on a complex interplay of regulatory activities that mediate the appropriate splicing of CD45 exon 4. ..
- Sonda S, Ting L, Novak S, Kim K, Maher J, Farese R, et al. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem. 2001;276:34434-40 pubmed..gondii. Moreover, we identified ACAT activity in T. gondii that can be modulated by pharmacological ACAT inhibitors with a consequent detrimental effect on parasite replication. ..
- Bodell W, Gaikwad N, Miller D, Berger M. Formation of DNA adducts and induction of lacI mutations in Big Blue Rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric brain tumors. Cancer Epidemiol Biomarkers Prev. 2003;12:545-51 pubmed..This study establishes TMZ has significant mutagenic potential and suggests that careful consideration in the use of TMZ for the treatment of low-grade adult and pediatric brain tumors should be given. ..
- Ewart Toland A, Balmain A. The genetics of cancer susceptibility: from mouse to man. Toxicol Pathol. 2004;32 Suppl 1:26-30 pubmed..Allelic variants in both mouse and human can then be used to better understand the mechanisms behind cancer risk and as targets for intervention. ..
- Rico B, Beggs H, Schahin Reed D, Kimes N, Schmidt A, Reichardt L. Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci. 2004;7:1059-69 pubmed..Thus, FAK functions as a negative regulator of axonal branching and synapse formation, and it seems to exert its actions, in part, through Rho family GTPases. ..
- Tiffin N, Adi S, Stokoe D, Wu N, Rosenthal S. Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation. Endocrinology. 2004;145:4991-6 pubmed..Thus, although Akt phosphorylation may be necessary, it is not sufficient for induction of myogenic differentiation by IGF-I and must be accompanied by a decrease in ERK1/2 phosphorylation. ..
- Xie Z, Chang S, Oda Y, Bikle D. Hairless suppresses vitamin D receptor transactivation in human keratinocytes. Endocrinology. 2006;147:314-23 pubmed..These data indicate that Hr functions as a corepressor of VDR to block 1,25(OH)2D3 action on keratinocytes. ..
- Haggie P, Verkman A. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem. 2009;284:7681-6 pubmed publisher..As such, alternative mechanisms are needed to explain increased ceramide in CF airways. Non-CFTR mechanisms, such as ClC-type chloride channels, are likely involved in maintaining electroneutrality during organellar acidification. ..
- Qian L, Srivastava D. Monkeying around with cardiac progenitors: hope for the future. J Clin Invest. 2010;120:1034-6 pubmed publisher..These findings move the field another step closer to clinical use of ES or iPS cell-derived cardiovascular progenitors in cardiac repair. ..
- Connolly E, Saunier E, Quigley D, Luu M, De Sapio A, Hann B, et al. Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term T?RI/II kinase inhibition with LY2109761. Cancer Res. 2011;71:2339-49 pubmed publisher..Therefore, TGF-? inhibitors might be clinically useful for applications requiring acute administration, but long-term patient exposure to such drugs should be undertaken with caution. ..
- Ferrari L, Bogen O, Chu C, Levine J. Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat. J Pain. 2013;14:731-8 pubmed publisher..This study provides evidence that ongoing protein translation in the sensory neuron terminals is involved in pain chronification, and local treatment that transiently interrupts this translation may be a useful therapy to chronic pain. ..
- Trumpp A, Depew M, Rubenstein J, Bishop J, Martin G. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999;13:3136-48 pubmed..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
- Ji Z, Miranda R, Newhouse Y, Weisgraber K, Huang Y, Mahley R. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem. 2002;277:21821-8 pubmed
- McQuillen P, Sheldon R, Shatz C, Ferriero D. Selective vulnerability of subplate neurons after early neonatal hypoxia-ischemia. J Neurosci. 2003;23:3308-15 pubmed..However, deficits in motor function still occur, as in babies with PVL. Subplate neuron cell death in PVL provides another mechanism for abnormal neurodevelopment after neonatal hypoxia-ischemia. ..
- Tecott L, Nestler E. Neurobehavioral assessment in the information age. Nat Neurosci. 2004;7:462-6 pubmed..These hold promise, both for improving the throughput of mouse behavioral assessment and for providing new insights into the neurobiology of mammalian behavioral regulation. ..
- Parrish J, Emoto K, Jan L, Jan Y. Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 2007;21:956-72 pubmed..We further show genetic interactions and association between PcG proteins and the tumor suppressor kinase Warts (Wts), providing evidence for their cooperation in multiple developmental processes including dendrite maintenance. ..
