Genomes and Genes
Experts and Doctors on amino acid sequence in San Diego, California, United States
Locale: San Diego, California, United States
Topic: amino acid sequence
Publications152 found, 100 shown here
- Klieforth R, Maalouf G, Stalis I, Terio K, Janssen D, Schrenzel M. Malignant catarrhal fever-like disease in Barbary red deer (Cervus elaphus barbarus) naturally infected with a virus resembling alcelaphine herpesvirus 2. J Clin Microbiol. 2002;40:3381-90 pubmed..These findings suggest that a herpesvirus closely related to AlHV-2 caused the MCF-like disease epizootic in Barbary red deer and that the virus may have originated from Jackson's hartebeest...
- Giguere V, Yang N, Segui P, Evans R. Identification of a new class of steroid hormone receptors. Nature. 1988;331:91-4 pubmed
- Baughman G, Wiederrecht G, Campbell N, Martin M, Bourgeois S. FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. Mol Cell Biol. 1995;15:4395-402 pubmed
- Huang L, Wang L, Ma Y, Durick K, Perkins G, Deerinck T, et al. NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol. 1999;145:951-9 pubmed..This represents the first example of a differentially targeted AKAP and adds an additional level of complexity to the PKA signaling network. ..
- Cathomen T, Collete D, Weitzman M. A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay. J Virol. 2000;74:2372-82 pubmed..These studies suggest that chimeric proteins may be used to harness the unique targeting feature of AAV for gene therapy applications. ..
- Westberg C, Yang J, Tang H, Reddy T, Wong Staal F. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. J Biol Chem. 2000;275:21396-401 pubmed..Overexpression of HAP95 significantly increases CTE-dependent gene expression but has no effect on general gene expression or that mediated by the Rev/Rev response element of human immunodeficiency virus type 1. ..
- Lamar E, Deblandre G, Wettstein D, Gawantka V, Pollet N, Niehrs C, et al. Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev. 2001;15:1885-99 pubmed..By down-regulating ICD levels, Nrarp could function as a negative feedback regulator of Notch signaling that attenuates ICD-mediated transcription. ..
- Morello C, Ye M, Spector D. Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replication. J Virol. 2002;76:4822-35 pubmed..Taken together, these results show that immunization with pDNA and inactivated virus provides strong antibody and cell-mediated immunity against CMV infection. ..
- Iyer G, Moore M, Taylor S. Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J Biol Chem. 2005;280:8800-7 pubmed
- Chamberlain P, Sandberg M, Sauer K, Cooke M, Lesley S, Spraggon G. Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B. Biochemistry. 2005;44:14486-93 pubmed..The IP(3)-3KB structure suggests a mechanism of enzyme activation, and raises the possibility that an interaction between IP(3)-3KB molecules may occur as part of the catalytic or regulatory cycle. ..
- Kim C, Ye F, Ginsberg M. Regulation of integrin activation. Annu Rev Cell Dev Biol. 2011;27:321-45 pubmed publisher..Here, we review recent progress in understanding how the membrane environment can, in cooperation with integrin-binding proteins, regulate integrin activation. ..
- Hung K, Stumph W. Localization of residues in a novel DNA-binding domain of DmSNAP43 required for DmSNAPc DNA-binding activity. FEBS Lett. 2012;586:841-6 pubmed publisher..The results have identified two clusters of residues within this domain required for the sequence-specific DNA-binding activity of DmSNAPc. ..
- CANDELARIO J, Tavakoli H, Chachisvilis M. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. PLoS ONE. 2012;7:e52583 pubmed publisher..Our findings demonstrate for the first time that LCPUFAs, EPA and DHA, can activate PTH1R receptor at nanomolar concentrations and consequently provide a putative molecular mechanism for the action of fatty acids in bone. ..
- Boulter J, O Shea Greenfield A, Duvoisin R, Connolly J, Wada E, Jensen A, et al. Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J Biol Chem. 1990;265:4472-82 pubmed..Finally, the genes that encode the beta 4, alpha 3, and alpha 5 proteins are transcribed with convergent polarities and form a tightly linked gene cluster spanning approximately 60 kilobase pairs. ..
- Zhou Q, Snipas S, Orth K, Muzio M, Dixit V, Salvesen G. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem. 1997;272:7797-800 pubmed..Therefore, our results support the hypothesis that FLICE catalyzes a crucial step in the promotion of cell death. ..
