Experts and Doctors on diterpenes in Tainan, Taiwan
Locale: Tainan, Taiwan
Kuo P, Damu A, Lee K, Wu T. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem. 2004;12:537-44 pubmed
..The thorough studies on the stereochemistry of the different quassinoid diterpenoids provide a clear reference to the scientists who are interested on this field...
Su C, Ueng Y, Dung N, Vijaya Bhaskar Reddy M, Wu T. Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007;70:1930-3 pubmed
..Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively...
Shi M, Lin H, Lee Y, Chao J, Lin R, Chen J. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chem Biol Interact. 2008;174:201-10 pubmed publisher
Su C, Chen Y, Liou M, Tsai H, Chang W, Wu T. Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria. Bioorg Med Chem. 2008;16:9603-9 pubmed publisher
..The inhibitory effects of these compounds are dose-dependent (1-4 microg/ml)...
Lai C, Lee J, Ho C, Liu C, Wang J, Wang Y, et al
. Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. J Agric Food Chem. 2009;57:10990-8 pubmed publisher
..Taken together, rosmanol might contribute to the potent anti-inflammatory effect of rosemary and may have potential to be developed into an effective anti-inflammatory agent. ..
Cheng A, Lee M, Tsai M, Lai C, Lee J, Ho C, et al
. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem Toxicol. 2011;49:485-93 pubmed publisher
..These results demonstrate that the rosmanol-induced apoptosis in COLO 205 cells is involvement of caspase activation and involving complicated regulation of both the mitochondrial apoptotic pathway and death receptor pathway. ..
Liang C, Wang G, Chou T, Wang S, Lin R, Chan L, et al
. 5-epi-Sinuleptolide induces cell cycle arrest and apoptosis through tumor necrosis factor/mitochondria-mediated caspase signaling pathway in human skin cancer cells. Biochim Biophys Acta. 2012;1820:1149-57 pubmed publisher
..This is the first report suggesting that the apoptosis mediates the anti-tumor effect of 5-epi-sinuleptolide. The results of this study might provide useful suggestions for designing of anti-tumor drugs for skin cancer patients. ..
Lee C, Kao C, Kao S, Chang C, Su J, Hwang T, et al
. Terpenoids from the octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Mar Drugs. 2012;10:427-38 pubmed publisher
..The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils. ..