Genomes and Genes
Experts and Doctors on animals in Novato, California, United States
Locale: Novato, California, United States
Publications219 found, 100 shown here
- Wiley C, Velarde M, Lecot P, Liu S, Sarnoski E, Freund A, et al. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab. 2016;23:303-14 pubmed publisher..Our data identify a distinct senescence response and provide a mechanism by which mitochondrial dysfunction can drive aging phenotypes. ..
- Neves J, Zhu J, Sousa Victor P, Konjikusic M, Riley R, Chew S, et al. Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science. 2016;353:aaf3646 pubmed publisher..Thus, immune modulation is required during tissue repair and regeneration. This approach may improve the efficacy of stem-cell-based regenerative therapies. ..
- Jin K, Xie L, Kim S, Parmentier Batteur S, Sun Y, Mao X, et al. Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice. Mol Pharmacol. 2004;66:204-8 pubmed..Thus, CB1 and VR1 receptors both seem to have roles in regulating adult neurogenesis. ..
- Sun Y, Jin K, Childs J, Xie L, Mao X, Greenberg D. Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. J Cereb Blood Flow Metab. 2004;24:1146-52 pubmed..VegfB also protected cultured cerebral cortical neurons from hypoxic injury, suggesting that its protective action is mediated at least in part through a direct effect on neurons. ..
- Polster B, Basañez G, Etxebarria A, Hardwick J, Nicholls D. Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem. 2005;280:6447-54 pubmed..Taken together, these results define a novel mechanism of AIF release involving calpain processing and identify a potential molecular checkpoint for cytoprotective interventions. ..
- Danielson S, Held J, Schilling B, Oo M, Gibson B, Andersen J. Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease. Anal Chem. 2009;81:7823-8 pubmed publisher..This is the first report of increased 3NT levels of a specific tyrosine in a PD model and the first use of MRM mass spectrometry to quantify changes in 3NT modifications at specific sites within a target protein. ..
- Sun Y, Jin K, Childs J, Xie L, Mao X, Greenberg D. Neuronal nitric oxide synthase and ischemia-induced neurogenesis. J Cereb Blood Flow Metab. 2005;25:485-92 pubmed..Selective inhibition of neuronal NO synthase may have the potential to both reduce infarct size and enhance neurogenesis in stroke. ..
- Agrawal P, Chen Y, Schilling B, Gibson B, Hughes R. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem. 2012;287:21164-75 pubmed publisher..Taken together, our data describe the identification of the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR activity and skeletal muscle differentiation. ..
- Jin K, Mao X, Eshoo M, Nagayama T, Minami M, Simon R, et al. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann Neurol. 2001;50:93-103 pubmed..These results suggest that microarray analysis of gene expression may be useful for elucidating novel molecular mediators of cell death and survival in the ischemic brain. ..
- Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev. 2011;21:107-12 pubmed publisher..These discoveries provide potential mechanisms by which cellular senescence might contribute to the diverse, and seemingly incongruent, processes of tumor suppression, tumor promotion, tissue repair, and aging. ..
- Mookerjee S, Brand M. Characteristics of the turnover of uncoupling protein 3 by the ubiquitin proteasome system in isolated mitochondria. Biochim Biophys Acta. 2011;1807:1474-81 pubmed publisher..We propose that matrix ATP and a high membrane potential are needed for UCP3 to be polyubiquitylated through lysine-48 of ubiquitin and exported to the cytosolic 26S proteasome, where it is de-ubiquitylated and degraded. ..
- Zhu Y, Sun Y, Mao X, Jin K, Greenberg D. Expression of poly(C)-binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons. Neuroscience. 2002;110:191-8 pubmed..Since we observed no poly(C)-binding protein expression in astroglia, alternative mRNA stability mechanisms may exist in these cells. ..
- Kaur D, Lee D, Ragapolan S, Andersen J. Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease. Free Radic Biol Med. 2009;46:593-8 pubmed publisher..This may have important implications for neurodegeneration associated with Parkinson's disease in which both glutathione reduction and iron elevation have been implicated. ..
- Greenberg D. The jaundice of the cell. Proc Natl Acad Sci U S A. 2002;99:15837-9 pubmed
- Zhang Y, Bharathi S, Rardin M, Lu J, Maringer K, Sims Lucas S, et al. Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem. 2017;292:10239-10249 pubmed publisher..Our findings suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function. ..