- Watkins J, Beuerlein G, Pecht G, McFadden P, Glaser S, Huse W. Determination of the relative affinities of antibody fragments expressed in Escherichia coli by enzyme-linked immunosorbent assay. Anal Biochem. 1997;253:37-45 pubmed..Thus, this approach may be applicable to the screening of antibody libraries against other cell surface antigens, such as transmembrane receptors, which are difficult to purify. ..
- Ollendorff V, Donoghue D. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. J Biol Chem. 1997;272:32011-8 pubmed..The direct interaction of PP5 with CDC16 and CDC27, as well as its overlapping spindle localization in mitosis, suggests that PP5 may be involved in the regulation of the activity of the anaphase-promoting complex. ..
- Hwang S, Steineckert B, Hook V. Expression and mutagenesis of the novel serpin endopin 2 demonstrates a requirement for cysteine-374 for dithiothreitol-sensitive inhibition of elastase. Biochemistry. 2000;39:8944-52 pubmed..These findings demonstrate the importance of Cys-374 for DTT-sensitive inhibition of elastase by endopin 2. ..
- Tukey R, Strassburg C. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol. 2001;59:405-14 pubmed..In addition, tools have now been developed and examples presented to identify the expression patterns of the UGTs in human tissues, paying particular attention to expression patterns of these genes in the hepato-gastrointestinal tract. ..
- Mohanty S, Lee S, Yadava N, Dealy M, Johnson R, Firtel R. Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes Dev. 2001;15:1435-48 pubmed..We propose that CulA and FbxA regulate multicellular development by targeting RegA for degradation via a pathway that requires ERK2 function, leading to an increase in cAMP and PKA activity. ..
- Leon B, Tsigelny I, Adams J. Electrostatic environment surrounding the activation loop phosphotyrosine in the oncoprotein v-Fps. Biochemistry. 2001;40:10078-86 pubmed..While this strain is not relieved in the phosphorylated form, the improvements in catalysis in activated v-Fps compensate for reduced metal and substrate binding affinities. ..
- Gabriel W, Blumberg B, Sutton S, Place A, Lance V. Alligator aromatase cDNA sequence and its expression in embryos at male and female incubation temperatures. J Exp Zool. 2001;290:439-48 pubmed..These data indicate that aromatase expression and, thus, estrogen production, are not the initial trigger for sex determination but play an essential role in ovarian differentiation in the alligator. J. Exp. Zool. 290:439-448, 2001. ..
- Eraly S, Monte J, Nigam S. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics. 2004;18:12-24 pubmed..This might reflect a requirement for redundancy or broader substrate specificity in vertebrates (compared to invertebrates), due to their greater physiological complexity and thus potentially broader exposure to organic ions. ..
- Maurer U, Charvet C, Wagman A, Dejardin E, Green D. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006;21:749-60 pubmed..The results demonstrate that the control of MCL-1 stability by GSK-3 is an important mechanism for the regulation of apoptosis by growth factors, PI3K, and AKT. ..
- Fan X, Venegas R, Fey R, van der Heyde H, Bernard M, Lazarides E, et al. An in vivo approach to structure activity relationship analysis of peptide ligands. Pharm Res. 2007;24:868-79 pubmed..This approach led to the isolation of a brain-specific peptide, CAGALCY, which appears to function as an effective antagonist of platelet adhesion to activated pial microvasculature. ..
- Ethayathulla A, Nguyen H, Viadiu H. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements. J Biol Chem. 2013;288:4744-54 pubmed publisher..Sequence variations in the RE elicit a p73 conformational response that might explain target gene specificity. ..
- Geisheker M, Heymann G, Wang T, Coe B, Turner T, Stessman H, et al. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017;20:1043-1051 pubmed publisher..Overall, we find significant clustering of de novo mutations in 200 genes, highlighting specific functional domains and synaptic candidate genes important in NDD pathology. ..
- Albrandt K, Brady E, Moore C, Mull E, Sierzega M, Beaumont K. Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene. Endocrinology. 1995;136:5377-84 pubmed..Analysis of a hCT receptor genomic clone demonstrated an exon/intron organization similar to that of the porcine CT receptor gene, except for a distinct exon coding for the alternatively spliced insert in the first intracellular domain. ..
