Experts and Doctors on plant extracts in Taichung, Taiwan


Locale: Taichung, Taiwan
Topic: plant extracts

Top Publications

  1. Chen S, Chung J, Chung Y, Chou S. In vitro antioxidant and antiproliferative activity of the stem extracts from Graptopetalum paraguayense. Am J Chin Med. 2008;36:369-83 pubmed
    ..These results demonstrated the antioxidant and anti-hepatoma potential of stem of Graptopetalum paraguayense...
  2. Lee C, Hwang T, He W, Tsai Y, Yen C, Yen H, et al. Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum. Phytochemistry. 2013;95:315-21 pubmed publisher
    ..66 and 3.59 ?M, while two others inhibited both inflammatory mediators with IC50 values of 0.66-3.49 ?M. Structure-activity relationships are discussed...
  3. Huang S, Chiu C, Lin T, Lee M, Lee C, Chang S, et al. Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima. J Ethnopharmacol. 2013;147:395-405 pubmed publisher
    ..Overall, the results showed that ACM demonstrated antioxidant and anti-inflammatory activity, which supports previous claims of the traditional use for inflammation and pain. ..
  4. Chen T, Sun H, Yao H, Lii C, Chen H, Chen P, et al. Suppressive effects of Indigofera suffruticosa Mill extracts on lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages. Food Chem Toxicol. 2013;55:257-64 pubmed publisher
    ..suffruticosa extracts. In summary, I. suffruticosa have a strong anti-inflammatory property that diminishes pro-inflammatory mediator expressions by lessening LPS-induced NF-?B activation and inducing HO-1 expression in macrophages...
  5. Yang H, Chen S, Chen C, Wang S, Hseu Y. Alpinia pricei rhizome extracts induce apoptosis of human carcinoma KB cells via a mitochondria-dependent apoptotic pathway. Food Chem Toxicol. 2008;46:3318-24 pubmed publisher
    ..A. pricei may, therefore, have anticancer properties valuable for application in food and drug products...
  6. Wu S, Lin C, Chuang Y, Chang F, Tseng C, Wu Y, et al. Anti-hepatitis C virus activity of 3-hydroxy caruilignan C from Swietenia macrophylla stems. J Viral Hepat. 2012;19:364-70 pubmed publisher
    ..We then demonstrated that 3-HCL-C interfered with HCV replication by inducing IFN-stimulated response element transcription and IFN-dependent anti-viral gene expression. ..
  7. Dung T, Chang H, Binh T, Lee M, Tsai C, Tsai F, et al. Zanthoxylum avicennae extracts inhibit cell proliferation through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells in vitro and in vivo. Int J Mol Med. 2012;29:1045-52 pubmed publisher
    ..Our findings indicate that the inhibition of HA22T cell proliferation by YBBEs is mediated through PP2A activation...
  8. Chung Y, Chou S, Jhan J, Liao J, Chen S. In vitro and in vivo safety of aqueous extracts of Graptopetalum paraguayense E. Walther. J Ethnopharmacol. 2012;140:91-7 pubmed publisher
    ..However, little data exist regarding its safety...
  9. Lu M, Lai T, Hwang J, Chen H, Chang S, Tsai F, et al. Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells. Cell Biochem Funct. 2009;27:186-92 pubmed publisher
    ..On the basis of the results, applying appropriate doses of ginseng and Rg1 with biomedical materials would be a potential approach for enhancing neuron regeneration. ..

More Information


  1. Wang H, Chung P, Wu C, Lan K, Yang M, Wang C. Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis. J Sci Food Agric. 2011;91:178-85 pubmed publisher
    ..The growth inhibition of HepG2 cells in vitro and in vivo was determined in the presence of SNPE...
  2. Chan K, Ho H, Huang C, Lin M, Chen H, Wang C. Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-kappaB signals. J Agric Food Chem. 2009;57:9147-53 pubmed publisher
    ..NF-kappaB expression was also inhibited by MLE. MLE could effectively inhibit the migration of VSMC by blocking small GTPase and Akt/NF-kappaB signals. ..