- Lucanic M, Kapahi P. Ubiquitin ligases join the field of dietary restriction in C.elegans. Aging (Albany NY). 2009;1:751-2 pubmed
- Davalos A, Coppe J, Campisi J, Desprez P. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010;29:273-83 pubmed publisher..Here, we summarize our knowledge of the SASP and the impact it has on tissue microenvironments and ability to stimulate tumor progression. ..
- Pan K, Palter J, Rogers A, Olsen A, Chen D, Lithgow G, et al. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. 2007;6:111-9 pubmed..Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans. ..
- Galvan V, Banwait S, Spilman P, Gorostiza O, Peel A, Ataie M, et al. Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis. 2007;28:65-75 pubmed..Thus, ASK1 may be the apical MAPKKK in a signaling complex assembled with APP as a response to stress. ..
- Gerencser A, Mark K, Hubbard A, Divakaruni A, Mehrabian Z, Nicholls D, et al. Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem. 2009;110:990-1004 pubmed publisher..However, a role for calpain as a contributing factor or in response to milder glutamate insults is not excluded. ..
- Zhu Y, Jin K, Mao X, Greenberg D. Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J. 2003;17:186-93 pubmed..These findings help to provide a molecular basis for some of the recently identified neuronal effects of VEGF. ..
- Khan A, Wang Y, Sun Y, Mao X, Xie L, Miles E, et al. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A. 2006;103:17944-8 pubmed..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms. ..
- Jeon O, Kim C, Laberge R, Demaria M, Rathod S, Vasserot A, et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017;23:775-781 pubmed publisher..Collectively, these findings support the use of SnCs as a therapeutic target for treating degenerative joint disease...
- Sarantos M, Papanikolaou T, Ellerby L, Hughes R. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. J Huntingtons Dis. 2012;1:195-210 pubmed publisher..Huntington's disease (HD) is a dominantly inherited neurodegenerative condition characterized by dysfunction in striatal and cortical neurons. There are currently no approved drugs known to slow the progression of HD...
- Chang J, Wang Y, Shao L, Laberge R, Demaria M, Campisi J, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016;22:78-83 pubmed publisher..Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents. ..
- Ruane T, Haskins M, Cheng A, Wang P, AGUIRRE G, Knox V, et al. Pharmacodynamics, pharmacokinetics and biodistribution of recombinant human N-acetylgalactosamine 4-sulfatase after 6months of therapy in cats using different IV infusion durations. Mol Genet Metab. 2016;117:157-63 pubmed publisher..Additional studies may determine if shorter infusion times are appropriate for MPS VI patients without significant infusion-associated reactions. ..
- Frankowski H, Castro Obregon S, Del Rio G, Rao R, Bredesen D. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. Neuromolecular Med. 2002;1:153-70 pubmed..Both isoforms of PLAIDD could be co-immunoprecipitated with p75NTR, suggesting an interaction between these molecules. ..
- Siddiqui A, Mallajosyula J, Rane A, Andersen J. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiol Dis. 2010;40:444-8 pubmed publisher..This has implications for early intervention therapies. ..
- Jin K, Li W, Nagayama T, He X, Sinor A, Chang J, et al. Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. J Neurosci Res. 2000;59:767-74 pubmed..Double-labeling studies showed that TIAR protein expression was co-localized with DNA damage in neuronal cells. The findings suggest that TIAR may be involved in neuronal cell death after cerebral ischemic injury. ..
- Duncan C, An M, Papanikolaou T, Rugani C, Vitelli C, Ellerby L. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Mol Neurodegener. 2013;8:42 pubmed publisher..This study implicates HDAC3 and ataxin-7 interaction as a target for therapeutic intervention in SCA7, adding to a growing list of neurodegenerative diseases that may be treated by HDAC inhibitors. ..
- Guo L, Karpac J, Tran S, Jasper H. PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan. Cell. 2014;156:109-22 pubmed publisher..Our results highlight the importance of commensal control for lifespan of metazoans and identify SC-class PGRPs as longevity-promoting factors. ..
- Morten K, Ackrell B, Melov S. Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment. J Biol Chem. 2006;281:3354-9 pubmed..Increased production of O2* resulting from complex II normalization had no effect on steady state levels due to the rapid conversion to H2O2, a process presumably aided by the presence of the EUK189, an SOD mimetic...