- Mahata S, O Connor D, Mahata M, Yoo S, Taupenot L, Wu H, et al. Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist. J Clin Invest. 1997;100:1623-33 pubmed..This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons. ..
- Walfield A, Roche E, Zounes M, Kirkpatrick H, Wild M, Textor G, et al. Primary structure of an oligomeric antigen of Treponema pallidum. Infect Immun. 1989;57:633-5 pubmed..Antigen C1-5 assembles into oligomers of 140,000 and greater. The nucleotide sequence predicts an open reading frame for a protein monomer of 19,400, confirmed by amino-terminal sequencing of the recombinant antigen. ..
- Koeppe J, Komives E. Amide H/2H exchange reveals a mechanism of thrombin activation. Biochemistry. 2006;45:7724-32 pubmed..Thus, cleavage of the Arg320-Ile321 peptide bond is the key to formation of the active enzyme, which involves increased dynamics of the substrate-binding loops and decreased dynamics of the catalytic site. ..
- Kim Y, Bark S, Hook V, Bandeira N. NeuroPedia: neuropeptide database and spectral library. Bioinformatics. 2011;27:2772-3 pubmed publisher..http://proteomics.ucsd.edu/Software/NeuroPedia.html firstname.lastname@example.org Supplementary materials are available at Bioinformatics online. ..
- Krieg J, Hunter T. Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. J Biol Chem. 1992;267:19258-65 pubmed..1 or talin. Tyr353 is localized within the alpha-helical domain of ezrin and comparison of the protein sequences reveals that this site is unique to ezrin. ..
- Li F, Templeton T, Popov V, Comer J, Tsuboi T, Torii M, et al. Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission. J Biol Chem. 2004;279:26635-44 pubmed..gallinaceum for A. aegypti. These results support the concept that ookinete micronemal proteins may constitute a general class of malaria transmission-blocking vaccine candidates. ..
- Yang R, Hsu D, Yu L, Ni J, Liu F. Cell cycle regulation by galectin-12, a new member of the galectin superfamily. J Biol Chem. 2001;276:20252-60 pubmed..Ectopic expression of galectin-12 in cancer cells causes cell cycle arrest at the G(1) phase and cell growth suppression. We conclude that galectin-12 is a novel regulator of cellular homeostasis. ..
- Mikolosko J, Bobyk K, Zgurskaya H, Ghosh P. Conformational flexibility in the multidrug efflux system protein AcrA. Structure. 2006;14:577-87 pubmed..Notably, unsuspected conformational flexibility in the alpha-helical hairpin domain of AcrA is observed, which has potential mechanistic significance in coupling between AcrA conformations and TolC channel opening. ..
- Presse F, Nahon J, Fischer W, Vale W. Structure of the human melanin concentrating hormone mRNA. Mol Endocrinol. 1990;4:632-7 pubmed..Furthermore, sequence identities, with perhaps functional implications, were found among the MCH, human ANF, and aplysia peptide A hormone precursors. ..
- Griffitts J, Huffman D, Whitacre J, Barrows B, Marroquin L, Müller R, et al. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. J Biol Chem. 2003;278:45594-602 pubmed..elegans. Resistance to Cry toxins has uncovered a four component glycosylation pathway that is functionally conserved between nematodes and insects and that provides the basis of the dominant mechanism of resistance in C. elegans. ..
- Blevitt J, Hack M, Herman K, Chang L, Keith J, Mirzadegan T, et al. A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. J Biol Chem. 2016;291:12724-31 pubmed publisher..In addition, a PK/PD method was established in canines to enable preclinical profiling of mouse-inactive compounds. ..
- Cheng A, Le T, Palacios M, Bookbinder L, Wassarman P, Suzuki F, et al. Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3. J Cell Biol. 1994;125:867-78 pubmed..Collectively, these results suggest that sp56 may be the sperm protein responsible for sperm-egg recognition in the mouse. ..
- Edelman D, Meech R, Jones F. The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB family. J Biol Chem. 2000;275:21737-45 pubmed..Overall, these findings provide a framework for understanding developmental and physiological contexts that influence repressor or activator functions of Barx2. ..
- Uchime O, Dai Z, Biris N, Lee D, Sidhu S, Li S, et al. Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. J Biol Chem. 2016;291:89-102 pubmed publisher..The synthetic Fabs reported here reveal, as probes, novel mechanistic insights into BAX inhibition and provide a blueprint for developing inhibitors of BAX activation. ..