  3. Yang D, Chang Y, Hsu C, Liu C, Lin Y, Lin Y, et al. Antiobesity and hypolipidemic effects of polyphenol-rich longan (Dimocarpus longans Lour.) flower water extract in hypercaloric-dietary rats. J Agric Food Chem. 2010;58:2020-7 pubmed publisher
    ..05) fecal triglyceride excretions. Therefore, polyphenol-rich LFWE indeed characterizes antiobesity and hypolipidemic effects in vivo. ..
  4. Chao C, Yin M, Huang C. Wild bitter gourd extract up-regulates mRNA expression of PPAR?, PPAR? and their target genes in C57BL/6J mice. J Ethnopharmacol. 2011;135:156-61 pubmed publisher
    ..05), as the rosiglitazone treated mice. Results of this study demonstrated that WBGE also activates PPAR? and PPAR? signaling pathway in vivo. ..
  5. Lu K, Tsai M, Chen J, Hsu S, Hsia T, Lin M, et al. Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9. Anticancer Res. 2008;28:1093-9 pubmed
    ..These results show that Gyp inhibits invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis...
  6. Lai C, Fang S, Rao Y, Geethangili M, Tang C, Lin Y, et al. Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts. J Ethnopharmacol. 2008;118:522-6 pubmed publisher
    ..This study is aimed at evaluating the antimicrobial activity of Phyllanthus urinaria Linnea (Euphorbiaceae), chloroform (PUC) and methanol (PUM) extracts, and its eight isolates on H. pylori-infected human gastric epithelial AGS cells...
  7. Ou H, Lee W, Lee I, Chiu T, Tsai K, Lin C, et al. Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells. J Appl Physiol (1985). 2009;106:1674-85 pubmed publisher
    ..05). Results from this study may provide insight into a possible molecular mechanism underlying GbE suppression of the oxLDL-mediated vascular endothelial dysfunction. ..
  8. Peng W, Tien Y, Huang C, Huang T, Liao J, Kuo C, et al. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. J Ethnopharmacol. 2010;127:606-13 pubmed publisher
    ..FR(EtOH) down-regulated the expressions of uPA, MMP-2 and MMP-9 in CCl(4)-induced liver fibrosis in rats. ..
  9. Lu K, Chen J, Lai T, Yang J, Weng S, Ma Y, et al. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Hum Exp Toxicol. 2011;30:406-15 pubmed publisher
    ..The inhibition of NF-?B and MMP-2, -7 and -9 signaling may be one of the mechanisms that is present in Gyp-inhibited cancer cell invasion and migration. ..
  10. Cheng H, Wu Y, Wang Q, Song M, Wu J, Chen D, et al. Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis. BMC Complement Altern Med. 2017;17:439 pubmed publisher
    ..This study demonstrated the clinical efficacy of Indigo naturalis in moderate psoriasis, and exemplified a novel experimental medicine approach to understand TCM targeting mechanisms. NCT01901705 . ..
  11. Lai Z, Ho Y, Huang S, Huang T, Lai S, Tsai J, et al. Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem. Am J Chin Med. 2011;39:1275-90 pubmed
    ..gracilis. The above experimental data indicated that the stem of K. gracilis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds...
  12. Liao Y, Rao Y, Tzeng Y. Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-?B/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells. Food Chem Toxicol. 2012;50:2930-6 pubmed publisher
    ..Taken together, our data indicate that A. indica can be considered as a source of new anti-metastatic agent for food and pharmaceutical industries. ..
  13. Ku C, Lin J. Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes. Food Chem. 2013;141:1104-13 pubmed publisher
    ..The relative Th1-inclination property of menthone, farnesol and oridonin may be applied to improve Th2-skewed allergic diseases. ..
