Experts and Doctors on microbial sensitivity tests in Tainan, Taiwan


Locale: Tainan, Taiwan
Topic: microbial sensitivity tests

Top Publications

  1. Yan J, Chiou C, Lauderdale T, Tsai S, Wu J. Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan. Emerg Infect Dis. 2005;11:947-50 pubmed
    ..All isolates resistant to extended-spectrum cephalosporins carried blaCMY-2, and all ciprofloxacin-resistant Salmonella enterica serotype Choleraesuis isolates were genetically related. ..
  2. Chen P, Ko W, Wu C. Complexity of ?-lactamases among clinical Aeromonas isolates and its clinical implications. J Microbiol Immunol Infect. 2012;45:398-403 pubmed publisher
    ..e., AmpC ?-lactamases and metallo-?-lactamases) and acquired extended-spectrum ?-lactamases in aeromonads are reviewed, and the clinical implications of the complexity of ?-lactamases are discussed. ..
  3. Toh H, Tay H, Kuar W, Weng T, Tang H, Tan C. Risk factors associated with Sphingomonas paucimobilis infection. J Microbiol Immunol Infect. 2011;44:289-95 pubmed publisher
    ..Multivariate analysis showed that community-acquired infection, diabetes mellitus, and alcoholism were significant risk factors for primary bacteremia. ..
  4. Lai C, Tan C, Lin S, Liu W, Liao C, Huang Y, et al. Bacteraemia caused by non-freundii, non-koseri Citrobacter species in Taiwan. J Hosp Infect. 2010;76:332-5 pubmed publisher
    ..Non-freundii and non-koseri Citrobacter species are difficult to identify and are a rare cause of intra-abdominal infections with secondary healthcare-associated bacteraemia in immunocompromised patients. ..
  5. Lai C, Liu W, Ko W, Chen Y, Tan H, Huang Y, et al. Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species. Antimicrob Agents Chemother. 2011;55:2084-91 pubmed publisher
    ..The results of this in vitro study suggest that nemonoxacin, linezolid, and tigecycline are promising treatment options for nocardiosis. Further investigation of their clinical role is warranted...
  6. Pelliccia S, Wu Y, Coluccia A, La Regina G, Tseng C, Famiglini V, et al. Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities. J Enzyme Inhib Med Chem. 2017;32:1091-1101 pubmed publisher
    ..These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases. ..
  7. Yan J, Ko W, Wu J. Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45:2368-71 pubmed publisher
    ..There are four nucleotide differences between bla(IMP-2) and bla(IMP-8), resulting in two amino acid differences. bla(IMP-8) was also found to be carried by an integron-borne gene cassette similar to the bla(IMP-2) cassette...
  8. Chien J, Chiu W, Chien S, Chiang C, Yu C, Hsueh P. Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates. Antimicrob Agents Chemother. 2016;60:2090-6 pubmed publisher
  9. Chien J, Lai C, Tan C, Chien S, Yu C, Hsueh P. Decline in rates of acquired multidrug-resistant tuberculosis after implementation of the directly observed therapy, short course (DOTS) and DOTS-Plus programmes in Taiwan. J Antimicrob Chemother. 2013;68:1910-6 pubmed publisher
    ..01) and treatment without DOTS (80% versus 44% for TDR-TB and non-TDR-TB, P?=?0.18) were risk factors for TDR-TB. DOTS and DOTS-Plus are both effective at preventing the acquisition of MDR-TB in Taiwan. ..

