Experts and Doctors on saccharomyces cerevisiae proteins in Al Ain, Abu Dhabi, United Arab Emirates
Locale: Al Ain, Abu Dhabi, United Arab Emirates
Topic: saccharomyces cerevisiae proteins
Hassan A, Awad S, Prochasson P. The Swi2/Snf2 bromodomain is required for the displacement of SAGA and the octamer transfer of SAGA-acetylated nucleosomes. J Biol Chem. 2006;281:18126-34 pubmed
..Thus, the Swi2/Snf2 bromodomain is required for the full functional activity of SWI/SNF on acetylated nucleosomes and is important for the displacement of SAGA from acetylated promoter nucleosomes. ..
Hassan A, Awad S, Al Natour Z, Othman S, Mustafa F, Rizvi T. Selective recognition of acetylated histones by bromodomains in transcriptional co-activators. Biochem J. 2007;402:125-33 pubmed
..The selective recognition of the bromodomains observed in the present study accounts for the broad effects of bromodomain-containing proteins observed on binding to histones. ..
Zaki N, Lazarova Molnar S, El Hajj W, Campbell P. Protein-protein interaction based on pairwise similarity. BMC Bioinformatics. 2009;10:150 pubmed publisher
..This similarity incorporates biological knowledge about proteins and it is extremely powerful when combined with support vector machine to predict PPI. ..
Awad S, Ryan D, Prochasson P, Owen Hughes T, Hassan A. The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem. 2010;285:9477-84 pubmed publisher
..Fun30 also possesses a weakly conserved CUE motif suggesting that it may interact specifically with ubiquitinylated proteins. However, in vitro Fun30 was found to have no specificity in its interaction with ubiquitinylated histones. ..
Zaki N, Efimov D, Berengueres J. Protein complex detection using interaction reliability assessment and weighted clustering coefficient. BMC Bioinformatics. 2013;14:163 pubmed publisher
..The higher accuracy achieved by PEWCC in detecting protein complexes is a valid argument in favor of the proposed method. The datasets and programs are freely available at http://faculty.uaeu.ac.ae/nzaki/Research.htm. ..