  14. Hsu C, Chiang S, Chang Y, Chen Y, Yang D, Chen Y, et al. Lychee flower extract inhibits proliferation and viral replication of HSV-1-infected corneal epithelial cells. Mol Vis. 2016;22:129-37 pubmed
    ..Therefore, in this study, we investigated the mechanism of the Statens Seruminstitut rabbit corneal (SIRC) epithelial cells infected by HSV-1 and examined the antiviral capabilities of LFE...
  15. Hsieh M, Chen M, Chen C, Hsieh M, Lo Y, Chuang Y, et al. Glabridin induces apoptosis and autophagy through JNK1/2 pathway in human hepatoma cells. Phytomedicine. 2016;23:359-66 pubmed publisher
    ..Glabridin induces Huh7 cell death through apoptosis through the p38 MAPK and JNK1/2 pathways and is a potential chemopreventive agent against human hepatoma. ..
  16. Fang S, Rao Y, Tzeng Y. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116:333-40 pubmed publisher
    ..Therefore, these isolates from Phyllanthus urinaria may be useful for the treatment of cell-mediated immune diseases...
  17. Chen J, Lu K, Lee J, Yeh C, Chung J. Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. Anticancer Res. 2006;26:4313-26 pubmed
    ..These results provide information towards an understanding of the mechanisms by which Gyp induces cell cycle arrest and apoptosis in human colon cancer cells. ..
  18. Chang Y, Huang K, Huang A, Ho Y, Wang C. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem Toxicol. 2006;44:1015-23 pubmed
    ..However, further investigations into the specificity and mechanism(s) of HAs are needed...
  19. Lin M, Chou F, Huang H, Hsu J, Chou M, Wang C. The tumor promoting effect of lime-piper betel quid in JB6 cells. Food Chem Toxicol. 2003;41:1463-71 pubmed
    ..When treating with 0.5 mg/ml LPB for 15 days as a promoter, type III foci were formed in the JB6 culture. These results demonstrated the tumor promotional effect of LPB in JB6 cells. ..
  20. Yang H, Chen S, Senthil Kumar K, Yu K, Lee Chao P, Tsai S, et al. Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach. J Agric Food Chem. 2012;60:522-32 pubmed publisher
    ..Hesperetin metabolites ex vivo showed potent antioxidant and anti-inflammatory activity in comparison with hesperidin/hesperetin. ..
  21. Lin H, Huang H, Huang C, Chen J, Wang C. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog. 2005;43:86-99 pubmed
    ..Thus, our data present the first evidence of HPE as an apoptosis inducer in AGS cells and these findings may open interesting perspectives to the strategy in human gastric cancer treatment. ..
  22. Lai M, Hsiu S, Hou Y, Tsai S, Chao P. Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis. Planta Med. 2004;70:132-7 pubmed
    ..In order to ensure the efficacy and safety of cyclosporine, the coadministration of SR and its preparations with oral cyclosporine should be avoided...
  23. Lin M, Wang C, Huang H, Chou M, Chou F. The tumorigenic characteristics of lime-piper betel quid-transformed JB6 cells. Arch Toxicol. 2004;78:167-73 pubmed
    ..These results demonstrated the promotion effect of LPB and indicate that it could be a tumor promoter...
  24. Wang H, Wu D, Chang Y, Li Y, Wang C. Solanum nigrum Linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo. J Agric Food Chem. 2010;58:11913-23 pubmed publisher
    ..This was associated with reduced serum MMP-9 as well as Akt activity and PKC?, Ras, and NF-?B protein expressions. Thus, this work indicates SNWE has potential application for treating metastatic melanoma...
  25. Hsiang C, Lo H, Huang H, Li C, Wu S, Ho T. Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-?B activity and interleukin-1? signalling pathway. Food Chem. 2013;136:170-7 pubmed publisher
    ..In conclusion, ginger improved TNBS-induced colitis via modulation of NF-?B activity and IL-1? signalling pathway. Moreover, zingerone might be the active component of ginger responsible for the amelioration of colitis induced by TNBS...
