Experts and Doctors on insect proteins in Tucson, Arizona, United States


Locale: Tucson, Arizona, United States
Topic: insect proteins

Top Publications

  1. Martinez T, Wheeler D. Identification of two storage hexamers in the ant, Camponotus festinatus: accumulation in adult queenless workers. Insect Biochem Mol Biol. 1993;23:309-17 pubmed
    ..However, with respect to their amino acid composition, they can not be classified as arylphorins. ..
  2. Corby Harris V, Meador C, Snyder L, Schwan M, Maes P, Jones B, et al. Transcriptional, translational, and physiological signatures of undernourished honey bees (Apis mellifera) suggest a role for hormonal factors in hypopharyngeal gland degradation. J Insect Physiol. 2016;85:65-75 pubmed publisher
    ..Undernourished bees also had higher acid phosphatase activity, a physiological marker of cell death, compared to well-nourished bees. These results support a connection between poor nutrition, hormonal signaling, and HG degradation. ..
  3. Oland L, Gibson N, Tolbert L. Localization of a GABA transporter to glial cells in the developing and adult olfactory pathway of the moth Manduca sexta. J Comp Neurol. 2010;518:815-38 pubmed publisher
    ..Glial cells take up GABA, and that uptake can be blocked by L-2,4-diaminobutyric acid (DABA). This is the first molecular evidence that the central glial cell population in this pathway is heterogeneous. ..
  4. Brandon M, Pennington J, Isoe J, Zamora J, Schillinger A, Miesfeld R. TOR signaling is required for amino acid stimulation of early trypsin protein synthesis in the midgut of Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2008;38:916-22 pubmed publisher
    ..It may be possible to target the TOR signaling pathway in the midgut to inhibit blood meal digestion, and thereby, decrease fecundity and the spread of mosquito borne diseases. ..
  5. Montfort W, Weichsel A, Andersen J. Nitrophorins and related antihemostatic lipocalins from Rhodnius prolixus and other blood-sucking arthropods. Biochim Biophys Acta. 2000;1482:110-8 pubmed
    ..prolixus, Ornithodoros moubata, and Triatoma pallidipennis; the antithrombin protein triabin from T. pallidipennis; and the tick histamine binding proteins from Rhipicephalus appendiculatus...
  6. Scaraffia P, Isoe J, Murillo A, Wells M. Ammonia metabolism in Aedes aegypti. Insect Biochem Mol Biol. 2005;35:491-503 pubmed publisher
    ..The mRNA expression patterns of these genes were examined by a real-time RT-PCR in fat body and midgut. The results show that female mosquitoes have evolved efficient mechanisms to detoxify large loads of ammonium/ammonia...
  7. Andreason S, Arif M, Brown J, Ochoa Corona F, Fletcher J, Wayadande A. Single-Target and Multiplex Discrimination of Whiteflies (Hemiptera: Aleyrodidae) Bemisia tabaci and Trialeurodes vaporariorum With Modified Priming Oligonucleotide Thermodynamics. J Econ Entomol. 2017;110:1821-1830 pubmed publisher
    ..tabaci complex members and T. vaporariorum, and the addition of 5'A/T-rich overhang sequences increases the sensitivity and amplification of some primer sets. ..
  8. Isoe J, Scaraffia P. Urea synthesis and excretion in Aedes aegypti mosquitoes are regulated by a unique cross-talk mechanism. PLoS ONE. 2013;8:e65393 pubmed publisher
    ..This process allows blood-fed mosquitoes to regulate the synthesis and/or excretion of nitrogen waste products, and avoid toxic effects that could result from a lethal concentration of ammonia in their tissues. ..
  9. Hayden C, Bosco G. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. BMC Genomics. 2008;9:61 pubmed publisher
    ..This provides a basis for the study of CPuORFs and their putative regulatory role in mitochondrial function and disease. ..

