Genomes and Genes
Experts and Doctors on heat shock proteins in Tucson, Arizona, United States
Locale: Tucson, Arizona, United States
Topic: heat shock proteins
- Delaney J. A cya deletion mutant of Escherichia coli develops thermotolerance but does not exhibit a heat-shock response. Genet Res. 1990;55:1-6 pubmed..These results suggest that heat-shock protein synthesis is not essential for development of thermotolerance in E. coli. ..
- Hilleren P, McCarthy T, Rosbash M, Parker R, Jensen T. Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Nature. 2001;413:538-42 pubmed..In exosome mutants, hypo- as well as hyperadenylated mRNAs are released and translated. These observations suggest that the exosome contributes to a checkpoint that monitors proper 3'-end formation of mRNA. ..
- Moran N, Degnan P. Functional genomics of Buchnera and the ecology of aphid hosts. Mol Ecol. 2006;15:1251-61 pubmed..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera...
- Lee U, Rioflorido I, Hong S, Larkindale J, Waters E, Vierling E. The Arabidopsis ClpB/Hsp100 family of proteins: chaperones for stress and chloroplast development. Plant J. 2007;49:115-27 pubmed..Thus, in plants, the function of ClpB/Hsp100 proteins is not restricted to heat stress, but a specific member of the family provides housekeeping functions that are essential to chloroplast development. ..
- Vierling E, Nagao R, DeRocher A, Harris L. A heat shock protein localized to chloroplasts is a member of a eukaryotic superfamily of heat shock proteins. EMBO J. 1988;7:575-81 pubmed..We hypothesize that the chloroplast HSP shares a common structural and functional domain with low mol. wt HSPs which localize to other parts of the cell, and may have evolved from a nuclear gene. ..
- Wehmeyer N, Hernandez L, Finkelstein R, Vierling E. Synthesis of small heat-shock proteins is part of the developmental program of late seed maturation. Plant Physiol. 1996;112:747-57 pubmed..In total the data indicate that the expression of sHSPs in seeds is part of the normal developmental program of late seed maturation and the presence of sHSPs has adaptive significance for plant reproduction. ..
- Hong S, Vierling E. Mutants of Arabidopsis thaliana defective in the acquisition of tolerance to high temperature stress. Proc Natl Acad Sci U S A. 2000;97:4392-7 pubmed..The phenotype of hot1 also provides direct evidence that Hsp101, which is required for thermotolerance in bacteria and yeast, is also essential for thermotolerance in a complex eukaryote. ..
- Lee U, Wie C, Escobar M, Williams B, Hong S, Vierling E. Genetic analysis reveals domain interactions of Arabidopsis Hsp100/ClpB and cooperation with the small heat shock protein chaperone system. Plant Cell. 2005;17:559-71 pubmed..These results also demonstrate that quantitative phenotypes can be used for in vivo genetic dissection of protein mechanism in Arabidopsis. ..
- Basha E, Friedrich K, Vierling E. The N-terminal arm of small heat shock proteins is important for both chaperone activity and substrate specificity. J Biol Chem. 2006;281:39943-52 pubmed publisher..In total, results demonstrate that sHSP-substrate interactions are complex, likely involve multiple sites on the sHSP, and vary depending on substrate...
- Hays A, Lantz R, Rodgers L, Sollome J, Vaillancourt R, Andrew A, et al. Arsenic-induced decreases in the vascular matrix. Toxicol Pathol. 2008;36:805-17 pubmed publisher..These AsIII-induced early pathological events may predispose humans to respiratory and cardiovascular diseases linked to chronic low-dose AsIII exposure...
- Jaya N, Garcia V, Vierling E. Substrate binding site flexibility of the small heat shock protein molecular chaperones. Proc Natl Acad Sci U S A. 2009;106:15604-9 pubmed publisher..Our results support a model in which the intrinsically-disordered N-terminal arm can present diverse geometries of interaction sites, which is likely critical for the ability of sHSPs to protect efficiently many different substrates. ..
- Larkindale J, Hall J, Knight M, Vierling E. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 2005;138:882-97 pubmed
- Dunbar H, Wilson A, Ferguson N, Moran N. Aphid thermal tolerance is governed by a point mutation in bacterial symbionts. PLoS Biol. 2007;5:e96 pubmed..Other cases in which symbiont microevolution has a major effect on host ecological tolerance are likely to be widespread because of the high mutation rates of symbiotic bacteria and their crucial roles in host metabolism and development...
- Cai Q, Nelson S, McReynolds M, Diamond Stanic M, Elliott D, Brooks H. Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect. Am J Physiol Renal Physiol. 2010;299:F712-9 pubmed publisher..These findings strongly support an important role of vasopressin in the activation of an ER stress response in renal collecting duct cells, in addition to its role in activating an increase in UT-A1 and UT-A3 abundance. ..