  26. Lee C, Hwang T, Peng C, Chen C, Chang Y, Wu Y. Anti-neutrophilic inflammatory secondary metabolites from the traditional Chinese medicine, Tiankuizi. Nat Prod Commun. 2012;7:1623-6 pubmed
    ..Overall, our studies demonstrated Tiankuizi (S. adoxoides) as a potential TCM and isolates 1 and 2 as promising lead compounds for neutrophilic inflammatory diseases. ..
  27. Yu Y, Hsu C, Yen G. Anti-inflammatory effects of the roots of Alpinia pricei Hayata and its phenolic compounds. J Agric Food Chem. 2009;57:7673-80 pubmed publisher
    ..7 cells. When these results are taken together, they indicate that EEAP and pinocembrin suppressed LPS-induced NO and PGE(2) production by inhibition of NF-kappaB nuclear translocation and ROS generation. ..
  28. Lin M, Kao S, Chung P, Chan K, Yang M, Wang C. Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf. J Agric Food Chem. 2009;57:5925-32 pubmed publisher
    ..Consequently, it is suggested that the flavonoid-enriched N. nucifera leaf extract supplement is beneficial for the improvement of lipid metabolisms and the alleviation of liver damage in high fat diet treatment...
  29. Chou Y, Wang S, Chen G, Lin Y, Chao P. The functional assessment of Alpinia pricei on metabolic syndrome induced by sucrose-containing drinking water in mice. Phytother Res. 2009;23:558-63 pubmed publisher
    ..These results indicated that visceral adiposity and insulin resistance induced by sucrose water drinking might be alleviated by AP supplementation...
  30. Chao J, Lu T, Liao J, Huang T, Lee M, Cheng H, et al. Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice. J Ethnopharmacol. 2009;125:297-303 pubmed publisher
    ..This study investigated the anti-inflammatory and analgesic activities, and protoberberine alkaloid contents of ethanol extract of MO roots (MOR(EtOH))...
  31. Yang C, Chao P, Hou Y, Tsai S, Wen K, Hsiu S. Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats. Food Chem Toxicol. 2006;44:1572-8 pubmed
    ..We suggest that concurrent intake of quercetin-rich herbs or foods with cyclosporin are better avoided in order to ensure the efficacy of cyclosporin. ..
  32. Liu K, Shih T, Kuo C, Ma Y, Yang J, Wu P, et al. Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells. Am J Chin Med. 2016;44:1289-1310 pubmed
    ..SFN induced ER stress-associated protein expression. Based on those observations, we suggest that SFN may be used as a novel anticancer agent for the treatment of human colon cancer in the future...
  33. Chang Y, Tseng T, Lee M, Hsu J, Wang C. Induction of apoptosis by penta-acetyl geniposide in rat C6 glioma cells. Chem Biol Interact. 2002;141:243-57 pubmed
    ..These results suggest that cell death caused by (Ac)(5)-GP through apoptosis and cell cycle arrest at G(0)/G(1) may be associated with the induction of p53, c-Myc and may be mediated with apoptosis-related Bcl-2 family proteins. ..
  34. Lo H, Ho T, Lin C, Li C, Hsiang C. Momordica charantia and its novel polypeptide regulate glucose homeostasis in mice via binding to insulin receptor. J Agric Food Chem. 2013;61:2461-8 pubmed publisher
    ..Moreover, TI was newly identified as a novel IR-binding protein of MC that triggered the insulin signaling pathway via binding to IR. ..
  35. Chau C, Huang Y, Lee M. In vitro hypoglycemic effects of different insoluble fiber-rich fractions prepared from the peel of Citrus sinensis L. cv. Liucheng. J Agric Food Chem. 2003;51:6623-6 pubmed
    ..The potential hypoglycemic effects of these FRFs suggested that they could be incorporated as low-calorie bulk ingredients in high-fiber foods to reduce calorie level and control blood glucose level...