- Calder R, Beems R, van Steeg H, Mian I, Lohman P, Vijg J. MPHASYS: a mouse phenotype analysis system. BMC Bioinformatics. 2007;8:183 pubmed..It provides a framework for developing data analysis applications, and tools for collecting and distributing high-quality data. The software is platform independent and freely available under an open-source license 1. ..
- Benedetti M, Foster A, Vantipalli M, White M, Sampayo J, Gill M, et al. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol. 2008;43:882-91 pubmed publisher..Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging. ..
- Miyamoto B, Kakkis E. The potential investment impact of improved access to accelerated approval on the development of treatments for low prevalence rare diseases. Orphanet J Rare Dis. 2011;6:49 pubmed publisher..Our research brings attention to the need for well-defined and practical qualification criteria for the use of surrogate endpoints to allow more access to the AA approval pathway in clinical trials for rare diseases. ..
- Post D, Yu L, Krasity B, Choudhury B, Mandel M, Brennan C, et al. O-antigen and core carbohydrate of Vibrio fischeri lipopolysaccharide: composition and analysis of their role in Euprymna scolopes light organ colonization. J Biol Chem. 2012;287:8515-30 pubmed publisher..These studies indicate that the unusual V. fischeri O-antigen sugars play a role in the early phases of bacterial colonization of the squid...
- Hermel E, Gafni J, Propp S, Leavitt B, Wellington C, Young J, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 2004;11:424-38 pubmed..These data support the involvement of caspase-2 in the selective neuronal cell death associated with HD in the striatum and cortex. ..
- Galvan V, Kurakin A, Bredesen D. Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. FEBS Lett. 2004;558:57-62 pubmed..An interaction of Chk1 and XIAP may imply a mechanism of coupling between the regulatory networks that control cell cycle progression and apoptosis during mitosis. ..
- Golden T, Hubbard A, Dando C, Herren M, Melov S. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 2008;7:850-65 pubmed publisher..Overall, our approach serves as a paradigm for identifying potential biomarkers of aging in higher organisms that can be repeatedly sampled throughout their lifespan. ..
- Miller J, Holcomb J, Al Ramahi I, de Haro M, Gafni J, Zhang N, et al. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 2010;67:199-212 pubmed publisher..Correspondingly, MMPs are activated in HD mouse models, and loss of function of Drosophila homologs of MMPs suppresses Htt-induced neuronal dysfunction in vivo. ..
- Peel A, Bredesen D. Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol Dis. 2003;14:52-62 pubmed..These findings support a role for PKR activation in the pathogenesis of AD. ..
- McColl G, Vantipalli M, Lithgow G. The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. FASEB J. 2005;19:1716-8 pubmed..These observations support the view that organismal stress resistance determines life span and Ku70 modulates these effects. ..
- L HEUREUX N, Dusserre N, Konig G, Victor B, Keire P, Wight T, et al. Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med. 2006;12:361-5 pubmed..These results indicate that a completely biological and clinically relevant TEBV can be assembled exclusively from an individual's own cells. ..
- Schilling B, Gafni J, Torcassi C, Cong X, Row R, LaFevre Bernt M, et al. Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity. J Biol Chem. 2006;281:23686-97 pubmed..Dissection of phosphorylation modifications in Htt may provide clues to Huntington disease pathogenesis and targets for therapeutic development. ..
- Choi S, Gerencser A, Ng R, Flynn J, Melov S, Danielson S, et al. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012;32:16775-84 pubmed publisher..Our results support the conclusion that the intrinsic bioenergetic capacities of presynaptic nerve terminals are maintained in these symptomatic AD mouse models. ..
- Tourette C, Li B, Bell R, O Hare S, Kaltenbach L, Mooney S, et al. A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. J Biol Chem. 2014;289:6709-26 pubmed publisher..These data indicate that HTT is involved directly in membrane dynamics, cell attachment, and motility. Furthermore, they implicate dysregulation in these pathways as pathological mechanisms in HD. ..
- Gafni J, Hermel E, Young J, Wellington C, Hayden M, Ellerby L. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. J Biol Chem. 2004;279:20211-20 pubmed..These results support the role of calpain-derived Htt fragmentation in HD and suggest that aberrant activation of calpains may play a role in HD pathogenesis. ..
