Genomes and Genes
Experts and Doctors on amino acid sequence in Irvine, California, United States
Locale: Irvine, California, United States
Topic: amino acid sequence
Publications114 found, 100 shown here
- Nguyen V, Saleh A, Arch A, Yan H, Piazza F, Kim J, et al. Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. J Biol Chem. 2002;277:9713-21 pubmed
- Javidpour P, Das A, Khosla C, Tsai S. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 2011;50:7426-39 pubmed publisher..The molecular features of hedKR important for regio- and stereospecificities can potentially be applied to biosynthesize new polyketides via protein engineering that rationally controls polyketide ketoreduction. ..
- Hoffman T, Javier A, Campeau S, Knight R, Schilling T. Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. J Exp Zool B Mol Dev Evol. 2007;308:679-91 pubmed
- El Sayed N, Shirazi A, El Meligy M, El Ziaty A, Nagieb Z, Parang K, et al. Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter. Int J Biol Macromol. 2016;87:611-22 pubmed publisher..The results showed a dramatic reduction in the cell viability on their treatment with RGD targeted COS NPs in comparison to paclitaxel (PTX), free drug, and drug-loaded COS NPs. ..
- Rozovics J, Virgen Slane R, Semler B. Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity. PLoS ONE. 2011;6:e16559 pubmed publisher..Furthermore, we have determined that unlinkase recognizes and cleaves a human rhinovirus-poliovirus chimeric substrate with the same efficiency as the poliovirus substrate. ..
- Shimizu H, Schuller D, Lanzilotta W, Sundaramoorthy M, Arciero D, Hooper A, et al. Crystal structure of Nitrosomonas europaea cytochrome c peroxidase and the structural basis for ligand switching in bacterial di-heme peroxidases. Biochemistry. 2001;40:13483-90 pubmed..Most importantly, a Glu residue situated near the peroxide binding site could possibly serve as an acid-base catalytic group required for cleavage of the peroxide O--O bond. ..
- Klein E, Wang J, Khalifa B, Gavigan S, Chandraratna R. Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions. J Biol Chem. 2000;275:19401-8 pubmed..In addition, using this recruitment assay, we show that SRC-1 and the related coactivator molecule ACTR associate with the ternary complex via utilization of different helical motifs within their conserved receptor interaction domains. ..
- Wulff H, Gutman G, Cahalan M, Chandy K. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001;276:32040-5 pubmed..The heterocyclic moiety may project into the selectivity filter and obstruct the ion-conducting pathway from the inside. ..
- Kaiser P, Wohlschlegel J. Identification of ubiquitination sites and determination of ubiquitin-chain architectures by mass spectrometry. Methods Enzymol. 2005;399:266-77 pubmed..This chapter describes mass spectrometric approaches for identifying ubiquitin acceptor lysines on target proteins and analyzing the ubiquitin chain topology. ..
- Robertson R, Baratta J, Haynes S, Longmuir K. Liposomes incorporating a Plasmodium amino acid sequence target heparan sulfate binding sites in liver. J Pharm Sci. 2008;97:3257-73 pubmed..These results indicate that liposomes containing a peptide from Plasmodium target liver tissue by binding to HSPGs in the extracellular matrix. ..
- Reissner K, Pu L, Schaffhausen J, Boyle H, Smith I, Parker I, et al. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. J Neurosci. 2010;30:8797-806 pubmed publisher..Our results support a model in which postsynaptic summation of IP(3) signals from suprathreshold and subthreshold inputs results in molecular coincidence detection that gives rise to a novel form of heterosynaptic plasticity. ..
- Keener J, Josaitis C, Dodd J, Nomura M. Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem. 1998;273:33795-802 pubmed..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription. ..
- Brummel T, Abdollah S, Haerry T, Shimell M, Merriam J, Raftery L, et al. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 1999;13:98-111 pubmed..Our results define a novel Drosophila Activin/TGF-beta pathway that is analogous to its vertebrate counterpart and show that this pathway functions to promote cellular growth with minimal effects on patterning. ..