- Park S, Das B, De Angelis A, Scrima M, Opella S. Mechanically, magnetically, and "rotationally aligned" membrane proteins in phospholipid bilayers give equivalent angular constraints for NMR structure determination. J Phys Chem B. 2010;114:13995-4003 pubmed publisher..The measurement of angular constraints relative to a common external axis system defined by the bilayer normal for all sites in the protein is an essential element of oriented sample (OS) solid-state NMR. ..
- Ehrhardt A, Chung W, Pyle L, Wang W, Nowotarski K, Mulvihill C, et al. Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. J Biol Chem. 2016;291:1854-65 pubmed publisher..Our findings support a targetable mechanism of CFTR regulation in which conformational changes in the NBDs cause reorientation of transmembrane domains via interactions with CL1 and result in channel gating. ..
- Doolittle R, Pandi L. Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini. Biochemistry. 2007;46:10033-8 pubmed..In lampreys, GPRPYam is a significantly better inhibitor, but in humans, it is less effective than GPRPam, indicating that in the lamprey system the same tyrosine-arginine interaction can also occur in the gamma-chain setting. ..
- Kronert W, Acebes A, Ferrus A, Bernstein S. Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles. J Cell Biol. 1999;144:989-1000 pubmed..Our study illustrates how expression of genetic defects are dependent upon genetic background, and therefore could have implications for understanding gene interactions in human disease. ..
- Liljas L, Tate J, Lin T, Christian P, Johnson J. Evolutionary and taxonomic implications of conserved structural motifs between picornaviruses and insect picorna-like viruses. Arch Virol. 2002;147:59-84 pubmed..We also discuss the possible relatives of the proposed assemblage and the likely implications of future structural studies that may be carried out on the putative relatives. ..
- Sims R, van der Lee S, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017;49:1373-1384 pubmed publisher..These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. ..
- Galindo B, Moy G, Vacquier V. A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion. Dev Growth Differ. 2004;46:53-60 pubmed..In the present study, we describe the sequence, domain structure and localization of suREJ2 and speculate on its possible function. ..
- Jing S, Spencer T, Miller K, Hopkins C, Trowbridge I. Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization. J Cell Biol. 1990;110:283-94 pubmed..Further, Tyr 20 is an important element of that sequence. ..
- Vaughan J, Fischer W, Hoeger C, Rivier J, Vale W. Characterization of melanin-concentrating hormone from rat hypothalamus. Endocrinology. 1989;125:1660-5 pubmed..Rat MCH has the following primary structure: Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln- Val. ..
- Contos J, Ishii I, Chun J. Lysophosphatidic acid receptors. Mol Pharmacol. 2000;58:1188-96 pubmed..Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles. ..
- Kraus W, Manning E, Kadonaga J. Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. Mol Cell Biol. 1999;19:8123-35 pubmed..These data exemplify a situation in which a network of multiple activation functions is required to achieve gene transcription. ..
- Muralidhar M, Thomas J. The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes. Neuron. 1993;11:253-66 pubmed..These results suggest a role for ubiquitin-mediated protein modification in nervous system development, including, but not exclusive to, the regulation of synaptic connectivity. ..
- Stan R, Ghitescu L, Jacobson B, Palade G. Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein. J Cell Biol. 1999;145:1189-98 pubmed
- Ko G, Reddy A, Kumar S, Bailey B, Garg R. Computational analysis of HIV-1 protease protein binding pockets. J Chem Inf Model. 2010;50:1759-71 pubmed publisher..This study provides important information in understanding the structural features of HIV-1 protease which cannot be studied by other existing in vivo genomic data sets. ..
- Miller B, Friedman A, Choi H, Hogan J, McCammon J, Hook V, et al. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod. 2014;77:92-9 pubmed publisher..These data reveal and characterize the novel activity of gallinamide A as a potent inhibitor of human cathepsin L. ..
- Mercurio F, Murray B, Shevchenko A, Bennett B, Young D, Li J, et al. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19:1526-38 pubmed..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation. ..