- Vijg J, Campisi J. Puzzles, promises and a cure for ageing. Nature. 2008;454:1065-71 pubmed publisher..A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect. ..
- Gerencser A, Chinopoulos C, Birket M, Jastroch M, Vitelli C, Nicholls D, et al. Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria. J Physiol. 2012;590:2845-71 pubmed publisher..Between samples treated in different ways, the typical equivalent error is ?5 mV. ..
- Gafni J, Papanikolaou T, DeGiacomo F, Holcomb J, Chen S, Menalled L, et al. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. J Neurosci. 2012;32:7454-65 pubmed publisher..However, our studies do suggest a role for caspase-6 activity in clearance pathways for mHtt protein. ..
- Peel A, Rao R, Cottrell B, Hayden M, Ellerby L, Bredesen D. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Hum Mol Genet. 2001;10:1531-8 pubmed..The increased immunolocalization of the activated kinase is more pronounced in areas most affected by the disease and, coupled with the RNA binding results, suggests a role for PKR activation in the disease process. ..
- Won S, Kim S, Xie L, Wang Y, Mao X, Jin K, et al. Reelin-deficient mice show impaired neurogenesis and increased stroke size. Exp Neurol. 2006;198:250-9 pubmed..These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain. ..
- Busuttil R, Lin Q, Stambrook P, Kucherlapati R, Vijg J. Mutation frequencies and spectra in DNA polymerase eta-deficient mice. Cancer Res. 2008;68:2081-4 pubmed publisher..No differences were found between poleta-null, heterozygous, or littermate control mice. We conclude that the poleta defect is specific for UV damage and has no effect on in vivo mutagenesis in mice. ..
- Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen D. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol. 2009;65:294-303 pubmed publisher..In addition, the results argue that the interaction between APP and p75(NTR) may represent a therapeutic target in Alzheimer's disease. ..
- Bharat S, Cochran B, Hsu M, Liu J, Ames B, Andersen J. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology. 2002;23:479-86 pubmed..Here we report that pre-treatment of PC12 cells with R-lipoic acid acts to prevent depletion of GSH content and preserves the mitochondrial complex I activity which normally is impaired as a consequence of GSH loss. ..
- Swistowska A, da Cruz A, Han Y, Swistowski A, Liu Y, Shin S, et al. Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells. Stem Cells Dev. 2010;19:71-82 pubmed publisher..We conclude that PA6-CM can induce dopaminergic differentiation in hESCs in a stage-specific manner. Shh is likely an important soluble dopaminergic inducing factor secreted by stromal cells and acts after the neural fate determination. ..
- Jin K, Mao X, Sun Y, Xie L, Jin L, Nishi E, et al. Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo. J Neurosci. 2002;22:5365-73 pubmed..Therefore, HB-EGF may help to trigger proliferation of neuronal precursors in brain after hypoxic or ischemic injury. ..
- Bredesen D, John V, Galvan V. Importance of the caspase cleavage site in amyloid-? protein precursor. J Alzheimers Dis. 2010;22:57-63 pubmed publisher..Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in A?PP. ..
- Sousa Victor P, Gutarra S, García Prat L, Rodriguez Ubreva J, Ortet L, Ruiz Bonilla V, et al. Geriatric muscle stem cells switch reversible quiescence into senescence. Nature. 2014;506:316-21 pubmed publisher..As p16(INK4a) is dysregulated in human geriatric satellite cells, these findings provide the basis for stem-cell rejuvenation in sarcopenic muscles. ..
- Won S, Xie L, Kim S, Tang H, Wang Y, Mao X, et al. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res. 2006;1123:237-44 pubmed..These findings point to differences in the response of aged versus young adult rats to FGF-2 in cerebral ischemia, and suggest that such differences need to be considered in the development of neuroprotective agents for stroke. ..
- Liu Q, Pedersen O, Peng J, Couture L, Rao M, Zeng X. Optimizing dopaminergic differentiation of pluripotent stem cells for the manufacture of dopaminergic neurons for transplantation. Cytotherapy. 2013;15:999-1010 pubmed publisher..Our results suggest that this optimized protocol can be used to generate dopaminergic neurons for Investigational New Drug enabling studies. ..