- Kasravi A, Walter M, Brand S, Mason J, Biessmann H. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. Genetics. 1999;152:1025-35 pubmed..The MU2 protein may be involved in controlling chromatin structure and thus may influence the processing of DNA DSBs. ..
- Ouellette A, Darmoul D, Tran D, Huttner K, Yuan J, Selsted M. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. Infect Immun. 1999;67:6643-51 pubmed..We speculate that this unique duplicated element may have a cis-acting regulatory role in the positional specificity of cryptdin 4 gene expression...
- Carlson M, Komine Y, Bryant S, Gardiner D. Expression of Hoxb13 and Hoxc10 in developing and regenerating Axolotl limbs and tails. Dev Biol. 2001;229:396-406 pubmed
- Tydell C, Yount N, Tran D, Yuan J, Selsted M. Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils. J Biol Chem. 2002;277:19658-64 pubmed
- Larson S, Day J, Barba de la Rosa A, Keen N, McPherson A. First crystallographic structure of a xylanase from glycoside hydrolase family 5: implications for catalysis. Biochemistry. 2003;42:8411-22 pubmed..The first 13 N-terminal residues form one beta-strand of this domain. Residues 44, 45, and 316-322 form the linkers between this domain and the catalytic domain. ..
- Nelson A, Borland L, Allbritton N, Sims C. Myristoyl-based transport of peptides into living cells. Biochemistry. 2007;46:14771-81 pubmed..This assessment of myristoyl-based transport provides fundamental data needed in understanding the intracellular delivery of myristoylated peptide cargoes for cell-based biochemical studies. ..
- Sandri Goldin R. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev. 1998;12:868-79 pubmed..Finally, binding of ICP27 to RNA in vivo required an arginine-glycine region that resembles an RGG box. These results indicate that ICP27 is an important viral export factor that promotes the transport of HSV-1 intronless RNAs. ..
- Kudryavtseva E, Sugihara T, Wang N, Lasso R, Gudnason J, Lipkin S, et al. Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor. Dev Dyn. 2003;226:604-17 pubmed..These data suggest that GET-1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals. ..
- Rangaraju S, Khoo K, Feng Z, Crossley G, Nugent D, Khaytin I, et al. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010;285:9124-36 pubmed publisher..Evolutionary pressure to maintain a channel-modulatory function may contribute to the conservation of this domain throughout the plant and animal kingdoms. ..
- Li M, Bermak J, Wang Z, Zhou Q. Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280). Mol Pharmacol. 2000;57:446-52 pubmed..Our results suggest a new molecular mechanism of modulating D(2) receptor signaling by cytoskeletal protein interaction. ..
- Reissner K, Aswad D. Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?. Cell Mol Life Sci. 2003;60:1281-95 pubmed..Herein we describe the mechanism of Asx rearrangement, summarize the evidence that PIMT serves an important repair function, and then focus on emerging evidence that deamidation and isoAsp formation may sometimes have a useful function. ..
- Vickery L, Cupp Vickery J. Molecular chaperones HscA/Ssq1 and HscB/Jac1 and their roles in iron-sulfur protein maturation. Crit Rev Biochem Mol Biol. 2007;42:95-111 pubmed..Additional genetic and biochemical studies are needed to extend these findings to mtHsp70 activities in higher eukaryotes. ..
- Nothacker H, Wang Z, Zhu Y, Reinscheid R, Lin S, Civelli O. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000;58:1601-8 pubmed..Moreover, we have identified BAY u9773 as a CysLT(2) selective agonist, which could prove to be of immediate use in understanding the functional roles of the CysLT(2) receptor. ..
- Subramanian V, Marchant J, Boulware M, Said H. A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia. J Biol Chem. 2004;279:27719-28 pubmed..Our results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity. ..
