Experts and Doctors on animals in Northport, Alabama, United States

Summary

Locale: Northport, Alabama, United States
Topic: animals

Top Publications

  1. Peress N, Fleit H, Perillo E, Kuljis R, Pezzullo C. Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease. J Neuroimmunol. 1993;48:71-9 pubmed
    ..These findings suggest that intrinsic Fc gamma R may play an important role in normal and disordered immune-related processes in the brain. They support the idea that microglia are brain macrophages. ..
  2. Hunanyan A, Alessi V, Patel S, Pearse D, Matthews G, Arvanian V. Alterations of action potentials and the localization of Nav1.6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats. J Neurophysiol. 2011;105:1033-44 pubmed publisher
  3. Arvanian V. Role of neurotrophins in spinal plasticity and locomotion. Curr Pharm Des. 2013;19:4509-16 pubmed
    ..The findings summarized here indicate that neurotrophins have translational research potential for SCI repair, most likely as an essential component of combination therapy. ..
  4. Ray K, Moss M, Franklin J, Weaver C, Higginbotham J, Song Y, et al. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. Oncogene. 2014;33:823-31 pubmed publisher
    ..These findings establish the importance of oncogenic synergy in cancer initiation and promotion, and establish a molecular link between inflammation and the earliest stages of tumor induction. ..
  5. Garcia Barros M, Coant N, Truman J, Snider A, Hannun Y. Sphingolipids in colon cancer. Biochim Biophys Acta. 2014;1841:773-82 pubmed publisher
    ..This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. ..
  6. Graber M, Pastoriza Munoz E. Regulation of cell pH by K+/H+ antiport in renal epithelial cells. Am J Physiol. 1993;265:F773-83 pubmed
    ..The K+/H+ antiporter appears to be one of the major systems regulation cell pH in these cells, balancing the H+ efflux mediated by Na+/H+ exchange. ..
  7. Rollo E, Hempson S, Bansal A, Tsao E, Habib I, Rittling S, et al. The cytokine osteopontin modulates the severity of rotavirus diarrhea. J Virol. 2005;79:3509-16 pubmed
    ..Rotavirus infection of intestinal epithelial cells and murine intestine caused marked increases in OPN mRNA levels and secreted OPN protein. OPN-deficient mice suffered prolonged disease. ..
  8. Zucker S, Cao J. Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: ready for prime time?. Cancer Biol Ther. 2009;8:2371-3 pubmed
  9. Pan J, Sun Y, Jiang Y, Bott A, Jaber N, Dou Z, et al. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Mol Cell. 2016;61:720-733 pubmed publisher
    ..Therefore, TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage. ..

More Information

Publications11

  1. Nelson V, Negrón A, Reid I, Thomas J, Yang L, Lin R, et al. Loss of PI3K p110? in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice. Biomed Res Int. 2017;2017:3756089 pubmed publisher
    ..We propose that chronic hyperleptinemia contributes to the negative impact that disrupting PI3K signaling in adipocytes has on puberty onset, steroidogenesis, and fertility in males. ..
  2. Cohen I, Lin R, Ballou L. Acquired long QT syndrome and phosphoinositide 3-kinase. Trends Cardiovasc Med. 2017;27:451-459 pubmed publisher
    ..Reduced PI3K signaling may also play a role in aLQTS associated with diabetes. Drug safety testing to identify aLQTS risk may be improved by examining PI3K-dependent effects that develop over time. ..