- Sun Y, Jin K, Childs J, Xie L, Mao X, Greenberg D. Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Dev Biol. 2006;289:329-35 pubmed..These results suggest a role for VEGFB in the regulation of adult neurogenesis, which could have therapeutic implications for diseases associated with central neuronal loss. ..
- Stoka V, Turk V, Bredesen D. Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med. 2007;9:255-63 pubmed..These results indicate that the activation pattern of the intrinsic pathway of apoptosis undergoes a marked shift during postnatal maturation. ..
- Lucanic M, Lithgow G, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013;12:445-58 pubmed publisher..Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies. ..
- Laberge R, Adler D, DeMaria M, Mechtouf N, Teachenor R, Cardin G, et al. Mitochondrial DNA damage induces apoptosis in senescent cells. Cell Death Dis. 2013;4:e727 pubmed publisher..Thus, cellular senescence and mtDNA damage are outcomes of synthetic nucleoside analog treatment, indicating that the GCV-HSVtk combination can be used effectively to promote the targeted formation or eradication of senescent cells. ..
- Sun Y, Jin K, Mao X, Xie L, Peel A, Childs J, et al. Effect of aging on neuroglobin expression in rodent brain. Neurobiol Aging. 2005;26:275-8 pubmed..Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders. ..
- Katewa S, Demontis F, Kolipinski M, Hubbard A, Gill M, Perrimon N, et al. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012;16:97-103 pubmed publisher..Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR. ..
- Jin K, Zhu Y, Sun Y, Mao X, Xie L, Greenberg D. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A. 2002;99:11946-50 pubmed..Cells labeled with BrdUrd after VEGF treatment in vivo include immature and mature neurons, astroglia, and endothelial cells. These findings implicate the angiogenesis factor VEGF in neurogenesis as well. ..
- Tollervey J, Lunyak V. Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics. 2012;7:823-40 pubmed publisher..Further investigation into stem cell epigenetics promises to provide novel advances in the diagnosis and treatment of a wide array of human diseases. ..
- Li H, Qi Y, Jasper H. Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan. Cell Host Microbe. 2016;19:240-53 pubmed publisher..Our results establish a mechanism by which age-related chronic inflammation causes the decline of intestinal compartmentalization and microbiota dysbiosis, limiting lifespan. ..
- Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld M, Hook V. Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. J Neurochem. 2003;86:556-63 pubmed..Overall, these studies demonstrated that the PC2 processing enzyme is critical for the in vivo production of alpha-MSH in pituitary and brain. ..
- Mallajosyula J, Kaur D, Chinta S, Rajagopalan S, Rane A, Nicholls D, et al. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PLoS ONE. 2008;3:e1616 pubmed publisher..Our inducible astrocytic MAO-B transgenic provides a novel model for exploring pathways involved in initiation and progression of several key features associated with PD pathology and for therapeutic drug testing. ..
- Peng J, Andersen J. Mutant ?-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Aging Cell. 2011;10:255-62 pubmed publisher..This could provide a novel therapeutic target for chronic brain repair in this condition...
- Choi S, Gerencser A, Lee D, Rajagopalan S, Nicholls D, Andersen J, et al. Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. J Neurosci. 2011;31:4524-34 pubmed publisher..We conclude that the intrinsic bioenergetic capacities of dopaminergic and nondopaminergic presynaptic synaptosomes from mice do not differ...
- Reis Rodrigues P, Czerwieniec G, Peters T, Evani U, Alavez S, Gaman E, et al. Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell. 2012;11:120-7 pubmed publisher..This demonstrates that proteomic approaches can be used to identify genes that modify lifespan. Finally, these observations indicate that the accumulation of insoluble proteins with diverse functions may be a general feature of aging...
- McGee M, Day N, Graham J, Melov S. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY). 2012;4:256-69 pubmed
- Golden T, Hubbard A, Morten K, Hinerfeld D, Melov S. Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. Free Radic Biol Med. 2005;39:152-63 pubmed..The normalization of expression of some of these pathways by antioxidant treatment suggests approaches to treating disease in which endogenous oxidative stress plays a role. ..
- Nguyen T, Galvan V, Huang W, Banwait S, Tang H, Zhang J, et al. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008;104:1065-80 pubmed