- Sahar S, Zocchi L, Kinoshita C, Borrelli E, Sassone Corsi P. Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS ONE. 2010;5:e8561 pubmed publisher..BMAL1 phosphorylation appears to be an important regulatory step in maintaining the robustness of the circadian clock. ..
- Torres R, Swift R, Chim N, Wheatley N, Lan B, Atwood B, et al. Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. PLoS ONE. 2011;6:e25084 pubmed publisher..Thus, the results of this molecular study of Y. pestis RipA provide a structural platform for rational inhibitor design, which may lead to a greater understanding of the role of RipA in this unique virulence pathway...
- Nguyen T, Fujioka H, Kang A, Rogers W, Fidock D, James A. Stage-dependent localization of a novel gene product of the malaria parasite, Plasmodium falciparum. J Biol Chem. 2001;276:26724-31 pubmed..This differential localization provides multiple opportunities to exploit the MB2 gene product as a vaccine or therapeutic target. ..
- Houmani J, Ruf I. Clusters of basic amino acids contribute to RNA binding and nucleolar localization of ribosomal protein L22. PLoS ONE. 2009;4:e5306 pubmed publisher..Our data support the growing consensus that the nucleolar accumulation of ribosomal proteins may not be mediated by a defined localization signal, but rather by specific interaction with established nucleolar components such as rRNA. ..
- Zheng J, Liu C, Sawaya M, Vadla B, Khan S, Woods R, et al. Macrocyclic ?-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2011;133:3144-57 pubmed publisher..This model provides a provocative and appealing target for future inhibitor design. ..
- Tripathi S, O Neill M, Wilks A, Poulos T. Crystal structure of the Pseudomonas aeruginosa cytoplasmic heme binding protein, Apo-PhuS. J Inorg Biochem. 2013;128:131-6 pubmed publisher..98Å resolution which shows a unique heme binding pocket and oligomeric structure compared to other known cytoplasmic heme transporter and accounts for some of the unusual biochemical properties of PhuS. ..
- Ho D, Bardwell A, Grewal S, Iverson C, Bardwell L. Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. J Biol Chem. 2006;281:13169-79 pubmed..We conclude that MKK7 contains three JNK-docking sites that interact to selectively bind JNK and contribute to JNK signal transmission and specificity. ..
- Kao A, Chiu C, Vellucci D, Yang Y, Patel V, Guan S, et al. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Mol Cell Proteomics. 2011;10:M110.002212 pubmed publisher..Given its effectiveness and simplicity, this cross-linking strategy can find a broad range of applications in elucidating the structural topology of proteins and protein complexes. ..
- Fuja T, Lin F, Osann K, Bryant P. Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res. 2004;64:942-51 pubmed..They also justify additional studies of the functional significance of the changes, as well as a search for additional changes in these and other genes identified from studies on model systems. ..
- Wang W, Chan J. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem. 2006;281:19676-87 pubmed..These results suggest that Nrf1 is normally targeted to the endoplasmic reticulum membrane and that endoplasmic reticulum stress may play a role in modulating Nrf1 function as a transcriptional activator. ..
- Bettahi I, Nesburn A, Yoon S, Zhang X, Mohebbi A, Sue V, et al. Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines. Invest Ophthalmol Vis Sci. 2007;48:4643-53 pubmed..The strength of protective immunity induced by these lipopeptides together with their safety provide a molecularly defined vaccine formulation that could combat ocular herpes infection and disease in humans. ..
- Figueredo S, Weeks C, Young S, Ouellette A. Anionic amino acids near the pro-alpha-defensin N terminus mediate inhibition of bactericidal activity in mouse pro-cryptdin-4. J Biol Chem. 2009;284:6826-31 pubmed publisher..These findings support the conclusion that the most distal N-terminal anionic residues of pro-Crp4-(20-92) are primarily responsible for blocking Crp4-mediated membrane disruption in the precursor. ..