  36. Yang S, Chu S, Liu S, Chen Y, Chang Y, Hsieh Y. Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo. J Ethnopharmacol. 2007;110:483-9 pubmed
    ..Furthermore, the inhibitory effect of STE on the growth and metastasis of LLC cells in vivo was also proven. These results demonstrated that STE could be a candidate antimetastatic agent against lung cancer...
  37. Lo W, Tsai F, Liu C, Tang N, Su S, Lin S, et al. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Am J Chin Med. 2010;38:745-59 pubmed
  38. Lin L, Hsieh M, Tsai F, Wang W, Wu C. Anti-nociceptive and anti-inflammatory activity caused by Cistanche deserticola in rodents. J Ethnopharmacol. 2002;83:177-82 pubmed
    ..Furthermore, the analgesic and anti-inflammatory effects of the butanolic layer of CD extract were not related to opioid receptors and immune system...
  39. Wang S, Lan X, Xiao J, Yang J, Kao Y, Chang S. Antiinflammatory activity of Lindera erythrocarpa fruits. Phytother Res. 2008;22:213-6 pubmed
    ..5 and 1 mg per ear, the percent edema reduction in treated mice was 44% and 25%, respectively. The results obtained in this study indicated that lucidone has a good potential to be developed as an antiinflammation agent...
  40. Wang Q, Chiang C, Wu C, Cheng C, Hsieh S, Chen J, et al. Gypenosides induce apoptosis in human hepatoma Huh-7 cells through a calcium/reactive oxygen species-dependent mitochondrial pathway. Planta Med. 2007;73:535-44 pubmed
    ..Based on these results, we propose that the rise in intracellular Ca(2+) concentration plays a pivotal role in the initiation of gypenosides-triggered apoptotic death...
  41. Chiu S, Tsao S, Hwang P, Vanisree S, Chen Y, Yang N. Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling. BMC Genomics. 2010;11:513 pubmed publisher
  42. Chen P, Hsieh Y, Chiou H, Chu S. Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem Biol Interact. 2005;156:141-50 pubmed
    ..These findings suggested that the inhibition on MMP-2 and u-PA expression by silibinin may be through a suppression on ERK1/2 or Akt phosphorylation, which in turn led to the reduced invasiness of the cancer cells. ..
  43. Chang C, Chen Y, Chen H, Yang N, Yang W. Natural cures for type 1 diabetes: a review of phytochemicals, biological actions, and clinical potential. Curr Med Chem. 2013;20:899-907 pubmed
    ..New views on phytocompound-based strategies for prevention and treatment of type 1 diabetes are also discussed. ..
  44. Shih P, Chan Y, Liao J, Wang M, Yen G. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease. J Nutr Biochem. 2010;21:598-605 pubmed publisher
    ..Overall, supplementation of ME might be advantageous to the induction of an antioxidant defense system and for the improvement of memory deterioration in ageing animals. ..
  45. Hung M, Fu T, Shih P, Lee C, Yen G. Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats. Food Chem Toxicol. 2006;44:1424-31 pubmed
    ..The data suggest that oral administration with WEDZ for 28 consecutive days significantly decrease the intensity of hepatic damage induced by CCl4 in rats...
  46. Lin L, Nalawade S, Mulabagal V, Yeh M, Tsay H. Micropropagation of Polygonum multiflorum THUNB and quantitative analysis of the anthraquinones emodin and physcion formed in in vitro propagated shoots and plants. Biol Pharm Bull. 2003;26:1467-71 pubmed
  47. Wang S, Huang W, Liu C, Wang M, Ho C, Huang W, et al. Pumpkin (Cucurbita moschata) fruit extract improves physical fatigue and exercise performance in mice. Molecules. 2012;17:11864-76 pubmed publisher
    ..Therefore, CME may be potential for the pharmacological effect of anti-fatigue...