- Liu C, Ma X, Jiang X, Wilson S, Hofstra C, Blevitt J, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001;59:420-6 pubmed
- Burns L, Canaves J, Pennypacker J, Blumenthal D, Taylor S. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 2003;42:5754-63 pubmed
- Weir B, Yaffe M. Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2004;15:1656-65 pubmed..cerevisiae gene complemented the S. pombe mutation. Mmd1p was localized to the cytosol. Mmd1p is the first identified component required for the alignment of mitochondria along microtubules in fission yeast. ..
- Ma Y, Taylor S. A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J Biol Chem. 2008;283:11743-51 pubmed publisher..The specificity of ER or mitochondria targeting is determined and switched by the availability of the negatively charged residue, Asp(31). ..
- Dahesh S, Hensler M, van Sorge N, Gertz R, Schrag S, Nizet V, et al. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. Antimicrob Agents Chemother. 2008;52:2915-8 pubmed publisher..BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x. ..
- Giguere V, Ong E, Segui P, Evans R. Identification of a receptor for the morphogen retinoic acid. Nature. 1987;330:624-9 pubmed..Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid. ..
- Huang L, Durick K, Weiner J, Chun J, Taylor S. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem. 1997;272:8057-64 pubmed..These results raise a novel possibility that the type I regulatory subunit may be anchored via anchoring proteins. ..
- Calvo K, Knoepfler P, McGrath S, Kamps M. An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1. Oncogene. 1999;18:8033-43 pubmed
- Aertgeerts K, Ye S, Shi L, Prasad S, Witmer D, Chi E, et al. N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding. Protein Sci. 2004;13:145-54 pubmed..Taken together, these data indicate that in contrast to the generally accepted view, glycosylation of DPPIV is not a prerequisite for catalysis, dimerization, or ADA binding. ..
- Robinson Rechavi M, Godzik A. Structural genomics of thermotoga maritima proteins shows that contact order is a major determinant of protein thermostability. Structure. 2005;13:857-60 pubmed..Thus, contact order, a structural feature that was originally introduced to explain differences in folding rates of different protein families, is a significant parameter that can now be correlated with thermostability. ..
- Duvoisin R, Deneris E, Patrick J, Heinemann S. The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4. Neuron. 1989;3:487-96 pubmed..1, indicating that the beta subunit can affect the sensitivity of neuronal nAChRs to this toxin. These results extend the functional diversity of nicotinic receptors in the nervous system. ..
- Jones D, Cockerill K, Gamino C, Hammaker J, Hayag M, Iverson G, et al. Synthesis of LJP 993, a multivalent conjugate of the N-terminal domain of beta2GPI and suppression of an anti-beta2GPI immune response. Bioconjug Chem. 2001;12:1012-20 pubmed..Host mice receiving cells that were treated with LJP 993 produced significantly lower amounts of anti-domain 1 antibodies than controls which received untreated cells, indicative of B cell tolerance. ..
- Neill A, Moy G, Vacquier V. Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa. Mol Reprod Dev. 2004;67:472-7 pubmed..The low cation selectivity of PC2 channels would explain data indicating that Na(+) and Ca(2+) may enter sea urchin sperm through the same channel during the acrosome reaction. ..
- Black B, Foltz D, Chakravarthy S, Luger K, Woods V, Cleveland D. Structural determinants for generating centromeric chromatin. Nature. 2004;430:578-82 pubmed..Thus, the centromere-targeting domain of CENP-A confers a unique structural rigidity to the nucleosomes into which it assembles, and is likely to have a role in maintaining centromere identity. ..
- Sanders R, Spector D. Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products. J Virol. 2010;84:5158-70 pubmed publisher..These results indicate that IE2 86, IE2 40, and UL84 serve to regulate protein expression in a posttranscriptional fashion and that this regulation is independent of other viral proteins. ..
- Aubol B, Adams J. Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1. Biochemistry. 2011;50:6888-900 pubmed publisher..These findings indicate that the protein substrate actively modulates initiation, extension, and termination events associated with prolonged, multisite phosphorylation...
- Teachenor R, Beck K, Wright L, Shen Z, Briggs S, Murre C. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. Mol Cell Biol. 2012;32:1671-82 pubmed publisher..In sum, these studies show that the entire ensemble of Id proteins has the ability to interact with E47, identify factors that associate with E47, and reveal a spectrum of phosphorylated residues in E47, including an AKT substrate site. ..