- Sun L, Gilligan J, Staber C, Schutte R, Nguyen V, O Dowd D, et al. A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J Neurosci. 2012;32:14145-55 pubmed publisher..Furthermore, our data indicate a natural temperature-dependent shift in sodium current deactivation (exacerbated by mutation) may contribute to febrile seizures in GEFS+ and perhaps normal individuals. ..
- Nagpal S, Patel S, Jacobe H, DiSepio D, Ghosn C, Malhotra M, et al. Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. J Invest Dermatol. 1997;109:91-5 pubmed
- Grens A, Shimizu H, Hoffmeister S, Bode H, Fujisawa T. The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra. Development. 1999;126:517-24 pubmed..These results suggest that peptides play signaling roles in patterning processes in cnidaria and, plausibly, in more complex metazoans as well...
- Tang Y, Yuan J, Miller C, Selsted M. Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes. Infect Immun. 1999;67:6139-44 pubmed..This study is the first to characterize the sequences and activities of alpha-defensins from nonhuman primates, data that should aid in delineating the role of these peptides in rhesus macaque host defense. ..
- Jung Y, Bonagura C, Tilley G, Gao Sheridan H, Armstrong F, Stout C, et al. Structure of C42D Azotobacter vinelandii FdI. A Cys-X-X-Asp-X-X-Cys motif ligates an air-stable [4Fe-4S]2+/+ cluster. J Biol Chem. 2000;275:36974-83 pubmed..The cluster conversion was ultimately accomplished using a new electrochemical method. Hydrophobic and electrostatic interaction and the lack of Gly residues adjacent to the Asp ligand explain the remarkable stability of this cluster. ..
- Shakkottai V, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001;276:43145-51 pubmed..Lei-Dab(7) will be a useful tool to investigate the functional role of SKCa2 in mammalian tissues. ..
- Ayabe T, Satchell D, Pesendorfer P, Tanabe H, Wilson C, Hagen S, et al. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002;277:5219-28 pubmed..MMP-7-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen. ..
- Ring C, Ogata S, Meek L, Song J, Ohta T, Miyazono K, et al. The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 2002;16:820-35 pubmed
- Tanabe H, Yuan J, Zaragoza M, Dandekar S, Henschen Edman A, Selsted M, et al. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004;72:1470-8 pubmed..These studies should facilitate further analyses of the role of alpha-defensins in primate enteric immunity...
- Reissner K, Paranandi M, Luc T, Doyle H, Mamula M, Lowenson J, et al. Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain. J Biol Chem. 2006;281:8389-98 pubmed
- Moody C, Tretyachenko Ladokhina V, Laue T, Senear D, Cocco M. Multiple conformations of the cytidine repressor DNA-binding domain coalesce to one upon recognition of a specific DNA surface. Biochemistry. 2011;50:6622-32 pubmed publisher..Aspects of CytR activity are unique among repressors; we identify here structural properties that are also distinct and that might underlie the different functional properties. ..
- Lee M, Ames B, Tsai S. Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 2012;51:3079-91 pubmed publisher..A unified ARO/CYC-mediated cyclization mechanism is proposed on the basis of these structural and functional results. ..
- Greene D, Kang S, Kosenko A, Hoshi N. Adrenergic regulation of HCN4 channel requires protein association with ?2-adrenergic receptor. J Biol Chem. 2012;287:23690-7 pubmed publisher..These results suggest that the ion channel-receptor complex is a critical mechanism in ion channel regulation. ..
- Lalo D, Steffan J, Dodd J, Nomura M. RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I. J Biol Chem. 1996;271:21062-7 pubmed..No significant similarity was detected between two sets of the proteins. Similarity as well as differences between CF and SL1 are discussed. ..