- Piper M, Unger E, Myers M, Xu A. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008;22:751-9 pubmed..These results further suggest that leptin's effects on growth and reproduction are mediated by other signaling pathways, and that Stat3-mediated control of these functions is mediated independently of leptin and LepRb neurons. ..
- Yuneva M. Finding an "Achilles' heel" of cancer: the role of glucose and glutamine metabolism in the survival of transformed cells. Cell Cycle. 2008;7:2083-9 pubmed..Here we discuss possible molecular mechanisms underlying oncogene-induced sensitivity to deprivation of these nutrients. ..
- Lanteri M, O Brien K, Purtha W, Cameron M, Lund J, Owen R, et al. Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest. 2009;119:3266-77 pubmed publisher..Together, these results suggest that higher levels of peripheral Tregs after infection protect against severe WNV disease in immunocompetent animals and humans. ..
- Ning N, Lin G, Lue T, Lin C. Effects of estrogen, raloxifene, and levormeloxifene on the expression of Rho-kinase signaling molecules in urethral smooth muscle cells. Urology. 2010;76:1517.e6-11 pubmed publisher..Estrogen, raloxifene, and levormeloxifene may affect urinary continence by inhibiting the expression of Rho-kinase signaling molecules. ..
- Sullivan B, Liang H, Bando J, WU D, Cheng L, McKerrow J, et al. Genetic analysis of basophil function in vivo. Nat Immunol. 2011;12:527-35 pubmed publisher..Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity...
- Young S, Sherman P, Lucks J, Pelto G. Why on earth?: Evaluating hypotheses about the physiological functions of human geophagy. Q Rev Biol. 2011;86:97-120 pubmed..Our results indicate that human geophagy is best explained as providing protection from dietary chemicals, parasites, and pathogens, whereas animal geophagy may involve both micronutrient acquisition and protection. ..
- Lee A, Kanter B, Wang D, Lim J, Zou M, Qiu C, et al. Prkcz null mice show normal learning and memory. Nature. 2013;493:416-9 pubmed publisher..Chelerythrine was a weak inhibitor of PKM-? (K(i) = 76??M). Our findings show that absence of PKM-? does not impair learning and memory in mice, and that ZIP can erase reward memory even when PKM-? is not present. ..
- Kroetz D, Huse L, Thuresson A, Grillo M. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Mol Pharmacol. 1997;52:362-72 pubmed..The findings suggest that the expression of CYP4A3 and CYP4A8 may be critical to the early changes in eicosanoid formation and renal function in the young spontaneously hypertensive rat. ..
- Sun T, Lu B, Feng J, Reinhard C, Jan Y, Fantl W, et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol. 2001;3:628-36 pubmed..These findings show that PAR-1, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways. ..
- Alessandri Haber N, Dina O, Yeh J, Parada C, Reichling D, Levine J. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci. 2004;24:4444-52 pubmed..These results suggest that TRPV4 plays a crucial role in a painful peripheral neuropathy, making it a very promising target for the development of a novel class of analgesics. ..
- Pioletti M, Findeisen F, Hura G, Minor D. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol. 2006;13:987-95 pubmed..Together, the data resolve how Kv4 channels and KChIPs interact and provide a framework for understanding how KChIPs modulate Kv4 function. ..
- Looney M, Nguyen J, Hu Y, Van Ziffle J, Lowell C, Matthay M. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009;119:3450-61 pubmed publisher..Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach. ..
- Lin G, Wang G, Banie L, Ning H, Shindel A, Fandel T, et al. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Cytotherapy. 2010;12:88-95 pubmed publisher..Effective treatment for stress urinary incontinence (SUI) is lacking. This study investigated whether transplantation of adipose tissue-derived stem cells (ADSC) can treat SUI in a rat model...
- Sun V, Zhou W, Nosrati M, Majid S, Thummala S, De Semir D, et al. Antitumor activity of miR-1280 in melanoma by regulation of Src. Mol Ther. 2015;23:71-8 pubmed publisher..Our results demonstrate a novel role for miR-1280 as a tumor suppressor in melanoma, identify the Src signaling pathway as a target of miR-1280 action, and suggest a potential therapeutic role for miR-1280 in melanoma. ..
- Forsayeth J, Kobrin E. Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor. J Neurosci. 1997;17:1531-8 pubmed..In this respect, nicotinic receptors that contain the beta3 subunit are structurally homologous to the muscle nicotinic receptor. ..