  48. Huang H, Hsieh W, Niu Y, Chang T. Inhibition of melanogenesis and antioxidant properties of Magnolia grandiflora L. flower extract. BMC Complement Altern Med. 2012;12:72 pubmed publisher
    ..grandiflora L. flower extract on mushroom tyrosinase, B16F10 intracellular tyrosinase activity and melanin content were determined spectrophotometrically. Meanwhile, the antioxidative capacity of the flower extract was also investigated...
  49. Yang Y, Wang C, Huang C, Chen M, Chen M, Peng C. Polyphenols of Hibiscus sabdariffa improved diabetic nephropathy via attenuating renal epithelial mesenchymal transition. J Agric Food Chem. 2013;61:7545-51 pubmed publisher
    ..Treatment of HPE recovered morphological changes of cell junction and basement membrane. We suggest that HPE has the potential to be an adjuvant for diabetic nephropathy by regulating AT-1/TGF-?1 and EMT. ..
  50. Hsin C, Wu B, Chuang C, Yang S, Hsieh Y, Ho H, et al. Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. BMC Complement Altern Med. 2013;13:234 pubmed publisher
    ..The present study aimed to examine the anti-metastatic properties of Selaginella tamariscina extract (STE) in human nasopharyngeal carcinoma HONE-1 cells in vitro...
  51. Tang C, Huang H, Lee Y, Tang Y, Wang C. Hepatoprotective effect of mulberry water extracts on ethanol-induced liver injury via anti-inflammation and inhibition of lipogenesis in C57BL/6J mice. Food Chem Toxicol. 2013;62:786-96 pubmed publisher
    ..This may be mediated by multiple pathways, including reduced lipid accumulation and lipid synthesis, increased fatty acid transport and fatty acid oxidation responses, decreased oxidative stress and facilitated anti-inflammation. ..
  52. Sagare A, Kuo C, Chueh F, Tsay H. De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC. Biol Pharm Bull. 2001;24:1311-5 pubmed
    ..The analysis revealed that the content of harpagoside in the aerial and underground parts of S. yoshimurae was significantly higher than the marketed crude drug (underground parts of Scrophularia ningpoensis)...
  53. Lin S, Lu T, Chao P, Lai Y, Tsai H, Chen C, et al. In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh. Phytother Res. 2011;25:1511-8 pubmed publisher
    ..The possibility that the other constituents act as antagonists of cinnamaldehyde cannot be excluded...
  54. Huang S, Lee F, Kuo T, Yang J, Chien C. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol. 2009;52:316-24 pubmed
    ..In conclusion, treatment of Rhodiola rosea extracts for 4 weeks could reduce swimming-enhanced oxidative stress possibly via the reactive oxygen species scavenging capability and the enhancement of the antioxidant defense mechanisms...
  55. Wu P, Liu K, Huang W, Chueh F, Ko Y, Chiu T, et al. Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo. Phytomedicine. 2011;18:672-6 pubmed publisher
    ..These findings indicated that DATS inhibits tumor growth in an allograft animal model. Thus, DATS may represent a colon cancer preventive agent and can be used in the future. ..
  56. Hsu C, Hong B, Yu Y, Yen G. Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds. J Agric Food Chem. 2010;58:2150-6 pubmed publisher
    ..These results demonstrate that EEOA and its bioactive compound, ursolic acid, suppress LPS-induced NO and PGE(2) production by inhibiting ROS generation, along with reducing expression of iNOS and COX-2 in RAW 264.7 cells...
  57. Lee H, Bau D, Kuo C, Tsai R, Chen Y, Chang Y. Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa. Am J Chin Med. 2011;39:201-13 pubmed
    ..diffusa, consisting of approximately 4.66-4.80% and 1.86-1.96%, respectively. Our study also demonstrated that ursolic acid has significant anti-tumor activity in COLO 205, Hep 3B and H460 cancer cells...
  58. Hou Y, Lin S, Tsai S, Ko M, Chang Y, Chao P. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Planta Med. 2011;77:455-60 pubmed publisher
    ..In conclusion, the glucuronides/sulfates of baicalein and wogonin were exclusively present in the circulation, whereas their free forms appeared in the lung, liver, and kidney...