- Smith M, Smith R, Plummer N, Meisler M, Goldin A. Functional analysis of the mouse Scn8a sodium channel. J Neurosci. 1998;18:6093-102 pubmed..The unique persistent current observed for Scn8a channels is consistent with the hypothesis that this channel is responsible for distinct sodium conductances underlying repetitive firing of action potentials in Purkinje neurons. ..
- Yount N, Yuan J, Tarver A, Castro T, Diamond G, Tran P, et al. Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. J Biol Chem. 1999;274:26249-58 pubmed..The exocytosis of BNBD-12 by activated neutrophils reveals different mobilization pathways for myeloid alpha- and beta-defensins. ..
- Neilson L, Schneider P, Van Deerlin P, Kiriakidou M, Driscoll D, Pellegrini M, et al. cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus. Genomics. 1999;60:272-80 pubmed..The cloning of the human homologue of the Chlamydomonas PF16 locus provides a new avenue to explore the role of the axoneme central pair in human sperm function. ..
- Schurter B, Koh S, Chen D, Bunick G, Harp J, Hanson B, et al. Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry. 2001;40:5747-56 pubmed..Our findings support the hypothesis that methylation of H3 may be involved in the mechanism of transcriptional coactivation by CARM1 of genes whose expression is under the control of nuclear receptors. ..
- Tran D, Tran P, Tang Y, Yuan J, Cole T, Selsted M. Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem. 2002;277:3079-84 pubmed publisher..Equal amounts of each theta-defensin bound to E. coli cells, indicating that the differences in antibacterial activities are the result of post-binding processes...
- Kolski Andreaco A, Tomita H, Shakkottai V, Gutman G, Cahalan M, Gargus J, et al. SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem. 2004;279:6893-904 pubmed
- Patel D, Isas J, Ladokhin A, Jao C, Kim Y, Kirsch T, et al. The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties. Biochemistry. 2005;44:2833-44 pubmed..The biological implications of this subdivision are discussed. ..
- Li C, Gershon P. pKa of the mRNA cap-specific 2'-O-methyltransferase catalytic lysine by HSQC NMR detection of a two-carbon probe. Biochemistry. 2006;45:907-17 pubmed..5, consistent with a perturbed pKa for the catalytic lysine and a model in which the surrounding charged groups direct the lysine epsilon-amino pKa via both local electrostatic environment and orbital directionality. ..
- Roca A, Almada A, Abajian A. ProfileGrids as a new visual representation of large multiple sequence alignments: a case study of the RecA protein family. BMC Bioinformatics. 2008;9:554 pubmed publisher..profilegrid.org. Furthermore, we present a curated RecA protein collection that is more diverse than previous data sets; and, therefore, this RecA ProfileGrid is a rich source of information for nanoanatomy analysis. ..
- Sims R, van der Lee S, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017;49:1373-1384 pubmed publisher..These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. ..
- Rosenfeld J, Osborne T. HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph. J Biol Chem. 1998;273:16112-21 pubmed..This is notable, since insects are reportedly incapable of de novo sterol biosynthesis. ..
- Gao Sheridan H, Kemper M, Khayat R, Tilley G, Armstrong F, Sridhar V, et al. A T14C variant of Azotobacter vinelandii ferredoxin I undergoes facile [3Fe-4S]0 to [4Fe-4S]2+ conversion in vitro but not in vivo. J Biol Chem. 1998;273:33692-701 pubmed..However, unlike native FdI which does not undergo facile cluster conversion, the 7Fe form T14C FdI quickly converts to the 8Fe form with a high efficiency under reducing conditions. ..
- Villarreal L, Defilippis V. A hypothesis for DNA viruses as the origin of eukaryotic replication proteins. J Virol. 2000;74:7079-84 pubmed..We consider arguments for the polarity of this relationship and present the hypothesis that the replication genes of DNA viruses gave rise to those of eukaryotes and not the reverse direction...
- Bermak J, Li M, Bullock C, Zhou Q. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat Cell Biol. 2001;3:492-8 pubmed..Our results indicate that DRiP78 may regulate the transport of a GPCR by binding to a specific ER-export signal. ..