- Lindberg R, Hunter T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990;10:6316-24 pubmed..Immunohistochemical analysis of several rat organs also showed staining in epithelial cells. These observations prompted us to name this protein kinase eck, for epithelial cell kinase. ..
- Clemm D, Sherman L, Boonyaratanakornkit V, Schrader W, Weigel N, Edwards D. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Mol Endocrinol. 2000;14:52-65 pubmed..That Ser 294 lies within an inhibitory domain that mediates the unique repressive functions of PR-A raises the possibility that differential phosphorylation of Ser 294 is involved in the distinct functional properties of PR-A and PR-B. ..
- Potluri P, Yadava N, Scheffler I. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur J Biochem. 2004;271:3265-73 pubmed..Although, the accumulation of ESSS-HA is not dependent upon the presence of mtDNA-encoded subunits (ND1-6,4 L), it is incorporated into complex I only in presence of compatible complex I subunits from the same species. ..
- Thompson A, Zou A, Yan J, Duggal R, Hao W, Molina D, et al. Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity. Biochemistry. 2009;48:906-16 pubmed publisher..Mutation of amino acids in the Walker A and B motifs of NS4B resulted in decreased affinity for both GTPgammaS and ATPgammaS as well as decreased ATP hydrolysis and AK activity. ..
- Wen D, Livingston B, Medzihradszky K, Kelm S, Burlingame A, Paulson J. Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family. J Biol Chem. 1992;267:21011-9 pubmed..This feature together with lack of homology in the remaining 85% of the sequence of the three sialyltransferases defines a pattern of sequence homology not found in cloned cDNAs of other glycosyltransferase families. ..
- Wong K, Kassavetis G, Leonetti J, Geiduschek E. Mutational and functional analysis of a segment of the sigma family bacteriophage T4 late promoter recognition protein gp55. J Biol Chem. 2003;278:7073-80 pubmed..2 and the recently determined structures of the Thermus thermophilus and Thermus aquaticus sigma(70)-RNA polymerase holoenzymes. ..
- Campana W, Myers R, Rearden A. Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. Glia. 2003;41:213-23 pubmed..Taken together, these results indicate that PINCH is an abundant shuttling/signaling protein in Schwann cells and DRG neurons. ..
- Kissinger C, Parge H, Knighton D, Lewis C, Pelletier L, Tempczyk A, et al. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1995;378:641-4 pubmed..The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein. ..
- Behan D, De Souza E, Lowry P, Potter E, Sawchenko P, Vale W. Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides. Front Neuroendocrinol. 1995;16:362-82 pubmed..Thus, by controlling the amount of free CRF which activates CRF receptors, it is likely that the CRF-BP is an important modulator of CRF both in the CNS and in the periphery. ..
- Hu B, Trinh K, Figueira W, Price P. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. J Biol Chem. 1996;271:19415-20 pubmed..YKL-39 accounts for 4% of the protein in chondrocyte-conditioned medium, prostromelysin accounts for 17%, and YKL-40 accounts for 33%. In contrast to YKL-40, YKL-39 is not a glycoprotein and does not bind to heparin. ..
- Kelner G, Lee M, Clark M, Maciejewski D, McGrath D, Rabizadeh S, et al. The copper transport protein Atox1 promotes neuronal survival. J Biol Chem. 2000;275:580-4 pubmed..Therefore, Atox1 is a component of the cellular pathways used for protection against oxidative stress. ..
- Clark M, Kelner G, Turbeville L, Boyer A, Arden K, Maki R. ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family. Genomics. 2000;67:343-50 pubmed..Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2-p14.3, an area known to be lost in hereditary renal tumors. ..
- Nicholson B, Manner C, Kleeman J, MacLeod C. Sustained nitric oxide production in macrophages requires the arginine transporter CAT2. J Biol Chem. 2001;276:15881-5 pubmed..In conclusion, our results show that sustained abundant NO synthesis by macrophages requires arginine transport via the CAT2 transporter. ..
- Bai X, Zhou D, Brown J, Crawford B, Hennet T, Esko J. Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). J Biol Chem. 2001;276:48189-95 pubmed..Its identity was confirmed in vivo by siRNA-mediated inhibition of glycosaminoglycan synthesis in HeLa S3 cells. Its localization in the medial Golgi indicates that this is the major site for assembly of the linkage region. ..
- Moore M, Kanter J, Jones K, Taylor S. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem. 2002;277:47878-84 pubmed