More Information


  1. Lee C, Chang C, Hong M, Hsu H, Ko W. Different impact of the appropriateness of empirical antibiotics for bacteremia among younger adults and the elderly in the ED. Am J Emerg Med. 2013;31:282-90 pubmed publisher
    ..To investigate the clinical impact of age on bacteremia among adults visiting the emergency department (ED)...
  2. Li C, Lee S, Chieh P, Lin C, Wang Y, Chan M. Arabidopsis root-abundant cytosolic methionine sulfoxide reductase B genes MsrB7 and MsrB8 are involved in tolerance to oxidative stress. Plant Cell Physiol. 2012;53:1707-19 pubmed publisher
    ..Transgenic plants overexpressing MsrB7 or MsrB8 were viable and survived after MV and H(2)O(2) treatment. Ectopic expression of specific cytosolic MsrB genes may be useful for application in crop improvement. ..
  3. Lai C, Hsu H, Tan C, Tsai H, Cheng A, Liu C, et al. Recurrent bacteremia caused by the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J Clin Microbiol. 2012;50:2982-6 pubmed publisher
    ..Molecular methods to identify the ACB complex to the genospecies level are essential for differentiating between reinfection and relapse of bacteremia caused by the ACB complex. ..
  4. Chung C, Cheng I, Chen H, Kan H, Yang W, Chang H. Screening of antibiotic susceptibility to ?-lactam-induced elongation of Gram-negative bacteria based on dielectrophoresis. Anal Chem. 2012;84:3347-54 pubmed publisher
  5. Wu C, Chen P, Wu J, Yan J, Lee C, Lee H, et al. Distribution and phenotypic and genotypic detection of a metallo-?-lactamase, CphA, among bacteraemic Aeromonas isolates. J Med Microbiol. 2012;61:712-9 pubmed publisher
    ..In conclusion, the distribution of cphA among aeromonads is species-specific, found in A. aquariorum, A. veronii and A. hydrophila, and the MHT may be a phenotypic screening test for CphA production...
  6. Yang F, Yan J, Hung K, Wu J. Characterization of ertapenem-resistant Enterobacter cloacae in a Taiwanese university hospital. J Clin Microbiol. 2012;50:223-6 pubmed publisher
    ..cloacae. The presence of IMP-8 may also play a partial role in ertapenem resistance in Taiwan...
  7. Liu W, Lai C, Ko W, Chen Y, Tang H, Huang Y, et al. Clinical and microbiological characteristics of infections caused by various Nocardia species in Taiwan: a multicenter study from 1998 to 2010. Eur J Clin Microbiol Infect Dis. 2011;30:1341-7 pubmed publisher
    ..Molecular methods for identifying Nocardia to the species level are mandatory for better understanding the epidemiology and clinical characteristics of patients with nocardiosis...
  8. Lai C, Wang C, Chu C, Tan C, Lu C, Lee Y, et al. Correlation between antibiotic consumption and resistance of Gram-negative bacteria causing healthcare-associated infections at a university hospital in Taiwan from 2000 to 2009. J Antimicrob Chemother. 2011;66:1374-82 pubmed publisher
    ..The relationship between antibiotic prescription and the rates of resistance for Gram-negative bacteria is complicated; every type of antimicrobial agent or even individual agent can have distinct associations with different pathogens. ..
  9. Huang S, Sheu B, Lee S, Yang H, Yang Y. Etiology and treatment of childhood peptic ulcer disease in Taiwan: a single center 9-year experience. J Formos Med Assoc. 2010;109:75-81 pubmed
    ..In children, H. pylori-related PUD is associated with familial peptic ulcer and the presence of DU. However, short-term NSAID use is correlated highly with GU. The outcome of childhood PUD is good. ..
  10. Chi C, Wang S, Lin C, Liu C. Microbiological characteristics of community-associated Staphylococcus aureus causing uncomplicated bacteremia and infective endocarditis. J Clin Microbiol. 2010;48:292-4 pubmed publisher
    ..No significant differences in distribution or frequency of genes encoding virulence factors, including genes encoding adhesins, were found between isolates from the IE and SAB groups (12 IE and 10 SAB patients). ..
  11. Chen P, Hsieh Y, Lee H, Ko N, Lee N, Wu C, et al. Suboptimal therapy and clinical management of gonorrhoea in an area with high-level antimicrobial resistance. Int J STD AIDS. 2009;20:225-8 pubmed publisher