- Krantz D, Peter D, Liu Y, Edwards R. Phosphorylation of a vesicular monoamine transporter by casein kinase II. J Biol Chem. 1997;272:6752-9 pubmed..These results provide the first demonstration of phosphorylation of a vesicular neurotransmitter transporter and a potential mechanism for differential regulation of the two VMATs. ..
- Sakanaka C, Williams L. Functional domains of axin. Importance of the C terminus as an oligomerization domain. J Biol Chem. 1999;274:14090-3 pubmed..The oligomerization of Axin through its C terminus is important for its function in regulation of beta-catenin-mediated response. ..
- Anderson H, Wang F, Gardner D. Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004;279:9287-97 pubmed..These findings suggest that metalloproteinase activity as an essential step in this pathway may prove to be a relevant therapeutic target in the management of cardiac hypertrophy. ..
- Poskanzer K, Fetter R, Davis G. Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size. Neuron. 2006;50:49-62 pubmed
- Subramanian S, Sijwali P, Rosenthal P. Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. J Biol Chem. 2007;282:24961-9 pubmed
- Hsieh M, Grantham E, Liu B, Macapagal R, Willingham E, Baskin L. In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism. J Urol. 2007;178:1637-42 pubmed..04). These findings suggest that benzophenone-2 may cause hypospadias via signaling through the estrogen receptor. Further study of human benzophenone-2 exposure and its effects is needed to support this hypothesis. ..
- Fife K, Liu Y, Schmelzer K, Tsai H, Kim I, Morisseau C, et al. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008;327:707-15 pubmed publisher..However, LPS did have significant effects on plasma eicosanoid levels and hepatic Ephx2 expression, suggesting that in vivo EET levels are modulated in response to an inflammatory signal. ..
- Drace K, McLaughlin S, Darby C. Caenorhabditis elegans BAH-1 is a DUF23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle. PLoS ONE. 2009;4:e6741 pubmed publisher..elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-beta signaling pathway. ..
- Bloise E, Lin W, Liu X, Simbulan R, Kolahi K, Petraglia F, et al. Impaired placental nutrient transport in mice generated by in vitro fertilization. Endocrinology. 2012;153:3457-67 pubmed publisher..05). We conclude that IVF alters both fetal and placental growth and, importantly, decreases placental transport efficiency in mice conceived by IVF. ..
- Mauer J, Chaurasia B, Goldau J, Vogt M, Ruud J, Nguyen K, et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014;15:423-30 pubmed publisher..Our results identify signaling via IL-6 as an important determinant of the alternative activation of macrophages and assign an unexpected homeostatic role to IL-6 in limiting inflammation. ..
- Cooper E, Harrington E, Jan Y, Jan L. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci. 2001;21:9529-40 pubmed..There is strong neuropil staining in many regions. In some instances, notably the hippocampal mossy fibers, evidence indicates this neuropil staining is presynaptic. ..
- Lubrano Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, et al. The human MC4R promoter: characterization and role in obesity. Diabetes. 2003;52:2996-3000 pubmed
- Corl A, Rodan A, Heberlein U. Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci. 2005;8:18-9 pubmed..These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug. ..
- ..However, the use of vitamin D metabolites and analogs for these applications remains limited by the classic actions of vitamin D leading to hypercalcemia and hypercalcuria. ..
- Siegenthaler J, Pleasure S. We have got you 'covered': how the meninges control brain development. Curr Opin Genet Dev. 2011;21:249-55 pubmed publisher..In this review, we will discuss what is known about assembly of the fetal meninges and review the role of meningeal-derived proteins in mouse and human brain development. ..
- Fu C, Sretavan D. Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma. Invest Ophthalmol Vis Sci. 2012;53:76-84 pubmed publisher..Exogenous application of EphB2 protein enhances RGC axon survival in explants, suggesting that modulation of Eph/ephrin signaling may be of therapeutic interest. ..
- Swei A, Briggs C, Lane R, Ostfeld R. Impacts of an introduced forest pathogen on the risk of Lyme disease in California. Vector Borne Zoonotic Dis. 2012;12:623-32 pubmed publisher..This study underscores the important direct and indirect impacts of invasive plant pathogens on biodiversity, the transmission cycles of zoonotic diseases, and ultimately human health...
- Jun J, Yang M, Chen H, Chakraborty A, Roose J. Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS. Mol Cell Biol. 2013;33:2470-84 pubmed publisher..Based on computational predictions and experiments exploring whether SOS functions as a RacGEF or adaptor in Rac-p38 activation, we established that the presence of SOS1, but not its enzymatic activity, is critical for p38 activation. ..