  59. Chang N, Wu C, Wang S, Pei R, Lin C. Alpinia pricei Hayata rhizome extracts have suppressive and preventive potencies against hypercholesterolemia. Food Chem Toxicol. 2010;48:2350-6 pubmed publisher
    ..These results suggest that APE has both suppressive and preventive potencies against hypercholesterolemia and has the potency to protect against lipid peroxidation...
  60. Sheih I, Wu T, Fang T. Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems. Bioresour Technol. 2009;100:3419-25 pubmed publisher
    ..These results demonstrate that inexpensive algae protein waste could be a new alternative to produce antioxidative peptides. ..
  61. Yu A, Lu C, Wang T, Tsai C, Liu K, Cheng Y, et al. Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells. J Agric Food Chem. 2010;58:7641-8 pubmed publisher
    ..These results suggest that stimulation of Nrf2-dependent HO-1 expression is involved in the suppression of TNF-alpha-induced ICAM-1 expression exerted by andrographolide. ..
  62. Yeh Y, Hsieh Y, Lee Y. Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats. J Agric Food Chem. 2013;61:7387-96 pubmed publisher
    ..Therefore, it was speculated that yam peel extract protects rats from liver damage through its anti-inflammation capacity. ..
  63. Huang Y, Hwang T, Yang Y, Wu S, Hsu M, Wang J, et al. Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils. Planta Med. 2010;76:447-53 pubmed publisher
    ..Compounds 1, 3, and 5 showed inhibitory activities on either superoxide anion generation or elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (FMLP/CB). ..
  64. Tang N, Yang J, Lin J, Hsia T, Fan M, Lin J, et al. Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice. In Vivo. 2009;23:761-6 pubmed
    ..Taken together, these results show that ABM extract promoted immunomodulations in normal BALB/c mice in vitro and in vivo. ..
  65. Chang W, Yu Y, Hsu Y, Wu C, Yin P, Chiang S, et al. Inhibitory effect of Magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits. J Cardiovasc Pharmacol. 2006;47:463-8 pubmed
    ..Therefore, the results indicate that the antiatherogenic effect of M. officinalis is involved with a suppression of oxidative stress and with the down-regulation of apoptosis-related gene expression in hyperlipidemic rabbits...
  66. Hsu C, Hsu C, Tsai S, Fu T, Yen G. Protective effect of Millettia reticulata Benth against CCl(4)-induced hepatic damage and inflammatory action in rats. J Med Food. 2009;12:821-8 pubmed publisher
  67. Lin Y, Hsieh C. Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats. J Ethnopharmacol. 2011;135:313-20 pubmed publisher
    ..Here we aim to determine the protective role of Uncaria rhynchophylla (UR), an herbal drug belong to Traditional Chinese Medicine (TCM), on epileptic rats...
  68. Lao C, Lin J, Kuo J, Chao P, Cheng C, Tang N, et al. Microglia, apoptosis and interleukin-1beta expression in the effect of sophora japonica l. on cerebral infarct induced by ischemia-reperfusion in rats. Am J Chin Med. 2005;33:425-38 pubmed
    ..This effect of SJ involves its suppressive action of microglia, interleukin-1beta and apoptosis...
  69. Hseu Y, Wu C, Chang H, Kumar K, Lin M, Chen C, et al. Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis. J Ethnopharmacol. 2011;135:762-71 pubmed publisher
    ..In this study, the ability of P. angulata to inhibit tumor metastasis and angiogenesis was investigated...
  70. Hsu J, Kao S, Tu C, Li Y, Wang C. Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes. J Agric Food Chem. 2009;57:8628-34 pubmed publisher
  71. Hseu Y, Chang W, Chen C, Liao J, Huang C, Lu F, et al. Antioxidant activities of Toona Sinensis leaves extracts using different antioxidant models. Food Chem Toxicol. 2008;46:105-14 pubmed
    ..Our findings suggest that T. sinensis may act as a chemopreventative agent, providing antioxidant properties and offering effective protection from atherogenesis. ..