    ..In conclusion, It is crucial to develop treatment guidelines according to regional antimicrobial resistances and educational programmes to improve clinical care for genital gonococcal diseases. ..
  12. Wu J, Ko W, Tsai S, Yan J. Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. Antimicrob Agents Chemother. 2007;51:1223-7 pubmed publisher
    ..cloacae isolates in the hospital may be due mainly to the intrahospital spread of a few clones and the dissemination of plasmids containing both qnrB and blaIMP-8...
  13. Su B, Tang H, Wang Y, Liu Y, Ko W, Liu C, et al. In vitro antimicrobial effect of cefazolin and cefotaxime combined with minocycline against Vibrio cholerae non-O1 non-O139. J Microbiol Immunol Infect. 2005;38:425-9 pubmed
    ..cholerae non-O1 non-O139 was inhibited over 48 h and no regrowth was noted. We conclude that the combination of cefazolin or cefotaxime with minocycline has a synergistic inhibitory effect on V. cholerae non-O1 non-O139 in vitro...
  14. Huang S, Lee H, Lee N, Liu K, Ko W. Clinical characteristics of invasive Haemophilus aphrophilus infections. J Microbiol Immunol Infect. 2005;38:271-6 pubmed
    ..aphrophilus infection. Appropriate antimicrobial therapy, such as a beta-lactam/beta-lactamase inhibitor, ceftriaxone or cefotaxime or a fluoroquinolone, can lead to a favorable clinical outcome...
  15. Yan J, Ko W, Chuang C, Wu J. Metallo-beta-lactamase-producing Enterobacteriaceae isolates in a university hospital in Taiwan: prevalence of IMP-8 in Enterobacter cloacae and first identification of VIM-2 in Citrobacter freundii. J Antimicrob Chemother. 2002;50:503-11 pubmed
    ..Ribotyping of the IMP-8-producing E. cloacae isolates indicated that the dissemination of bla(IMP-8) was due largely to the spread of an epidemic clone, but horizontal transfer among unrelated strains also occurred...
  16. Wu J, Wang L, Liu Y, Chen H, Yan J. Prevalence and characteristics of ertapenem-resistant Klebsiella pneumoniae isolates in a Taiwanese university hospital. Microb Drug Resist. 2011;17:259-66 pubmed publisher
    ..In conclusion, the increasing prevalence of ertapenem resistance that was predominantly attributed to noncarbapenemase-mediated resistance mechanisms in K. pneumoniae is becoming a serious treat to patients in Taiwan. ..
  17. Chu Y, Wang Y, Wu J, Lei H. Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance. Infect Immun. 2010;78:4157-65 pubmed publisher
    ..The multiplication of H. pylori within cells provides a niche for its resistance to antibacterial therapy and has a significant impact on its biological life cycle. ..
  18. Ko W, Hsueh P. Increasing extended-spectrum beta-lactamase production and quinolone resistance among Gram-negative bacilli causing intra-abdominal infections in the Asia/Pacific region: data from the Smart Study 2002-2006. J Infect. 2009;59:95-103 pubmed publisher
    ..The Study for Monitoring Antimicrobial Resistance Trends (SMART) was intended to reveal the evolving profiles of antimicrobial resistance among Gram-negative pathogens causing intra-abdominal infections (IAIs)...
  19. Ko W, Lee N, Su S, Dijkshoorn L, Vaneechoutte M, Wang L, et al. Oligonucleotide array-based identification of species in the Acinetobacter calcoaceticus-A. baumannii complex in isolates from blood cultures and antimicrobial susceptibility testing of the isolates. J Clin Microbiol. 2008;46:2052-9 pubmed publisher
    ..calcoaceticus-A. baumannii complex emphasize that the differentiation of species within the complex is relevant from a clinical-epidemiological point of view. ..
  20. Yan J, Hsueh P, Lu J, Chang F, Ko W, Wu J. Characterization of acquired beta-lactamases and their genetic support in multidrug-resistant Pseudomonas aeruginosa isolates in Taiwan: the prevalence of unusual integrons. J Antimicrob Chemother. 2006;58:530-6 pubmed
    ..aeruginosa isolates in Taiwan. The spread of bla(VIM-2)-related genes by horizontal transfer might have occurred. ..