More Information


  1. Sinakevitch I, Strausfeld N. Comparison of octopamine-like immunoreactivity in the brains of the fruit fly and blow fly. J Comp Neurol. 2006;494:460-75 pubmed
    ..The results are also discussed with respect to recent studies on octopamine-immunoreactive organization in honey bees and cockroaches and the suggested roles of octopamine in sensory processing, learning, and memory...
  2. Selleck S. Proteoglycans and pattern formation: sugar biochemistry meets developmental genetics. Trends Genet. 2000;16:206-12 pubmed
    ..In this review, these biological findings are placed in the context of proteoglycan biochemistry and molecular function. ..
  3. Jockusch E, Nulsen C, Newfeld S, Nagy L. Leg development in flies versus grasshoppers: differences in dpp expression do not lead to differences in the expression of downstream components of the leg patterning pathway. Development. 2000;127:1617-26 pubmed
    ..However, it is consistent with the early divergence in developmental mode between fly and grasshopper limbs. ..
  4. Veenstra J, Pattillo J, Petzel D. A single cDNA encodes all three Aedes leucokinins, which stimulate both fluid secretion by the malpighian tubules and hindgut contractions. J Biol Chem. 1997;272:10402-7 pubmed
    ..The differences of the three Aedes leucokinins in their potencies to induce fluid secretion or depolarizations in the malpighian tubules suggest that there may be more than one type of leucokinin receptor in this tissue. ..
  5. O Grady P, Clark J, Kidwell M. Phylogeny of the Drosophila saltans species group based on combined analysis of nuclear and mitochondrial DNA sequences. Mol Biol Evol. 1998;15:656-64 pubmed publisher
    ..As with previous morphological studies, phylogenetic relationships within the saltans subgroup were not satisfactorily resolved by the molecular data...
  6. Jackson S, Nakato H, Sugiura M, Jannuzi A, Oakes R, Kaluza V, et al. dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp. Development. 1997;124:4113-20 pubmed
    ..These findings support a role for members of the glypican family in controlling TGF-beta/BMP activity in vivo by affecting signaling at the cell surface. ..
  7. Evans J, Wheeler D. Differential gene expression between developing queens and workers in the honey bee, Apis mellifera. Proc Natl Acad Sci U S A. 1999;96:5575-80 pubmed
    ..Caste determination in honey bees is typically thought of as primarily queen determination; our results make it clear that the process involves specific activation of genes in workers as well as in queens...
  8. Brower D. Platelets with wings: the maturation of Drosophila integrin biology. Curr Opin Cell Biol. 2003;15:607-13 pubmed
    ..Drosophila also is beginning to yield some insights into integrin heterodimer structure and function. ..
  9. Isoe J, Zamora J, Miesfeld R. Molecular analysis of the Aedes aegypti carboxypeptidase gene family. Insect Biochem Mol Biol. 2009;39:68-73 pubmed publisher
    ..aegypti carboxypeptidase genes were induced up to 40-fold in the midgut in response to blood meal feeding, with peak expression times ranging from 3 to 36 h post-feeding depending on the gene...
  10. Zhou G, Velasquez L, Geiser D, Mayo J, Winzerling J. Differential regulation of transferrin 1 and 2 in Aedes aegypti. Insect Biochem Mol Biol. 2009;39:234-44 pubmed publisher
  11. Ziegler R, Isoe J, Moore W, Riehle M, Wells M. The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression. J Insect Sci. 2011;11:40 pubmed publisher
    ..We also compare the M. sexta adipokinetic hormone receptor with the known adipokinetic hormone receptors of other insects and with gonadotropin releasing hormone-like receptors of invertebrates. ..
  12. Lin Y, Hamblin M, Edwards M, Barillas Mury C, Kanost M, Knipple D, et al. Structure, expression, and hormonal control of genes from the mosquito, Aedes aegypti, which encode proteins similar to the vitelline membrane proteins of Drosophila melanogaster. Dev Biol. 1993;155:558-68 pubmed publisher