- Seif T, Chang S, Simms J, Gibb S, Dadgar J, Chen B, et al. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013;16:1094-100 pubmed publisher..Our results identify a mechanism by which hyperpolarization-active NMDA receptors under mPFC- and insula-to-NAcore inputs sustain aversion-resistant alcohol intake. ..
- Costa S, Marini O, Bevilacqua D, DeFranco A, Hou B, Lonardi S, et al. Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. J Leukoc Biol. 2017;102:791-803 pubmed publisher..hematopoietic cells to disease initiation and progression in the IMQ-induced mouse model of psoriasis and uncover a potential novel pathogenic role for monocytes/M? to psoriasis development. ..
- Madison J, Brown J. Differential inhibitory effects of forskolin, isoproterenol, and dibutyryl cyclic adenosine monophosphate on phosphoinositide hydrolysis in canine tracheal smooth muscle. J Clin Invest. 1988;82:1462-5 pubmed..The findings suggest a novel mechanism for selective modulation by cAMP of receptor-mediated cellular activation...
- Highsmith S, Polosukhina K, Eden D. Myosin motor domain lever arm rotation is coupled to ATP hydrolysis. Biochemistry. 2000;39:12330-5 pubmed..The data are consistent with a model in which only substrates that produce a motor domain-NDP-P(i) complex as the steady-state intermediate make the motor domain more compact, and only those substrates support force production. ..
- Sheu M, Fowler A, Kao J, Schmuth M, Schoonjans K, Auwerx J, et al. Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol. 2002;118:94-101 pubmed
- Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem. 2003;278:9609-19 pubmed..Smad3/4 did not reduce the ability of C/EBP to bind to its cognate DNA sequence, but repressed transcription by inhibiting the transactivation function of C/EBP. ..
- Mackey Z, O Brien T, Greenbaum D, Blank R, McKerrow J. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004;279:48426-33 pubmed..Therefore, tbcatB, but not rhodesain, is essential for T. brucei survival in culture and is the most likely target of the diazomethane protease inhibitor Z-Phe-Ala-CHN(2) in T. brucei...
- Shirai M, Yamanaka M, Shiina H, Igawa M, Ogishima T, Fujime M, et al. Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment. Urology. 2004;64:1244-9 pubmed..This is the first study to demonstrate that insulin treatment may restore erectile function through restoration of sex hormone receptor gene and protein expression in the diabetic rat crura. ..
- Papadopoulos M, Binder D, Verkman A. Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching. FASEB J. 2005;19:425-7 pubmed..Our data provide in vivo evidence for enhanced ECS diffusion in vasogenic brain edema, yet greatly slowed diffusion in cytotoxic edema and in and around tumors. ..
- Wakabayashi Y, Mao J, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007;445:761-5 pubmed..We propose that Ptch occupies a critical niche in determining basal or squamous cell lineage, and that both tumour types can arise from the same target cell depending on carcinogen exposure and host genetic background. ..
- Reese T, Liang H, Tager A, Luster A, Van Rooijen N, Voehringer D, et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007;447:92-6 pubmed..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase. ..
- Sennino B, Falcon B, McCauley D, Le T, McCauley T, Kurz J, et al. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res. 2007;67:7358-67 pubmed..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression...
- Gow J, Chinn L, Kroetz D. The effects of ABCB1 3'-untranslated region variants on mRNA stability. Drug Metab Dispos. 2008;36:10-5 pubmed..Although the examined ABCB1 3'-UTR variants have no effect on ABCB1 mRNA stability, these data represent one of the first attempts to determine the influence of genetic variation in UTRs on ABCB1 mRNA levels. ..
- Trinidad J, Thalhammer A, Specht C, Lynn A, Baker P, Schoepfer R, et al. Quantitative analysis of synaptic phosphorylation and protein expression. Mol Cell Proteomics. 2008;7:684-96 pubmed..These findings suggest that the hippocampus utilizes reversible protein phosphorylation to a greater extent than other brain regions when modifying synaptic strength. ..
- Schlegel A, Stainier D. Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism. PLoS Genet. 2007;3:e199 pubmed..We summarize findings in these organisms that shed light on highly conserved pathways of energy homeostasis. ..
- Dalgard C, Van Quill K, O Brien J. Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. Clin Cancer Res. 2008;14:3113-23 pubmed publisher..MS-275 significantly reduced tumor burden in both mouse and rat models of RB. HDACi should be considered for clinical trials in children with RB. ..