  72. Chang Y, Chang H, Tsai C, Lin H, Ho T, Ye C, et al. Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration. BMC Complement Altern Med. 2017;17:184 pubmed publisher
    ..We provide positive results that demonstrate that Alpinia oxyphylla Miq. fruits facilitate the survival and proliferation of RSC96 cells via insulin-like growth factor-1 signaling. ..
  73. Chang M, Huang H, Chang H, Chang T. Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin. Arch Dermatol Res. 2008;300:317-23 pubmed publisher
    ..68 +/- 0.79% for emulsion LES5.00. Taken together, our data demonstrate that LES is more effective in increasing skin humidity and decreasing the TEWL values, indicating the potential skin care effects of LES...
  74. Wu C, Mulabagal V, Nalawade S, Chen C, Yang T, Tsay H. Isolation and quantitative analysis of cryptotanshinone, an active quinoid diterpene formed in callus of Salvia miltiorrhiza BUNGE. Biol Pharm Bull. 2003;26:845-8 pubmed
    ..2 mg l(-1) BA for 60 d. Cryptotanshinone was isolated from callus through silica gel column chromatography followed by preparative TLC and characterized based on NMR and mass spectral data. ..
  75. Hsieh M, Peng W, Wu C, Ng K, Cheng C, Xu H. Review on experimental research of herbal medicines with anti-amnesic activity. Planta Med. 2010;76:203-17 pubmed publisher
    ..Developing new drugs from herbal medicines for the treatment of amnesia is a hopeful attempt to meet the unmet medical needs. ..
  76. Yang J, Wu C, Kuo C, Yeh C, Chueh F, Hsu C, et al. Solanum lyratum extract affected immune response in normal and leukemia murine animal in vivo. Hum Exp Toxicol. 2010;29:359-67 pubmed publisher
    ..Therefore, the SLE treatment increased macrophage and NK cell activities. These consistent results indicate SLE could be a potent immune responses agent...
  77. Wang Y, Huang K. In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells. Food Chem Toxicol. 2013;53:376-83 pubmed publisher
    ..pylori-infected MKN45 cells. The compound shows great potential as a candidate agent for the inhibition of H. pylori-induced extensive gastric epithelial cell inflammation. ..
  78. Hung G, Li P, Lee H, Chang H, Chien C, Lee K. Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat. J Formos Med Assoc. 2012;111:550-9 pubmed publisher
    ..We evaluated the long-term effects of green tea extract (GTE) supplementation on oxidative stress, biliary acute phase protein expression, and liver function in CCl(4)-induced chronic liver injury...
  79. Chao D, Lin L, Hsiang C, Li C, Lo H, Liang J, et al. Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes. Phytother Res. 2011;25:1018-23 pubmed publisher
    ..In conclusion, EVO inhibited the AP-1 activity and cellular transformation in human hepatocytes, suggesting that EVO was a potential agent for antitumor therapy. ..
  80. Chu C, Lee M, Liao C, Lin W, Yin Y, Tseng T. Inhibitory effect of hot-water extract from dried fruit of Crataegus pinnatifida on low-density lipoprotein (LDL) oxidation in cell and cell-free systems. J Agric Food Chem. 2003;51:7583-8 pubmed
    ..5-1.0 mg/mL in the cell-free system and at 0.01-0.10 mg/mL in the cell system. Furthermore, it was found that CF-H decreased the SNP-induced cell lipid peroxidation and reduced glutathione depletion...
  81. Hsieh C, Lin Y, Ko W, Peng C, Huang C, Peng R. Inhibitory effect of some selected nutraceutic herbs on LDL glycation induced by glucose and glyoxal. J Ethnopharmacol. 2005;102:357-63 pubmed
    ..45% efficiency on AGEs induced by glucose. We conclude that PE virtually is a potent antiglycative agent, which can be of great value in the preventive glycation-associated cardiovascular and neurodegenerative diseases...