Experts and Doctors on acetylation in Al Ain, Abu Dhabi, United Arab Emirates
Locale: Al Ain, Abu Dhabi, United Arab Emirates
Al Dhaheri Y, Attoub S, Arafat K, Abuqamar S, Eid A, Al Faresi N, et al
. Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation. Biochim Biophys Acta. 2013;1830:3121-35 pubmed publisher
..Our data are the first to link senescence and histone modifications to Salinomycin. This study provides a new insight to better understand the mechanism of action of Salinomycin, at least in breast cancer cells. ..
Hassan A, Awad S, Prochasson P. The Swi2/Snf2 bromodomain is required for the displacement of SAGA and the octamer transfer of SAGA-acetylated nucleosomes. J Biol Chem. 2006;281:18126-34 pubmed
..Thus, the Swi2/Snf2 bromodomain is required for the full functional activity of SWI/SNF on acetylated nucleosomes and is important for the displacement of SAGA from acetylated promoter nucleosomes. ..
Hassan A, Awad S, Al Natour Z, Othman S, Mustafa F, Rizvi T. Selective recognition of acetylated histones by bromodomains in transcriptional co-activators. Biochem J. 2007;402:125-33 pubmed
..The selective recognition of the bromodomains observed in the present study accounts for the broad effects of bromodomain-containing proteins observed on binding to histones. ..