- Miller M, Tomita H, Rauer H, Gargus J, Gutman G, Cahalan M, et al. Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. J Biol Chem. 2001;276:27753-6 pubmed..Together, these two effects may play a part in the pathogenesis of schizophrenia and other neuropsychiatric disorders. ..
- Walter B, Parsley T, Ehrenfeld E, Semler B. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J Virol. 2002;76:12008-22 pubmed..Our data have implications for differential picornavirus template utilization during viral translation and RNA replication and suggest that specific PCBP2 domains may have distinct roles in these activities. ..
- Ho D, Bardwell A, Abdollahi M, Bardwell L. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003;278:32662-72 pubmed..The MEK1 and MEK2 D-sites displayed a strong selectivity for their cognate MAPK (ERK2) versus a non-cognate MAPK (JNK). In contrast, the MKK4 D-site exhibited only limited selectivity for JNK versus ERK. ..
- Korman T, Hill J, Vu T, Tsai S. Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry. 2004;43:14529-38 pubmed publisher..The structures of act KR provide an important step toward understanding aromatic PKS and will enhance our ability to design novel aromatic polyketide natural products with different reduction patterns...
- Sokolchik I, Tanabe T, Baldi P, Sze J. Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins. J Neurosci. 2005;25:1015-23 pubmed..Thus, different sensory functions of OCR-2 arise from separable intrinsic determinants, and specific functional properties of TRPV channel proteins may be selectively conserved across phyla. ..
- Vilmos P, Sousa Neves R, Lukacsovich T, Marsh J. crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. EMBO Rep. 2005;6:262-7 pubmed..These findings and the presence of two types of Tsg-like protein in several insects suggest that Cv represents a subgroup of the Tsg-like BMP-modulating proteins. ..
- Tapley T, Cupp Vickery J, Vickery L. Structural determinants of HscA peptide-binding specificity. Biochemistry. 2006;45:8058-66 pubmed
- Krishnamani V, Lanyi J. Molecular dynamics simulation of the unfolding of individual bacteriorhodopsin helices in sodium dodecyl sulfate micelles. Biochemistry. 2012;51:1061-9 pubmed publisher..The reason may be either that the sampling time was not sufficiently long or, more interestingly, that interhelix residue interactions play a role in the unfolding of the helices...
- Morrison G, Ganesan R, Qin Z, Aswad D. Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein. PLoS ONE. 2012;7:e43288 pubmed publisher..The results presented here indicate that synuclein is not a major target of PIMT in vivo, and emphasize the need to minimize methyl ester hydrolysis when using methylation to assess the abundance of isoaspartyl sites in proteins. ..
- Graff J, Richards O, Swiderek K, Davis M, Rusnak F, Harmon S, et al. Hepatitis A virus capsid protein VP1 has a heterogeneous C terminus. J Virol. 1999;73:6015-23 pubmed..The data suggest that HAV 3C is not the protease responsible for generation of the VP1 C terminus. We propose the involvement of host cell protease(s) in the production of HAV VP1. ..
- Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein E, et al. Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem. 1999;274:22563-8 pubmed
- Bardwell A, Flatauer L, Matsukuma K, Thorner J, Bardwell L. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem. 2001;276:10374-86 pubmed..Thus, both the MEK-MAPK docking interaction and binding to the Ste5 scaffold make mutually reinforcing contributions to the efficiency of signaling by this MAPK cascade in vivo. ..
- Dioumaev A, Brown L, Needleman R, Lanyi J. Coupling of the reisomerization of the retinal, proton uptake, and reprotonation of Asp-96 in the N photointermediate of bacteriorhodopsin. Biochemistry. 2001;40:11308-17 pubmed..The reisomerization of the retinal occurs only after recovery from a long-living protein conformation in which reprotonation of Asp-96 is either entirely blocked or blocked at low pH. ..