    ..melanogaster vitelline membrane protein genes. This second gene contained a coding sequence similar to a decapeptide recently isolated from mosquito ovaries as an "oostatic factor" (Borovsky et al., FASEB J. 4, 3015-3020, 1990)...
  13. Sandstrom D, Bayer C, Fristrom J, Restifo L. Broad-complex transcription factors regulate thoracic muscle attachment in Drosophila. Dev Biol. 1997;181:168-85 pubmed
    ..We conclude that 20-hydroxyecdysone acts through the Broad-Complex to control the development of thoracic myotendinous junctions. ..
  14. Joy T, Jeffrey Gutierrez E, Ernst K, Walker K, Carriere Y, Torabi M, et al. Aging field collected Aedes aegypti to determine their capacity for dengue transmission in the southwestern United States. PLoS ONE. 2012;7:e46946 pubmed publisher
    ..SCP-1 expression levels of individual, field collected mosquitoes were analyzed in conjunction with parity status. Based on SCP-1 transcript levels and parity data, 9% of collected mosquitoes survived more than 15 days post emergence. ..
  15. Alabaster A, Isoe J, Zhou G, Lee A, Murphy A, Day W, et al. Deficiencies in acetyl-CoA carboxylase and fatty acid synthase 1 differentially affect eggshell formation and blood meal digestion in Aedes aegypti. Insect Biochem Mol Biol. 2011;41:946-55 pubmed publisher
  16. Isoe J, Collins J, Badgandi H, Day W, Miesfeld R. Defects in coatomer protein I (COPI) transport cause blood feeding-induced mortality in Yellow Fever mosquitoes. Proc Natl Acad Sci U S A. 2011;108:E211-7 pubmed publisher
    ..Together, these data show that COPI functions are critical to mosquito blood digestion and egg maturation, a finding that could also apply to other blood-feeding arthropod vectors...
  17. Yang F, Knipp M, Shokhireva T, Berry R, Zhang H, Walker F. 1H and 13C NMR spectroscopic studies of the ferriheme resonances of three low-spin complexes of wild-type nitrophorin 2 and nitrophorin 2(V24E) as a function of pH. J Biol Inorg Chem. 2009;14:1077-95 pubmed publisher
    ..1H{13C} heteronuclear multiple quantum coherence (HMQC) spectra are very helpful for the assignment of heme and nearby protein side chain resonances. ..
  18. Murataliev M, Guzov V, Walker F, Feyereisen R. P450 reductase and cytochrome b5 interactions with cytochrome P450: effects on house fly CYP6A1 catalysis. Insect Biochem Mol Biol. 2008;38:1008-15 pubmed publisher
    ..Because CYP6A1 is a P450 involved in insecticide resistance, this suggests that xenobiotic metabolism by constitutively overexpressed P450s may be linked to significant oxidative stress in the cell that may carry a fitness cost. ..
  19. Cupp M, Ribeiro J, Champagne D, Cupp E. Analyses of cDNA and recombinant protein for a potent vasoactive protein in saliva of a blood-feeding black fly, Simulium vittatum. J Exp Biol. 1998;201:1553-61 pubmed
    ..SVEP is a novel salivary-gland-derived vasoactive protein that may be essential for blood feeding by black flies and could potentially enhance transmission of filarial parasites...
  20. Narayanan R, Kramer H, Ramaswami M. Drosophila endosomal proteins hook and deep orange regulate synapse size but not synaptic vesicle recycling. J Neurobiol. 2000;45:105-19 pubmed
    ..Our observations suggest a model in which Hook and Dor function in later stages of endocytosis is essential for regulating synaptic plasma membrane composition but not synaptic vesicle recycling. ..
  21. Feyereisen R. Juvenile hormone resistance: ! no PASaran !. Proc Natl Acad Sci U S A. 1998;95:2725-6 pubmed
  22. Veenstra J. Isolation and structure of the Drosophila corazonin gene. Biochem Biophys Res Commun. 1994;204:292-6 pubmed
    ..The structure of the predicted preprocorazonin is remarkably similar to the preprohormone of adipokinetic hormone, which suggests that corazonin and adipokinetic hormone have a common evolutionary origin. ..
  23. Sanyal S, Consoulas C, Kuromi H, Basole A, Mukai L, Kidokoro Y, et al. Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability. Genetics. 2005;169:737-50 pubmed
    ..Finally, our identification of dominant loss-of-function mutations in SERCA indicates novel intra- and intermolecular interactions for SERCA in vivo, overlooked by current structural models. ..