Genomes and Genes
Experts and Doctors on humans in Northport, Alabama, United States
Locale: Northport, Alabama, United States
- Gold A. Functional somatic syndromes, anxiety disorders and the upper airway: a matter of paradigms. Sleep Med Rev. 2011;15:389-401 pubmed publisher..Finally, building upon an existing paradigm of neural sensitization, sleep disordered breathing is linked to functional somatic syndromes and anxiety disorders through chronic activation of the hypothalamic-pituitary-adrenal axis. ..
- Gold A, Gold M, Harris K, Espeleta V, Amin M, Broderick J. Hypersomnolence, insomnia and the pathophysiology of upper airway resistance syndrome. Sleep Med. 2008;9:675-83 pubmed..A physical model is proposed to account for the excess somnolence in UARS relative to expectations and the increasing frequency of sleep-onset insomnia along the continuum from severe OSA/H to UARS. ..
- Amin M, Gold M, Broderick J, Gold A. The effect of nasal continuous positive airway pressure on the symptoms of Gulf War illness. Sleep Breath. 2011;15:579-87 pubmed publisher..004), sleep quality (41%; p = 0.0003), physical health (34%; p = 0.0003), and mental health (16%; p = 0.03). Our findings in this pilot study suggest that nasal CPAP may greatly improve symptoms in veterans with GWI and SDB. ..
- Zucker S, Cao J. Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: ready for prime time?. Cancer Biol Ther. 2009;8:2371-3 pubmed
- Rollo E, Hempson S, Bansal A, Tsao E, Habib I, Rittling S, et al. The cytokine osteopontin modulates the severity of rotavirus diarrhea. J Virol. 2005;79:3509-16 pubmed..Rotavirus infection of intestinal epithelial cells and murine intestine caused marked increases in OPN mRNA levels and secreted OPN protein. OPN-deficient mice suffered prolonged disease. ..
- Cohen I, Lin R, Ballou L. Acquired long QT syndrome and phosphoinositide 3-kinase. Trends Cardiovasc Med. 2017;27:451-459 pubmed publisher..Reduced PI3K signaling may also play a role in aLQTS associated with diabetes. Drug safety testing to identify aLQTS risk may be improved by examining PI3K-dependent effects that develop over time. ..
- Yeh S, Lovitt S, Schuster M. Usage of megestrol acetate in the treatment of anorexia-cachexia syndrome in the elderly. J Nutr Health Aging. 2009;13:448-54 pubmed
- Pan J, Sun Y, Jiang Y, Bott A, Jaber N, Dou Z, et al. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Mol Cell. 2016;61:720-733 pubmed publisher..Therefore, TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage. ..
- Nelson V, Negrón A, Reid I, Thomas J, Yang L, Lin R, et al. Loss of PI3K p110? in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice. Biomed Res Int. 2017;2017:3756089 pubmed publisher..We propose that chronic hyperleptinemia contributes to the negative impact that disrupting PI3K signaling in adipocytes has on puberty onset, steroidogenesis, and fertility in males. ..